cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Abd. Kakhar Umar
Contact Email
abdulkaharumar@gmail.com
Phone
-
Journal Mail Official
sciphy@etflin.com
Editorial Address
Sungai Manonda Street, Duyu, Tatanga, Palu City 94225, Indonesia.
Location
Kota palu,
Sulawesi tengah
INDONESIA
Sciences of Phytochemistry
Published by ETFLIN
ISSN : 29625793     EISSN : 2962553X     DOI : https://doi.org/10.58920/sciphy
Core Subject : Health, Science, Engineering,
Chemical Engineering, Chemistry & Bioengineering Chemistry Medicine & Pharmacology
Sciences of Phytochemistry (SciPhy or Sci Phytochem) is an international, peer-reviewed, open access journal published by ETFLIN. SciPhy aims to offer a widely visible and highly indexed platform for scholars and intellectuals to share their insights and works. From July 2023 onwards, SciPhy will accept only four types of articles: Research, Review, Mini-review, and Opinion. SciPhy accepts research, review, mini-review, and opinion/perspective that falls within the scope of the journal. SciPhy will publish articles that describes new and relevant findings on the following topics: Phytochemical Analysis Techniques: Reviewing advancements in methodologies for identifying and quantifying phytochemicals in plant samples, such as chromatography, spectroscopy, and mass spectrometry. Pharmacological Activities of Plant Compounds: Investigating the biological activities of phytochemicals, including their potential as antioxidants, antimicrobials, anti-inflammatory agents, and anticancer compounds. Natural Product Isolation and Characterization: Detailing the extraction, purification, and structural elucidation of bioactive compounds from plants, fungi, and marine organisms. Bioinformatics and Computational Approaches in Phytochemistry: Exploring computational tools and techniques for analyzing phytochemical data, predicting bioactivities, and identifying potential drug candidates from natural sources. Ethnobotany and Traditional Medicine: Examining the ethnopharmacological uses of plants in traditional medicine systems and their relevance to modern drug discovery and development. Phytochemical Diversity in Plant Families: Studying the chemical composition and variability of secondary metabolites across different plant families and genera. Biological Interactions of Phytochemicals: Investigating the interactions between phytochemicals and biological targets, including enzymes, receptors, and cellular pathways. Phytoremediation and Environmental Applications: Discussing the role of plants in detoxifying pollutants, restoring degraded ecosystems, and contributing to sustainable environmental management. Nutraceuticals and Functional Foods: Highlighting the health-promoting properties of phytochemical-rich foods and their potential as functional ingredients in nutraceutical products. Biotechnological Approaches in Phytochemistry: Reviewing biotechnological methods such as plant tissue culture, genetic engineering, and metabolomics for enhancing the production of valuable phytochemicals or developing novel plant-based products.
Arjuna Subject : Ilmu Material (semua kategori) - Kimia Material
Articles 64 Documents
 1   2   3   4   5 
Phytochemical Profiling, Cytotoxicity, and Antiproliferative Potential of Solenostemon monostachyus (Fabaceae) Leaves Odion, Emmanuel Eimiomodebheki; Ambe, Daniel Akpe-Efiak; Ifejika, Kidochukwu Naomi; Odiete, Eravweroso Congrat; Osigwe, Chinyelu Clementina
Sciences of Phytochemistry Volume 3 Issue 2
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphy0302244

Abstract

Solenostemon monostachyus (S. monostachyus) is a widely distributed and important herb in central and west Africa, traditionally used in treating various ailments, including tumors. This study aims to identify the phytoconstituents in the methanol leaf extract of S. monostachyus and evaluate the cytotoxic and anti-proliferative potentials of the methanol extract and its fractions (n-hexane, dichloromethane, and ethyl acetate). Preliminary phytochemical screening was conducted to determine different classes of phytochemical constituents in the powdered leaf. Phytoconstituents were identified from the methanol extract by chromatographic analysis (HPLC and GC-MS). The extract and fractions of S. monostachyus were tested against Raniceps raninus tadpoles and Sorghum bicolor radicles to evaluate their cytotoxic and growth suppression potentials. HPLC analysis revealed catechin, cyanogenic glycosides, flavanone, sparteine, sapogenin, and phytate. GC-MS analysis displayed (Z)-2,3-dihydroxypropyl 9-octadecenoic acid ester, 2-dodecyl-1,3-propanediol, 1-nitro-bicyclo[6.1.0]nonan-2-one, and furazano[3,4-b]pyrazine-5,6-diamine, N, N’-di(propynyl) as the prominent compounds. A cytotoxic effect was observed at 160 µg/mL, with a recorded 56.67 ± 3.33% mortality within 0.5 h, increasing to 100.00 ± 0.00% mortality of the tadpoles within 1 h of treatment. A concentration of 16 mg/mL of S. monostachyus extract significantly (p<0.05) exerted 56.15% (0.82 ± 0.08) suppression of the emerging radicles in 24 h, which later increased to 94.55% (1.10 ± 0.07) after 96 h. This indicates that S. monostachyus leaf extract contains phytochemicals with cytotoxic and growth-suppression potentials.
A comparative study of in-vivo wound healing properties of Tithonia Diversifolia. A gray crude extracts to Silver Sulphadiazine in Albino Wistar rats. Daka, Jimmy J; Nyimbili, Temwani; Mwaba, Grace; Dowati, Gladys; Mwanza, Albert; Siankuku, Munsaka; Banda, Derrick; Tembo, Zebron N; Kayamba, Francis; Banda, Danny; Kalirajan, Arunachalam; Simwatachela, Hyden
Sciences of Phytochemistry Volume 3 Issue 2
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphy0302237

Abstract

One species of flowering plant in the Asteraceae family is Tithonia diversifolia A. Gray (T. diversifolia), which grows as a shrub or weed. Significant anti-infective therapeutic characteristics, such as anti-mycobacterial, antifungal, antibacterial, anti-inflammatory, anti-malaria, and anthelmintic effects, have been discovered in the plant's extracts. Ethnic communities have been using the plant extract to cure wounds. They appear to prefer it above conventional treatments in many circumstances, to the point where their aqueous solution may be smuggled into medical institutions in order to augment the care provided. The purpose of this study was to compare T. diversifolia with silver sulphadiazine's capacity for wound healing. For 72 hours, a 70% ethanol alone and water alone was used to extract the plant. After the extracts dried out, the powder was measured and 10 mL of reconstituted volume was assessed at various concentrations for the purpose of treating wounds. Silver sulphadiazine was used as the positive control and distilled water as the negative control. According to the findings, the aqueous extract had a 48.0% healing rate after 14 days of treatment, ethanol had a 20.0% healing rate, and silver sulphadiazine had a 22.0% healing rate. It is possible to draw the conclusion that the aqueous extract concentration of 0.6 mg/10 mL demonstrated a higher healing percentage than silver sulphadiazine and the ethanol extract.
Aphrodisiac Activity of Clove Leaves (Syzygium aromaticum L.) Ethanol Extract and Fractions in Wistar rats Yanuarty, Rezky; Tuldjanah, Muthmainnah; Wulandari, Ayu
Sciences of Phytochemistry Volume 3 Issue 1
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphy0301183

Abstract

Erectile dysfunction (ED) and premature ejaculation are prevalent male sexual dysfunctions affecting various age groups. This study explores the potential aphrodisiac effects of Clove leaves (Syzygium aromaticum L.), a plant rich in secondary metabolites, including alkaloids, flavonoids, saponins, and steroids. Fractionation of the ethanol extract yielded n-hexane, ethyl acetate, and water fractions. Phytochemical screening revealed the presence of alkaloids, flavonoids, and saponins in the water fraction, while steroids were detected in the ethanol extract, ethyl acetate, and n-hexane fractions. In vivo tests on male rats demonstrated that the ethanol extract, n-hexane, and ethyl acetate fractions significantly reduced mounting latency (ML), increased mounting frequency (MF), and accelerated intromission latency (IL), indicating heightened sexual arousal and endurance. Moreover, these fractions delayed ejaculatory latency (EL) and increased ejaculation frequency (EF), akin to the positive control, X-Gra. Notably, the n-hexane fraction showed the closest efficacy to X-Gra. The presence of steroids in the active fractions suggests their role in eliciting aphrodisiac effects. Further isolation and purification of the active compound(s) may optimize therapeutic outcomes. This study underscores the potential of Clove leaf fractions as natural aphrodisiacs, warranting further investigation for clinical applications.
Lemon Oil Enhances the Anti-Rheumatic Activity of Woody Essential Oils in Formaldehyde-Induced Arthritis in Wistar Rats Uronnachi, Emmanuel; Okpalaku, Onyinyechi; Ikeotuonye, Chidalu
Sciences of Phytochemistry Volume 3 Issue 1
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphy0301228

Abstract

Rheumatoid Arthritis (RA) is a major challenge, especially in the elderly. Many orthodox drugs have been helpful in managing the disease; however, deleterious side effects have been reported. Essential oils have been shown to exhibit anti-arthritic properties. This study highlights and compares the chemical composition and anti-arthritic activities of essential oils from Citrus limon, Zingiber officinale, and Curcuma longa. Twenty-seven Wister rats of both sexes were divided into 9 groups of three animals each. Acute non-immunological arthritis was induced by a sub-plantar injection of 0.1 mL formaldehyde (2% v/v). The animals were treated topically with essential oils extracted by hydro-distillation and analyzed by gas chromatography. Measurement of paw volumes was done daily for 10 days using the volume displacement method. Ginger oil and turmeric oil achieved a 100% reduction in paw volume from the 8th day (p<0.05). The coconut oil as carrier for the essential oils exhibited sub-optimal reductions when administered alone as a control. Combinations of the oils showed an antagonistic effect in the ginger/turmeric oil blend, while the essential blends of turmeric/lemon and ginger/lemon oil performed better than the individual oils. The findings from this study showed that the woody essential oils (ginger and turmeric) exhibited the greatest anti-arthritic activity of all the oil treatment groups. Terpenes like ar-turmerone, turmerone, zingiberene, and D-limonene may have been responsible for the activities observed with the turmeric, ginger, and lemon essential oils, respectively. Lemon, ginger, and turmeric essential oils are effective for the management of rheumatoid arthritis.
Boswellia dalzielii Methanol Stem Bark Extract Demonstrates Significant Analgesic Activity in Swiss Albino Mice Abubakar, Hauwau; Tahir, Albashir; Umar, Aminu Kura
Sciences of Phytochemistry Volume 3 Issue 1
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphy0301225

Abstract

Medicinal plants are gaining popularity as safer and more natural alternatives to orthodox medicines for managing health challenges and diseases. One such plant is Boswellia dalzielii, a renowned tree in northern Nigeria extensively used due to its ethnomedicinal importance. To determine the analgesic properties of Boswellia dalzielii methanol extract (BDME), the extract was screened in mice using thermal and acetic acid-induced pain models. The extract's acute toxicity and phytochemical constituents were determined using standard protocols. The results showed that the acute toxicity of the methanol stem bark extract was greater than 2000 mg/kg. Phytochemical screening of BDME revealed the presence of flavonoids, tannins, saponins, and glycosides. The extract, at the dose of 50 mg/kg significantly (p < 0.05) prolonged the pain reaction time at 15 and 30 minutes in the hot plate test, and reduced acetic acid-induced writhing at the 12.5, 25, and 50 mg/kg doses. The analgesic activity of the extract may be attributed to the phytochemical contents. The findings suggest that BDME have analgesic properties and could be beneficial in alleviating painful conditions.
Chemical profiling of essential oils: Investigations into modulating milk production in dairy cows using in silico methods GÖZE, İsmihan; KAYMAK, Sibel; VURAL, Nilüfer
Sciences of Phytochemistry Volume 3 Issue 1
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphy0301227

Abstract

This study aimed to assess the biological and biotherapeutic activities of essential oils derived from the medicinal plants Tanacetum vulgare L., Myrtus communis L. subsp. communis L., and Pimpinella flabellifolia (Boiss.) Benth. Et Hook. ex Drude. Plant samples were systematically collected from the Sivas region of Türkiye. Subsequently, essential oils were extracted using a Clevenger-type apparatus, and their compositions were assessed by gas chromatography–mass spectrometry (GC-MS) analysis. Then, antioxidant activities of the essential oil samples were investigated using β-carotene-linoleic acid and 2,2-diphenyl-1-picrylhydrazyl (DPPH) assays. Furthermore, the antimicrobial activity of these species was assessed via the disc diffusion assay. Finally, the potential effects of the essential oil compositions from these plants on milk production in dairy cows were analyzed through in-silico methods.
In Silico Larvicidal Activity Study of Six Limonoids Against Mosquito Larvae (Aedes aegypti L.) Ecdysone Receptor Protein Rajab, Mohamed Said
Sciences of Phytochemistry Volume 3 Issue 1
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphy0301217

Abstract

In an earlier study, six limonoids namely pyroangolensolide, calodendrolide, limonin, limonin diosphenol, harrisonin and pedonin were reported to exhibit varying larvicidal activity against Aedes aegypti L. second instar larvae. The degraded limonoids exhibited a higher larvicidal activity relative to the more complex compounds. To investigate this observation at the relevant Aedes aegypti L. receptor level, the six limonoids were subjected to an in silico docking study to evaluate the binding characteristics of the selected limonoids in the ecdysone receptor (EcR) protein (PDB code 1z5x). This was compared with the binding affinity of the dipteran specific ecdysone agonist, RH 5849 (1,2-Dibenzoyl-1-tert-butylhydrazine). The EcR protein1z5x-LBP was identified from literature data. The binding energies of the ligands docked in the EcR protein 1z5x-LBP ranged from 3.0 to -9.1 kcal/mol and the dissociation constants (Kd) ranged from 2.10×10-7 M to 1.59×10+2 M. RH 5849 had a binding energy of -8.9 kcal/mol which was comparable with those displayed by pyroangolensolide (-9.1 kcal/mol) and calodendrolide (-9.0 kcal mol). Two pharmacophoric factors were important in the observed binding: (a) the hydrogen-bonding interactions by the residues Arg 271, Arg 275 Tyr 296. Thr231 and Ala 286 and (b) the hydrophobic pocket residues Met 268, Met 272, Met 269, Phe 285, and Leu 308. The binding affinities of the selected limonoids in the EcR pocket compared well with the observed larvicidal activity as reported earlier and in the literature. This study offers an opportunity to develop structurally simpler and specific receptor targeted larvicides against Aedes aegypti L.
Phytochemical Profiling of Passiflora edulis Vines Odion, Emmanuel Eimiomodebheki; Nwigwe, Godfavour Nzubechukwu; Ambe, Daniel Akpe-Efiak; Nnamani, Monica Nnenna; Osigwe, Chinyelu Clementina; Odiete, Eravweroso Congrat; Iyanyi, Loveth Uchechukwu
Sciences of Phytochemistry Volume 3 Issue 1
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphy0301219

Abstract

Over time Passiflora edulis f. flavicarpa (PEFF) have been utilized in traditional medicine for the treatment of different health ailments. This study aims to identify the phytochemical constituents in the vines of PEFF responsible for its traditional usage. Maceration in methanol was used in the extraction of the powdered vines and standard procedures were also used to screen for its phytochemical contents. Two chromatographic techniques such as High Pressure Liquid Chromatography (HPLC) and Gas Chromatography - Mass Spectrometry (GC-MS) were exploited to identify and quantify the phytoconstituents in the methanol extract. Phytochemical screening showed alkaloids, glycosides, flavonoids, tannins, steroids, saponins and terpenoids in the vines of PEFF. Prominent compound revealed by HPLC analysis include pyrogallol (18.64%), ferulic acid (13.71%), ellagic acid (12.88%), salicylic acid (10.83%), ribalinidine (10.50%) and cresol (9.67%). While the GC-MS analysis showed Octadec-9-enoic acid (67.78%); 3-methylindole-2-carboxlic acid,4,5,6,7-tetrahydro-, ethyl ester (16.89%) and 3-aminopyrrolidine (14.52%). Thus, the vines of PEFF contain phytoconstituents responsible for it use in traditional medicine.
Phytoconstituents, Fourier-Transform Infrared Characterization, and Antioxidant Potential of Ethyl Acetate Extract of Corchorus olitorius (Malvaceae) Dahiru, Mubarak Muhammad; Umar, Abubakar Sadiq; Muhammad, Musa; Waziri, Asma'u Abubakar; Fari, Ibrahim Ishaq; Musa, Zuwaira Yusuf
Sciences of Phytochemistry Volume 3 Issue 1
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphy0301208

Abstract

Oxidative stress is a condition that is characterized by the generation of reactive oxygen species more than the amount endogenous antioxidants can absorb. Several diseases are associated with oxidative stress, notably during disease progression. Thus, the present study aimed to determine the phytoconstituents and antioxidant potential of the ethyl acetate leaf extract of Corchorus olitorius (ELEC). The phytochemicals were qualitatively and quantitatively determined, followed by characterization using Fourier-transform infrared (FTIR) spectroscopy. The antioxidant potential was determined in vitro. Alkaloids, saponins, and flavonoids were detected in concentrations of 8.50 ±2.65, 11.83 ±0.73, and 19.17% ±0.73, respectively. The FTIR spectrum revealed 9 peaks including six at the group frequency region corresponding to alcohols, carboxylic acid, amine salts, alkenes, alkyne, esters, and oxime functional groups. The ELEC exhibited lower total reducing power (11.06 ±1.34 AAE µg/ml) compared to its total antioxidant capacity (49.26 ±2.44 AAE µg/ml) with a higher (60.47% ±2.44) percentage inhibition of peroxidation than AA (37.98% ±1.88). Furthermore, the ELEC exhibited a lower (0.20 ±0.01 nmol/ml) MDA concentration than AA (0.42 ±0.02 nmol/ml). Conclusively, C. olitorius might be applied for the management of oxidative stress-linked ailments and a source of novel therapeutics for these ailments.
Pharmacognostic study and sedative activity of Bryophyllum pinnatum stem methanol extract and fractions
Sciences of Phytochemistry Volume 2 Issue 2
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphy02020127

Abstract

Insomnia is known as sleep insufficiency and is considered a capital public health concern. Bryophyllum pinnatum which belongs to the family Grassulaceae is used in folkloric medicine to treat various kind of ailment. The aim of the study was to undertake a pharmacognostic study of the stem and determine the sedative/hypnotic ability of the methanol extract and fraction of the stem. The physicochemical analysis indicated moisture content (12.68%), total ash (3.75%), acid insoluble ash (2.60%), water soluble ash (2.00%), water soluble extractive (6.02%) and alcohol soluble extractive (10.80%). The organoleptic evaluation of the powdered leaves revealed an odorless, green plant with bitter taste. The microscopic analysis of the leaf revealed palisade cell, spongy cell, stoma, collenchyma, xylem tissue, phloem tissue. The transverse section of the stem revealed epidermis, endodermis, xylem and cortex. The acute toxicity result revealed that Picralima nitida had no adverse effect in Wistar mice. The result showed that ethyl acetate fraction had sedative/hypnotic ability, affected the level of liver enzymes (ALT, AST, ALP), improved kidney function, and insignificantly increased body weight of mice. This study demonstrated that B. pinnatum could be an alternative medicine in pharmacological treatment of insomnia.

Page 1 of 7 | Total Record : 64

 1   2   3   4   5 

Filter by Year

2022 2025


Reset
Filter By Issues
All Issue Volume 4 Issue 2 Volume 4 Issue 1 Volume 3 Issue 2 Volume 3 Issue 1 Volume 2 Issue 2 Volume 2 Issue 1 Volume 1 Issue 2 Volume 1 Issue 1