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Journal of Diverse Medical Research: Medicosphere
Published by Universitas Pembangunan Nasional Veteran Jawa Timur
ISSN : -     EISSN : 30639433     DOI : https://doi.org/10.33005
Core Subject : Health, Science, Social, Engineering,
Immunology & microbiology Mechanical Engineering Medicine & Pharmacology Public Health Social Sciences
Journal of Diverse Medical Research is an open access and peerreviewed journal published every month by Faculty of Medicine Universitas Pembangunan Nasional Veteran Jawa Timur. This journal is a dissemination medium for research result from various areas in medical science.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 140 Documents
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The Efficacy of Nanoliposomes in Cancer Therapy: A Systematic Review of In Vitro Evidence: A Literature Review Nizar Bahrul Ulum Suwardi; Nay Kinsey Kalingga Sawitra; Ahmad Syarif
Journal of Diverse Medical Research : Medicosphere Vol. 3 No. 6 (2026): Journal of Diverse Medical Research : Medicosphere 2026
Publisher : Faculty of Medicine - Universitas Pembangunan Nasional Veteran Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33005/jdiversemedres.v3i6.351

Abstract

Background: Cancer therapy is frequently limited by suboptimal drug internalization, chemical instability, off-target toxicity, and the rapid emergence of multidrug resistance. Nanoliposomes and related lipid-based nanocarriers offer a promising solution by enhancing the pharmacokinetic and cellular delivery profiles of anticancer agents. Objective: This systematic review critically appraises the available scientific evidence regarding the in vitro efficacy of nanoliposome formulations in cancer therapy. Methods: A systematic literature review (SLR) was conducted following the PRISMA framework across PubMed, Medline, and Google Scholar. From 988 initial records, 441 full-text articles were assessed against predefined eligibility criteria, ultimately yielding 15 original studies for qualitative synthesis. Results: The synthesized data consistently demonstrate that nanoliposome encapsulation significantly enhances the biological performance of anticancer agents compared to free drugs in cell culture models. This enhancement is characterized by markedly reduced IC₅₀ values, decreased cancer cell viability, and increased apoptosis across diverse malignant cell lines. Mechanistically, these improvements are driven by liposome-facilitated active endocytosis, efficient endosomal escape via the Vesicle Budding-and-Collapse (VBC) pathway, and the ability to bypass P-glycoprotein-mediated efflux. Advanced formulations incorporating stimuli-responsive features, genetic payloads (siRNA, mRNA, CRISPR/Cas9), and tumor microenvironment-modifying enzymes demonstrated superior cytotoxic profiles. Conclusion: Nanoliposomes represent a highly functional nanotechnology platform for preclinical cancer intervention, effectively protecting active compounds and facilitating efficient intracellular delivery. However, the inherent limitations of two-dimensional cell cultures which lack the physiological complexity, dynamic tissue barriers, perfusion, and immune interactions of intact organisms necessitate cautious interpretation and further validation in advanced 3D models and in vivo systems.
Exploration of Alpha-Curcumene and Curdione from Turmeric (Curcuma longa L.) to MurB Enzyme as Antibacterial through Molecular Docking Analysis: Original/Research Article Argha Rodzikin Adilaga; Annisa Mutiara Mecca; Ilham Kurniawan
Journal of Diverse Medical Research : Medicosphere Vol. 3 No. 7 (2026): Journal of Diverse Medical Research : Medicosphere 2026
Publisher : Faculty of Medicine - Universitas Pembangunan Nasional Veteran Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33005/jdiversemedres.v3i7.354

Abstract

Antimicrobial resistance (AMR) has emerged as a critical global health threat, necessitating the discovery of antibacterial agents with novel mechanisms of action. MurB, an essential enzyme in bacterial cell wall biosynthesis, represents an attractive target due to its absence in humans.  This study aimed to evaluate the in silico antibacterial potential of α-curcumene and curdione, two bioactive constituents of turmeric  essential oil, as inhibitors of the MurB enzyme.  The three-dimensional structure of MurB was retrieved from the Protein Data Bank. The chemical structures of α-curcumene and curdione were obtained from the PubChem database. Molecular docking was performed using AutoDock Vina, with naphthyl tetronic acid (co-crystallized ligand) as a positive control. Binding affinities and interaction profiles were analyzed using PyMOL and Discovery Studio Visualizer.  The native ligand exhibited a binding energy of -8.6 kcal/mol. Curdione demonstrated a binding energy of -6.7 kcal/mol, while α-curcumene showed -5.9 kcal/mol. Both compounds docked within the catalytic pocket, interacting with key residues Glu325, Ser229, and Arg159. Curdione exhibited superior binding affinity compared to α-curcumene.  Although both compounds showed weaker binding affinity than the native ligand, their ability to occupy the MurB active site suggests they are promising lead scaffolds for antibacterial drug development. Further in vitro and in vivo studies are warranted to validate their biological activity.
Indexed, Ranked, but Not Verified: Why Bibliometric Status Cannot Guarantee Scholarly Integrity in the Age of AI-Hallucinated Citations? Editorial Letter Ilham Kurniawan
Journal of Diverse Medical Research : Medicosphere Vol. 3 No. 5 (2026): Journal of Diverse Medical Research : Medicosphere 2026
Publisher : Faculty of Medicine - Universitas Pembangunan Nasional Veteran Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33005/jdiversemedres.v3i5.355

Abstract

Preamble A question that should unsettle every editor, reviewer, and author is this: What happens when fabricated, unverifiable references appear in peer‑reviewed articles published in indexed journals? This is no longer hypothetical. It is a reality that forces us to confront an uncomfortable truth indexation is not innocence, and a Scopus badge is not a certificate of integrity. As Deputy Editor-in-Chief of Medicosphere, I believe this demands urgent attention. The integrity of the scholarly record the foundation of scientific progress is under threat from generative artificial intelligence.
The Assistant, Not the Author: Confronting the Misuse of Artificial Intelligence in Academic Writing: Editorial Letter Ilham Kurniawan
Journal of Diverse Medical Research : Medicosphere Vol. 3 No. 6 (2026): Journal of Diverse Medical Research : Medicosphere 2026
Publisher : Faculty of Medicine - Universitas Pembangunan Nasional Veteran Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33005/jdiversemedres.v3i6.357

Abstract

Preamble A fundamental question facing academic publishing today is this: Where do we draw the line between legitimate assistance and unacceptable delegation when it comes to artificial intelligence? As generative AI tools become increasingly integrated into research workflows, the distinction between using AI as a helper and presenting it as a creator has never been more critical or more frequently misunderstood. As Deputy Editor-in-Chief of Medicosphere, I write to address a growing concern: the misuse of AI in scholarly manuscripts, particularly the tendency to treat AI-generated content as if it were the author’s own work, or worse, to list AI tools as co-authors. This is not a technological problem it is an ethical one. And it demands our immediate attention.
Gold Nanoparticle-Based Drug Delivery Systems for Reducing Chemotherapy Side Effects: A Literature Review Zeedni Ilman Azhar azhar; Manuela De Belsyazar Theopilus; Aulia Umi Rohmatika
Journal of Diverse Medical Research : Medicosphere Vol. 3 No. 6 (2026): Journal of Diverse Medical Research : Medicosphere 2026
Publisher : Faculty of Medicine - Universitas Pembangunan Nasional Veteran Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33005/jdiversemedres.v3i6.358

Abstract

Background: Cancer remains a leading global health burden, with nearly 20 million new cases recorded in 2022. Chemotherapy, while central to treatment, is limited by systemic toxicity, poor tumor selectivity, and multidrug resistance, compromising both survival and quality of life. Objective: This systematic review evaluates the extent to which gold nanoparticle-based drug delivery systems (AuNP-DDS) reduce chemotherapy-associated side effects while enhancing tumor-selective delivery, by examining their underlying mechanisms, preclinical and clinical efficacy, and safety profiles. Methods: A systematic literature search was conducted following PRISMA 2020 guidelines across PubMed, Scopus, ScienceDirect, and Google Scholar for articles published between 2020 and 2025. Ten studies comprising clinical trials, in vitro, and in vivo models met eligibility criteria and were qualitatively synthesized. Results: Across the included evidence, AuNP-DDS consistently demonstrated reduced systemic toxicity and enhanced tumor-selective accumulation through combined passive (EPR-driven) and active (ligand-based) targeting. Benefits were documented for doxorubicin, gemcitabine, cisplatin, and siRNA-based constructs. No dose-limiting toxicities emerged from reviewed clinical studies, and stimuli-responsive formulations further curtailed off-target drug exposure. Conclusion: AuNP-DDS demonstrate considerable promise for limiting chemotherapy-induced harm through targeted delivery and controlled drug release. However, additional clinical validation and standardized production methods remain essential before widespread clinical adoption.
Integration of Smart Glasses Technology in Emergency Medical Services: A Literature Review: A Literature Review Wayan Dhea Agastya; Ahmad Syarif; Amalia Rahmadinie; Fakhirah Nailah Anrofi; Alya Raguan Al’Habsyi; Fibran Aryan Nahya; Bisarda Kanira Permata Putri Winangest; Shofie Ayu Nur Firdausiyah
Journal of Diverse Medical Research : Medicosphere Vol. 3 No. 6 (2026): Journal of Diverse Medical Research : Medicosphere 2026
Publisher : Faculty of Medicine - Universitas Pembangunan Nasional Veteran Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33005/jdiversemedres.v3i6.359

Abstract

In today's digital era, wearable technologies such as Augmented Reality (AR)-based smart glasses offer significant potential to improve the efficiency and accuracy of EMS emergency response. The objective of this study was to assess the effectiveness of smart glasses in improving the speed and accuracy of triage and communication during mass casualty response. The method used was a systematic literature review with data analysis from various relevant recent studies, including simulations and field studies. The results showed that the use of smart glasses can increase the triage accuracy rate by up to 98.3%, compared to 78-79% for manual methods, and reduce triage time from an average of 72.4 seconds to 23.5 seconds (p < 0.001). Furthermore, this technology improves team coordination and real-time communication, contributing to an increase in operational efficiency of up to 30%. The discussion revealed that despite challenges such as training requirements and data privacy issues, the benefits of smart glasses are significant in improving the success of emergency response and rapid response, potentially revolutionizing the EMS system. The conclusion of this study is that AR-based smart glasses consistently improve the accuracy and efficiency of triage and communication, and if implemented with adequate training and a robust data security system, this technology could be a major innovation in supporting a more effective and rapid EMS response
Medical Education in the Age of AI: Shaping Technologically Literate yet Humanistic Doctors: Editorial Letter Rika Yuliwulandari; Ilham Kurniawan; Laurentius Johan Ardian
Journal of Diverse Medical Research : Medicosphere Vol. 3 No. 7 (2026): Journal of Diverse Medical Research : Medicosphere 2026
Publisher : Faculty of Medicine - Universitas Pembangunan Nasional Veteran Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33005/jdiversemedres.v3i7.362

Abstract

Preamble A fundamental question facing medical educators today is this: How do we prepare future doctors for a world where artificial intelligence is reshaping every aspect of clinical practice, without losing the humanistic core that defines the art of medicine? This is no longer a theoretical debate it is an urgent pedagogical imperative. As Editor-in-Chief and Deputy Editor-in-Chief of Medicosphere, we believe this question demands our immediate attention. AI is rapidly transforming healthcare reshaping clinical decision-making, diagnostic imaging, and patient care. Deep learning algorithms have demonstrated remarkable performance in tasks such as image classification, leading to improved diagnostic accuracy. Yet, paradoxically, at the very moment when technology offers unprecedented capabilities, the need for distinctly human qualities in medicine empathy, compassion, ethical reasoning, and clinical wisdom has never been greater. The challenge before us is clear: we must train doctors who are not only technologically literate but also deeply humanistic. This is not an either‑or proposition. It is both.
Association between Poverty Rate and Stunting Prevalence in Central Java: A Narrative Review Qonita Abdillah Rosyida; Keyla Cantika Ismail; Evrick Yonantiko; Raihan Mahesa Ardiansyah
Journal of Diverse Medical Research : Medicosphere Vol. 3 No. 7 (2026): Journal of Diverse Medical Research : Medicosphere 2026
Publisher : Faculty of Medicine - Universitas Pembangunan Nasional Veteran Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33005/jdiversemedres.v3i7.365

Abstract

Stunting refers to impaired growth and development in children resulting from chronic nutritional deficiencies, especially during the critical period of the first 1,000 days of life. This study aimed to generate more comprehensive empirical evidence on the association between poverty prevalence and stunting rates among districts and municipalities in Central Java. This study using a quantitative approach, this study analyzed secondary data through a correlational framework. The dataset covered all 36 administrative regions in Central Java Province, where district-level poverty rates and stunting prevalence served as the primary variables of analysis. The relationship between poverty and stunting identified should be interpreted as an association rather than a direct causal link. The findings suggest that poverty contributes to variations in child nutritional status, although it does not fully account for the complexity of underlying determinants. Therefore, poverty should be regarded as an important, yet not exclusive, factor. This study provides evidence of a significant positive association between district-level poverty rates and stunting prevalence in Central Java. The moderate correlation indicates that regions with higher poverty rates are more likely to have elevated stunting prevalence.
Complete Resection of A Giant Convexity Meningioma Involving The Middle Cerebral Artery: A Case Report and Surgical Considerations: A Case Report M. Irfan Rahmatullah; Ordelia Nur Inayah Sunarto; Muhammad Daffa Ratsmawan; Ilham Kurniawan
Journal of Diverse Medical Research : Medicosphere Vol. 3 No. 7 (2026): Journal of Diverse Medical Research : Medicosphere 2026
Publisher : Faculty of Medicine - Universitas Pembangunan Nasional Veteran Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33005/jdiversemedres.v3i7.371

Abstract

Meningioma is the most common primary intracranial tumor in adults, accounting for approximately 37.6% of all primary central nervous system neoplasms. Although convexity meningiomas are generally surgically accessible, large tumors with neurovascular involvement present significant operative challenges, especially when acute neurological deterioration necessitates emergent intervention. A 46-year-old female presented with decreased consciousness (GCS E2V3M4) and progressive hemiparesis. Preoperative CT revealed a large temporoparietal extra-axial mass with significant mass effect and middle cerebral artery (MCA) involvement. Emergent craniotomy and stepwise debulking were performed utilizing gravity-assisted retraction, central dural incision, pial plane preservation, early arterial feeder coagulation, and systematic hemostasis. The philosophy of prioritizing patient safety over gross total resection guided the strategy. Postoperatively, the patient regained full consciousness (GCS E4V5M6) with marked motor improvement. Emerging evidence supports subtotal resection with adjuvant stereotactic radiosurgery for residual tumors. Emergent surgical debulking of large convexity meningiomas with neurovascular involvement is feasible and effective when guided by stepwise resection, pial plane preservation, and patient safety. Adjuvant radiosurgery should be considered for any residual tumor on follow-up imaging.
Biopigments from Monascus sp. as Potential Peroxisome Proliferator-Activated Receptor Alpha (PPAR-α) Modulators: A Computational Approach: Original/Research Article Dyahati Wahyurini; Evrick Yonantiko; Immanuelle Kezia
Journal of Diverse Medical Research : Medicosphere Vol. 3 No. 7 (2026): Journal of Diverse Medical Research : Medicosphere 2026
Publisher : Faculty of Medicine - Universitas Pembangunan Nasional Veteran Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33005/jdiversemedres.v3i7.372

Abstract

Monascus sp. produces biopigments (ankaflavin, monascin, and rubropunctatin) that have various biological activities, including a role in lipid metabolism through interaction with peroxisome proliferator-activated receptor alpha (PPAR-α). It plays an important role in regulating lipid metabolism and is a therapeutic target. Fenofibrate is one of the antihyperlipidemic drugs that targets PPAR-α. Therefore, this study aimed to evaluate the interaction of ankaflavin, monascin, and rubropunctatin with PPAR-α. The biopigments were analyzed using SwissADME and molecular docking with PPAR-α (PDB ID: 5HYK). The results showed that ankaflavin, monascin, and rubropunctatin complied with Lipinski’s Rule. Molecular docking revealed that all biopigments analyzed had good interactions with PPARα, with binding affinity values of ankaflavin -10.03 kcal/mol, monascin -10.38 kcal/mol, and rubropunctatin -10.62 kcal/mol. Rubropunctatin had the most negative binding affinity and the lowest predicted Ki (16.45 µM) among the tested biopigments and was most similar to the positive control, fenofibrate (−10.78 kcal/mol and 12.59 µM). In conclusion, these findings suggest that biopigments from Monascus sp. are potential candidates for PPAR-α modulators, particularly rubropunctatin. Further in vivo and in vitro investigations are necessary to validate these findings.

Page 14 of 14 | Total Record : 140

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