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All Journal Majalah Kedokteran Neurosains Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Neurona Acta Neurologica Indonesia
Taufik Mesiano
Divisi Neurovaskular Departemen Neurologi FK Universitas Indonesia/RSUPN Dr. Cipto Mangunkusumo, Jakarta
Biochemistry, Genetics & Molecular Biology Education Health Professions Medicine & Pharmacology Neuroscience Public Health

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POLA GANGGUAN FUNGSI ORGAN DAN FUNGSI KOGNITIF PADA USIA LANJUT Taufik Mesiano*, Samino*
NEURONA Vol 27 No. 3 April 2010
Publisher : Neurona Majalah Kedokteran Neuro Sains

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PENDAHULUANDENGAN MENINGKATNYA USIA HARAPAN HIDUP MANUSIA DI DUNIA TERUTAMA NEGARA INDONESIA AKAN MENAMBAH JUMLAH PENDUDUK DENGAN USIA DI ATAS 60 TAHUN ATAU YANG LEBIH SERING KITA KENAL SEBAGAI WARGA SENIOR LANJUT USIA INDONESIA PADA TAHUN 2010 DIPERKIRAKAN MENGALAMI KENAIKAN JUMLAH WARGA SENIOR MENJADI 172 JUTA ORANG YANG AKAN SEMAKIN MENINGKAT HINGGA PADA TAHUN 2020 AKAN TERDAPAT 29 JUTA ORANG WARGA SENIOR BPS PROFIL KESEHATAN INDONESIA DEPKES RI DAN TIDAK SEDIKIT DARI JUMLAH TERSEBUT AKAN MENGALAMI HENDAYA DALAM KEHIDUPAN SEHARIHARINYA DARI MULAI AKTIFITAS PRIBADI HINGGA AKTIFITAS YANG BERHUBUNGAN DENGAN MASYARAKAT LUAS
HUBUNGAN KADAR ALBUMIN SERUM DENGAN KELUARAN PASIEN STROKE ISKEMIK AKUT Taufik Mesiano*, Salim Harris*, Al Rasyid*
NEURONA Vol 27 No. 4 Juli 2010
Publisher : Neurona Majalah Kedokteran Neuro Sains

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INTRODUCTION ALBUMIN IN BLOOD HAS VARIOUS IMPORTANT FUNCTIONS ITS LEVEL DECREASED AS RESPONSE TO ACUTE INFLAMATION THAT ALSO OCCURS IN ACUTE ISCHEMIC STROKE DECREASE IN SERUM ALBUMIN LEVEL HYPOALBUMIN WILL AFFECT THE OUTCOME OF ACUTE ISCHEMIC STROKE PATIENT
PENGARUH KADAR INTERLEUKIN6 DAN NEURON SPECIFIC ENOLASE TERHADAP LUARAN STROKE ISKEMIK AKUT Al Rasyid,* Salim Harris,* Muhammad Kurniawan,* Taufik Mesiano,* Rakhmad Hidayat*
NEURONA Vol. 35 No. 4 September 2018
Publisher : Neurona Majalah Kedokteran Neuro Sains

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INTRODUCTION BRAIN BLOOD FLOW DISRUPTION IN ISCHEMIC STROKE WILL TRIGGER CELLS DAMAGE CASCADE AND CAUSED INFARCTION INTERLEUKIN6 IL6 AND NEURON SPECIFIC ENOLASE NSE ARE BRAIN CELLS DAMAGE MARKER THAT CAN BE MARKERS OF ACUTE ISCHEMIC STROKE OUTCOME
TERAPI TROMBOLISIS INTRAVENA PADA PASIEN STROKE ISKEMIK DENGAN AWITAN KURANG DARI 6 JAM Muhammad Kurniawan, Ramdinal Aviesena Zairinal, Taufik Mesiano, Rakhmad Hidayat, Salim Harris, Teguh
NEURONA Vol 32 No. 1 Desember 2014
Publisher : Neurona Majalah Kedokteran Neuro Sains

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CASES OF ACUTE STROKE WITH 4 HOURS ONSETWERE INCLUDED INTO THE CIPTO MANGUNKUSUMO HOSPITAL RSCM CODE STROKE PROTOCOLS AT THE EMERGENCY ROOM OF THE RSCM JAKARTA CLINICAL EXAMINATION AND NEUROIMAGING WERE PERFORMED IMMEDIATELY THE TIME NEEDED FOR THE INTERPRETATION OF COMPUTED TOMOGRAPHY SCAN CT SCAN WAS 30 MINUTES FROM PATIENTS ARRIVAL TO CONFIRM ABSENCE OF INTRACRANIAL BLEEDING INTRAVENOUS THROMBOLYSIS THERAPY USING ALTEPLASE 06MGKG BODY WEIGHT WAS THEN GIVEN STRICT 24HOUR MONITORING WAS CARRIED OUT TO CONTROL BLOOD PRESSURE AND OTHER METABOLIC PARAMETERS DURING THE TREATMENT PERIOD THE PATIENTS IMPROVED CLINICALLY THE PATIENTS NIHSS SCORES UPON ADMISSION AND DISCHARGE WERE 7 AND 4 RESPECTIVELY INTRACRANIAL BLEEDING COMPLICATIONS DID NOT OCCUR
TROMBEKTOMI MEKANIKAL PADA STROKE ISKEMIK DENGAN AWITAN KURANG DARI 6 JAM Rakhmad Hidayat,* Affan Priyambodho,** Reyhan Eddy Yunus,*** Taufik Mesiano,* Mohammad Kurniawan,* A
NEURONA Vol. 34 No. 3 Juni 2017
Publisher : Neurona Majalah Kedokteran Neuro Sains

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REPORT A CASE OF ACUTE STROKE WITHIN 3 HOUR ONSET ADMITTED TO THE EMERGENCY ROOM CIPTO MANGUNKUSUMO HOSPITAL RSCM JAKARTA THE RSCM CODE STROKE PROTOCOL WAS THEN INITIATED WHICH INCLUDED CLINICAL EXAMINATION AND NEUROIM AGING HEAD CT SCAN SHOWED NO INTRACRANIAL HEMORRHAGE
PREDIKTOR SYMPTOMATIC INTRACEREBRAL HEMORRHAGE PASCATROMBOLISIS INTRAVENA PADA STROKE ISKEMIK AKUT Al Rasyid; Salim Harris; Mohammad Kurniawan; Rakhmad Hidayat; Taufik Mesiano
NEURONA Vol 35 No 3 (2018)
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v35i3.12

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PREDICTORS OF SYMPTOMATIC INTRACEREBRAL HEMORRHAGE FOLLOWING INTRAVENOUS THROMBOLYSIS IN ACUTE ISCHEMIC STROKEABSTRACTDespite its effectiveness, the percentage of ischemic stroke patients who received definitive treatment, thrombolysis, never went above 10%, due to one of the reason is the occurrence of severe, post-therapeutic complications, such as symptomatic intracerebral hemorrhage (sICH). Several factors contribute to sICH occurrence are age, severity of stroke, early changes of ischemic sign, hyperglycemia, blood pressure, antiplatelet use and its interval. Patients with highest risk of sICH has been shown to have the greatest benefits from thrombolysis among other subgroup patients, therefore withholding therapy is not a choice. Compliance to the stroke’s guidelines could reduce the risk of complications as well as boost effectiveness of treatment.Keywords: Safety predictors, acute ischemic stroke, thrombolysis, sICH ABSTRAK Walau terbukti efektif, persentase pasien yang dapat dilakukan tindakan definitif stroke iskemik akut berupa trombolisis  tidak  pernah  mencapai  angka  10%,  salah  satunya  disebabkan  pertimbangan  terhadap  komplikasi  berat, seperti symptomatic intracerebral hemorrhage (sICH). Beberapa faktor yang berpengaruh terhadap kejadian sICH antara lain usia, derajat stroke, perubahan tanda iskemik dini, hiperglikemia dan diabetes melitus, tekanan darah, penggunaan antiplatelet, serta waktu pemberian. Pasien dengan risiko sICH tertinggi memiliki keuntungan terbesar dari trombolisis sehingga menunda tindakan bukanlah suatu opsi. Kepatuhan terhadap panduan tindakan dapat mengurangi angka kejadian komplikasi berat.Kata kunci: Prediktor keamanan, stroke iskemik akut, trombolisis, sICH
PENGARUH KADAR INTERLEUKIN-6 DAN NEURON SPECIFIC ENOLASE TERHADAP LUARAN STROKE ISKEMIK AKUT Al Rasyid; Salim Harris; Muhammad Kurniawan; Taufik Mesiano; Rakhmad Hidayat
NEURONA Vol 35 No 4 (2018)
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v35i4.26

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     THE EFFECT OF INTERLEUKIN-6 AND NEURON SPECIFIC ENOLASE LEVEL ON ACUTE ISCHEMIC STROKE OUTCOME WITH PACS AND LACS SUBTYPEABSTRACTIntroduction: Brain blood flow disruption  in ischemic stroke will trigger  cells damage  cascade  and  caused infarction. Interleukin-6 (IL-6) and neuron specific enolase (NSE) are brain cells damage marker that can be markers of acute ischemic stroke outcome.Aim: To investigate the effect of IL-6 and NSE levels on acute ischemic stroke outcome and its interacting factors.Methods: An observational cohort study on ischemic stroke patients with onset ≤3 days in several hospitals in Jakarta and Depok in 2014. Medical history and physical examination were carried out as well as laboratory parameters; hematocrit, fibrinogen, low density lipoprotein (LDL), high density lipoprotein (HDL), triglyceride, IL-6, and NSE. The National Institute of Health Stroke Scale (NIHSS) were assessed ≤72 hours of onset and 7 days along with Modified Rankin Scale (mRS) at 1 month of onset. Bivariate and multivariate logistic regression were done to investigate the association of IL-6 and NSE with stroke outcome and other factors.Results: One-hundred thirty-five subjects were included, mostly male (62%), with age mean 59,4±10,7 years and subtype PACS (76%). Interleukin-6 and NSE level were elevated in 61,5% and 21,5% subjects. Interleukin-6 and fibrinogen influenced the mRS, while diabetes and fibrinogen influenced the NIHSS. NSE serum didn’t show any association with mRS nor NIHSS, but influenced by dyslipidemia.Discussion: There was a tendency of worse outcome on high IL-6 level patients, although by multivariate analysis IL-2 alone was not sufficient enough as prognostic marker in acute ischemic stroke outcome. Neuron specific enolase serum didn’t show any association with acute stroke outcome due to also influenced by sex, smoking, and fibrinogen levels.Keywords: Acute ischemic stroke, IL-6, NSE, outcomeABSTRAKPendahuluan: Gangguan aliran darah otak pada stroke iskemik akut akan memicu kaskade kerusakan sel otak yang menyebabkan infark dan inflamasi. Interleukin-6 (IL-6) dan neuron specific enolase (NSE) merupakan penanda kerusakan sel otak yang dapat menjadi penanda luaran stroke iskemik akut.Tujuan: Mengetahui pengaruh kadar IL-6 dan NSE pada luaran stroke iskemik akut serta faktor-faktor yang memengaruhinya.Metode: Penelitian kohort observasional terhadap pasien stroke iskemik akut dengan awitan ≤3 hari yang dirawat di beberapa RS di Jakarta dan Depok pada tahun 2014. Dilakukan anamnesis dan pemeriksaan fisik serta pemeriksaan hematokrit, fibrinogen, low density lipoprotein (LDL), high density lipoprotein  (HDL), trigliserida, IL-6, dan NSE serum. Dilakukan pemeriksaan National Institute of Health Stroke Scale (NIHSS) awal awitan ≤72 jam dan 7 hari serta modified rankin scale (mRS) pada 1 bulan. Analisis statistik bivariat dan regresi logistik multivariat dilakukan untuk mengetahui hubungan kadar IL-6 dan NSE dengan luaran stroke serta hubungannya terhadap faktor-faktor lainnya.Hasil: Didapatkan 135 subjek yang mayoritas laki-laki (62%) dengan rerata usia 59,4±10,7 tahun dan subtipe PACS (76%). Peningkatan kadar IL-6 dan NSE ditemukan pada 61,5% dan 21,5% subjek. Luaran berdasarkan skor mRS dipengaruhi oleh kadar IL-6 dan fibrinogen, sedangkan  berdasarkan NIHSS dipengaruhi oleh diabetes melitus dan fibrinogen. Kadar NSE tidak berhubungan dengan mRS dan NIHSS, namun dipengaruhi oleh status dislipidemia.Diskusi: Terdapat kecenderungan luaran buruk pada kadar IL-6 tinggi, namun dengan analisis multivariat IL-6 belum bisa menjadi penanda prognosis luaran stroke iskemik akut. Kadar NSE serum tidak berperan terhadap luaran stroke iskemik akut, oleh karena juga dipengaruhi oleh jenis kelamin, merokok, dan kadar fibrinogen.Kata kunci: Stroke iskemik akut, IL-6, neuron specirefic enolase, luaran
PERDARAHAN INTRASEREBRAL SEBAGAI KOMPLIKASI NEUROLOGI EMBOLI SEPTIK PADA ENDOKARDITIS INFEKTIF: SEBUAH LAPORAN KASUS Mohammad Kurniawan; Salim Harris; Al Rasyid; Taufik Mesiano; Rakhmad Hidayat; Yesi Astri
NEURONA Vol 36 No 4 (2019)
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v36i4.93

Abstract

      INTRACEREBRAL HEMORRHAGE AS A NEUROLOGICAL COMPLICATION OF SEPTIC EMBOLISM IN INFECTIVE ENDOCARDITIS: A CASE REPORTABSTRACTInfective endocarditis (IE) is a life-threatening disease. The incidence of IE in developing countries is reported at 1.7-6.2 per 100,000 individuals per year. IE is also known as a potential condition for embolization, especially septic embolism to the brain. Septic embolism results in various neurological complications and manifestations due to vascular occlusion, aneurysm formation and rupture of the aneurysm. We report a case of 34-year-old male with definitive IE based on Duke criteria who experienced neurological complications of intracerebral bleeding. Patient was given pharmacological treatment according to the guidelines of the American Heart Association (AHA)with improvement in clinical symptoms.Keywords: Infective endocarditis, intracerebral hemorrhage, septic embolismABSTRAKEndokarditis infektif (EI) merupakan penyakit yang mengancam nyawa, walaupun angka kejadiannya kecil, yaitu 1,7-6,2 per 100.000 individu per tahun di negara berkembang. EI juga sangat potensial menyebabkan embolisasi, khususnya emboli septik ke otak. Emboli ini mengakibatkan manifestasi gangguan neurologis yang disebabkan karena oklusi pembuluh pembentukan dan ruptur aneurisma. Dilaporkan kasus seorang laki-laki 34 tahun dengan EI definitif berdasarkan kriteria Duke yang mengalami komplikasi neurologis perdarahan intraserebral. Pasien ditatalaksana sesuai panduan American Heart Association (AHA) dengan perbaikan gejala klinis.Kata kunci: Endokarditis infektif, emboli septik, perdarahan intrakranial  
MEMBANGUN SISTEM CODE STROKE PADA DUA RUMAH SAKIT PENDIDIKAN DI INDONESIA Rakhmad Hidayat; Hirari Fattah Yasfi; Dinda Diafiri; Reyhan Eddy Yunus; Andi Ade Wijaya Ramlan; Taufik Mesiano; Mohammad Kurniawan; Al Rasyid; Salim Harris
NEURONA Vol 37 No 3 (2020)
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v37i3.165

Abstract

Code stroke system is rapid respond system for ischemic stroke patient’s care to have immediate therapy in order to increase effectiveness and achieve maximum outcome. Cipto Mangunkusumo Hospital and Universitas Indonesia Hospital are educational hospitals with different background, resources, facilities, and conditions in code stroke system implementation. This paper compares the code stroke system between both hospitals from some aspects, such as emergency unit health care providers, cost and facility, diagnostic imaging, initiator of code stroke system, observation room, availability of catherization lab, and communication within code stroke team. Code stroke system can be implemented in many hospitals correspondingly adjusting each of hospital conditions by maximizing advantages to cover the hospital’s shortcomings. Keywords: Code stroke, hospital, ischemic stroke, thrombectomy, thrombolysis
KEJADIAN STROKE ISKEMIK PADA PASIEN POSITIF COVID-19 TERKONFIRMASI DI RUMAH SAKIT UNIVERSITAS INDONESIA Rakhmad Hidayat; Gemia Clarisa Fathi; Ramdinal Aviesena Zairinal; Raden Rara Diah Handayani; Mohammad Kurniawan; Taufik Mesiano; Al Rasyid; Salim Harris
NEURONA Vol 38 No 2 (2021)
Publisher : PERDOSNI

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Coronavirus disease 2019 (COVID-19) is not only disrupts the respiratory system, it can disrupt various organ systems, one of which is the central nervous system. Indonesia still has a little literature that discusses COVID-19 and its relation to ischemic stroke. This study aims to report the course of ischemic stroke cases in patients who have been confirmed positive for COVID-19. A 56 year old man presented with confirmed COVID-19, the patient had a history of type 2 diabetes mellitus and also a history of dyslipidemia. At initial presentation the patient did not complain of neurological symptoms, but after 12 days of treatment the patient complained of weakness in the left side of the upper leg. The CT scan of the head with contrast revealed an infarction in the peripheral area, perfusion CT found that the patient was hypoperfused in the right cerebral hemisphere area without the presence of a large core infarction or a clear perfusion mismatch defect. CT angiography did not reveal stenosis or occlusion of the large vessels. It can be concluded that ischemic stroke in COVID-19 patients can occur due to various underlying factors, one of which is hypercoagulability. Keywords: COVID-19, Stroke, Universitas Indonesia Hospital
Co-Authors Affan P. Permana Affan Priyambodo Permana Al Rasyid Al Rasyid Alyssa Putri Mustika Andi Ade Wijaya Ramlan Anna Mira Lubis Astri Budikayanti Cipuk Muhaswitri Dinda Diafiri Diyah Eka Andayani Dyah Tunjungsari, Dyah Fitri Octaviana Gemia Clarisa Fathi Hadiki Habib Hirari Fattah Yasfi Imamul Aziz Albar Kevin Gunawan Kevin Kevin Kurniawan, Mohammad Lestari, Dhara Ayu Mohamad Saekhu Mohammad Kurniawan Muhammad Hafiz Aini Muhammad Kurniawan Nurdin, Ilham Pangeran, David Putri Auliya Putri, Stefanie Karina Raden Rara Diah Handayani Radi Muharris Mulyana Rahmana, Arizari Haj Rakhmad Hidayat Rakhmad Hidayat Ramdinal Aviesena Zairinal Ramli, Yetty Reyhan Eddy Yunus Rima, Siti Pujiwati Permata Safri, Ahmad Yanuar Salim Harris Salim Harris Salim Harris Salim Harris Salim Harris Salim Harris, Salim Septo Sulistio Tiara Aninditha Winnugroho Wiratman Yesi Astri Zharifah Fauziyyah Nafisah Zlatikha Djuliannisaa