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Journal of Diverse Medical Research: Medicosphere
Published by Universitas Pembangunan Nasional Veteran Jawa Timur
ISSN : -     EISSN : 30639433     DOI : https://doi.org/10.33005
Core Subject : Health, Science, Social, Engineering,
Immunology & microbiology Mechanical Engineering Medicine & Pharmacology Public Health Social Sciences
Journal of Diverse Medical Research is an open access and peerreviewed journal published every month by Faculty of Medicine Universitas Pembangunan Nasional Veteran Jawa Timur. This journal is a dissemination medium for research result from various areas in medical science.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 140 Documents
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Integrating One Health into Food Systems: A Literature Review on Health Risks and Sustainability: A Literature Review Leonardo Tedjaprasadja
Journal of Diverse Medical Research : Medicosphere Vol. 3 No. 4 (2026): Journal of Diverse Medical Research : Medicosphere 2026
Publisher : Faculty of Medicine - Universitas Pembangunan Nasional Veteran Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33005/jdiversemedres.v3i4.333

Abstract

Background: The food system is a complex network that shapes health outcomes across human, animal, and environmental domains. Increasing globalization, agricultural intensification, and environmental changes have amplified risks such as zoonotic diseases and antimicrobial resistance (AMR). The One Health approach provides an integrated framework to address these interconnected challenges. This study aimed to examine the role of One Health in food systems through a literature review of studies published between 2014 and 2025. Methods: Articles were retrieved from PubMed, Scopus, and Google Scholar using relevant keywords. Selected studies were analyzed using a thematic approach focusing on human, animal, and environmental health perspectives. Results: The findings indicate that food systems serve as important pathways for zoonotic disease transmission and the spread of AMR, particularly through intensive livestock production and inappropriate antibiotic use. In addition, food production contributes to environmental degradation, including pollution and greenhouse gas emissions, which further affect health outcomes. Conclusion: Despite increasing recognition of the One Health approach, its implementation remains limited, especially in developing countries. Strengthening interdisciplinary collaboration and integrated policies is essential to improve food system safety, public health, and environmental sustainability.
Association Between Long-Term Progesteron Exposure and Intracranial Meningioma: A Case Report in a 44-Year-Old Woman: A Case Report Andini Nur Ramadhani; Feda Anisah Makkiyah
Journal of Diverse Medical Research : Medicosphere Vol. 3 No. 4 (2026): Journal of Diverse Medical Research : Medicosphere 2026
Publisher : Faculty of Medicine - Universitas Pembangunan Nasional Veteran Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33005/jdiversemedres.v3i4.335

Abstract

Background: Meningioma is a common benign intracranial tumor originating from arachnoid cap cells and accounts for approximately one-third of all primary brain tumors. Its higher incidence in women suggests hormonal involvement, particularly from progesterone and progestogen exposure. Prolonged use of hormonal contraceptives, such as depo medroxyprogesterone acetate (DMPA), has been associated with the development and progression of meningioma. Objective: To describe the clinical presentation, neuroimaging findings, management, and possible association between long-term progesterone exposure and intracranial meningioma in a middle-aged woman. Methods: We report the case of a 44-year-old woman with a history of long-term DMPA use who presented with progressive neurological symptoms. Clinical evaluation, neuroimaging studies, surgical treatment, and histopathological examination were performed and reviewed. Results: The patient presented with recurrent severe headache, blurred vision, and a progressively enlarging right-sided scalp mass. She had received DMPA injections for more than 15 years. Contrast-enhanced brain CT demonstrated a well-defined right frontotemporal extra-axial mass consistent with meningioma. The patient subsequently underwent craniotomy and complete tumor excision. Histopathological examination confirmed a WHO Grade I meningioma with mixed meningothelial and angiomatous patterns. Conclusion: This case highlights a potential association between prolonged DMPA exposure and intracranial meningioma. Early recognition of neurological symptoms, timely neuroimaging evaluation, and appropriate surgical management are essential to optimize outcomes. Discontinuation of hormonal exposure should also be considered in patients with hormone-sensitive meningiomas.
Massive Pulmonary Embolism Initially Misdiagnosed as Anxiety Attack in a Young Adult: A Case Report: A Case Report Farozan Radjamin; Retina Wirjopranoto
Journal of Diverse Medical Research : Medicosphere Vol. 3 No. 6 (2026): Journal of Diverse Medical Research : Medicosphere 2026
Publisher : Faculty of Medicine - Universitas Pembangunan Nasional Veteran Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33005/jdiversemedres.v3i6.336

Abstract

Massive pulmonary embolism (PE) is a life-threatening cardiovascular emergency associated with significant morbidity and mortality, particularly when diagnosis is delayed because of atypical clinical presentation. Young adults may present with nonspecific symptoms mimicking psychiatric disorders, leading to diagnostic uncertainty and delayed intervention. We report the case of a 29-year-old male presenting with progressive dyspnea, palpitations, chest tightness, dizziness, hyperventilation, and severe anxiety symptoms initially diagnosed as panic attacks during repeated emergency department visits. Despite symptomatic treatment with anxiolytic medication, the patient experienced worsening respiratory distress and hemodynamic instability. Electrocardiography demonstrated sinus tachycardia, S1Q3T3 pattern, incomplete right bundle branch block, and anterior T-wave inversion suggestive of acute right ventricular strain. Laboratory investigations revealed elevated D-dimer, troponin-I, and brain natriuretic peptide levels. Transthoracic echocardiography demonstrated severe right ventricular dilatation, pulmonary hypertension, septal flattening, and McConnell’s sign. Computed tomography pulmonary angiography confirmed extensive bilateral pulmonary embolism involving both main pulmonary arteries with evidence of right ventricular strain. Systemic thrombolytic therapy followed by anticoagulation resulted in significant clinical improvement. This case emphasizes the importance of maintaining high clinical suspicion for pulmonary embolism in young adults presenting with unexplained anxiety-like cardiopulmonary symptoms to prevent delayed diagnosis and potentially fatal outcomes.
Beyond the Patient: Family-Level Consequences of Cancer on Quality of Life, Productivity, and Economic Stability: A Literature Review Fitrotul Ainiyyah; Ghulam Haikal Adn; Fairuz Azizi Hanafi; Hanif Ahsan Abdillah; Keyla Cantika Ismail; Niswah Hamidah Al Udzmaa; Nisrina Zahra; Lovenita Visca Karenina; Irma Seliana
Journal of Diverse Medical Research : Medicosphere Vol. 3 No. 5 (2026): Journal of Diverse Medical Research : Medicosphere 2026
Publisher : Faculty of Medicine - Universitas Pembangunan Nasional Veteran Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33005/jdiversemedres.v3i5.340

Abstract

Background: Cancer imposes a substantial global health burden, with consequences extending beyond the individual patient to affect family members who serve as primary caregivers throughout the disease trajectory. Despite growing recognition of caregiver burden, the multidimensional impacts on family quality of life, productivity, and economic stability remain insufficiently addressed in clinical practice and health policy. Objective: This narrative review aims to synthesize current evidence on the impact of cancer on family caregivers, particularly regarding quality of life, psychological well-being, work productivity, and financial stability. Methods: A literature search was conducted using PubMed, ScienceDirect, Springer Nature, Oxford Academic, and Google Scholar for articles published between 2020 and 2026 in English or Indonesian. A combination of Boolean operators (AND, OR) was applied with keywords including cancer, family, caregiver, quality of life, productivity, and financial toxicity. Following title, abstract, and full-text screening, 24 studies met the inclusion criteria and were analyzed using a comparative-critical synthesis approach. Results: The synthesis revealed that caregiving burden is a major determinant of reduced family quality of life, particularly in physical, emotional, and social domains. Psychological distress including anxiety, depression, and fatigue served as a significant mediator between caregiving burden and reduced well-being. Financial toxicity resulting from treatment costs and loss of work productivity further exacerbated these effects, especially in low- and middle-income countries. Conversely, protective factors including family resilience, perceived social support, and high-quality interpersonal relationships were consistently associated with lower perceived burden and better quality of life. Conclusion: Cancer caregiving generates cascading consequences on family well-being, mediated by psychological distress and economic strain. A family-centered care approach that integrates routine caregiver screening, psychosocial support, resilience-building interventions, and financial protection policies is urgently needed to improve outcomes for both patients and their families.
Education on Ari Risk Mitigation Caused by Environmental Mold and Waste Management in The Community of Tembok Dukuh Sub-District, Bubutan District, Surabaya: Research Article Queency Felicia; Aisyah Candra Maharani Putri; Ayesha Jasmine Firdausi; Chofifah Ilma Nafie
Journal of Diverse Medical Research : Medicosphere Vol. 3 No. 5 (2026): Journal of Diverse Medical Research : Medicosphere 2026
Publisher : Faculty of Medicine - Universitas Pembangunan Nasional Veteran Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33005/jdiversemedres.v3i5.342

Abstract

Background: Acute Respiratory Infection (ARI) is the disease with the highest number of cases in Indonesia, with one of the often-overlooked environmental risk factors being mold growth caused by indoor humidity and poor waste management. Objective: This community service activity aimed to improve public knowledge and awareness regarding the relationship between environmental mold, waste management, and the risk of ARI, as well as to encourage the implementation of clean and healthy living behavior (PHBS). Methods: The activity was conducted on Saturday, 23 April 2026, from 07:45 to 10:00 WIB at Tembok Dukuh X Balai RT 12 RW 01, Tembok Dukuh Sub-district, Bubutan District, Surabaya, targeting 25 residents. The implementation method consisted of a pretest, education and outreach, interactive discussion, a waste management demonstration, and a posttest as the evaluation instrument using an 8-item multiple-choice questionnaire. Results: The results showed an increase in the participants’ average knowledge score from 6.88 (median 7; range 4–8) at pretest to 7.69 (median 8; range 7–8) at posttest, accompanied by a narrowing score range indicating more even understanding among participants. Conclusion: This activity proved effective in improving community knowledge regarding ARI risk mitigation due to environmental mold and waste management, and is expected to be applied sustainably in daily life.
IoMT-Based Wearable Sweat Sensors: A Systematic Review of Non-Invasive Biomarker Monitoring for the Management of Metabolic Diseases: A Literature Review Nayla Canthyka Yuniaf; Aulia Umi Rohmatika
Journal of Diverse Medical Research : Medicosphere Vol. 3 No. 4 (2026): Journal of Diverse Medical Research : Medicosphere 2026
Publisher : Faculty of Medicine - Universitas Pembangunan Nasional Veteran Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33005/jdiversemedres.v3i4.343

Abstract

Metabolic diseases such as type 2 diabetes mellitus, obesity, and metabolic syndrome continue to represent a growing global health burden. Conventional invasive monitoring methods often cause discomfort, repeated skin injury, and increased risk of infection, thereby encouraging the development of non-invasive monitoring technologies based on the Internet of Medical Things (IoMT). This systematic literature review aimed to synthesize recent advances in IoMT-based wearable sweat sensors as non-invasive biomarker monitoring platforms for metabolic disease management. A systematic literature search was conducted in PubMed and Google Scholar for articles published between 2021 and 2026 using keywords related to wearable sensors, sweat biomarkers, IoMT, and metabolic diseases. Following eligibility screening, 36 studies were included and analyzed. The findings revealed rapid advancements in wearable sweet-sensing technologies, particularly electrochemical, colorimetric, and microfluidic platforms integrated with IoMT architectures. Major biomarkers monitored through glucose, lactate, cortisol, and inflammatory cytokines such as IL-6 and TNF-α. Several studies demonstrated strong correlations between sweat biomarkers and conventional clinical measurements, while IoMT architectures integrated with Bluetooth Low Energy (BLE) and machine learning enabled accurate real-time monitoring. Overall, IoMT-based wearable sweat sensors demonstrate considerable potential as non-invasive tools for continuous metabolic disease monitioring and management. Nevertheless, challenges related to clinical validation, sensor stability, standardization, and data security must be addressed before widespread clinical adoption.
Integration of Telemedicine and Digital Environmental Monitoring for Early Detection of Environmentally Related Diseases in Remote Areas: A Literature Review Cakraningrum Jakti Giza Wibowo
Journal of Diverse Medical Research : Medicosphere Vol. 3 No. 4 (2026): Journal of Diverse Medical Research : Medicosphere 2026
Publisher : Faculty of Medicine - Universitas Pembangunan Nasional Veteran Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33005/jdiversemedres.v3i4.344

Abstract

Environment-based diseases such as Acute Respiratory Infections (ARI), diarrhea, malaria, and leptospirosis remain major causes of morbidity in remote areas of Indonesia. This condition is exacerbated by limited access to healthcare facilities and the lack of real-time environmental monitoring systems that support early disease detection. This study aims to design and analyze an integrated model of telemedicine and Internet of Things (IoT)-based digital environmental monitoring systems to improve the early detection of environment-related diseases. The study employed a systematic literature review using the PRISMA protocol on 15–20 references from journals indexed in Scopus, PubMed, and SINTA published within the last 5–10 years, complemented by implementation case studies in remote regions of Indonesia. The analyzed parameters included PM2.5 levels, water quality indicators (E. coli, turbidity, and pH), temperature, relative humidity, vector presence, and telemedicine clinical responses. The literature synthesis indicates that the integration of telemedicine with digital environmental monitoring has the potential to improve the early detection of environment-based diseases compared to the use of each system separately. The integrated model, which applies automatic threshold mechanisms such as PM2.5 > 100 µg/m³, E. coli > 100 CFU/100 mL, and humidity > 80%, enables the system to provide earlier and more proactive alerts to healthcare workers through telemedicine applications. Furthermore, this integration is expected to reduce diagnostic delays, improve healthcare service efficiency, and lower referral costs in remote areas.
Exploring the Antibacterial Potential of Xanthorrhizol from Curcuma xanthorrhiza Through Molecular Docking Technology: Research Article Raihan Rezky Fahrezy; Azizah Fathunisa Oktivia Rohaedi
Journal of Diverse Medical Research : Medicosphere Vol. 3 No. 5 (2026): Journal of Diverse Medical Research : Medicosphere 2026
Publisher : Faculty of Medicine - Universitas Pembangunan Nasional Veteran Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33005/jdiversemedres.v3i5.346

Abstract

The escalating threat of antimicrobial resistance (AMR) has emerged as a pressing global health challenge, with Gram-negative organisms most notably Escherichia coli bearing substantial responsibility for its clinical impact. This review critically assesses the feasibility of targeting UDP-N-acetylenolpyruvoylglucosamine reductase (MurB) as an antibacterial drug target and the pharmacological potential of xanthorrhizol. The latter compound represents the predominant bioactive constituent isolated from the rhizome of Curcuma xanthorrhiza, a plant with established medicinal application. This review describes the robust antimicrobial spectrum of xanthorrhizol and defines the structural arrangements of the MurB enzyme that allow its pharmacological inhibition, through a thorough and exhaustive assessment of published literature. Central to our findings is the observation that MurB occupies an indispensable position within the peptidoglycan assembly pathway of bacteria, a function for which no mammalian counterpart exists an attribute that underscores its exceptional suitability as a selective therapeutic target, providing for a highly selective targeting mechanism with little risk of toxicity to the host. Xanthorrhizol also showed potent bactericidal activity against Gram-negative bacteria by successfully attacking their cellular defenses, preventing biofilm formation, and significantly reducing the count of viable cells. Therefore, xanthorrhizol looks like a very rational candidate for the development of new drugs. In conclusion, xanthorrhizol as an inhibitor of the MurB enzyme is a promising novel strategy in the fight against resistant E. coli infections and provides a good theoretical basis that needs further molecular docking simulations and in vitro validation.
Hazard Analysis and Critical Control Points (HACCP) as a Food Safety System Recommendation Compared to Conventional Sanitation in the Free Nutritious Meal Program (MBG) A Literature Review: A Literature Review Diyanty Nur Hidayah Putry Putry; Hilmi Rakha Aryasatya
Journal of Diverse Medical Research : Medicosphere Vol. 3 No. 5 (2026): Journal of Diverse Medical Research : Medicosphere 2026
Publisher : Faculty of Medicine - Universitas Pembangunan Nasional Veteran Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33005/jdiversemedres.v3i5.348

Abstract

Background: Food safety is a critical concern in structured nutrition programmes, such as Indonesia's Free Nutritious Meal Programme (MBG). Traditional hygiene practices alone may not effectively prevent food contamination, and the Hazard Analysis and Critical Control Points (HACCP) framework has been proposed as a more thorough, proactive alternative. Objective: This review compared HACCP with conventional sanitation practices and assessed its potential as a formal food safety framework for MBG.Methods: PubMed and ScienceDirect for articles published between 2020 and 2026 were searched using the PICO framework for open-access, English-language studies on HACCP and food safety in institutional catering published within the past decade. Following PRISMA-guided screening, 11 studies met all eligibility criteria and were included. Results: Included studies consistently found weaknesses in sanitation practices, food handlers' knowledge and behaviour, temperature control, and microbial contamination under conventional systems, while HACCP adoption improved hazard identification, compliance, hygiene monitoring, and microbial control.Conclusion: HACCP offers a more thorough, proactive approach than conventional sanitation alone and is recommended as MBG's core food-safety framework to reduce contamination risk and support the programme's long-term sustainability
Optimizing Hazard Analysis and Critical Control Points (HACCP) Implementation in School Feeding Programs to Enhance Food Safety in LMICs: A Literature Review Kayla Ardina Syaharani S; Anindya Fidhlis
Journal of Diverse Medical Research : Medicosphere Vol. 3 No. 5 (2026): Journal of Diverse Medical Research : Medicosphere 2026
Publisher : Faculty of Medicine - Universitas Pembangunan Nasional Veteran Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33005/jdiversemedres.v3i5.349

Abstract

Background: School feeding programmes are among the largest nutrition and social protection  interventions  in low- and middle-income countries (LMICs). However,  foodborne hazards  remain  a  major  challenge that may  compromise programme effectiveness. As Indonesia expands its Makan Bergizi Gratis (MBG) programme,  optimizing Hazard Analysis  and Critical Control Point (HACCP) implementation is essential to ensure food safety. Objective: This literature review aimed to synthesize current evidence on HACCP implementation in school feeding programmes and identify evidence-based strategies to optimize food safety in LMICs, with implications for Indonesia’s MBG programme. Methods: A literature review was conducted through a systematic search of the PubMed and Europe PMC databases for studies published between 2016 and 2026. The search strategy was developed using the Population, Intervention, Comparison, and Outcome (PICO) framework, and study selection followed the Preferred Reporting  Items  for  Systematic Reviews  and  Meta-Analyses  (PRISMA)  2020 guidelines. Six eligible primary studies were synthesized narratively, while international guidelines and Indonesian policy documents were reviewed to contextualize the findings. Results: Three major themes were identified: behavioural factors, microbiological contamination, and institutional capacity. The evidence demonstrated that conventional food safety measures were insufficient to ensure consistent food safety performance. Optimizing HACCP implementation required strengthening prerequisite programmes, workforce competency, continuous monitoring, systematic verification, integrated governance, and implementation fidelity. Conclusion: HACCP provides a comprehensive framework for improving food safety in school feeding programmes. The findings support strengthening implementation fidelity, institutional capacity, and multisectoral collaboration to ensure the safe and sustainable implementation of Indonesia’s MBG programme.

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