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Published by Antis Publisher
ISSN : -     EISSN : 30321085     DOI : https://doi.org/10.61796/jmgcb.v1i1
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology
The European Journal of Medical Genetics and Clinical Biology is a peer-reviewed journal that publishes articles in English on various aspects of human and medical genetics, the genetics of experimental models, and developmental anomalies. Original clinical and experimental research articles, short clinical reports and review articles are welcome on topics such as: Clinical genetics and genomics, including neurodevelopmental disorders and single or multiple malformations syndromes and dysmorphology; Inherited predisposition to cancer: rare inherited cancer predisposition syndromes and biology and pathophysiology of inherited cancers; Fetal medicine and prenatal diagnosis, including prenatal diagnosis, prenatal screening, fetal therapies and teratology; Diagnostic methods including sequencing studies (gene level), transcriptome studies, methylome and other Omics technologies, variant interpretation and functional validation; Bioinformatics and statistical methods in genetics; Personalized Medicine and therapies, including gene therapy and gene editing, non-genetic treatment of genetic disease, pharmacogenetics and genomics, theranostics and clinical trials; Molecular biology and pathophysiology of genetic and genomic diseases: biology of cell, pathways and systems, epigenetics and gene regulation, biology and pathophysiology of specific genes and non-coding DNA; Genetics and variants in populations: carrier screening, population genetics, evolutionary genetics, genetic epidemiology of diseases, genome variation and architecture in normal population;
Arjuna Subject : Biokimia, Genetika dan Biologi Molekuler - Biokimia, Genetika dan Biologi Molekuler (Lain-Lain)
Articles 223 Documents
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Assessment of the Biochemical Status of Women in Labor with Preeclampsia Yuldasheva Gulnoz Giozovna; Rustamov Bakhtiyor Bobokulovich
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 1 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT ANTIS INTERNATIONAL PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i1.68

Abstract

This review presents the results of scientific work on the study of the immuno-biochemical status of women in labor with preeclampsia. Indicators of developing problems in the body of a pregnant woman are changes in the biochemical composition of the blood, which make it possible to predict maladaptation syndrome in newborns.
Clinicоfunctional Efficacy of Complex Treatment of Chronic Adenoiditis Using Phototherapy Ikramova F. S.; Alimova Sh. A.
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 1 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT ANTIS INTERNATIONAL PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i1.69

Abstract

In the period from 2021 to 2022, we examined 70 children who applied to the Bukhara Regional Children's Multidisciplinary Medical Center ENT department. The age distribution was as follows: children of the first year (7 months to 11 months) – 2 (3%), early age (from 1 to 2 years) – 16 (22.8%), preschool (3 l – 6 years) - 33 (47.2%) and school age (7 l – 11 years old) – 19 (27.3%) children. Patients of preschool age (from 3 to 6 years, 47.2%) prevailed among the patients. The use of the method of complex low-frequency ultrasound therapy of chronic adenoiditis with rhinosinusitis in children reduces the duration of treatment by 40%, increases its effectiveness by 4 times and increases the proportion of recoveries 3 times for immediate and 4 times for long-term results compared with traditional treatment and eliminates tubar dysfunction and snoring 5 times faster and normalizes nasal breathing 3 times faster than with traditional treatment, improving the indicators of anterior active rhinomanometry in total volume flow 4 times, and in total resistance 20 times, which indicates adequate inclusion of hypertrophied pharyngeal tonsil to the zone of therapeutic effect of the new method.
Perception of Medical Error Among Resident Doctors at the University College Hospital (Uch), Ibadan Tawose Oluwatomisin Victoria; Alawale Oluwabukola; Ayinde Abayomi Oluwasegun; Abbas Olaniyi Gbolahan; Aknifemi Akinyode
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 1 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT ANTIS INTERNATIONAL PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i1.109

Abstract

To enhance the standard of patient care, it is necessary to look into the complex issue of resident doctors' perceptions of medical error at tertiary hospitals. To foster a culture of safety in medical practice, medical mistake must be addressed in Nigeria, where it is a major contributor to patient mortality and morbidity. Therefore, this study aimed to determine the perception of medical error among resident doctors in the University College Hospital, Ibadan. In order to choose a sample of 302 resident doctors from a pool of 515 at the University College Hospital (UCH), a two-stage sampling approach was used. The research methodology used in this study was a cross-sectional survey employing a pretested self-administered semi-structured questionnaire. At the 0.05 level of significance, data were analyzed using descriptive statistics as well as inferential statistics like chi-square 228 (75.5%) of the responders were men, and 74 (24.5%) were women. Approximately 33.4% of the respondents were pre-part 1, 64.9% of resident doctors were post-part 1, and 1.7% were post-part 2 of their fellowship tests. The majority of responders (82.1%) had between one and three years of resident doctor experience. A majority (70.2%) of the respondents reported that misdiagnosis generally often occur in a medical setting. About 40.4% of the respondents said that delayed diagnosis is the most common type of medical error in the institution. There was a statistical significant association between the frequency of occurrence of delayed diagnosis and the departments of the resident doctors (X²=16.892, P<0.001). A majority (62.3%) of respondents reported that high work load, ill-equipped facility, work environment, patient factor and institutional factors influence their daily medical practice. Most (88.1%) of the respondents believed prevention of medical error is very crucial in the healthcare system. About 31.5% of the respondents indicated that continuous education on preventing and managing medical error was not adequately provided for resident medical doctors. The institution needs to invest in better-equipped facilities that will support high-quality patient care, continue medical education to advance medical knowledge and skills related to medical error, deploy more medical personnel to lessen the burdensome workload on current staff members, and establish proactive error avoidance strategies for the management of medical malpractice. This will thus improve the quality of healthcare delivery and reinforce possible standards of care that are evidence-based against medical error.
Surgical Treatment of Picevodogasteric Bleeding in Patients with Liver Cirrhosis Niyazmetov Atanazar
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 1 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT ANTIS INTERNATIONAL PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i1.141

Abstract

A little more than half a century has passed since the fundamental ideas about the morphological types of such liver lesions as hepatitis, hepatosis, cirrhosis were formed (Bluger A.F., Novitsky I.N., 1984), Subsequent morphological studies have established that LC- it is the result of a pathological reconstruction of the lobular structure of the organ. From a clinical point of view, cirrhosis can be defined as a progressive (or slowly progressive) diffuse chronic polyetiologic liver disease. This is the final stage of adversely occurring forms of chronic hepatitis, due to obstruction of the outflow of bile or blood from the liver or genetically determined metabolic defects. The disease is characterized by a significant decrease in the mass of functioning liver cells, a pronounced fibrosing reaction, a restructuring of the parenchyma and the vasculature of the liver (Loginov A.S., 1987).
Modern Non-Steroidal Anti-Inflammatory Drugs Bekchanov Bakhtiyar Gafurovich; Masharipov Otaboy Olimovich; Komilova Dilrabo Rakhimboy qizi; Masharipov Ogabek Atabaevich
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 1 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT ANTIS INTERNATIONAL PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i1.142

Abstract

Over the past decade, employees of the departments of pharmacology, general and bioorganic chemistry of the Tashkent State Medical Institute (since 1990, I Tashkent State Medical Institute) have been conducting targeted research to find, study new, more advanced anti-inflammatory drugs in a number of new pyrazole derivatives and related compounds (in general, nutrition more than 300 new drugs were exposed). These studies revealed a number of highly active and low-toxic compounds, and also established the dependence of the anti-inflammatory activity of these compounds on the chemical structure.
Analysis Database Systems and Solve Medical Problems Rakhimov Bakhtiyar Saidovich; Rakhimova Feroza Bakhtiyarovna; Saidova Zarina Bakhtiyar Qizi
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 1 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT ANTIS INTERNATIONAL PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i1.143

Abstract

Due to this mechanism, threshold synchronization is achieved with a minimum amount of time. It is usually designed for communication between scalar processors via shared memory. The main function of graphics processors since their inception has been graphics processing. Subsequently, after it became possible to program the processing of model vertices and pixels of rendered three-dimensional scenes using special programs (shaders), the architecture of graphic processors changed significantly. After the advent of the first general-purpose programmable graphics it became possible to process commands not only for graphic data in vector form, but also to perform ordinary calculations for arbitrary data on a variety of special cores, while implementing data parallelism.
Effect of Dry Extracts of Medicinal Plants on Urinary Excretion and Ion Exchange Djanaev G. Yu.; Makhsumov Sh. M.; Zaytseva O. A.; Khudayberdiev Kh. I.; Askarov O. O.
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 1 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT ANTIS INTERNATIONAL PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i1.147

Abstract

According to the results of an experimental scientific study, in relatively small doses of dry extracts of the studied plants (100 μg/kg + 50 mg/kg), the average urinary excretion was 61.9% compared to the control group, and in large doses (250 μg + 100 mg/kg) was found to increase by 73.8%. Therefore, when plant extracts are used in the studied doses, their effect on urine excretion remains at full blood level.
Applications of Physics in Diagnostic Imaging Kholmatov Jasurbek Abdikhoshimovich; Askarov Osim Olimdjanovich; Hansie Pilania; Kunal Vijay Kawale
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 1 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT ANTIS INTERNATIONAL PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i1.150

Abstract

This article will explore the various ways in which physics is applied in diagnostic imaging, with a focus on X-ray, computed tomography (CT), magnetic resonance imaging (MRI), and ultrasound. Diagnostic imaging has become a cornerstone of modern medicine, since the advent of radiography. Over the years, various diagnostic imaging techniques have been developed, each with its indications and contraindications. However, all diagnostic imaging techniques have one underlying commonality: they rely on the fundamental principles of physics. Consequentially, it becomes of further importance to know and understand the concepts of applied physics, to produce better healthcare professionals.
Investigation of Preventive Practices and Perception of Cervical Cancer Among Female Students at the Polytechnic In Ibadan, Oyo State Ayinde Abayomi Oluwasegun
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 1 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT ANTIS INTERNATIONAL PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i1.173

Abstract

The objective of this study is to determine the perception of female students of the polytechnic of Ibadan, Oyo State, towards cervical cancer and preventive. A cross-sectional study design was used to determine the above objective. The survey included 429 female students who lived on the Polytechnic Ibadan campus. A systematic sampling technique was used to choose 210 rooms out of a total of 420 rooms, and all of the selected rooms' occupants were questioned under the premise that there were two people in each room. Data were gathered using a self-administered questionnaire that had been pretested. Respondents with one or more risk factors were classified as being at a higher risk for cervical cancer and those with no risk factors as being at a lower risk. Data was analyzed using descriptive statistics and Chi square test at p<0.05. Mean age of respondents was 24.2±3.7 years. More than half (60.3%) had good knowledge about cervical cancer and 55.1% had a good perception of cervical cancer. The identified risk factors were sexual debut before the age of 18 years (25.1%) multiple sexual partnering (11.6%), unprotected sexual intercourse (59.2%) and positive family history of cervical cancer (2.2%). Majority of the respondents (96.9%) were at a higher risk for developing cervical cancer. Few respondents (8.0%) had ever heard of the pap smear test and the major sources of information were the internet (33.3%) and hospital (25%). The uptake of pap smear test was low (1.8%). Majority of the respondents (71.9%) were not aware of where the pap smear test could be done. Only 4.7% were willing to receive the human papilloma virus (HPV) vaccine, while 5.1% were willing to do a pap smear test. The major reasons cited for not wanting to do the pap smear test was lack of perceived need for the test (13.4%) and financial constraint (1.5%). Respondents who were 25 years and below and single were more likely to have a good perception of cervical cancer. Those aged <30 years (OR 1.39, 95% CI 0.34-5.66), single (OR 1.07, 95% CI 0.45-2.50), those from faculty of science (OR 1.22, 95% CI 0.57-2.58) and those that had low risk score (OR 2.66, 95% CI 0.54-12.98) were likely to have a good perception of cervical cancer. Even though respondents had a fair amount of awareness about cervical cancer, they nevertheless exhibited significant behavioral risk factors for the condition. The pap smear test had very poor awareness and uptake. Therefore, it is necessary to develop health communication initiatives that would motivate tertiary students to apply their learning to prevent cervical cancer.
Locally Advanced Prostate Cancer at High Risk of Progression: A Treatment Strategy, A Review of Clinical Studies M. S. Salomov
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 2 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT ANTIS INTERNATIONAL PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i2.197

Abstract

The clinician doctors should be decided the difficult task of determining the exact stage of prostate cancer. This concerns, first of all, stage T3 - or locally progressive, the presence of which indicates that the tumor is spreading beyond the capsule. Prostate cancer is the most common solid tumor in Europe, with an incidence rate of 214 cases per 1,000 men, which is higher than for lung and colorectal cancers [3]. In 2013, prostate cancer ranked 3rd in the structure of oncological diseases in men in Russia, 29,158 new cases of the disease were recorded, 9,535 patients died from prostate cancer. Over the past 5 years, the number of patients with PCa in our country has increased, in particular, in 2015 - 372, in 2016 - 443, in 2019 the number of patients reached 483 (an increase of 23%). There is also an increase in the incidence, which in 2015 amounted to 1.2 patients per 100 thousand of the population, in 2019 this figure was 1.5. (Tillyashaikhov M.N. et al., 2020). The optimal therapy for patients with clinically locally progressive prostate cancer has not been finally determined, and the tactics of treating these patients cause a lively discussion. Many controversial issues regarding the choice of a particular method remain unresolved.

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