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INDONESIA
Indonesian Journal Health Science and Medicine
Published by Universitas Muhammadiyah Sidoarjo
ISSN : -     EISSN : 30638186     DOI : https://doi.org/10.21070/ijhsm
Core Subject : Health,
Health Professions Medicine & Pharmacology Public Health Veterinary
Focus: The Indonesian Journal on Health Science and Medicine (IJHSM) focus to advance the field of health science and medicine by publishing high-quality, peer-reviewed research articles, reviews, and case studies. Our journal serves as a platform for researchers, clinicians, and healthcare professionals to share innovative findings, critical insights, and emerging trends in the broad domain of health science and medicine. Scope: Clinical Research and Practice Studies on the diagnosis, treatment, and prevention of diseases. Clinical trials and evidence-based practices. Advances in medical technology and therapeutics. Public Health Epidemiology and health statistics. Health policy and management. Community health initiatives and health education. Biomedical Science Research on cellular and molecular biology. Genetics and genomics. Pharmacology and toxicology. Health Care Systems and Services Health care delivery and management. Quality improvement in health care services. Health economics and health informatics. Global Health Health issues affecting populations worldwide. International health regulations and practices. Global health governance and diplomacy. Health Promotion and Disease Prevention Lifestyle and behavioral interventions. Preventive medicine and early detection. Nutritional science and physical activity. Mental Health Research on mental health disorders and treatments. Psychological well-being and mental health promotion. Integration of mental health services in primary care. Innovations in Health Education and Training Medical and health science education methodologies. Training programs for health professionals. Continuing education and professional development.
Arjuna Subject : Profesi Kesehatan - Profesi Kesehatan (Lain-Lain)
Articles 71 Documents
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Search results for , issue "Vol. 2 No. 2 (2025): Oktober" : 71 Documents clear
A Study Regarding the Basic Anatomy and Physiology of the Eye among Nursing Students: A Cross-Sectional Study: Studi Mengenai Anatomi dan Fisiologi Dasar Mata di Kalangan Mahasiswa Keperawatan: Sebuah Studi Cross-Sectional Hamid, Samahir Sabri; Kareem, Afkar Fadhil; Tiryag, Ali Malik; Abdul-Ra’aoof, Husham Hussain
Indonesian Journal on Health Science and Medicine Vol. 2 No. 2 (2025): Oktober
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/ijhsm.v2i2.127

Abstract

Objective: to determine the correlation between students' demographic information (age, sex, and stage) and their knowledge of the anatomy and physiology of the eye. Methods: A cross-sectional study was conducted at the College of Nursing at the Bab Al-Zubair Campus in Al-Basrah City. Nursing students are a sample of the study (100), and purposive (non-probability) sampling. The period of the study extended from the 12th of May 2024 to the 10th of February 2025. The questionnaire was constructed by the researchers on reliability (Cronbach’s alpha) for 32 items (0.81) and validity of the questionnaire by 13 experts in the field. Results: The findings of these results indicate that most students (60%) have moderate knowledge about the anatomy and physiology of the eye, and (40%) have good knowledge. Conclusion: The results of the study show that most students only have a moderate knowledge of the anatomy and physiology of the eye Highlights: Assess link between demographics and eye anatomy knowledge. Cross-sectional study using questionnaire with 100 nursing students. Most students had moderate understanding of eye anatomy.. Keywords: Nursing, Students, Anatomy, Physiology, Eye
Comprehensive Midwifery Care for Mrs. F Through Continuity of Care: Asuhan Kebidanan Komprehensif untuk Ny. F Melalui Kesinambungan Asuhan Dewi, Wistri Cendra Mulya; Hanum, Sri Mukhodim Faridah
Indonesian Journal on Health Science and Medicine Vol. 2 No. 2 (2025): Oktober
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/ijhsm.v2i2.134

Abstract

Introduction Comprehensive midwifery care includes pregnancy, childbirth, postpartum, newborns, and family planning (KB). The aim is to reduce the maternal mortality rate (MMR) in Indonesia through Continuity of Care (COC). This research method uses a descriptive method with case studies, collecting data through interviews, observation, physical examination and documentation. The data was analyzed for midwifery care using the SOAP technique. The results of the mother experiencing back pain during pregnancy were overcome with prenatal yoga. The delivery went normally without complications, the baby was born spontaneously weighing 3,200 grams and an Apgar score of 8-9. In the postpartum period, the mother complained of perineal wound pain and with early ambulation the pain was reduced. When the mother has finished postpartum, she is ready to become an IUD birth control acceptor. The conclusion was that no problems or abnormalities were found, so Mrs. F is categorized as normal/physiological. Highlights: Full cycle midwifery care applied from pregnancy to family planning. Non-pharmacological methods like prenatal yoga proved effective. Case supports COC as a model for safe, physiological maternal care. Keywords: Continuity of Care, Midwifery Care, Comprehensive
Continuing Midwifery Care for Pregnancy With Anemia: Asuhan Kebidanan Berkelanjutan untuk Kehamilan dengan Anemia Agustin, Lilik; Hanum, Sri Mukhodim Faridah
Indonesian Journal on Health Science and Medicine Vol. 2 No. 2 (2025): Oktober
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/ijhsm.v2i2.135

Abstract

Anemia during pregnancy is a significant problem, especially in developing countries. Based on data from 2018 Basic Health Research (Riskesdas), the prevalence of anemia in pregnant women was 48.9% which can cause complications such as low birth weight and postpartum bleeding. One of the midwives' efforts to reduce the prevalence rate of pregnant women with anemia is by providing midwifery care (CoC). ) comprehensive/sustainable. This case study aims to describe the results of implementing CoC midwifery care for pregnant women from postpartum to family planning. Method: This case study of midwifery care uses qualitative methods,  where mother D is given care starting from the third trimester of pregnancy, childbirth, newborns, and postpartum to family planning. The CoC midwifery care given to mother D is standard. Results: After providing midwifery care to Mrs. We want all midwives to be able to provide comprehensive and sustainable midwifery services. Highlights: Prevalence of Anemia: Anemia in pregnant women affects 48.9% of cases, leading to complications like low birth weight and postpartum bleeding. CoC Midwifery Care: Comprehensive and sustainable midwifery care (CoC) has shown promise in reducing anemia and improving maternal health outcomes. Implementation and Implications: The study emphasizes the need for all midwives to provide CoC to enhance maternal well-being and reduce anemia-related risks. Keywords: Continue of Care, Pregnancy, Anemia
Continuity of Care Implementation for Mrs. R at Al Islam H.M. Mawardi Hospital: Pelaksanaan Asuhan Kesinambungan pada Ny. R di Rumah Sakit Al Islam H.M. Mawardi Rafi, Zahro Firdausa; Widowati, Hesty; Purwanti, Yanik
Indonesian Journal on Health Science and Medicine Vol. 2 No. 2 (2025): Oktober
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/ijhsm.v2i2.136

Abstract

The Maternal Mortality Rate (MMR) in East Java Province was significantly reduced in 2020 but is still far from the SDGs target. Continuity of Care is a healthcare approach continuously starting from pregnancy, childbirth, postpartum, newborns, and family planning. The purpose of this case study is to describe the implementation of CoC at Al Islam H.M. Mawardi Hospital during pregnancy to postpartum. Method : midwivery descriptive method, Mrs. R was given care from the third trimester of pregnancy up to family planning method. Result : The implementation of CoC on Mrs. R was in accordance with the standard of physiological midwivery care and the treatment went well without any pathological conditions. Low back pain is a frequent condition in pregnancy, Ny. R was given accupressur on hegu point to relieve the pain. Conclusion : The care provided to the research subjects has been adjusted to the standards of midwifery care and the condition of the mother and baby and it worked physiologically. Highlights:   Continuity of Care (CoC): The implementation of CoC from pregnancy to family planning at Al Islam H.M. Mawardi Hospital followed standard physiological midwifery practices. Effective Pain Management: Mrs. R experienced low back pain during pregnancy, which was relieved through acupressure on the hegu point. Physiological Care Success: The care provided aligned with midwifery standards, ensuring the well-being of both the mother and baby without complications. Keywords:  Pregnancy, Childbirth, Postpartum, Newborn, Contraception
Midwifery Continuity of Care to Support Early Breastfeeding Success: Kesinambungan Asuhan Kebidanan untuk Mendukung Keberhasilan Menyusui Dini Arcellya, Rosalina Septi; Widowati, Hesty
Indonesian Journal on Health Science and Medicine Vol. 2 No. 2 (2025): Oktober
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/ijhsm.v2i2.137

Abstract

Pregnancy, childbirth, postpartum, newborns and family planning are physiological and continuous processes. The aim of providing midwifery care with continuity of care is to use SOAP midwifery management. qualitative descriptive method using a case study approach where Mrs. M was given care starting from TM III pregnancy, childbirth, newborns, postpartum to family planning in a sequence starting from reviewing data, formulating problems, planning care, carrying out care and evaluation, finally documenting using the SOAP method with SOAP development data. Midwifery care in NY. M, 24 year old postpartum mother, first day 6 hours post partum with blood pressure examination results of 110/80, conjunctiva not anemic, perineal suture wound still wet, bleeding less than 100 cc, uterine fundus height 2 fingers below the center and good uterine contractions, breast milk The first day hasn't come out yet. Mothers are advised to breastfeed their babies on demand and as often as possible to stimulate breast milk to come out and do acupressure massage at the PC 6 and GB11 points. For approximately 30 minutes of continuity of care midwifery care for Mrs. M has been done, the problem is slightly resolved. Breast milk slowly comes out, even if only a few drops. It is hoped that the mother will always breastfeed her baby a maximum of every 2 hours for good results. Furthermore, it was concluded that midwifery care provided when breast milk has not yet come in, can be an experience for mothers in order to achieve sustainable breastfeeding success. The hope is that midwives can implement and maintain quality and sustainable service quality in accordance with the SOP. Highlights:  Continuity of Care: Midwifery care was provided from late pregnancy to postpartum and contraception using the SOAP method. Early Breastfeeding Support: Immediate postpartum care focused on stimulating breast milk through frequent breastfeeding and acupressure. Quality Midwifery Practice: The experience emphasizes the importance of consistent, SOP-based care to support breastfeeding success. Keywords: Childbirth, Midwifery Care, COC, Acupressure
Continuous Midwifery Care Ensures Safe Maternal and Neonatal Outcomes: Asuhan Kebidanan Berkesinambungan Memastikan Hasil yang Aman bagi Ibu dan Bayi Baru Lahir Akhmalia, Nela; Azizah, Nurul
Indonesian Journal on Health Science and Medicine Vol. 2 No. 2 (2025): Oktober
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/ijhsm.v2i2.138

Abstract

Midwives try to reduce MMR by providing continuous midwifery care (CoC) for pregnant women to postpartum women. Continued care (COC) is midwifery care with a continuous service model for women during pregnancy to postpartum and family planning. The purpose of this study was to analyze midwifery care using the continuous care method in the independent practice of midwives. The design of this case study research uses a descriptive method, where Mrs. M was given midwifery care starting from the third trimester of pregnancy, childbirth, newborns, postpartum to family planning. Continuous midwifery care (CoC) for Mrs. M is standard midwifery care. The results of the study showed that after providing midwifery care to Mrs. M, it was found that the condition of the mother and baby was healthy or within normal limits, there were no complications until the implementation of care was completed. During the postpartum period, Kegel exercises were performed because Mrs. M was afraid that her vagina would not return to normal because heaching was not performed. Conclusion: Continuous midwifery care provided to the subject was in accordance with the applicable midwifery service standards. Highlights:  Comprehensive Care: Midwifery services covered pregnancy to family planning. Positive Outcomes: Mother and baby remained healthy without complications. Standard Compliance: Care followed established midwifery service standards. Keywords: Continue of Care, Midwifery, Service
Metabolic Improvements From CoQ10 and ALA in PCOS Patients Hussein, Dhirgham Saif Aldean; Kadhim, Sinaa Abdul Amir; Swadi, Asma Abdul Jaleel
Indonesian Journal on Health Science and Medicine Vol. 2 No. 2 (2025): Oktober
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/ijhsm.v2i2.197

Abstract

Background: As more women search for natural solutions or prescription medications to manage their symptoms, supplements like Alpha Lipoic Acid and CoQ10 are growing in popularity. Combining these with a personalized plan can lead to better health outcomes and a higher quality of life. Aim of the study: the aim of the current research project is to evaluate the effect of combined administration of metformin, ALA and CoQ10 on PCOS metabolic and fertility parameters. Patients and methods: This clinical trial, which was randomized, single-blind, and actively controlled, took place in Diwaniyah, Iraq, from October 2024 to June 2025. Participants were randomly assigned to three different groups. The random assignment was carried out using computer-generated random numbers. Patients in Group Met. received Glucophage (500 mg; Merck, West Drayton, UK) three times per day; Group Met.+ALA patients were given metformin as in the first group along with ALA (600 mg, Batch no. 6N5483; Holzkrichen, Bavaria, Germany) three times daily; Group Met.+ALA+CoQ10 patients received metformin and ALA as in the second group, along with 200 mg of CoQ10 each day. All treatments were provided over a duration of 12 weeks. Result: Post-treatment, all three forms of management showed significant decline in average free Testosterone, LH and LH:FSH ratio, GnRH anti-body and ovarian volume (p < 0.001); the effect of Met. plus ALA plus CoQ10 was significantly more profound when contrasted to other 2 modes of therapy (p < 0.05). However, none of these treatment approaches was able to affect serum levels of FSH, prolactin and TSH significantly (p > 0.05).Conclusion: The combined use of metformin therapy, CoQ10 supplements and ALA supplements is associated with the most optimum hormonal and ultrasound characteristic in PCOS women by reducing the pathogenic effect of anti GnRHR antibody level. Highlights: Combined Metformin, ALA, and CoQ10 improved hormonal and ultrasound parameters in PCOS. Significant reductions were observed in LH, free testosterone, LH:FSH ratio, and ovarian volume. No significant changes were found in FSH, prolactin, or TSH levels. Keywords: Polycystic Ovary Syndrome, Metformin, Alpha Lipoic Acid, Co-Enzyme Q10
Acute Phase Reactants and Hematologic Profiles vs Blood Culture in Late Preterm Neonatal Sepsis Naji, Aiub Bassim; Hadi, Ammer Muhssin; Muhssin, Akram Hamdi; Alkhateeb, Dheyaa Aldeen
Indonesian Journal on Health Science and Medicine Vol. 2 No. 2 (2025): Oktober
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/ijhsm.v2i2.201

Abstract

Background: Neonatal sepsis involves physical and laboratory findings due to infection within the first 30 days of life, with preterm infants being six times more at risk than term infants due to their immature immune systems and prolonged hospitalization. Sepsis is more common in males and in developing countries. The World Health Organization estimates 5 million neonatal deaths annually, mostly in developing countries. Despite advances in neonatal care, late-onset sepsis remains a significant cause of morbidity and mortality. Aim: To evaluate the significance of acute phase reactants and hematological findings versus blood culture in diagnosing sepsis in late preterm infants. Method: A cross-sectional study of 70 neonates with suspected sepsis from January 2011 to March 2012 at Babylon Teaching Hospital. Patients were classified as having early or late-onset neonatal sepsis. Tests included blood culture, c-reactive protein, erythrocyte sedimentation rate, white blood cell, platelets, and band cells. Results: Of the 70 patients, 55.7% were male and 44.3% were female. Early sepsis was observed in 40% of patients, and late sepsis in 60%. Blood culture was positive in 25.7% of cases, with 83.3% of these in early sepsis. CRP was positive in 91.4% of patients, including 100% of early sepsis cases and 85.7% of late sepsis cases. Positive band cells were found in 45.7% of cases, with 83.3% of these having positive blood cultures. Abnormal WBC counts (<5000 or >21000) were found in 64.3% of cases. Low platelet counts (<150,000) were observed in 55.7% of patients, with 67.8% in early sepsis and 47.6% in late sepsis. Elevated ESR (>6mm/h) was seen in 91.4% of cases. Conclusion: Blood culture remains the gold standard for diagnosing sepsis, though its accuracy can be affected by antibiotic use. Combining multiple diagnostic tests improves predictive values over single tests. Highlights: Late-onset sepsis remains a major cause of neonatal morbidity and mortality. CRP and ESR showed high positivity, supporting their value in early detection. Blood culture is essential but benefits from combined diagnostic markers. Keywords: Late Preterm Infant, Neonatal Sepsis, Blood Culture, Infant, CRP.
Synthesis, Characterization and Evaluation of Thiourea Derivatives for Cytotoxicity of Breast Cancer KT, Awad; AL-Salman, H. N. K.; Najm, Mazin A.A.
Indonesian Journal on Health Science and Medicine Vol. 2 No. 2 (2025): Oktober
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/ijhsm.v2i2.202

Abstract

Background: Breast cancer is the leading cause of death in women worldwide and the second most common cause in the US. Rescovitine a clinical CDK2 inhibitor has been studied as a potential anticancer agent in breast cancer. has a short half-life (2–5 h), necessitating new analogs with improved pharmacokinetics. Objective: To design and synthesize five thiourea derivatives (VIa–VIe) that mimic rescovitine selectivity and low toxicity, while addressing its pharmacokinetic limitations. Evaluation the cytotoxicity in MCF-7 breast cancer cells. Materials & Methods: Derivatives were synthesized by reacting substituted benzoic acids with SOCl2, followed by the formation of isothiocyanates (IIa–e). Subsequent reflux with 5-amino-1H-pyrazole-4-carbonitrile yielded the thioureas VIa–VIe. Characterization: Melting points, NMR (¹H/¹³C), FT-IR spectroscopy, and EI-MS. antiproliferative activity against MCF-7 cell (MTT assay, IC₅₀), compared to rescovitine. Results: VIa and VIe showed best MCF-7 inhibition (93.77%, IC₅₀ = 123.64 μM; 94.55%, IC₅₀ = 118.49μM) vs. rescovitine (97.33%, IC₅₀ = 20.27μM). VIe (4-F substituent) and VIa (unsubstituted) exhibited strongest cytotoxicity against. All compounds complied with Lipinski’s Rule of Five (0 violations) and showed excellent GI absorption but no BBB permeability. Electronic substituents (e.g., F in VIe) enhanced the activity, while steric groups (e.g., CH₃ in VIb) reduced the efficacy. Conclusion: VIa and VIe emerged as lead candidates with cytotoxicity comparable to that of rescovitine. Fluorine substitution (VIe) optimized the activity, highlighting structure-activity relationships for future to get more potent molecules. Highlights: Lead Compounds Identified: VIa and VIe demonstrated strong antiproliferative activity in MCF-7 cells, approaching that of rescovitine, despite higher IC₅₀ values. Structure-Activity Relationship (SAR): Electron-withdrawing substituents like fluorine (VIe) enhanced cytotoxicity, while bulky groups reduced efficacy. Pharmacokinetics Advantage: All synthesized compounds complied with Lipinski’s Rule and exhibited excellent GI absorption—supporting their potential as orally available anticancer agents. Keyword: MCF-7 Inhibition, Thiourea Derivatives, Rescovitine, Anticancer Agents, .
Prevalence of THRB Gene Mutations in Misan Province Thyroidism Patients: Prevalensi Mutasi Gen THRB pada Pasien Tiroid di Provinsi Misan Al-Taie, Duha T.; Jumaa, Zahr'aa Kateb; Husain, Rehal Jehad; Rahi, Eman H.
Indonesian Journal on Health Science and Medicine Vol. 2 No. 2 (2025): Oktober
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/ijhsm.v2i1.205

Abstract

General Background: Thyroid disorders such as hypothyroidism and hyperthyroidism are common endocrine abnormalities characterized by disrupted levels of triiodothyronine (T3), thyroxine (T4), and thyroid-stimulating hormone (TSH). Specific Background: Mutations in the thyroid hormone receptor beta (THRB) gene are implicated in thyroid hormone resistance syndromes and potentially in other thyroid dysfunctions. Knowledge Gap: However, there is limited data regarding the prevalence of THRB gene mutations among thyroid disorder patients in Misan Province, Iraq. Aims: This study aimed to evaluate the presence of THRB gene mutations among women diagnosed with thyroid disorders and assess corresponding hormonal variations across age groups. Results: Hormonal analysis revealed significant deviations in FT3, FT4, and TSH levels in both hypothyroid and hyperthyroid patients across multiple age groups. Molecular analysis, however, did not detect any pathogenic mutations in the THRB gene. Novelty: Despite the identification of several unique haplotypes among patients, none corresponded to known pathogenic mutations, suggesting possible population-specific genetic profiles without direct impact on receptor function. Implications: These findings underscore the need for broader genetic screening beyond THRB in diagnosing thyroid disorders and highlight the limited role of THRB mutations in the pathogenesis of thyroid dysfunction in this regional cohort.Highlight : No mutations were found in the THRB gene in patients with hypothyroidism and hyperthyroidism. Hormone analysis showed significant differences in FT3, FT4, and TSH levels between age groups. There were ten varying THRB gene haplotypes, but no mutations were detected. Keywords : Thyroid disorders, Thyroid hormone, TRHB gene, Novel mutation, Hyperthyroidism

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