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Poltekita: Jurnal Ilmu Kesehatan
Published by Poltekkes Kemenkes Palu
ISSN : 1907459X     EISSN : 25277170     DOI : https://doi.org/10.33860/jik.v18i1.3700
Core Subject : Health, Science, Social,
Dentistry Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology
Poltekita : Jurnal Ilmu Kesehatan (e-ISSN: 2527-7170, p-ISSN: 1907-459X) is a peer-reviewed open access scientific journal published by Poltekkes Kemenkes Palu. The scope for Poltekita: Jurnal Ilmu Kesehatan includes nutrition, midwifery, nursing, public health, environmental health, food, and nutrition.Each volume of Poltekita: Jurnal Ilmu Kesehatan is counted in each calendar year that consists of 4 issues. Poltekita: Jurnal Ilmu Kesehatan is published two times per year every February, May, August, and November. Articles could be written in either Bahasa Indonesia or English
Arjuna Subject : Profesi Kesehatan - Profesi Kesehatan (Lain-Lain)
Articles 123 Documents
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The Effect of Anthocyanins from Purple Sweet Potato Extract In-vitro on IL-6 mRNA Expression in PBMC Cell Cultures Infected With Hepatitis B Virus Made Agus Hendrayana; I Gusti Kamasan Nyoman Arijana
Poltekita: Jurnal Ilmu Kesehatan Vol. 20 No. 2 (2026)
Publisher : Poltekkes Kemenkes Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33860/jik.v20i2.4233

Abstract

Background: The immune system is a crucial component of the defense against viral infections.  Some cytokines directly regulate the immune response by suppressing viral replication. Interleukin-6 (IL-6) is a pleiotropic cytokine that plays a crucial role in regulating the biological responses of several target cells to viral infections. Natural compounds, such as anthocyanins, possess antiviral properties that may be beneficial in treating various viral infections. The aims of this study are to analyze the effects of anthocyanins on IL-6 expression in PBMC cultures infected with the Hepatitis B virus. Methods: This study was an in-vitro experimental study. This study used a control group and a treatment group, with 18 PBMC cell culture wells. The treatment involved adding 50 µL of purple sweet potato water extract, with an anthocyanin content of 0.01575 µg/µL, to RPMI1640 culture medium in PBMC culture wells for 24 hours. The effect on the IL-6 cytokine response was assessed by quantifying IL-6 mRNA expression in RNA isolated from PMBC cell culture samples using the quantitative real-time PCR method and interpolating from a standard curve of serial dilutions, based on cycle threshold. Data analysis was performed using statistical analysis. Results: Statistical analysis of the effects of purple sweet potato extract exposure on the treatment and control groups was carried out using a paired t-test, showing that there was an effect of exposure to purple sweet potato extract on IL-6 mRNA expression in the treatment group with a p value of 0.001 (p<0.05), while no significant effect of exposure to purple sweet potato extract was found in the control group with a p value of 0.420 (p>0.05). The results of the independent t-test showed that in the treatment group, the mean difference in IL-6 mRNA expression was -75.87±45.77 fg/µL, whereas in the control group, it was -49.26±173.70 fg/µL. In the treatment and control groups, the mean difference in IL-6 mRNA expression was -26.61 fg/µL, with a p value of 0.66 (p>0.05). Conclusion: This study showed that anthocyanins in purple sweet potato water extract did not significantly increase IL-6 mRNA expression in HBV-infected PBMC cultures compared to controls.
Effect of the Happy Mom Application on Pregnant Women’s Knowledge of Fetal Development Nurul Komariah; Sari Wahyuni
Poltekita: Jurnal Ilmu Kesehatan Vol. 20 No. 2 (2026)
Publisher : Poltekkes Kemenkes Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33860/jik.v20i2.1157

Abstract

Background: Stimulation is crucial for development during the first 1,000 days; a lack of stimulation can lead to developmental delays. Parents’ knowledge influences the stimulation they provide. One way to improve mothers’ knowledge of fetal development is to provide education to pregnant women. With advances in technology, mobile apps have emerged as innovative solutions for prenatal education. Based on a survey of pregnancy apps around 2020, most of them were iOS-based. Meanwhile, the majority of users in Indonesia are Android users. Happy Mom is an Android app. The aim is to assess the impact of the education provided through Happy Mom on mothers’ knowledge. Methods: The design was a quasi -experimental, one-group pre-post test design. The sample consisted of all pregnant women who checked in at PMB Teti Herawati in 2021, were present at the time of the study, and met the inclusion and exclusion criteria. The sampling technique was non-probability sampling. Purposive sampling. The sample is 34 respondents. Results: Of the 34 respondents (100%), there is a difference of 3 points in the median score between pre- and post-test knowledge. The maximum score increased by 1 point. The results of the statistical test show a p-value of 0.001. Education via the Happy Mom app has an effect on the knowledge of pregnant women. Conclusion: The Happy Mom app has the potential to improve knowledge of expectant mothers. It is recommended that further studies with a more robust design be conducted.
Enhancing Readiness for Preeclampsia–Eclampsia among Pregnant Women and Their Husbands through Family-Based Digital Education: A Quasi-Experimental Study Haryadi Haryadi; Fidyah Aminin; Ayi Diah Damayani; Dewi Mey Lestanti Mukodri; Aura Bella Gizta
Poltekita: Jurnal Ilmu Kesehatan Vol. 20 No. 2 (2026)
Publisher : Poltekkes Kemenkes Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33860/jik.v20i2.4273

Abstract

Background: Preeclampsia–eclampsia remains a major contributor to maternal morbidity and mortality, highlighting the need for early recognition and family involvement. Family-based digital education may support preparedness by improving knowledge and behavioral responses. This study aimed to evaluate the association between a family-based digital education application (Si PaPa GaSi) and changes in knowledge, attitudes, and motivation regarding preeclampsia–eclampsia. Methods: A quasi-experimental study with a pre–post test control group design was conducted among 100 pregnant women–husband pairs (50 intervention, 50 control) at Berakit Primary Health Center in November 2024. The intervention group received standard health education plus access to the application, while the control group received health education only. Outcomes were assessed using structured questionnaires before and two weeks after the intervention. Data were analyzed using Wilcoxon signed-rank tests for within-group comparisons and Mann–Whitney U tests for between-group comparisons. Results: Within-group analysis showed significant improvements in knowledge, attitudes, and motivation in both groups (p < 0.05). However, between-group analysis revealed no significant difference in knowledge (U = 1119.5; p = 0.214; r = 0.12), while significant differences were observed in attitudes (U = 957.5; p = 0.028; r = 0.22) and motivation (U = 887.0; p = 0.005; r = 0.28), indicating small to moderate effect sizes. Conclusion: The Si PaPa GaSi application was associated with improvements in attitudes and motivation, but not additional gains in knowledge compared to standard education alone. These findings suggest that family-based digital education may enhance behavioral readiness and partner involvement in maternal health, although further research with longer follow-up and randomized designs is needed.

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