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Contact Name
mahardika
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p3i@umsida.ac.id
Phone
6285159046771
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anamnetic@umsida.ac.id
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jl. Mojopahit no.666B Sidoarjo, Jawa Timur
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Kab. sidoarjo,
Jawa timur
INDONESIA
Journal of Medical and Health Science
ISSN : -     EISSN : 30321182     DOI : https://doi.org/10.21070/anamnetic
Core Subject : Health, Science,
Focus: Journal of Medical and Health Science aims to communicate the research results of professors, teachers, practitioners, and scientists in the fields of health information management and health science. The journal provides a platform for sharing significant and innovative findings that contribute to the advancement of these areas. Scope: The journal covers a wide range of topics within health information management and health science, including but not limited to: Health Information Management: Systems and technologies for managing health information Health data analytics and informatics Electronic health records and health information systems Medical Sciences: Clinical research and medical advancements Diagnostics and treatment methodologies Biomedical research and innovations Pharmacy: Pharmaceutical sciences and drug development Pharmacology and therapeutics Pharmacy practice and medication management Public Health: Epidemiology and public health policies Health promotion and disease prevention Community health initiatives and programs Environmental Health: Impact of environmental factors on health Environmental health risk assessment Strategies for environmental health improvement Midwifery: Maternal and child health care practices Midwifery education and training Innovations in prenatal and postnatal care Nursing: Nursing practices and patient care Nursing education and professional development Research in nursing and healthcare outcomes Other Health Professionals: Interdisciplinary research involving various health professionals Health services management and policy Innovations in healthcare delivery and practice
Articles 41 Documents
Association of Toxoplasma gondii Seropositivity and TNF-α -308G/A Polymorphism with Type 2 Diabetes Mellitus in Women Al-Kalabi, Firas Kareem Al-Kalabi
JOURNAL OF MEDICAL AND HEALTH SCIENCE Vol. 4 No. 1 (2026): July
Publisher : Universitas Muhammadiyah Sidaorjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/anamnetic.v4i1.1646

Abstract

General Background: Type 2 Diabetes Mellitus (T2DM) is a multifactorial metabolic disorder involving genetic and environmental components with chronic low-grade inflammation. Specific Background: Infectious agents such as Toxoplasma gondii and inflammatory cytokine gene variations, including TNF-α -308G/A polymorphism, have been investigated for their association with metabolic disturbances. Knowledge Gap: The combined relationship between T. gondii seropositivity and TNF-α genetic variation in women with T2DM remains insufficiently characterized. Aims: This study aimed to evaluate the association of T. gondii infection and TNF-α -308G/A polymorphism with T2DM in women. Results: In a case-control design involving 480 women, T2DM cases showed higher T. gondii IgG seropositivity (68.3% vs. 45.8%) and elevated IgG titers (47.3 ± 28.6 vs. 32.1 ± 24.8 IU/mL). Additionally, the A allele frequency of TNF-α -308G/A was higher in cases than controls (0.256 vs. 0.208; OR = 1.31, P = 0.047). Novelty: This study integrates parasitic infection status with inflammatory genetic polymorphism in a single analytical framework among women. Implications: Findings suggest that chronic infection and genetic susceptibility are associated with T2DM, supporting further investigation into inflammatory and infectious pathways in metabolic disorders. Highlights:• Higher IgG seroprevalence observed among diabetic participants• Elevated antibody titers indicate persistent parasitic exposure patterns• Allelic variation linked with increased disease susceptibility Keywords: Toxoplasma Gondii, Type 2 Diabetes Mellitus, TNF Alpha Polymorphism, Seropositivity, Case Control Study