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Sciences of Phytochemistry
Published by ETFLIN
ISSN : 29625793     EISSN : 2962553X     DOI : https://doi.org/10.58920/sciphy
Core Subject : Health, Science, Engineering,
Chemical Engineering, Chemistry & Bioengineering Chemistry Medicine & Pharmacology
Sciences of Phytochemistry (SciPhy or Sci Phytochem) is an international, peer-reviewed, open access journal published by ETFLIN. SciPhy aims to offer a widely visible and highly indexed platform for scholars and intellectuals to share their insights and works. From July 2023 onwards, SciPhy will accept only four types of articles: Research, Review, Mini-review, and Opinion. SciPhy accepts research, review, mini-review, and opinion/perspective that falls within the scope of the journal. SciPhy will publish articles that describes new and relevant findings on the following topics: Phytochemical Analysis Techniques: Reviewing advancements in methodologies for identifying and quantifying phytochemicals in plant samples, such as chromatography, spectroscopy, and mass spectrometry. Pharmacological Activities of Plant Compounds: Investigating the biological activities of phytochemicals, including their potential as antioxidants, antimicrobials, anti-inflammatory agents, and anticancer compounds. Natural Product Isolation and Characterization: Detailing the extraction, purification, and structural elucidation of bioactive compounds from plants, fungi, and marine organisms. Bioinformatics and Computational Approaches in Phytochemistry: Exploring computational tools and techniques for analyzing phytochemical data, predicting bioactivities, and identifying potential drug candidates from natural sources. Ethnobotany and Traditional Medicine: Examining the ethnopharmacological uses of plants in traditional medicine systems and their relevance to modern drug discovery and development. Phytochemical Diversity in Plant Families: Studying the chemical composition and variability of secondary metabolites across different plant families and genera. Biological Interactions of Phytochemicals: Investigating the interactions between phytochemicals and biological targets, including enzymes, receptors, and cellular pathways. Phytoremediation and Environmental Applications: Discussing the role of plants in detoxifying pollutants, restoring degraded ecosystems, and contributing to sustainable environmental management. Nutraceuticals and Functional Foods: Highlighting the health-promoting properties of phytochemical-rich foods and their potential as functional ingredients in nutraceutical products. Biotechnological Approaches in Phytochemistry: Reviewing biotechnological methods such as plant tissue culture, genetic engineering, and metabolomics for enhancing the production of valuable phytochemicals or developing novel plant-based products.
Arjuna Subject : Ilmu Material (semua kategori) - Kimia Material
Articles 64 Documents
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Unveiling the diverse medicinal properties of Murraya koenigii
Sciences of Phytochemistry Volume 2 Issue 2
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphy02020107

Abstract

Since the beginning of time, nature has provided medicines for treating fatal illnesses. Herbalists believe that certain plants have medicinal qualities. In tribal and rural communities, medicinal plants provide as an easily accessible source of treatment. The identification of various rejuvenating molecules that can halt or lessen the pathology of a variety of diseases will be regarded as a significant development of the present. There has been a scientific advancement in this area, and current studies on herbal medicines and traditional cures have attracted significant interest from all over the world. This plant, popularly known as the curry tree, is frequently used as herb and is also used to treat a variety of problems in traditional Indian medicine. About 80–85% of people worldwide rely on herbal products because they are thought to be efficient, secure, and cost-effective. Reviewing the plant taxonomy, ethnobotanical characteristics, folkloric or traditional uses, phytochemical, and pharmacological qualities of the Murraya koenigii plant was the goal of the current study. The leaves are used internally for dysentery as a carminative, tonic, stomachic, and inducer of vomiting. The usage of other parts includes treating piles, preventing helminthiasis, and reducing body heat, itchiness, and inflammation. Following several reports that this plant may treat a wide range of illnesses, scientists have worked to confirm the effectiveness of this plant by biological screening. A review of the literature suggests that Murraya koenigii has various medical benefits, including activity of antimicrobial, cardiac, anti-oxidative, anti-diabetic and cholesterol reduction, cytotoxic action, antiulcer, and anti-diarrhea.
Phytochemical profiling, heavy metals composition, in silico aphrodisiac potential, and ADMET study of Gardenia erubescens
Sciences of Phytochemistry Volume 2 Issue 2
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphy02020091

Abstract

This study aimed to explore the phytochemical profile, heavy metal composition, in silico aphrodisiac potential, and ADMET study of Gardenia erubescens due to its folkloric acclaimed aphrodisiac use. The phytochemicals were quantified gravimetrically while the identification of bioactive compounds was carried out using a combined Gas spectrophotometer-mass spectrophotometer (GC-MS). Heavy metals were quantified using an atomic absorption spectrophotometer while the aphrodisiac and ADMET studies were in silico. The result showed the presence of alkaloids (22.33% ±1.45), saponins (20.17% ±1.88), glycosides (0.55% ±0.03), and flavonoids (32.67% ±1.45), with the absence of steroids and terpenoids. GC-MS analysis identified 25 compounds with linoleic acid having the highest peak area (28.01%) next to palmitic acid (14.08%). Chromium, Cadmium, and Lead were present in concentrations of 0.145 ±0.03, 0.001 ±0.00, and 0.065 ±0.03 ppm respectively. Ethyl D-glucopyranoside had the least BA (-8) and Ki (1.35 µM) docked with human arginase II while Tyrosinol had the least BA (-6.2) and Ki (28.21 µM) docked with phosphodiesterase 5 though both were higher than Sildenafil citrate. All the top docked compounds were predicted to be neither substrates nor inhibitors of P-glycoproteins and cytochrome P450 enzymes without CNS permeability and hepatotoxicity. Conclusively, the present study supports the folkloric aphrodisiac application of Gardenia erubescens, and the heavy metals level was below the acceptable regulatory level, thus, might be safe for occasional use. Additionally, the identified compounds might be considered a novel source of therapeutics against erectile dysfunction.
Exploring the potential impact of herbal antioxidants on human cardiovascular diseases
Sciences of Phytochemistry Volume 2 Issue 2
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphy02020070

Abstract

The body's antioxidant system efficiently neutralizes reactive oxygen species, which are intermediates formed during routine metabolic activity. Oxidative stress resulting from an imbalance in this neutralization process is known to be a key factor in many human ailments, including atherosclerosis and various cardiovascular diseases. Observational epidemiological research conducted over the past several decades has shown that consumption of vegetables and fruits rich in vitamins and antioxidants is associated with a reduced incidence of cardiovascular disease. However, it is crucial to exercise caution when considering the use of herbal antioxidants as a treatment for various ailments, including cardiovascular conditions. This caution arises from concerns related to their safety, potentially life-threatening side effects, toxicity, and potential interactions with other medications. Multiple research studies have highlighted these risks associated with antioxidant usage as a form of medical intervention. This overview briefly summarizes cardiovascular disease, associated risk factors, and the role of reactive oxygen species and oxidative stress in its development. Next, delve into some of the most significant plant-based antioxidants, their therapeutic uses, as well as the potential benefits and drawbacks of using them to treat various diseases, with a particular focus on their relevance to cardiovascular disease.
A narrative review on clinical trials showing contraindicated drugs with grapefruit juice
Sciences of Phytochemistry Volume 2 Issue 2
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphy02020048

Abstract

Medication and food are frequently consumed together. However, some foods have interactions with medicines by changing key regulators of systemic medication availability. Their consumption is linked to interactions with a wide range of medications. One of the most significant beverages that can be harmful when combined with certain medicines is grapefruit juice. Furanocoumarins' mechanism-based suppression of intestinal cytochrome P450 3A4, which increases the bioavailability of drugs that are substrates, is the main mechanism by which interactions are mediated. There have also been reports of interactions between grapefruit products and uptake transporters such as P-glycoprotein (P-gp) and organic anion-transporting polypeptides (OATPs). It has been suggested that polyphenolic substances like flavonoids are what cause the interactions between P-gp and OATP. The amounts of furanocoumarins and flavonoids in the grapefruit product, the amount of juice consumed, the medium PH, and the inherent diversity of enzymes and transporter components in humans can all have an impact on the processes and magnitudes of interactions. In this review, we are going to shed light on clinical trials showing grapefruit juice-drug interactions and what should the health provider do for better clinical care.
Nutritional analysis of Colocasia esculenta l. tubers aqueous extract and comparative analysis with existing literature
Sciences of Phytochemistry Volume 2 Issue 2
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphy02020040

Abstract

Taro (C. esculenta L.) is a plant in the Araceae family that is farmed as a tuber. This plant is one of the non-animal sources of nutrients, minerals, and trace elements and has had numerous biological activities. Taro plants offer antidiabetic, antibacterial, antifungal, antioxidant, and antihepatotoxic properties. To have better nutritional content and wider and longer-lasting applications in culinary products, the taro tuber requires going through a process that increases its use value, one of which is extraction. The research aim of this work was to use several analytical methods to determine the nutrition components in the aqueous extract of C. esculenta L. Some of the nutrients found in the aqueous extract of C. esculenta L. consist of total protein 10.9%, total carbohydrate 75.5%, amylose 8.20%, amylopectin 43.6%, starch 51.8%, omega 6 0.2%, and fat-soluble vitamins A, D, and E at 0.5 IU/100gr, 24.8 g/100gr, and 0.01 mg/100 gr. Water-soluble vitamins B1, B2, B6, and C were present in amounts of 4.55, 1.96, 0.17, and 0.70 mg/kg, respectively. C. esculenta L. aqueous extract also included minerals such as the trace elements sodium (Na), potassium (K), calcium (Ca), magnesium (Mg), iron (Fe), and zinc (Zn) in the amounts of 35.2, 4638, 137, 129, 47.9, and 13.8 (mg/100gram), respectively. The aqueous extract of C. esculenta L. tubers includes a variety of nutrients and offers the potential to be consumed as a functional food.
In-vitro antimicrobial activity of lemon bark extract against Salmonella shigella and Escherichia coli
Sciences of Phytochemistry Volume 2 Issue 2
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphy02020031

Abstract

The main objective of the study was the extraction and testing of the antimicrobial activity of the Lemon bark extract against the microorganisms involved in air and waterborne infections. The antibiotics are not very effective in the present day as the microorganisms are becoming resistant, the study concentrates on the antimicrobial activity and time ahead of the prophylactic potential of the lemon bark extract. Phytochemical analysis for the constituents of Lemon bark showed the presence of saponins, flavonoids and tannins in the aqueous form of solution. The potency test on microorganisms proved to be active against Salmonella shigella with the minimum inhibitory concentration of 100 mg/L was 16.27 mm, 150 mg/L was 16.43 mm and 250 mg/L was 16.73 mm. Meanwhile, for Escherichia coli for 100 mg/L was 13.20 mm, 100 mg/L was 13.10 mm and 150 mg/L was 13.13 mm.
Insights on the Efficacy and Safety of Selected Herbal Teas
Sciences of Phytochemistry Volume 2 Issue 2
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphy02020022

Abstract

Herbal teas are very common around the world. It has a good therapeutic effect. But due to adulteration, we face an obstacle to using them. The author has collected some clinical trials on commercial herbal tea formulations on the market that have proven their efficacy and safety. So, the future is for herbal medicine owing to people's psychology, minimum adverse reactions, and lower cost. The pharmaceutical manufacturing of herbal tea formulations should be encouraged to use them as add-on therapy or healthy daily beverages at least.
A review focusing on the benefits of green tea catechins as nutraceuticals
Sciences of Phytochemistry Volume 2 Issue 2
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphy02020001

Abstract

Any product generated from food sources that offer additional health advantages over and above the essential nutritional content present in foods is referred to as a nutraceutical under the broad umbrella term. The catechins in Camellia sinensis (Theaceae) namely (-)-epicatechin, (-)-epicatechin-3-gallate, (-)-epigallocatechin, and (-)-epigallocatechin-3-gallate (EGCG), which can be used as nutraceuticals in food or as a component of food items has been discussed. Catechins being polyphenols and antioxidants are found to have a wide range of therapeutic application like weight loss, anticancer, anti-inflammatory, and a few more therapeutic applications, through various mechanisms like stimulating AMP-activated protein kinase, enhanced apoptosis, decreased expression of interleukin (IL)-6 and IL-8. The most recent method for extracting catechins include combining the extraction processing of PEF or IPL with Subcritical water extraction. Food additives have been mixed with green tea extracts to develop a desired formulation like chewing gum and capsule. As green tea catechins are a beneficial phytoconstituents to improve overall health, its prospects include formulation of a gelatin gummy formulation which will improve its palatability by masking the bitter taste. Gelatin gummy formulation can be carried conveniently and will provide easy access to the consumer as compared to green tea. Furthermore, we found a scope to develop an analytical method for EGCG and carry out its validation by HPLC which will be more reliable and cost-efficient in comparison to the existing UHPLC methods for EGCG.
A mini review on the analytical method and its validation for Psidium guajava
Sciences of Phytochemistry Volume 2 Issue 2
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphy02010013

Abstract

The well-known tropical tree Psidium guajava, also known as the guava, is widely farmed for its fruit. This article consists of literature about various analytical techniques like TLC, UV spectrophotometry, HPLC, and HPTLC that could be used to analyze the Guava plant. The HPLC analysis of Quercetin isolated from the leaves of the guava plant uses a 4 x 125 mm Hypersil ODS column with a mobile phase of 0.5 percent ortho-phosphoric acid in water and methanol at a flow rate of 1ml/min. The column wash times are 20 min and 18 min, respectively. 250C is the temperature in the column. Silica gel 60F 254 pre-coated plates (10x10 cm) were used with toluene: acetone: formic acid (38:10:5) as the solvent system for HPTLC analysis of quercetin obtained from the tender leaves of guava. The λ max was observed in the U.V. spectrum of the isolated compound (quercetin) on three standard wavelengths: 212 nm, 256 nm, and 372 nm. An effort can be made to produce a new analytical method that will be cost-effective and time-saving.
In-vitro and in-silico evaluation of Brugmansia sauveolens' ability to treat asthma
Sciences of Phytochemistry Volume 2 Issue 1
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphy02010159

Abstract

Asthma is a common chronic inflammatory disease of the airways. The airway epithelium produces bioactive cellular mediators that trigger the chronic inflammatory response. These mediators then attract and activate inflammatory cells in the airways of the lungs and release more biochemical mediators. With several benefits, such as a significant reduction in the cost and time of drug discovery as well as the use of laboratory animals, in-silico studies have grown to be an important and simple method for examining various chemical compounds against various targets. One of the common herbs found in the local Himalayan area is Brugmansia sauveolens, known as Datura, which is a source of tropane alkaloids and asthma can be effectively managed with alkaloids. Using a Soxhlet extractor, the collected plant components were first extracted with petroleum ether (to remove fats) followed by methanol. Online technologies like PASS Online, Molinspiration, SEA, SWISS, and SLAP data were used for a variety of in-silico predictions. After that, we tested the ability of Brugmansia extracts to reduce inflammation using an in-vitro approach. Rat RBC membrane lyses were stabilized using the plant extract fractions. The outcomes were also compared with aspirin (a common anti-inflammatory drug). Bioinformatics techniques were used to detect structural activity. After investigating all the data It was shown that B. sauveolens had anti-asthmatic activity.

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