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Medical Sains : Jurnal Ilmiah Kefarmasian
Published by Universitas Muhammadiyah Ahmad Dahlan Cirebon
ISSN : 25482114     EISSN : 25412027     DOI : https://doi.org/10.37874/ms
Core Subject : Health,
Medicine & Pharmacology
The Medical Sains journal is a scientific publication media published by the Muhammadiyah Cirebon College of Pharmacy which is published 4 (four) times in 1 (one) year, namely January-March, April-June, July-September and October-December. The journal contains research in the field of pharmacy covering the fields of formulation, pharmacology, communication pharmacy, A natural chemical chemistry, pharmacognomy and other health sciences which is a means for lecturers and researchers in the health sector to share knowledge and establish cooperation in implementing the Tri Dharma of Higher Education. Purpose and Scope The objective of the publication of the Medical Science journal is to publish articles in the field of pharmacy and other health as well as application of pharmaceutical . Based on this, the editorial board of Medical Sains invites lecturers and researchers to contribute to submit research articles related to the following themes: 1. Pharmaceutical formulation technology 2. Pharmacology 3. Community pharmacy 4. Clinical Pharmacy 5. Natural material chemistry 6. Pharmacognosy 7. Pharmaceutical Analysis and Medicinal Chemistry . All papers submitted to medical science journals will be examined by peer review partners who are tailored to their respective fields.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 42 Documents
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Search results for , issue "Vol 8 No 3 (2023)" : 42 Documents clear
AKTIVITAS ANTIOKSIDAN MIKROPARTIKEL KITOSAN DENGAN KANDUNGAN SARI UMBI BIT (Beta vulgaris Linn): ANTIOXIDANT ACTIVITY OF CHITOSAN MICROPARTICLE CONTAINING BEETROOT (Beta vulgaris Linn) EXTRACT Anita Sukmawati; Yumna Azzuhdiyah; Clara Cendera Marthadilla; Isna Vira Risdiyanti
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 3 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i3.754

Abstract

Umbi bit (Beta vulgaris L.) merupakan salah satu tanaman yang memiliki kandungan antioksidan yang tinggi. Antioksidan dalam umbi bit berasal dari pigmen warna merah betasianin yang merupakan turunan dari betalain. Untuk meningkatkan stabilitas betasianin dalam umbi bit dilakukan formulasi sari umbi bit dalam mikropartikel menggunakan kitosan sebagai matriks. Penelitian ini bertujuan untuk mengetahui pengaruh variasi konsentrasi matriks kitosan pada pembuatan mikropartikel sari umbi bit terhadap aktivitas antioksidan sari umbi bit. Mikropartikel kitosan dengan kandungan sari umbi bit dibuat dengan variasi konsentrasi matriks kitosan (0.5, 1 dan 2%) dibuat dengan metode gelasi ionik. Evaluasi yang dilakukan untuk mikropartikel meliputi evaluasi drug loading (DL), efisiensi enkapsulasi (EE) dan aktivitas antioksidan mikropartikel menggunakan metode DPPH. Hasil penelitian menunjukkan DL mikropartikel sari bit merah matriks kitosan konsentrasi 0,5%, 1%, dan 2% secara berturut-turut adalah 8,02% ± 0,102; 22,81% ± 1,449; dan 17,85% ± 0,171. Mikropartikel kitosan menunjukkan penghambatan terhadap oksidasi dimana aktivitas antioksidan mikropartikel sari umbi bit sejalan dengan nilai DL dari mikropartikel. Aktivitas antioksidan akan semakin tinggi jika DL mikropartikel tinggi. Kata kunci : antioksidan, kitosan, mikropartikel, umbi bit
OPTIMASI FORMULA SEDIAAN GRANUL EFFERVESCENT EKSTRAK DAUN KELOR (Moringa oleifera L.): FORMULA OPTIMIZATION OF EFFERVESCENT GRANULE OF MORINGA LEAF EXTRACT (Moringa Oleifera L.) Marlina Indriastuti; Ayu Fuji Astuti; Anna L Yusuf; Faisal Akbar; Rahmah Kurnia R
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 3 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i3.760

Abstract

Daun tanaman kelor (Moringa oleifera L.) sering dimanfaatkan oleh masyarakat sebagai tanaman obat tradisional yang memiliki kandungan antioksidan. Penelitian yang dilakukan bertujuan untuk mengembangkan formulasi, memperbaiki rasa, dan mengevaluasi granul effervescent ekstrak daun kelor (Moringa oleifera L.) menggunakan perbedaan variasi konsentrasi sorbitol dengan metode granulasi basah. Evaluasi granul effervescent meliputi uji organoleptik, uji kadar air, uji daya alir, uji sudut diam, uji waktu dispersi, uji pH, dan uji ketinggian buih. Tiga formula yang berbeda divariasi dengan memilih konsentrasi sorbitol yang berbeda yaitu formula 1 dengan konsentrasi sorbitol 0,5%, formula 2 1%, dan formula 3 2%. Evaluasi sediaan menunjukkan formula terbaik adalah formula 3 dengan hasil uji evaluasi fisik formula 3 yaitu, berbentuk serbuk berwarna hijau dengan bau khas daun kelor, kadar air 1,93%, daya alir 7,41 g/s, sudut diam 28,07°, waktu dispersi 72 detik, pH 6,47, dan ketinggian buih 2,6 cm. Hasil dari evaluasi formula 3 dengan konsentrasi sorbitol tertinggi tersebut memenuhi persyaratan. Selain itu, formula 3 juga menghasilkan rasa effervescent yang paling baik, yaitu dengan rasa manis asam dengan sensasi segar. Kata kunci : kelor, granul effervescent, sorbitol, Moringa oleifera
REVIEW: TERAPI STUNTING DENGAN MADU JINTEN HITAM TEMULAWAK: REVIEW: STUNTING THERAPY WITH TEMULAWAK BLACK CUMIN HONEY Agus Sulaeman; Cecep Sabarudin
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 3 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i3.770

Abstract

Stunting merupakan kondisi dimana kurangnya tinggi badan seseorang dibandingkan dengan tinggi normal berdasarkan usianya. Salah satu dampak dalam jangka panjang adalah kekebalan tubuh menurun sehingga mudah sakit dan risiko tinggi terjadi penyakit. Oleh karena itu, secara teori balita stunting akan rentan terkena penyakit, terutama penyakit infeksi. Madu jinten hitam dan temulawak, diketahui mekanisme kerjanya terutama ke arah sistem imun yang dapat memperbaiki penyakit stunting. Madu secara oral menstimulasi produksi antibodi. Jintan hitam meningkatkan kadar IgM dan temulawak menimbulkan efek imunosupresor dengan menurunkan proliferasi limfosit. Ulasan ini merangkum madu jinten hitam temulawak sebagai terapi stunting dengan penelusuran jurnal ilmiah terpublikasi taraf international dan nasional pada 10 tahun terakhir dari itahun 2012-2022 melalui database elektronik berupa Pubmed, ScienceDirect dan Google Scholar. Kata kunci: stunting, imunitas, IgM, madu jinten hitam temulawak
MOUTHWASH SPRAY KOMBINASI EKSTRAK DAUN MENGKUDU (Morinda citrifolia L.) DAN RIMPANG TEMULAWAK (Curcuma xanthorrhiza Roxb) UNTUK MENGATASI HALITOSIS: MOUTHWASH SPRAY COMBINATION OF NONI LEAVES (Morinda citrifolia L.) AND CURCUMIN RHIZOME (Curcuma xanthorrhiza Roxb) EXTRACT FOR HALITOSIS Nuri Utami; Ahmad Farras Musyayaf; Zakiyatul Fadhilah; Peni Indrayudha
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 3 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i3.783

Abstract

Bau mulut atau halitosis akibat bakteri anaerob dalam mulut harus dicegah, salah satunya dengan spray antibakteri seperti mouthwash spray. Daun mengkudu memiliki senyawa aktif fenol dan flavonoid berfungsi sebagai antibakteri yang dikombinasi dengan temulawak karena mengandung minyak atsiri dan terdapat gugus fungsi hidroksil dan karbonil untuk melisiskan dinding sel pada bakteri. Penelitian ini bertujuan untuk memformulasi dan melakukan uji aktivitas antibakteri mouthwash spray yang memiliki kandungan daun mengkudu dan temulawak. Daun mengkudu dan rimpang temulawak diekstraksi menggunakan metode ekstraksi maserasi. Evaluasi pada sediaan mouthwash spray dilakukan dengan uji organoleptik berupa warna, aroma dan rasa, uji pH dengan kertas pH, uji viskositas dengan viskosimeter dan uji aktivitas antibakteri dengan metode difusi disk sumuran melalui pengukuran zona hambat. Hasil uji organoleptik menunjukkan bahwa mouthwash spray yang berbentuk cairan memiliki bau khas dan berwarna kuning hingga hijau pekat, homogen, dengan nilai pH pada kontrol negatif, F1, F2 dan F3 yaitu 5,0; 5,0; 5,0 dan 5,0. Uji viskositas pada kontrol negatif, F1, F2 dan F3 yaitu 7,2 cPoises; 7,2 cPoises; 8 cPoises dan 9,6 cPoises. Uji antibakteri diperoleh zona hambat pada kontrol negatif, F1, F2, F3 dan kontrol positif yaitu 0 mm; 4,25 mm, 10,7 mm,12,5 mm dan 13 mm. Hasil ini menunjukkan bahwa mouthwash spray memiliki formula yang aman sebagai sediaan oral dan memiliki aktivitas antibakteri. Kata kunci : daun mengkudu, rimpang temulawak, mouthwash spray, antibakteri  
ANALYSIS OF FACTORS AFFECTING THE ADHERENCE OF TAKING ANTITUBERCULOSIS DRUGS AT PUSKESMAS KOTA MALANG Rudy Mardianto
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 3 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i3.791

Abstract

Tuberculosis (TBC) is an infectious disease caused by Mycobacterium tuberculosis. The high mortality rate from TBC is associated with cases of resistance due to low adherence to medication. This study aimed to determine the effect of age, number of family members, and family support on adherence to antituberculosis drugs. The study was observational using a cross-sectional design. The subjects were 52 outpatients with tuberculosis who met the inclusion and exclusion criteria during the July-August 2022 period at Puskesmas Malang. The results of the study of the most age were 26-35 years as much as 26.92%. The highest number of family members was 3-4 people at 61.54%. Most family support was in the strong category at 86.54%. The results of the ordinal regression test showed that age had a p value of 0.045. The number of family members had a p value of 0.127. Family support had a p-value of 0.040. The conclusion was that age and family support affected medication adce with (p < 0.05). The number of family members did not affect medication adherence (p > 0.05). Age, number of family members, and family support simultaneously influenced medication adherence by 23.7%, while 76.3% were influenced by other factors that were not studied. Keywords: Adherence to taking medication, Family motivation, Tuberculosis
GREEN SYNTHESIS OF SILVER NANOPARTICLES (AgNPS) CONTAINING COMBINATION OF AQUEOUS EXTRACT OF Capsicum annuum L. AND SAFFRON: BIOSYNTHESIS, CHARACTERIZATION, AND ANTIBACTERIAL ACTIVITY Erna Fitriany; Andri Priyoherianto; Masfah Raudlotus S.; Indah Tri Lestari; Fahmi Ardianti Purnawiranita
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 3 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i3.802

Abstract

Silver nanoparticles or Ag-Nanoparticles (AgNPs), which exhibit antimicrobial and biomedical activities, have many benefits in the health sector. AgNPs can be prepared using chemicals such as sodium borohydride (NaBH4). The green synthesis of AgNPs is an environmentally friendly alternative and is cost-effective. Capsicum annuum L. combined with saffron extract was used to synthesize the AgNPs. The biosynthesis, characterization, and antibacterial activity of AgNPs were studied in this study. The synthesized AgNPs were characterized by UV-visible (UV-Vis) spectroscopy, Fourier-transform Infrared Spectroscopy (FTIR), and particle size analysis (PSA). The formation of AgNPs was confirmed by optical performance using UV-VIS spectroscopy, which showed a peak of AgNPs at 407 nm. Capsicum annuum L. combined with saffron extract containing C-H, C-N, and C=O groups. Particle size was characterized using PSA, measuring 37.74 nm with an average SD ±22.10. Capsicum annuum L. combined with the saffron extract showed effective antibacterial activity.  Keywords: Green Synthesis, AgNPs, Capsicum annuum L, Saffron
REVIEW: NATURAL BIOACTIVE COMPOUNDS POTENTIAL ON INHIBITION OF TRANSMEMBRANE SERINE PROTEASE 2 WITH STRUCTURE-BASED VIRTUAL SCREENING METHOD Haviani Rizka Nurcahyaningtyas; Masteria Yunovilsa Putra; Arry Yanuar
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 3 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i3.806

Abstract

The COVID-19 pandemic has led to a global health emergency. Suitable medications are required to prevent severe SARS-CoV-2 infection. Human transmembrane serine protease 2, which is required for viral entry into the host cells, was identified as the target protein. The present study was designed to synthesize, through a systematic review, evidence of phytochemicals found in plants that can inhibit transmembrane serine protease 2 in silico. The databases ScienceDirect, PubMed, Scopus, Nature, and SpringerLink were used for systematic exploration. Among the 113 studies retrieved, 11 were selected for the entire read and 7 studies were deemed appropriate for the qualitative synthesis. Flavonoids, including the bioactive substances luteolin, vicenin 2, naringin, 8-geranylapigenin, phenylethyl-D-rutinoside morusin, sanggenol L, and kaempferol, are the most widely studied classes of secondary metabolites. Other classes that were also evaluated were lactones, terpenoids, and saponins with withanoside-V, 11-hydroxy-2-(3,4-dihydroxybenzoyloxy)abieta-5,7,9(11),13-tetraene-12- one, and licorice as active substances, respectively. This review indicates the most bioactive components of each group of metabolites that demonstrated the greatest binding affinity for the transmembrane serine protease 2 receptor, as an initial point for selecting substances and exploring additional laboratory research and clinical studies to identify novel medication candidates for COVID-19 treatment.  Keywords: Secondary metabolite, SARS-CoV-2, structure-based virtual screening, transmembrane serine protease 2, Plants
ANTIBACTERIAL EFFECTIVENESS (Propionibacterium acnes) OF KOMBUCHA FACE TONER FORMULA WITH GREEN TEA LEAF (Camellia sinensis L.) Aprilia Fatma Ely; Shelly Taurhesia; Teti Indrawati
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 3 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i3.809

Abstract

Acne is a process of chronic inflammation of the sebaceous glands in the skin caused by the bacteria Propionibacterium acnes. Approximately 80-100% incidence of acne occurs in adolescents. One solution is to use an antibacterial agent called catechins. It can be easily obtained from green tea, which has high catechin content. The amount of catechins used as antibacterial substances in green tea can also be increased by fermentation. In addition, lactic acid-fermented green tea can inhibit the growth of P. acnes. This study aimed to produce green tea kombucha face toner with anti-acne activity and good physical stability. This study included an experimental research. The research population was in the form of antibacterial compounds in face toner. The sample was green tea kombucha, which showed antibacterial activity at a concentration of 50% with an 18 mm Diameter of Inhibition Zone (DIZ). And the best formula is F1 with 0.84 mm DIZ, has a pH of 4 which is safe for the skin, clear solution, has clean power, it is also stable during storage at 30o and 40oC, but it has a rather disagreeable scent of toner. Keywords: Acne, Antibacterial, Green Tea Leaves Kombucha, Face Tone
IN SILICO STUDY: SECONDARY METABOLITES FROM RED GINGER RHIZOME (Zingiber Officinale Var. Rubrum) AS POTENTIAL INHIBITORS OF3CLpro AND PLpro OF SARS-CoV-2 Meilia Suherman; Selvira Anandia Intan Maulidya
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 3 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i3.810

Abstract

The COVID-19 outbreak prompted the development of novel drugs to treat the disease. Targeting of virus proteins has attracted great interest in the discovery of COVID-19 drugs. 3CLpro and PLpro are promising targets because of their important role in viral replication. Hence, various efforts have been made to find specific therapeutics for COVID-19, including those derived from plants as anti-Covid-19. Red ginger rhizome (Zingiber officinale var. rubrum) contains secondary metabolites that are known for their health benefits. This in silico study aimed to determine the potency of red ginger rhizome as PLpro and 3CLpro of SARS-CoV-2 inhibitor which may be applied to treat COVID-19. This research was conducted using molecular docking and molecular dynamics simulations. The molecular docking simulation of red ginger compounds in complex with SARS-CoV-2 PLpro showed that 27 compounds have a binding free energy (?G) lower than that of the reference ligand. On the other hand, none of the complexes between red ginger compounds and 3CLpro had a lower binding free energy than the reference ligand. Visualization of interaction features at the PLpro of SARS-CoV-2’s active site shows that secondary metabolites dominantly interact with hydrogen bonds. The ar-curcumene and PLpro complex of SARS-CoV-2 appears very stable and has the lowest flexibility compared to HBA as a native ligand and molnupiravir as a reference ligand based on RMSD and RMSF plot analysis using molecular dynamic simulation...
ANALYSIS OF ADVERSE DRUG REACTIONS TO ANTIRETROVIRALS USE IN A SECONDARY HOSPITAL Vitarani Dwi Ananda Ningrum; Nadia Hanrisari; Tiara Amalia; Sufiyah
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 3 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i3.812

Abstract

Although antiretrovirals (ARV) evidently extend the life expectancy of people living with HIV/AIDS (PLWH), their associated Adverse Drug Reactions (ADRs) are unavoidable, particularly in long-duration regimens. Several studies have reported a correlation between ADRs and adherence to ARV therapy. Meanwhile, ARV is the main determinant of achieving an immunological and virologic response. Pharmacists play the role of counselors in improving therapeutic outcomes including ADR management. This study aimed to analyze ADRs induced by ARV based on pharmacy documentation and to describe the frequency of PLWH follow-up visits over a two-year period. The study was conducted at Sleman Regional Hospital, an HIV/AIDS referral hospital in Yogyakarta. A cross-sectional design was used with saturated sampling, including all ARV use for HIV/AIDS. Data were collected from the pharmacy unit and patients’ spontaneous reports. Prescribed ARV came from the electronic system, whereas ADR reports were from patients during voluntary consultation with the pharmacist or in PITC services. A total of 110 ARV were administered mostly to male patients aged 25-40 years. The most regimen was tenofovir+lamivudine+efavirenz (91%) with the highest frequency of follow-up visits ? 12 times (53%). The top three ADRs were dizziness (30%), nausea (11%), and headache (8%). Three of the four pediatric patients experienced ADRs, each with AZT-induced fatigue, bloating, and diarrhea in LPV/r monotherapy. Most of the patients did not maintain appointments for hospital visits. Further studies are recommended to analyze the causative factors of non-adherence, including the loss to follow-up group.  Keywords: Adverse Drug Reaction, Antiretroviral, Hospital, Indonesia

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