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JMGCB
Published by Antis Publisher
ISSN : -     EISSN : 30321085     DOI : https://doi.org/10.61796/jmgcb.v1i1
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology
The European Journal of Medical Genetics and Clinical Biology is a peer-reviewed journal that publishes articles in English on various aspects of human and medical genetics, the genetics of experimental models, and developmental anomalies. Original clinical and experimental research articles, short clinical reports and review articles are welcome on topics such as: Clinical genetics and genomics, including neurodevelopmental disorders and single or multiple malformations syndromes and dysmorphology; Inherited predisposition to cancer: rare inherited cancer predisposition syndromes and biology and pathophysiology of inherited cancers; Fetal medicine and prenatal diagnosis, including prenatal diagnosis, prenatal screening, fetal therapies and teratology; Diagnostic methods including sequencing studies (gene level), transcriptome studies, methylome and other Omics technologies, variant interpretation and functional validation; Bioinformatics and statistical methods in genetics; Personalized Medicine and therapies, including gene therapy and gene editing, non-genetic treatment of genetic disease, pharmacogenetics and genomics, theranostics and clinical trials; Molecular biology and pathophysiology of genetic and genomic diseases: biology of cell, pathways and systems, epigenetics and gene regulation, biology and pathophysiology of specific genes and non-coding DNA; Genetics and variants in populations: carrier screening, population genetics, evolutionary genetics, genetic epidemiology of diseases, genome variation and architecture in normal population;
Arjuna Subject : Biokimia, Genetika dan Biologi Molekuler - Biokimia, Genetika dan Biologi Molekuler (Lain-Lain)
Articles 223 Documents
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TACTICS AND TREATMENT FOR ACUTE ANAEROBIC PARAPROCTITIS Sherkulov K.U.; Bobokulov A.U; Usmonkulov M.K.; Babakulova F.U.
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 2 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT ANTIS INTERNATIONAL PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i2.278

Abstract

Acute paraproctitis is the most complex form of purulent inflammatory processes. When local clinical manifestations of the disease are mild, such patients are often misdiagnosed, which often leads to untimely and sometimes incorrect surgical treatment. Acute horseshoe-shaped paraproctitis, despite treatment, often ends in the formation of a complex horseshoe-shaped fistula and purulent cavities and leaks.
IS GAZIDAN ZAHARLANISH — ALOMATLARI, BIRINCHI YORDAM, DAVOLASH VA OLDINI OLISH Xodjamqulova Subhida Nizom qizi; Nuraliyeva Sitora Shokir qizi; Mingboyeva Nilufar Anvar qizi; Rayimnazarov Shaxzot Muxiddin o‘g‘li; O‘rozaliev Bahrombek Xolmirza o‘g‘li
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 2 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT ANTIS INTERNATIONAL PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i2.289

Abstract

Ushbu maqolada is gazidan zaharlanish haqida batafsil ma’lumotlar keltirib o‘tilgan, jumladan is gazidan zaharlanganda insonda kuzatiladigan alomatlari, birinchi yordam ko‘rsatish, davolash hamda zaharlanishni oldini olish haqida ma’lumotlar keltirilgan.
INFLUENCE OF TYPE 2 DIABETES ON THE FUNCTION OF THE CENTRAL NERVOUS SYSTEM Djuraeva Zilola Aramovna; Boltayeva Muxlisa; Elliyeva Elnura; Choriyev Ramziddin
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 2 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT ANTIS INTERNATIONAL PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i2.290

Abstract

Diabetes mellitus (DM) is a global health problem that affects all age groups, races and ethnicities[1,3,4]. Currently, about 177 million people worldwide suffer from this disease[33,34]. According to WHO forecast, the number of patients with diabetes will increase to 300 million people by 2025[2,5,6]. Non-insulin-dependent diabetes mellitus (NIDDM) is the most common and accounts for about 90% of diabetes cases[7,8,9].
FEATURES OF THE COURSE OF DIABETIC NEUROSTEOARTHROPATHY IN PATIENTS WITH TYPE 2 DIABETES MELLITUS Djuraeva Zilola Aramovna; Asliddinova Sevara; Qodirova Feruza; Valijonova To`maris
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 2 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT ANTIS INTERNATIONAL PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i2.291

Abstract

Diabetic neuroosteoarthropathy (DNOA, Charcot foot) is a relatively rare complication of diabetes mellitus (DM), which can lead not only to impaired support function of the lower limb in such patients, but also to high amputation. DNOAP is characterized by persistent aseptic inflammation of the bone structures of the foot, which creates significant difficulties in planning treatment measures[1,2,3,4]. In the medical literature, there is data demonstrating the role of individual cytokines and neurohumoral factors in the prolongation of the inflammatory process in diabetes, however, studies identifying significant markers Aseptic inflammation with DNOAP is currently extremely rare[5,6,7].
REPRODUCTIVE CHANGES IN WOMEN WITH PREMATURE OVARIAN FAILURE Boboxonova Muhayyoxon Mo‘minjonovna
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 2 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT ANTIS INTERNATIONAL PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i2.292

Abstract

Failure to become pregnant after therapy forces the patient to use assisted reproductive technologies using donor embryos and oocytes, while the effectiveness of in vitro fertilization does not exceed 58%. To prevent this outcome, if a woman has risk factors for developing premature ovarian failure, it is necessary to timely assess the ovarian reserve with the preservation of her own oocytes for subsequent assisted reproductive technologies.
REPRODUCTIVE CHANGES IN WOMEN WITH PREMATURE OVARIAN FAILURE Boboxonova Muhayyoxon Mo‘minjonovna
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 2 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT ANTIS INTERNATIONAL PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i2.294

Abstract

Failure to become pregnant after therapy forces the patient to use assisted reproductive technologies using donor embryos and oocytes, while the effectiveness of in vitro fertilization does not exceed 58%. To prevent this outcome, if a woman has risk factors for developing premature ovarian failure, it is necessary to timely assess the ovarian reserve with the preservation of her own oocytes for subsequent assisted reproductive technologies.
Complications of arterial hypertension Usmonov Jamshidbek Rustamjon oʻgʻli
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 2 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT ANTIS INTERNATIONAL PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i2.319

Abstract

Complications of arterial hypertension (AH), beginning to show a direct relationship with the level of blood pressure 145/95 mm Hg. Art., for many decades are the leading cause of death among all causes of death. Arterial hypertension, without a doubt, is the leading medical and social problem of our time, the role of which in mortality and disability of people continues to grow, despite the great attention paid to this problem by the scientific community, practitioners and authorities. Against the backdrop of growing knowledge and progress in the field of pharmacology and therapy of hypertension, the frequency of achieving target blood pressure today in the United States and European countries has stabilized by 25-34%, in Russia in the 1990s. was - in men 5.7%, in women - 17.5%, decreasing with age[2]. According to the National Guidelines for the Prevention, Diagnosis and Treatment of Arterial Hypertension (draft) in Russia in 2006, this indicator slightly improved (21.5%)[2, 4]. Apparently, it is within these limits that one can speak of the limit of population possibilities of the unconditionally dominant drug therapy of hypertensive conditions today.
METHODS OF CORRECTING PSYCHIC DEPRIVATION IN THE PUPILS OF THE “KINDNESS” HOUSE Rustamova Manzura Ne'matjanovna
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 2 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT ANTIS INTERNATIONAL PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i2.326

Abstract

This article will talk about the specific psychological characteristics of the Breeders of the Houses of “kindness”, the tasks set before the state and society in preparing them for an independent life as a full-fledged person. Ham also touched on the work activities of a practical psychologist with children and adolescents brought up in orphanages.
EDUCATIONAL INTERVENTION ON EARLY MOBILIZATION COMPLIANCE AMONG POST-CESAREAN MOTHERS Nidya Comdeca Nurvitriana; Karunia Wijayanti; Devi Maya
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 2 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT ANTIS INTERNATIONAL PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i2.358

Abstract

Many mothers lack awareness of the benefits of early mobilization following caesarean section (post-Sc). This study aimed to assess the influence of educational intervention on early mobilization among post-Sc mothers at RSAD Level III Brawijaya Surabaya, utilizing a pre-experimental design with a single cohort. The sample consisted of 43 mothers who underwent caesarean section from December 2023 to January 2024, selected through purposive sampling. Early mobilization served as the dependent variable, with education as the independent variable. Results revealed a positive shift post-education, with 20 participants (47%) improving from the "good" category to only 2 (5%) post-education. Additionally, 22 respondents (51%) moved to the "sufficient" category, up from 19 (44%) previously. Conversely, the "less" category decreased from 22 (51%) to 1 (3%) post-education. Statistical analysis (ρ=0.001, α=0.05) confirmed significant impact of counseling on early mobilization post-caesarean section, rejecting H0. In conclusion, educational intervention positively affected maternal compliance with early mobilization after caesarean section at RSAD Level III Brawijaya Surabaya. Suggestions include integrating comprehensive early mobilization content into midwife education curriculum.
Estimate of Some Immune-Biomarkers in Children with Entamoeba Histolytica Infection Sunbul Jalal Shakour
Journal of Medical Genetics and Clinical Biology Vol. 1 No. 3 (2024): Journal of Medical Genetics and Clinical Biology
Publisher : PT ANTIS INTERNATIONAL PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61796/jmgcb.v1i3.367

Abstract

The current work was aimed to evaluate of some immune-biomarkers in children with Entamoeba histolytica infection. General stool examination was done to patients for detection of E. histolytica infection. A total 150 patients of less than 13 years, whom attended the parasitology section at period February to June 2023. The chosen patients were suffered from abdominal pain and diarrhea. The results showed that gender is not related to infection with E. histolytica, as there were no significant (P≤0.05) differences between the proportions of males and females. The IgG concentration of infected children (24.05±3.94 ng/L) indicated a significant (P≤0.05) rise compared to the healthy children (11.72±2.55 ng/L). IgA concentration of infected children (159.42±18.62 ng/L) indicated a significant (P≤0.05) rise compared to the healthy children (38.93±7.01 ng/L). IgM concentration of infected children (4.84±0.45 ng/L) indicated a significant (P≤0.05) rise compared to the healthy children (2.17±0.35 ng/L). The IL-4 concentration of infected children (29.47±4.04 pg/ml) indicated a significant (P≤0.05) rise compared to the healthy children (16.54±3.94 pg/ml). IL-6 concentration of infected children (183.25±21.37 pg/ml) indicated a significant (P≤0.05) rise compared to the healthy children (26.12±4.51 pg/ml). The TLR2 levels of infected children (24.05±3.94 ng/L) indicated a significant (P≤0.05) rise compared to the healthy children (11.72±2.55 ng/L). therefore, its concluded that E. histolytica lead to a high immune response that leads to an increase in levels of immune parameters in infected children

Page 5 of 23 | Total Record : 223

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