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Ophthalmologica Indonesiana
Published by Perhimpunan Dokter Spesialis Mata Indonesia
ISSN : 01261193     EISSN : 2460545X     DOI : 10.35749
Core Subject : Health,
Health Professions Medicine & Pharmacology Public Health
Ophthalmologica Indonesiana is an open accessed online journal and comprehensive peer-reviewed ophthalmologist journal published by the Indonesian Ophthalmologist Association / Perhimpunan Dokter Spesialis Mata (PERDAMI). Our main mission is to encourage the important science in the clinical area of the ophthalmology field. We welcome authors for original articles (research), review articles, interesting case reports, special articles, clinical practices, and medical illustrations that focus on the clinical area of ophthalmology medicine.
Arjuna Subject : Kedokteran - Ophthalmology
Articles 869 Documents
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Intraocular Pressure Changes After Selective Laser Trabeculoplasty (SLT) in Open-Angle Glaucoma Amalia Mayasari; Maharani Cahyono
Majalah Oftalmologi Indonesia Vol 42 No 2 (2016): Ophthalmologica Indonesiana
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/journal.v42i2.85

Abstract

Background: Selective laser trabeculoplasty (SLT) use laser to selectively target pigmented trabecularmeshwork without producing collateral damage to adjacent non-pigmented cells or structures. A previousdata suggests that SLT is effective at every stage of open-angle glaucoma (OAG). SLT can be used asa first-line therapy, alternative to medical therapy, or as an adjunctive therapy to topical glaucomadrops. The aim of this study was to determine the changes in intraocular pressure (IOP) after SLT inpatients with OAG.Methods: Design of this research was cohort-prospective study. Twenty-six eyes of 18 patients withOAG were participated in this study. All the patients were treated with 180o SLT to the temporaltrabecular meshwork and followed by 180o SLT to the nasal trabecular meshwork 1 week after the firsttreatment. A frequency-doubled (532 nm) Q-switched Nd:YAG laser with a 400 μm spot size wasused to deliver 0.4-1.0 mJ of energy for 0.3 ns to perform the procedure. Additionally, IOP in thetreated eye was assessed and measured with Goldman applanation before SLT, and 1 hour, 1 week,and 2 weeks following complete SLT. All patientes were given corticosteroid (prednisolone acetat 1%eyedrop) 4 times a day for 7 days after SLT to prevent elevation of IOP caused by inflammation.Results: The average pre-SLT IOP were 19.94 mmHg. The mean IOP 1 hour post-SLT was slightlyincrease. IOP 2 weeks after complete SLT showed a significant decrease compared to before SLT(Wilcoxon-test, before: p=0.033; 1 hour: p=0.915; 1 week: p=0.098; 2 weeks: p=0.009)Conclusion: Intraocular pressure lowering effect was significant at 2 weeks after SLT treatment. SLTeffectively reduces IOP in open-angle glaucoma. It can be used as a primary or adjunctive therapy inpatient with open-angle glaucoma.Keywords: obstructive MGD, quality of meibum, ocular surface damage
Correlation between Meibum Quality and Ocular Surface Staining in Obstructive Meibomian Gland Dysfunction Ike Hikmawati; M Rinaldi Dahlan; Susi Heryati
Majalah Oftalmologi Indonesia Vol 42 No 2 (2016): Ophthalmologica Indonesiana
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/journal.v42i2.86

Abstract

Background: Obstructive Meibomian gland dysfunction (MGD) leads to a decreased availability ofmeibomian lipid at the ocular surface that could result in ocular surface damage due to increasedevaporation of the aqueos layer of the tear film. Alteration of meibomian oil (meibum) is one of thecausative factors of the obstructive process and the sign of the obstruction as well.Methods: This was a cross-sectional study using Spearman’s Rank Correlation Coeeficient (rs) to findcorrelation between meibum quality and the ocular surface damage. Subjects were patients withobstructive MGD selected consecutively in Infection and Immunology Unit of Indonesia National EyeCenter, Cicendo Eye Hospital. There were 48 eyes from 29 subjects comprised 28 inflamed MGD and20 non-inflamed MGD. Meibum quality was assessed by performing digital expression on eightmeibomian glands located on the lower lid. Ocular surface damage was done by performing cornealstaining using fluorescein eye drop and conjunctival staining using Lissamine Green strip. The stainingresults were then documented using camera of slit lamp biomicroscopy and based on the documentation,scoring of the ocular surface staining was done using National Eye Institute/Industry (NEI)scheme/diagram.Results: This study showed no correlation (rs: -0.067) between meibum quality and ocular surfacedamage (p=0.652). Statistical analysis was also done on subjects categorized based on inflammationon the eyelid and there was found correlation (rs: 0.238) between meibum quality and ocular surfacedamage in inflamed MGD (p=0.312).Conclusion: There is no correlation between the quality of meibum and ocular surface staining.Keywords: obstructive MGD, quality of meibum, ocular surface damage
Age-Related Macular Degeneration Cases in Prof. RD Kandou General Hospital, Manado Inga Santoso; Vera Sumual
Majalah Oftalmologi Indonesia Vol 42 No 2 (2016): Ophthalmologica Indonesiana
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/journal.v42i2.87

Abstract

Background: To report the data of patients with age-related macular degeneration (AMD) at Vitreo-Retina Division of Ophthalmology Department of Prof. RD Kandou General Hospital, Manado.Methods: This study was descriptive retrospective using medical records at the OphthalmologyDepartment of Prof. RD Kandou General Hospital, Manado period of January 2014 until June 2016.The subjects of research were the medical records of patients diagnosed with age-related maculardegeneration.Results: Of 27 patients, 14 (51.9%) were male and 13 (48.1%) were female with age ranging from 41to 81 years old. By type of AMD, the distribution was 85.2% dry and 14.8% wet AMD. Among therisk factors of AMD were hypertension in 12 patients (44.4%), diabetes mellitus in 2 patients (7.4%),and both hypertension and diabetes mellitus in 3 patients (11.1%).Conclusion: The number of patients diagnosed with AMD was 27 patients, with insignificant genderdifference. Most of the patients fell on the 61 to 71 years old group (48.2%), with majority type weredry AMD. Hypertension was the most influential risk factor.
Clinical Characteristic and Management of Central Serous Chorioretinopathy Rio Rhendy; Andi Arus Victor
Majalah Oftalmologi Indonesia Vol 42 No 2 (2016): Ophthalmologica Indonesiana
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/journal.v42i2.88

Abstract

Background: Central serous chorioretinopathy (CSCR) is an abnormality in posterior segment of theeye, characterized by detachment of retinal neurosensory caused by localized accumulation of serousfluid. CSCR is commonly found in male (90%) with age ranging of 25 to 55 years old and oftenoccurs in white, Asia, and Hispanic. Subretinal fluid will be absorb spontaneously within 3-4 months,thus observation and risk factors modification are the initial management for CSCR for couple ofmonths. However, drugs use on CSCR can be considered to accelerate fluid resorption.Methods: This study is a descriptive-retrospective study, done in Vitreoretina Division of OphthalmologyDepartment, Cipto Mangunkusumo Hospital, Jakarta, from December 2015 to January 2016. Thesubjects were all CSCR patients, using medical records for data selection.Results: There were 90 patients with CSCR, but only 20 eyes from 19 patients could be included tothe study. Most of CSCR patients were male (84%), with age ranging from 25 to 55 years old, meanage of 40.31 years.Conclusion: Management of CSCR in Cipto Mangunkusumo Hospital gave significant improvementin UCVA and CMT.
Anti-Inflammation and Anti-Fibrotic Effects of Amniotic Membrane on Post-Trabeculectomy Conjunctiva (Experimental Research on Oryctolagus cuniculus) Listya Dyah Rihardini; Suparman Suparman; Evelyn Komaratih
Majalah Oftalmologi Indonesia Vol 42 No 2 (2016): Ophthalmologica Indonesiana
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/journal.v42i2.89

Abstract

Background: To evaluate the effects of amniotic membrane transplantation on the modulation ofwound healing after trabeculectomy.Methods: Eighteen eyes of nine New Zealand rabbits: nine left eyes underwent glaucoma filteringsurgery, nine right eyes underwent trabeculectomy and amniotic membrane transplantation. Freshfrozen human amniotic membranes were transplanted above scleral flap, below the conjunctiva withthe stromal side-up. Daily examination of anterior segment were performed using hand held slit lamp.After 7 days, all eyes were enucleated and sent for histopathology examination to evaluate theinflammatory and fibroblast cells. The rabbits were terminated. Blebs were well formed until 7 days.Results: There were statistically no significant difference between two groups in quantity ofinflammatory cells (p=0.258) and fibroblast cells (p=0.436). The tendency in the treatment group,however, the Masson’s Trichrome obtained less fibrosis (88.9%) compared to the control group(44.4%). Hematoxilin eosin staining revealed inflammatory reaction tends to be more severe than thecontrol group, suggesting a xenograft rejection.Conclusion: AMT is still potential as an alternative option to reduce fibrosis in glaucoma filteringblebs but need further research. In rabbits, human amniotic membrane elicited a xenograft reaction.Keywords: amniotic membrane, trabeculectomy, inflammation, fibrosis
Grave Ophthalmopathy, Menuju Penatalaksanaan yang Lebih Komperhensif M Sidik
Majalah Oftalmologi Indonesia Vol 42 No 3 (2016): Ophthalmologica Indonesiana
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/journal.v42i3.90

Abstract

no abstract available
Devastating Lower Eyelid Squamous Cell Carcinoma in Patient with Xeroderma Pigmentosum Novia Rahayu; Neni Anggraini; Rossalyn Sandra Andrisa
Majalah Oftalmologi Indonesia Vol 42 No 3 (2016): Ophthalmologica Indonesiana
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/journal.v42i3.91

Abstract

Background: Xeroderma pigmentosum (XP), an inherited condition of cellular sensitivity to ultraviolet (UV) radiation, mainly presents as cutaneous and ocular abnormalities, including neoplasia. This report aimed to demonstrate a devastating case of lower eyelid squamous cell carcinoma in XP patient.Case Illustration: Twenty four-year-old female with XP came with white plaque on both cornea. Excisional biopsy revealed a conjunctival intraepithelial neoplasia DD/ carcinoma in situ on right eye, and hyperplastic squamous epithelia on left eye. For nearly two years, she was lost to follow up, and revisited our clinic with a rapid growing, ulcerated, susceptible to bleed, red-yellowish mass, expanding to bulbar and tarsal conjunctiva, about 27 x 15 x 10 mm size, on her lower left eyelid, with restricted ocular movement. Incisional biopsy revealed a well-differentiated squamous cell carcinoma. In 6 weeks time, mass has grown to size 75 x 50 x 20 mm, and already infiltrated to superior eyelid and orbit.Conclusion: The nature of malignancy in XP patient is exceptionally progressive. Thorough education, close monitoring and early treatment is critical to prevent rapid deterioration and minimize possible impairment caused.  Keywords: xeroderma pigmentosum, squamous cell carcinoma, eyelid squamous cell carcinoma, squamous cell carcinoma treatment
Challenge in Diagnosing and Managing Carotid Caverous Fistula in Patient with Intermittent Angle Closure Glaucoma Maria Magdalena; Virna Dwi Oktariana; M Sidik
Majalah Oftalmologi Indonesia Vol 42 No 3 (2016): Ophthalmologica Indonesiana
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/journal.v42i3.92

Abstract

Background: The purpose of this case report is to present a patient with Carotid Cavernous Fistula (CCF) superimposed angle closure glaucoma and how to manage the IOP and to describe treatment options for CCF. Case Report: A 72-year old female patient was consulted to Glaucoma Division with chief complain the redness of the right eye (RE). She also had blurred vision on both eyes and high IOP of the RE. The IOP of the RE tend to be fluctuated even after laser peripheral iridotomy (LPI) from prior hospital, and was different from the LE, which was stable on anti-glaucoma medication. A careful history taking, clinical examination including visual acuity and visual field defect test, and also ancillary test to confirm the diagnosis were done. The patient was assessed with intermittent angle closure glaucoma (ACG) of both eyes superimposed with carotid-cavernous fistula (CCF) of the RE and planned to undergo trabeculectomy and phacoemulsification surgery from glaucoma division, and also embolization procedure from neuro ophthalmology division. However, the schedule of embolization will be done one year later due to long waiting list at Radiology Departement.Conclusion: This case demonstrates CCF of the RE superimposed intermittent ACG of both eyes. The Clinical manifestation of CCF were subtle, therefore clinical examination and acillary test such as CT angiography were needed to establish the diagnosis and to exclude differential diagnosis. The definitive therapy for CCF is to closure the fistula, but due to long waiting list we have to consider carotid massage as conservative management. In this case carotid massage gave good result in reducing ocular manifestation of CCF.  Keyword: Carotid Cavernous Fistula, Glaucoma, Angle-closure Glaucoma, Carotid Massage
Kebutaan Akibat Kelainan Mitokondria : Gejala, Diagnosis, dan Tata Laksana Suportif Ratna Sitompul
Majalah Oftalmologi Indonesia Vol 42 No 3 (2016): Ophthalmologica Indonesiana
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/journal.v42i3.94

Abstract

Mitochondria is an important organelle in the cell acting as its powerhouse. Damage in the mitochondria leads to cell death thus it is crucial to organs utilizing plenty of energy such as the eyes. Mitochondrial disease in the eye can be primary or secondary. Primary mitochondrial diseases of the eye include dominant optic atrophy,  leber hereditary optic neuropathy, chronic progressive external ophthalmoplegia,  and retinitis pigmentosa. Secondary mitochondrial eye diseases include diabetic retinopathy, age-macular degeneration and glaucoma. Mitochondrial damage can also trigger growth of ocular neoplasm (retinoblastoma and uveal melanoma) are also part of mitochondrial eye diseases. However, it is still a challenge to diagnose mitochondrial eye diseases. Methods that can be used are genetic sequencing, radiological examinations to look for other syndromic signs, as well as biochemistry and histochemistry assays. Definitive therapy for mitochondrial eye diseases are still under research and to date the management is supportive in the form of food supplementation.  Keywords: primary mitochondrial diseases, secondary mitochondrial disease, mtDNA.ROS, ocular tumour
Visual Field Defect in Pulmonary Tuberculosis Patients with Ethambutol Therapy Agus Nugroho; Devi Azri Wahyuni
Majalah Oftalmologi Indonesia Vol 42 No 3 (2016): Ophthalmologica Indonesiana
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/journal.v42i3.95

Abstract

Background: Ethambutol (EMB) is important as antimicrobal in the treatment of pulmonary TB which effects ethambutol toxic optic neuropathy (EON). EON can be detected with visual field examination. Research by Vimla Menon stated that toxicity condition of EMB obtained visual field defects by 7.69%. Currently, there is no data on visual field defects in patients with TB treated with (EMB) in Mohammad Hoesin Hospital (RSMH).Methods: This was a cross-sectional observational study with a follow-up studies without controls. The samples of this research was 24 and samples taken consecutive. Visual field examination using the Humphrey Field Analyzer was performed three times: before therapy, 1 month, and 2 months after EMB therapy. Data that can be carried out were analyzed by using SPSS program. Results: Average MD before administration of EMB was -2.36±1.21; average MD after 1 month administration of EMB was -2.35±1.41; and 2 months after was -3.09±1.85. There was a mean change of -0.73±1.43 MD 2 months after EMB administration. Abnormal MD enhancement of 6.52% occured 1 month after EMB administration and 28.26% 2 months after EMB administration. Arcuate visual field defects obtained 9.3% in 2 months after EMB aministration.Conclusion: There was no significant difference in visual field examination on the object before therapy and 1 month after EMB therapy. Examination after obtaining EMB for 2 months, based on the mean deviation of visual field defects, were minimal to moderate; while based on gray scale picture was obtained arcuate visual field defects.  Keywords: ethambutol, EON, visual field defect

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