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Sciences of Phytochemistry
Published by ETFLIN
ISSN : 29625793     EISSN : 2962553X     DOI : https://doi.org/10.58920/sciphy
Core Subject : Health, Science, Engineering,
Chemical Engineering, Chemistry & Bioengineering Chemistry Medicine & Pharmacology
Sciences of Phytochemistry (SciPhy or Sci Phytochem) is an international, peer-reviewed, open access journal published by ETFLIN. SciPhy aims to offer a widely visible and highly indexed platform for scholars and intellectuals to share their insights and works. From July 2023 onwards, SciPhy will accept only four types of articles: Research, Review, Mini-review, and Opinion. SciPhy accepts research, review, mini-review, and opinion/perspective that falls within the scope of the journal. SciPhy will publish articles that describes new and relevant findings on the following topics: Phytochemical Analysis Techniques: Reviewing advancements in methodologies for identifying and quantifying phytochemicals in plant samples, such as chromatography, spectroscopy, and mass spectrometry. Pharmacological Activities of Plant Compounds: Investigating the biological activities of phytochemicals, including their potential as antioxidants, antimicrobials, anti-inflammatory agents, and anticancer compounds. Natural Product Isolation and Characterization: Detailing the extraction, purification, and structural elucidation of bioactive compounds from plants, fungi, and marine organisms. Bioinformatics and Computational Approaches in Phytochemistry: Exploring computational tools and techniques for analyzing phytochemical data, predicting bioactivities, and identifying potential drug candidates from natural sources. Ethnobotany and Traditional Medicine: Examining the ethnopharmacological uses of plants in traditional medicine systems and their relevance to modern drug discovery and development. Phytochemical Diversity in Plant Families: Studying the chemical composition and variability of secondary metabolites across different plant families and genera. Biological Interactions of Phytochemicals: Investigating the interactions between phytochemicals and biological targets, including enzymes, receptors, and cellular pathways. Phytoremediation and Environmental Applications: Discussing the role of plants in detoxifying pollutants, restoring degraded ecosystems, and contributing to sustainable environmental management. Nutraceuticals and Functional Foods: Highlighting the health-promoting properties of phytochemical-rich foods and their potential as functional ingredients in nutraceutical products. Biotechnological Approaches in Phytochemistry: Reviewing biotechnological methods such as plant tissue culture, genetic engineering, and metabolomics for enhancing the production of valuable phytochemicals or developing novel plant-based products.
Arjuna Subject : Ilmu Material (semua kategori) - Kimia Material
Articles 50 Documents
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Anticonvulsant Activities of Asperphenamate and Nepetaefuran Isolated from Leucas martinicensis (Jacq.) Ait. f. Bodrix, Noudou Solitaire; Armand, Malle Lando; Celine, Mbazoa Djama; Godfred, Aponglen Ayimele; Jean, Wandji; Germain, Taiwe Sotoing; Dereck, Ndinteh Tantoh; Rostan, Talla Mangoua
Sciences of Phytochemistry Volume 5 Issue 1
Publisher : ETFLIN

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphy0501523

Abstract

A known peptide, Asperphenamate (1) and a labdane diterpenoid, Nepetaefuran (2) were isolated for the first time from the aerial parts of Leucas martinicensis (Jacq.) Ait. f. (Lamiaceae) together with five known compounds: ß-sitosterol-3-O-ß-D-glucopyranoside and β-sitosterol, oleanolic acid and ursolic acid and Apegenin-7-O-glycoside. The structures of these compounds were established on the basis of mass spectrometry, NMR data and by the comparison with literature data. The dichloromethane-methanol (1:1, v/v) (LM) extract, the peptide and the labdane diterpenoid compounds were evaluated for their anticonvulsant effects on pentylenetetrazol, picrotoxin or bicuculine induced convulsions in mice. All the tested treatments showed anticonvulsant effects on experimental models of epileptic seizures chemically induced in mice. Asperphenamate (1) (JW514) showed up to 100% protection of animals against convulsions, Nepetaefuran (2) (JW512) and the dichloromethane-methanol (1:1, v/v) (LM) extract showed a maximum of 83.33% protection against pentylenetetrazol induced convulsions.
In Vitro Antioxidant, Anti-Inflammatory, Anthelmintic, Anti-Microbial, FTIR and TLC Analysis of the Leaves of Memecylon amoenum Buah, Patrick; Acheampong, Akwasi; Amengor, Cedric Dzidzor; Oti-Boakye, Adolf; Baah, Kennedy Ameyaw; Odei, Judith; Acheampong, Lydia Opoku; Sarfo-Mainoo, Lydia Tima
Sciences of Phytochemistry Volume 5 Issue 1
Publisher : ETFLIN

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphy0501529

Abstract

Memecylon amoenum is traditionally employed across West Africa for treating waist pains, diarrhoea, wounds, toothache and various skin ailments. The study aimed to identify major phytoconstituents using standard phytochemical screening, chromatographic separation, and FTIR analysis and to evaluate the biological activities of the methanol and petroleum ether leaves extracts. Phytochemical investigations revealed twelve constituents in the pulverized plant material and eleven in the methanolic extract, while the petroleum ether extract contained six. In the DPPH assay, the methanol and petroleum ether extracts of M. amoenum demonstrated IC₅₀ values of 11.42 ± 0.05 and 43.42 ± 0.62 µg/mL, respectively, outperforming ascorbic acid (58.46 ± 0.8 µg/mL). Total antioxidant capacity values (gAAE/100 g) were 36.04 ± 1.43 for the hetmethanol extract and 31.35 ± 3.98 for the petroleum extract. The extracts also exhibited potent anthelmintic activity, surpassing mebendazole at all tested concentrations for example the death time at 6mg/mL are 2min 05s, 4min 16s and 8min 33s respectively for the methanol extract, pet-ether extract and mebendazole. Both extracts showed broad antimicrobial effects, with minimum inhibition concentrations, 0.0122 to 25 mg/mL, and demonstrated notable anti-inflammatory properties. Thin-layer chromatographic profiling revealed four spots in the methanolic extract and seven in the petroleum ether extract, suggesting chemical diversity between the solvent fractions. FTIR spectra confirmed the presence of functional groups consistent with the compounds detected through phytochemical screening. The results indicate that the methanol and petroleum ether extracts of M. amoenum possess significant antioxidant, anti-inflammatory, antimicrobial and anthelmintic activities, supporting their potential as therapeutic effect.
Anti-Inflammatory Properties of Acetone Extract of Green Coffee Beans: An In Vitro Assay Chukwuemeka, Chimezie Alexdaniel; Ofoegbu, Chukwudi Jude; Amadi, Nnaemeka Promise
Sciences of Phytochemistry Volume 5 Issue 1
Publisher : ETFLIN

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphy0501589

Abstract

This study evaluated the anti-inflammatory potential of the acetone extract of green coffee beans (Coffea excelsa) using in vitro assays. The extract was assessed for its ability to inhibit protein denaturation and stabilize biological membranes using heat-induced hemolysis of human erythrocytes as a model. The extract exhibited an overall increase in inhibitory effect across the tested concentrations in both assays. In the protein denaturation assay, percentage inhibition increased from 13.10% at 100 µg/mL to 70.45% at 1000 µg/mL, with an IC₅₀ value of 249.8 µg/mL. Similarly, in the membrane stabilization assay, inhibition ranged from 21.16% to 62.06% across the same concentration range, with an IC₅₀ value of 391.6 µg/mL. Statistical analysis using one-way ANOVA followed by Dunnett’s post hoc test indicated that all tested concentrations produced significant effects compared to the control (p < 0.0001). IC₅₀ values were determined using nonlinear regression analysis (n = 3). Although the extract showed lower activity compared with acetylsalicylic acid, it demonstrated moderate anti-inflammatory activity. These effects may be associated with the presence of bioactive compounds such as phenolics and flavonoids; however, this cannot be confirmed since no phytochemical analysis was conducted in this study. Overall, these results indicate that the acetone extract of green coffee beans possesses measurable anti-inflammatory properties in vitro, suggesting that it may serve as a potential source of bioactive compounds for further investigation. Further studies, including phytochemical characterization and in vivo evaluations, are required to validate these findings.
Harnessing plant secondary metabolites for vaccine development in Africa: Current insights and future prospects Chandipwisa, Courage; Banda, Harrison; Shimilimo, Agness
Sciences of Phytochemistry Volume 5 Issue 1
Publisher : ETFLIN

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphy0501524

Abstract

Plant secondary metabolites are natural compounds with immunomodulatory and adjuvant properties that may complement conventional vaccines and support regionally relevant vaccine strategies in Africa. This structured narrative review analyzed English-language studies published between 2000 and 2025 from PubMed, Google Scholar, Elsevier, and EBSCOhost. Included publications comprised original research, systematic reviews, and clinical trials addressing mechanisms, formulation, safety, and clinical development. Evidence included in vitro studies, animal models, formulation research, and human investigations. Preclinical findings show that selected metabolites enhance antigen presentation, promote dendritic cell maturation, and strengthen humoral and cellular immune responses through modulation of key signaling pathways. Triterpenoid saponins from Quillaja saponaria have progressed into clinical adjuvant platforms, while polysaccharides from Moringa oleifera and flavonoids from Curcuma longa and Artemisia annua demonstrate immunostimulatory effects and improved antigen stability in preclinical models. Nanoencapsulation improves compound stability and delivery but lacks sufficient clinical validation. Clinical translation requires standardized phytochemical characterization, comprehensive safety evaluation, regulatory harmonization, validated manufacturing processes, and adequately powered clinical trials with defined immunological endpoints.
Comprehensive phytochemical profiling and in-silico evaluation of endemic medicinal plant Symplocos obtusa Malavika, J.; Thenmozhi, K.
Sciences of Phytochemistry Volume 5 Issue 1
Publisher : ETFLIN

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphy0501584

Abstract

Plants rich in phytochemical compounds are a vital reservoir with great medicinal potential. Among them, Symplocos obtusa Wall. Ex G. Don., commonly known as 'blunt-leaved Symplocos', is an unexplored endemic medicinal plant species belonging to the distinguished plant family Symplocaceae. The present study undertakes a comprehensive phytochemical profiling of S. obtusa, coupled with in vitro and in-silico approaches. Screening of the ethanolic leaf extract of S. obtusa revealed several phytochemical constituents, with highest extractive yield (6.0%) and higher total phenolic (4.30±0.02mg GAE/g), tannin (2.91±0.02mg GAE/g), and flavonoid content (71.15±0.86mg RE/g). Furthermore, a thorough analysis of the phytocompounds and their therapeutic efficacy was conducted using Fourier Transform Infrared Spectroscopy (FTIR), Gas Chromatography-Mass Spectrometry (GC-MS), and other major in-silico approaches, such as toxicity prediction. Moreover, in vitro antioxidant studies were conducted to evaluate the therapeutic potential of S. obtusa. FTIR confirmed the presence of different functional groups, and GC-MS analysis identified 19 key phytochemical compounds with pharmacologically significant functions. In vitro antioxidant assays confirmed potential antioxidant activities of the plant species with an IC50 of (26.55±0.61µg/mL) in DPPH, 27.09±0.11 µmol/g (ABTS•+@), 51.38±0.08 mg/g in phosphomoleybdenum assay, and suggest its therapeutic relevance. In-silico evaluations further supported the pharmacological relevance and safety of the identified compounds. Integrative in vitro and in-silico evaluation indicated favourable drug likeness and low predicted toxicity, with most compounds belonging to toxicity classes IV-VI. These findings establish S. obtusa may serve as a promising candidate for pharmacological exploration and drug discovery, particularly in the development of plant-derived therapeutic agents.
A Comprehensive Review of the Phytochemistry of Sphagneticola trilobata (L.) Pruski Patil, Harshal Shivaji; Baviskar, Ashwini Sanjay; Kolat, Swati P
Sciences of Phytochemistry Volume 5 Issue 1
Publisher : ETFLIN

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphy0501390

Abstract

Sphagneticola trilobata (L.) Pruski (Asteraceae) has attracted increasing scientific interest due to its rich phytochemical diversity and reported biological activities. This review systematically evaluates published literature retrieved from major scientific databases (including PubMed, Scopus, and Web of Science) covering studies, using defined inclusion and exclusion criteria focused on phytochemical identification and bioactivity assessment. Available evidence indicates that S. trilobata contains multiple classes of secondary metabolites, including terpenoids, flavonoids, alkaloids, steroids, and saponins. Among these, terpenoids emerge as the most frequently reported and quantitatively dominant constituents, particularly in aerial parts, and are consistently associated with antimicrobial, anti-inflammatory, and cytotoxic activities. Flavonoids and alkaloids, though less abundant, contribute complementary antioxidant and pharmacological effects. The review synthesizes current findings to prioritize phytochemical groups based on abundance and bioactivity rather than simple classification. While several compounds demonstrate promising bioactivities, most evidence remains limited to in vitro and preclinical studies. Consequently, the potential of S. trilobata–derived metabolites for drug discovery should be interpreted cautiously, highlighting the need for further mechanistic, toxicological, and clinical investigations. Future research should emphasize standardized extraction protocols, advanced analytical techniques such as LC-MS/MS and NMR, and robust bioassay-guided fractionation to accurately link specific compounds with observed biological effects. In addition, structure–activity relationship studies and molecular docking approaches may help elucidate mechanisms of action and identify lead candidates. Importantly, well-designed in vivo experiments and controlled clinical trials are essential to validate safety, efficacy, and pharmacokinetic profiles before therapeutic application can be considered viable across diverse populations and disease models in translational research.
Phytochemical Extraction from Mediterranean Plants: A Comparative Study of Traditional Techniques Melro, Elodie; Jesus, Carolina F.; Duarte, Tomás; Alves, Andreia A. S.; Antunes, Filipe E.; Lindo, Margarida; Ribeiro, Daniel
Sciences of Phytochemistry Volume 5 Issue 1
Publisher : ETFLIN

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphy0501592

Abstract

This study investigates how solvent polarity and extraction technique influence the recovery of bioactive compounds from four Portuguese native plants: Geranium robertianum (herb Robert), Olea europaea (olive leaves), Salvia rosmarinus (rosemary) and Laurus nobilis (bay laurel). Maceration and Soxhlet extractions were performed using five solvents spanning a polarity range (methanol, ethanol, ethyl acetate, dichloromethane and hexane), followed by colorimetric phytochemical screening and extraction-yield comparison; aqueous infusion and water-based Soxhlet extraction were also assessed. Among the organic solvents tested, extraction yield increased with solvent polarity, with methanol consistently giving the highest recoveries; aqueous extraction showed species-dependent behavior. Phytochemical assays indicated a wide metabolite coverage in methanolic extracts, whereas tannins were not detected in ethanolic extracts and were only evidenced in bay laurel under less-polar conditions. GC–MS profiling of ethanolic extracts revealed distinct species-specific fingerprints dominated by fatty acids and terpenoid constituents, with Soxhlet generally enhancing late-eluting hydrophobic metabolites; rosemary was enriched in phenolic diterpenes, herb Robert and olive leaves showed a stronger contribution of carbohydrate-related compounds, and bay laurel displayed a comparatively simpler lipid/terpenoid profile. These results highlight the suitability of these Portuguese native plants as versatile sources of bioactive fractions whose composition can be selectively tuned through solvent polarity and extraction strategy.
Green-synthesized Zinc Oxide Nanoparticles from Cissus aralioides: Characterization, and Antimicrobial Potentials Onunkwo, Innocent Chukwujekwu; Edema, Mary Olire; Ogwuche, Christiana E.; Akpeji, Bamidele H.
Sciences of Phytochemistry Volume 5 Issue 1
Publisher : ETFLIN

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphy0501537

Abstract

Antimicrobial resistance represents a critical global challenge due to microbial enzymes that neutralize antibiotic efficacy, prompting the use of nanotechnology to enhance the therapeutic potential of plant properties. In this study, zinc oxide nanoparticles (ZnONPs) were biosynthesized using a methanol extract of Cissus aralioides leaves obtained through Soxhlet extraction. Characterization via UV-vis, FTIR, PXRD, SEM, EDX, and TEM revealed a maximum absorption at 398 nm, a bandgap energy of 3.12 eV, and a hexagonal wurtzite structure with an average particle size of 15.90 ± 2.81 nm. FTIR analysis confirmed essential chemical groups (C-H, C=O, O-H), while SEM and EDX showed rough surfaces with a predominant zinc content of 80.76%. The antimicrobial potential of these ZnONPs was evaluated against Escherichia coli, Staphylococcus aureus, Aspergillus fumigatus, and Candida albicans using the agar well diffusion method at concentrations of 100–400 mg/mL. Results demonstrated significant antimicrobial activity, with the highest sensitivity observed against S. aureus (24.0 ± 0.01 mm), followed by C. albicans, E. coli, and Aspergillus sp., and an estimated minimum inhibitory concentration of 100–300 mg/mL. Consequently, this research highlights the potential of green-synthesized ZnONPs as a viable alternative for managing pathogenic microorganisms.
Uncovering the Anti-bacterial Potential of Wildly Growing Chamaedorea seifrizii Fruits Targeting Peptidoglycan Editing Factor Proteins: Chemical Profiling, In-silico Analysis and Wet Lab Validation Sharma, Arun Dev; Kaur, Inderjeet; Chauhan, Amrita
Sciences of Phytochemistry Volume 5 Issue 1
Publisher : ETFLIN

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphy0501439

Abstract

Chamaedorea seifrizii is an ornamental plant with limited documented pharmacological properties. Peptidoglycan editing factor (PdeF), a bacterial cytoplasmic amidase, plays a critical role in peptidoglycan biosynthesis of the bacterial cell wall, making it a promising antibacterial target. This study investigated the chemical profiling and in-silico analysis of phytocomponents derived from methanol fruit extracts (CFME) of wild-growing Chamaedorea seifrizii targeting PdeF proteins, followed by in vitro antibacterial validation. The chemical profile of CFME was examined using gas chromatography with flame ionization detection (GC-FID). Molecular simulation studies were performed using docking tool Cb-dock2 against bacterial PdeF. In vitro activity was validated against Gram-negative strains, Pseudomonas aeruginosa (MTCC 424) and Escherichia coli (MTCC 40), and Gram-positive strains, Staphylococcus aureus (MTCC 3160) and Bacillus subtilis (MTCC 121). GC-FID analysis revealed 13 peaks, with osthole as the most abundant phytocompound at 27.49%. Docking of osthole against PdeF showed binding energy of -6.8 kcal/mol, indicating moderate affinity, with the complex stabilized through hydrogen bonding, alkyl and pi-alkyl interactions. In vitro experiments confirmed effective bacterial growth inhibition, with zones of inhibition ranging from 2 mm to 17 mm, compared to reference antibiotic yielding nil to 15 mm. To the best of our knowledge, this is the first report on bioactive components from Chamaedorea seifrizii fruit methanol extracts with antibacterial activity targeting PdeF through a combined in vitro and in-silico approach. These findings highlight the potential of Chamaedorea seifrizii as an antibacterial agent, underscoring the need for further compound-level characterization and safety assessment for applications in pharmaceutical industries.
Formulation and Pharmaceutical Evaluation of Capsules Containing the n-Hexane Fraction of Moringa oleifera Leaves Mathias, Sylvester Nefai; Ahmed, Aliyu Hamidu; Mshelia, Emmanuel Halilu; Mohammed, Achor; Ugwah-Oguejiofor, Chinenye Jane; Lawal, Mansur; Alkali, Ibrahim Yusuf; Igbokwe, Nkeiruka Nkeonyere; Ukwubile, Cletus Anes; Biambo, Ahmed Aminu
Sciences of Phytochemistry Volume 5 Issue 1
Publisher : ETFLIN

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphy0501561

Abstract

This study investigated the phytochemical composition, safety profile, and pharmaceutical formulation of capsules containing the hexane fraction of Moringa oleifera leaves (MOHx). The main objective of this study was to comprehensively evaluate the phytochemical constituents, toxicity profile, and develop a standardized oral capsule formulation of the hexane fraction of M. oleifera leaves suitable for potential therapeutic application. Phytochemical profiling was performed using LC–MS and GC–MS, and compounds were tentatively identified based on spectral library matching and fragmentation patterns. Selected phytochemicals were evaluated using in silico ADMET prediction and molecular docking analyses. Acute oral toxicity was assessed in Wistar rats using Lorke’s method. Pre-formulation studies were conducted prior to capsule formulation using the wet granulation technique. The granules were evaluated for micromeritic properties, and the capsules were subjected to pharmacopoeial quality tests including weight uniformity, disintegration, and dissolution. The estimated LD₅₀ of the extract was 3.808 mg/kg body weight, indicating relatively low acute toxicity. Dissolution testing showed more than 80% release within 20 min under the experimental conditions employed. These findings suggest that the developed capsule formulation provides a suitable pharmaceutical dosage form for the hexane fraction of M. oleifera, although further studies including stability testing, quantitative phytochemical standardization, and pharmacological evaluation are required.

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