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Journal of Diverse Medical Research: Medicosphere
Published by Universitas Pembangunan Nasional Veteran Jawa Timur
ISSN : -     EISSN : 30639433     DOI : https://doi.org/10.33005
Core Subject : Health, Science, Social, Engineering,
Immunology & microbiology Mechanical Engineering Medicine & Pharmacology Public Health Social Sciences
Journal of Diverse Medical Research is an open access and peerreviewed journal published every month by Faculty of Medicine Universitas Pembangunan Nasional Veteran Jawa Timur. This journal is a dissemination medium for research result from various areas in medical science.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 151 Documents
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Nutritional Interventions for Improving Insulin Resistance in Type 2 Diabetes Mellitus: A Comprehensive Narrative Review Aisyah Candra Maharani Putri; Fara Disa Durry; Fitri Sepviyanti Sumardi
Journal of Diverse Medical Research : Medicosphere Vol. 3 No. 9 (2026): Journal of Diverse Medical Research : Medicosphere 2026
Publisher : Faculty of Medicine - Universitas Pembangunan Nasional Veteran Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33005/jdiversemedres.v3i9.386

Abstract

Type 2 diabetes mellitus is a metabolic disorder characterized by persistent hyperglycemia due to impaired insulin secretion and insulin resistance. Indonesia ranks among countries with the highest diabetes burden. Insulin resistance worsens glycemic control and increases cardiometabolic complications, making nutritional interventions promising non-pharmacological strategies. This narrative review synthesized evidence from 2020 to 2025 on nutritional interventions for improving insulin resistance in type 2 diabetes mellitus. A literature search was conducted in three databases using keywords. Articles were selected using the PICO framework and synthesized narratively. Ketogenic and low-carbohydrate diets reduced glycated hemoglobin, fasting glucose, and homeostatic model assessment of insulin resistance. Dietary fiber improved insulin sensitivity through gut microbiota modulation and increased short-chain fatty acid production. Probiotics and prebiotics improved glycemic control and reduced inflammation. The Mediterranean diet improved insulin resistance and reduced cardiometabolic risk. Chrononutrition helped suppress postprandial glycemia and improve insulin sensitivity. Nutritional interventions play a role in type 2 diabetes mellitus management by targeting insulin resistance through gut microbiota modulation, reduced inflammation and oxidative stress, and improved lipid metabolism. Low-carbohydrate, high-fiber diets, probiotic and prebiotic supplementation, the Mediterranean diet, and chrononutrition are promising adjunctive strategies, but long-term randomized controlled trials are needed to establish sustainability and safety.

Page 16 of 16 | Total Record : 151

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