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Neurona
Published by Perhimpunan Dokter Spesialis Neurologi Indonesia
ISSN : 02166402     EISSN : 25023748     DOI : https://doi.org/10.52386/neurona
Core Subject : Health, Science,
Health Professions Medicine & Pharmacology Neuroscience
Neurona merupakan satu-satunya jurnal yang memuat perkembangan penelitian dan kasus terbaru bidang neurosains oleh Perhimpunan Dokter Spesialis Saraf (PERDOSSI) Pusat di Indonesia. Jurnal ini diterbitkan bulan Maret, Juni, September dan Desember. Bidang studi cakupan NEURONA meliputi: Stroke dan Pembuluh darah Neurotrauma Neuroonkologi Neuro Infeksi Neuro Behavior Neurorestorasi Neuropediatri Gangguan Tidur Nyeri Kepala Neurootologi Neuro Intervensi Neuro Intensif Neurogeriatri Gangguan Gerak Epilepsi Neuro Epidemiologi
Arjuna Subject : Kedokteran - Neurologi Klinis
Articles 12 Documents
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Search results for , issue "Vol 36 No 4 (2019)" : 12 Documents clear
PERDARAHAN INTRASEREBRAL SEBAGAI KOMPLIKASI NEUROLOGI EMBOLI SEPTIK PADA ENDOKARDITIS INFEKTIF: SEBUAH LAPORAN KASUS Mohammad Kurniawan; Salim Harris; Al Rasyid; Taufik Mesiano; Rakhmad Hidayat; Yesi Astri
NEURONA Vol 36 No 4 (2019)
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v36i4.93

Abstract

      INTRACEREBRAL HEMORRHAGE AS A NEUROLOGICAL COMPLICATION OF SEPTIC EMBOLISM IN INFECTIVE ENDOCARDITIS: A CASE REPORTABSTRACTInfective endocarditis (IE) is a life-threatening disease. The incidence of IE in developing countries is reported at 1.7-6.2 per 100,000 individuals per year. IE is also known as a potential condition for embolization, especially septic embolism to the brain. Septic embolism results in various neurological complications and manifestations due to vascular occlusion, aneurysm formation and rupture of the aneurysm. We report a case of 34-year-old male with definitive IE based on Duke criteria who experienced neurological complications of intracerebral bleeding. Patient was given pharmacological treatment according to the guidelines of the American Heart Association (AHA)with improvement in clinical symptoms.Keywords: Infective endocarditis, intracerebral hemorrhage, septic embolismABSTRAKEndokarditis infektif (EI) merupakan penyakit yang mengancam nyawa, walaupun angka kejadiannya kecil, yaitu 1,7-6,2 per 100.000 individu per tahun di negara berkembang. EI juga sangat potensial menyebabkan embolisasi, khususnya emboli septik ke otak. Emboli ini mengakibatkan manifestasi gangguan neurologis yang disebabkan karena oklusi pembuluh pembentukan dan ruptur aneurisma. Dilaporkan kasus seorang laki-laki 34 tahun dengan EI definitif berdasarkan kriteria Duke yang mengalami komplikasi neurologis perdarahan intraserebral. Pasien ditatalaksana sesuai panduan American Heart Association (AHA) dengan perbaikan gejala klinis.Kata kunci: Endokarditis infektif, emboli septik, perdarahan intrakranial  
PERAN SISTEM IMUN TERHADAP TERJADINYA PNEUMONIA TERKAIT STROKE Al Rasyid
NEURONA Vol 36 No 4 (2019)
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v36i4.94

Abstract

THE ROLE OF IMMUNE SYSTEM ON THE OCCURRENCE OF STROKE- ASSOCIATED PNEUMONIAABSTRACTStroke associated pneumonia (SAP) is one of the medical complication which associated with high mortality rate. Several studies conclude two factors involve significantly in pathophysiology of SAP, one of which is immunodepression state. Immunodepression occurs by 3 main pathways, symphathetic system activation, parasymphathetic system activation, and HPA (hypothalamus-pituitary-adrenal)  axis activation. Simultaneously, they induce proinflammatory response suppression and immune cells alternation, which lead to an infection like pneumonia. Therefore, establishing an effective immunomodulation therapy could be one of the main focus in comprehensive stroke management’s future studies.Keywords: Immunodepression, stroke-associated pneumoniaABSTRAKKomplikasi pneumonia terkait stroke menjadi salah satu faktor penyebab mortalitas tertinggi. Studi-studi menyimpulkan bahwa ada dua faktor yang berperan pada patofisiologi pneumonia, salah satunya adalah imunodepresi terkait stroke. Imunodepresi terjadi melalui 3 jaras, yaitu aktivitas simpatis, aktivitas parasimpatis, dan aksis hipotalamus- pituitari-adrenal. Secara simultan, ketiganya menekan respons proinflamasi dan mengubah sel-sel imun sehingga pneumonia dapat mudah terjadi. Pembuatan terapi imunomodulasi yang dapat mencegah infeksi namun tidak memperburuk kondisi iskemia dapat menjadi fokus studi penanganan stroke komprehensif di masa datang.Kata kunci: Imunodepresi, pneumonia terkait stroke  

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