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Neurona
Published by Perhimpunan Dokter Spesialis Neurologi Indonesia
ISSN : 02166402     EISSN : 25023748     DOI : https://doi.org/10.52386/neurona
Core Subject : Health, Science,
Health Professions Medicine & Pharmacology Neuroscience
Neurona merupakan satu-satunya jurnal yang memuat perkembangan penelitian dan kasus terbaru bidang neurosains oleh Perhimpunan Dokter Spesialis Saraf (PERDOSSI) Pusat di Indonesia. Jurnal ini diterbitkan bulan Maret, Juni, September dan Desember. Bidang studi cakupan NEURONA meliputi: Stroke dan Pembuluh darah Neurotrauma Neuroonkologi Neuro Infeksi Neuro Behavior Neurorestorasi Neuropediatri Gangguan Tidur Nyeri Kepala Neurootologi Neuro Intervensi Neuro Intensif Neurogeriatri Gangguan Gerak Epilepsi Neuro Epidemiologi
Arjuna Subject : Kedokteran - Neurologi Klinis
Articles 39 Documents
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Search results for , issue "2024" : 39 Documents clear
RANGKAIAN KASUS CEDERA OTAK PENETRASI: PATOMEKANISME, IMPLIKASI KLINIS, DAN PENATALAKSANAAN DENGAN SUMBER DAYA TERBATAS Andini, Putri; Yugo, Mohammad Reynalzi; Yunus, Reyhan Eddy; Prawiroharjo, Pukovisa
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 40 No 4 (2024): Volume 40, No 4 - September 2024
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v40i2.396

Abstract

Penetrating brain injury differs markedly from blunt injury in dural tears and the transmission of kinetic energy to the surrounding structures along the penetrating tract. Unique clinical characteristics of penetrating brain injury (PBI) certainly require a case-by-case approach, however there are some principles that can be applied in almost every case and need to be considered to improve the outcomes. We present three cases of PBI with different mechanisms and outcomes. Two of the cases presented with non-missile PBI, while the third case presented with missile PBI. We also present a review of current literature highlighting various pathomechanisms, clinical implications and key approaches in managing PBI, particularly in resource-limited settings.
Stigma Epilepsi Dari Masyarakat dan ODE Natasya, Natasya
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 40 No 4 (2024): Volume 40, No 4 - September 2024
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v40i2.425

Abstract

Epilepsy is a chronic disorder of the brain characterized by recurrent seizures. In Indonesia, epilepsy is still often seen as a curse or possessed by an evil spirit, which in turn creates a negative stigma against epilepsy. This study aims to look at the stigma of epilepsy from the public and people with epilepsy (PWE). Using a descriptive method through questionnaires distributed to the Tarumanagara University area and to the PWE community for the period December 2022 - February 2023. With PWE criteria, students and employees at Tarumanagara University who willing to fill out the questionnaire. A total of 108 respondents from ordinary people and 57 PWE respondents participated in filling out the questionnaire. In terms of friendship: the general public wants to be friends with people with epilepsy (80.4%), while PWE are afraid of being shunned by friends and the surrounding environment (41.4%). In terms of education: the general public considers epilepsy can affect a sufferer's education (24.3%), while PWE find it difficult to reach their goals where epilepsy can interfere with a person's cognitive impairment (27.0%). In the field of work: ordinary people are willing to employ a person with epilepsy (56.1%), while PWE think that it is difficult for people with epilepsy to find work (45.0%). Based on this description, the stigma of epilepsy in society does not hinder PWE from socializing and working, but the stigma within PWE hinders PWE themselves from socializing and working. But with regard to education, there are not too many differences regarding education in PWE and how PWE achieves their goals. This is what seems to encourage many people with epilepsy who prefer to work as entrepreneurs rather than work as employees because they find it difficult to find work.
Obstructive Sleep Apnea pada Usia Muda Maulida, Adinda Ilsa
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 40 No 4 (2024): Volume 40, No 4 - September 2024
Publisher : PERDOSNI

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Abstract

Obstructive Sleep Apnea (OSA) is a respiratory disorder during sleep characterized by periodic narrowing and obstruction of the pharyngeal airway. OSA patients experience many symptoms that involve a series of physiological processes that lead to various diseases. A number of studies have explained that OSA does not only occur in middle-aged adults but can also occur at a young-aged adults. OSA especially at a young-aged adults remains a challenge because this sleep disorder is mild or even asymptomatic at a young-aged adults and the gold standard examination that is polysomnography, is expensive and time consuming to do. This literature review discusses the incidence of OSA at a young age, especially regarding its impact on students' health, academic achievement and economics
ANALISIS KEJADIAN STRESS ULCER PADA PASIEN STROKE SEBAGAI PREDIKTOR ANGKA MORTALITAS Tjondronegoro, Astuti; Nur Azizah, Aji Muthiah; Claudia, Vemmy Octaviana
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 40 No 4 (2024): Volume 40, No 4 - September 2024
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v40i2.492

Abstract

Introduction: Stroke is a life-threatening disease with high incidence and mortality rates, causing significant disability. WHO predicts that deaths due to stroke will increase to 8 million in 2030. Stroke can also cause damage to peripheral organs, one of which is stress ulcers. These complications can affect treatment and prognosis and are associated with increased mortality. Aim: This study aims to determine the relationship between the incidence of stress ulcers and mortality rates in stroke patients. Methods: This research used a retrospective observational approach. Data was obtained through medical records of patients diagnosed with stroke at Prambanan Hospital Inpatient Installation from January 2022 to December 2022. Characteristics assessment of stroke patients used univariate analysis, while stress ulcer incidence with patient mortality rates used bivariate analysis (Pearson Chi-Square and coefficient contingency). Results: In this study, male patients (50.7%) and those over 60 (67.9%) had the highest stroke rates. The incidence of stress ulcers in stroke patients was 22 people (15.7%), and 32 stroke patients were declared dead (22.9%). Bivariate analysis showed that stress ulcers in stroke patients were a strong risk factor for mortality (OR=12.731, 95% CI=4.528-35.799, p < 0.001). Discussion: Risk factors for stroke are age, gender, history of disease (hypertension, cardiovascular, dyslipidemia, diabetes mellitus), and smoking. Hemorrhagic strokes have more potential to cause stress ulcers than ischemic strokes. Stress ulcers resulting from chronic stress response from HPA-axis dysregulation strongly predict mortality rates for stroke patients in the Prambanan Hospital Inpatient Installation. Keywords: Mortality, stress ulcer, stroke
Paralisis Periodik Hipokalemia Menyerupai Sindom Guillain-Barre pada Wanita 36 Tahun : Laporan Kasus Alidris, Rahardita; Tri Kuncoro, Prasetyo
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 40 No 4 (2024): Volume 40, No 4 - September 2024
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v40i2.495

Abstract

ABSTRACT Introduction: Hypokalaemic Periodic Paralysis (HPP) is a group of diseases manifested by acute flaccid paralysis and hypokalemia (<3.5 mmol/L). HPP is divided into hereditary and acquired causes. In addition to limb weakness, other complaints have been reported was sensory symptoms such as tingling and numbness in the limbs. These complaints can masquerading other diseases such as Guillain-Barre syndrome (GBS). Misdiagnosis between HPP and GBS may occur because the manifestations of HPP disease are similar in the early stages of GBS disease. Misdiagnosis can lead to wrong therapy and potentially life-threatening. Case Report: A 36-year-old woman was referred to the hospital with suspected of GBS. The patient complained of limb weakness since five days. Weakness begins in the legs and then into the hands. The complaint was accompanied by a feeling of soreness in the hands and feet about two weeks earlier and a tingling feeling in the mouth, hands and feet. The motoric strength 3/3/3, except in inferior dextra 2/2/2. Physiological reflexes +1 and reduced in muscle tone. Sensory examination is intact. There was a difference in potassium values ​​between before and after being referred (K+ 3.76 mmol/L vs 1.0 mmol/L). Significant clinical improvement after potassium correction therapy. Discussion: The manifestations of HPP that appear are not only related to the patient's motor abnormalities, but also sensory in the form of tingling and numbness. The mechanism by which the sensory dysfunction occurs is not well understood, but is suggested due to metabolic disturbances at the level of the dorsal root ganglia. So that the differential diagnosis of HPP can be raised in acute flaccid weakness accompanied by sensory symptoms. It may be considered to re-check electrolytes if risk factors and clinical symptoms lead to a clinical diagnosis of HPP. Keywords: Acute Flaccid Paralysis, Hypokalemic Periodic Paralysis, Guillain-Barre Syndrome
EFEKTIVITAS TOKSIN BOTULINUM TIPE A TERHADAP SKALA SPASME, SKALA DEPRESI DAN KUALITAS HIDUP PASIEN HEMIFASIAL SPASME DI RSUD CIAWI Cornelia, Celine; Hamdani, Ismi Adhanisa; Gaharu, Maula N.; Agustina, Lydia
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 40 No 4 (2024): Volume 40, No 4 - September 2024
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v40i2.560

Abstract

Introduction: Approximately 10/100.000 individuals worldwide experience hemifacial spasm (HFS) with a ratio of women-to-men at 2:1. Around 90% HFS patients face social life challenges, leading to self-isolation and decreased quality of life. Therapy modalities for HFS include oral therapy, botulinum toxin injection and surgery, but the oral therapy response rate is low. Aim: To determine the effectiveness of botulinum toxin type A injection on, spasm scale, depression scale and quality of life of HFS patients Methods: A quasi-experimental study was conducted at Ciawi Regional Hospital in May-December 2023. Data were collected using a total sampling technique, injection of Clostridium botulinum neurotoxin type A and succeeded by a 2-weeks, 1 month and 2 month follow-up. We used modified Jankovic scale, Mini International Neuropsychiatric Interview and HFS-7 criteria for our instruments. Results: 29 patients are included in this research, aged 30-93 years (31% are male and 69% are female). 69% suffered left-sided HFS and 31% right-sided HFS. 44,8% patients had hypertension. After 2 weeks post-injection, 81.8% patients with 2nd degree HFS and 71.4% patients with 1st degree HFS reported significant symptom improvement (p = 0.046 and 0.025). Both patient’s degree reported depression improvement without significant p-value (p = > 0.05) after 2 weeks until 2 month post injection. Increased quality of life (p = 0.001). Discussion: Clostridium botulinum neurotoxin type A injection is an effective treatment modality to improve spasm, depression and quality of life in HFS patients at Ciawi Regional Hospital. Keywords: Botulinum Toxin, Degree of Spasm, Experimental, Hemifacial Spasm, Quality of Life
Hari Epilepsi Sedunia: Hari Ungu untuk Memberantas Stigma Epilepsi: Memberantas Stigma Epilepsi Ar Rochmah, Mawaddah
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 40 No 4 (2024): Volume 40, No 4 - September 2024
Publisher : PERDOSNI

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Abstract

World Epilepsy Day (Hari Epilepsi Sedunia), yang juga dikenal sebagai Purple Day (Hari Ungu), dirayakan setiap tahun pada tanggal 26 Maret. Hari ini didedikasikan untuk meningkatkan kesadaran tentang epilepsi, menghilangkan mitos dan stigma, serta menunjukkan dukungan bagi individu penderita epilepsi di seluruh dunia. Hari Ungu dimulai pada tahun 2008 oleh Cassidy Megan, seorang gadis asal Kanada yang ingin mendorong orang untuk berbicara tentang epilepsi dan memberi tahu seluruh penderita epilepsi di dunia bahwa mereka tidak sendirian. Sejak itu, Hari Ungu telah menjadi gerakan global, dengan orang-orang mengenakan ungu dan mengadakan acara untuk menunjukkan solidaritas kepada mereka yang terdampak epilepsy, tidak hanya penderita epilepsi, namun juga keluarga dan kerabat dekat mereka.
Edisi Suplemen Neurona NEURONA
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia 2024
Publisher : PERDOSNI

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Abstract

Supplementary Edition Neurona
VALIDITAS MICHIGAN NEUROPATHY SCREENING INSTRUMENT VERSI BAHASA INDONESIA DALAM MENDETEKSI POLINEUROPATI DISTAL SIMETRIS DIABETIKA Bintang, Andi Kurnia; Aulina, Susi; Goysal, Yudy; Amran, Muhammad Yunus; Hamid, Firdaus; Setiawan, Denise Dewanto
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 40 No 3 (2024): Volume 40, No 3 - Juni 2024
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v40i3.436

Abstract

Introduction: Distal Symmetric Polyneuropathy (DSPN) is the most common neuropathy subtype found in Diabetes Mellitus (DM) patients. Early screening is important to prevent complications. Michigan Neuropathy Screening Instrument (MNSI) was created in 1994 as an alternative screening tool for diabetic neuropathy. This instrument has not been validated in Indonesia. Aim: Assess validity and reliability of Indonesian version of MNSI in detecting diabetic DSPN. Methods: This cross-sectional study was done in Wahidin Sudirohusodo hospital, Makassar in December 2021-June 2022. Indonesian version of MNSI and Nerve Conduction Studies (NCS) was applied to subjects. Statistics were performed with Statistical Package for the Social Sciences (SPSS) version 25. Study protocol was approved by Health Research Ethics Committee, Faculty of Medicine, Hasanuddin University. Results: 102 subjects were eligible and divided into DM with DSPN (n=60) and DM without DSPN (n=42). Significant differences were found in age, body mass index, duration of DM diagnosis, treatment, HbA1c, Indonesian version of MNSI part B, and all NCS parameters (p<0,05). Area Under Curve (AUC) of part B was bigger than A (0,942 vs 0,606). Cut-off >=2,5 of part B had sensitivity, specificity, Positive Predictive Value (PPV), and Negative Predictive Value (NPV) of 95,0%, 90,5%, 93,4%, and 92,7%, respectively. Discussion: Cut-off >=2,5 for Indonesian version of MNSI part B was considered optimal. EMNG was recommended for DM patients with part B score >=2,5. Conclusion: Indonesian version of MNSI is a valid and reliable instrument to detect DSPN in Indonesian population. Keywords: diabetic neuropathy, DSPN, Indonesia, MNSI
FAKTOR-FAKTOR YANG MEMPENGARUHI NYERI KEPALA PASKA ENDOVASKULAR COILING PADA PERDARAHAN SUBARAKHNOID Puspita Ratnasari, Nurlia; Desti Ramadhoni, Pinto; Sugiharto, Henry; Octavinawaty, Lenny; Haswatty, Bayu
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 40 No 3 (2024): Volume 40, No 3 - Juni 2024
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v40i3.456

Abstract

Introduction: Post endovascular coiling headache, according to ICHD-3, defined as a new headache due to coiling embolization which is still felt by aneurysm rupture subarachnoid patients 3 months after the procedure, which other acute SAH-related headaches have been ruled out. A previous prospective study showed that 50% unruptured aneurysms patients who undergo endovascular coiling experience headache. However, there are currently no studies on headache after endovascular coiling in ruptured aneurysms. Aim: To identify the factors that influence post-endovascular coiling headache in subarachnoid hemorrhage patients with aneurysm rupture. Method: Retrospective cohort study, using medical record data at RSUP Dr. Mohammad Hoesin Palembang. Headache intensity was assessed using the Numerical Pain Rating Scale at 3 months after the procedure according to the ICHD-3 standard. Results: Most patients were > 50 years old, female (60.5%), had a history of hypertension (81.40%), Hunt and Hess grade 2 (41.9%), mFisher grade I (41.9%), located in ICA ( 34.9%), aneurysm diameter 5 mm (69.8%), onset of action at 10 days (58.1%), mRRC class I (53.5%) and Packing Attenuation 25% (53.5%). It was found that 50% of the subjects experienced mild headache after endovascular coiling. In bivariate analysis, it was found that Hunt and Hess 4-5 (p=0.048) and Packing Attenuation >25% (p=0.03) had a significant relationship with incidence of post-endovascular coiling headache. Discussion: Severe Hunt and Hess grade (4-5) and high packing attenuation (> 25%) are associated with the incidence of post-endovascular coiling headache in aneurysm rupture SAH patients Keywords: Subarachnoid haemorrhage, aneurysm rupture, Endovascular coiling, Headache

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