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Fakultas Kedokteran Universitas Brawijaya Gedung Graha Medika Lt. 1, Ruang 104
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Jurnal Kedokteran Brawijaya
Published by Universitas Brawijaya
ISSN : 02169347     EISSN : 23380772     DOI : http://dx.doi.org/10.21776/ub.jkb
Core Subject : Health,
Medicine & Pharmacology
JKB contains articles from research that focus on basic medicine, clinical medicine, epidemiology, and preventive medicine (social medicine).
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 3 Documents
 1 
Search results for , issue "Vol 19, No 3 (2003)" : 3 Documents clear
PENGARUH EKSTRAK BUAH MENGKUDU (Morinda citrifolia) TERHADAP AORTA TERPISAH MARMUT (Cavia porcellus) TANPA ENDOTEL Hidayat, Taufiq; Wahyuni, Endang Sri; Karyono, Setyawati S
Jurnal Kedokteran Brawijaya Vol 19, No 3 (2003)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (160.64 KB) | DOI: 10.21776/ub.jkb.2003.019.03.3

Abstract

Buah mengkudu sering digunakan masyarakat sebagai obat antihipertensi, namun belum diketahui dimana tempat kerjanya. Penelitian ini bertujuan membuktikan efek buah mengkudu terhadap otot polos pembuluh darah. Digunakanmodel percobaan aorta terpisah marmut yang endotelnya telah dihilangkan.  Variabel yang diukur adalah besar perubahan kontraksi otot polos aorta tanpa endotel yang distimulasi fenilefrin [10-5M] terlebih dulu kemudian ditambahkan ekstrak buahmengkudu dosis 0,2%, 0,6%, dan 1,0%. Hasil penelitian menunjukkan bahwa ekstrak buah mengkudu dosis 0,2% menyebabkan peningkatan kontraksi,sedangkan dosis 0,6% dan 1,0% menyebabkan relaksasi. Efek relaksasiini terbukti bermakna (p < 0,05) dan terdapat hubungan yang kuat dan bermakana antara dosis dan efek relaksasi (R = 0,894; p < 0,05). Dari hasil penelitian di atas dapat disimpulkan bahwa ekstrak buah mengkudu dapat menyebabkan relaksasi otot polos aorta terpisah marmut tanpa endotel pada dosis > 0,2%,sedang pada dosis 0,2% terjadi peningkatan kontraksi. Disarankan untuk melakukan penelitian lebih lanjut untuk mengetahui dosis efektif mengkudu sebagai terapi antihipertensi. Kata kunci:mengkudu, relaksasi, aorta, endotel
SINDROMA TURNER (SINDROMA BONNEVIE-URLICH) Wiyasa, Arsana; Pudjiastuti, Retno
Jurnal Kedokteran Brawijaya Vol 19, No 3 (2003)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (89.038 KB) | DOI: 10.21776/ub.jkb.2003.019.03.1

Abstract

It was reported a case of Turner syndrome of fifteen years old girl who complain have not started menses. Physical examination included short stature, shield chest with wide spaced nipples and secondary sex was absent. External genitalia was normally, internal genitalia was found hipoplasia of uterine. Laboratory examination showed low estrogen, high FSH and LHand normothyroid. Karyotype was 45, X, USG examination showed there was no development of uterine. X-ray of extremity showed that epiphiseal line has not closed, bone age used of method of Todd (manus), linear growth (femur, tibia, fibula), quantity of growth (femur, tibia) accordingly 11-12 years. Expectant to increase her  height was low because growth hormon preparation was difficult to find and the price was not attainable by the pasien. Just low dose ethinil estradiol have been given for pasien until bone age more than 12 years when epiphiseal line have been closed and will continue with full dose ethinil estradiol until post menopause. Key words:Turner syndrome, growth hormon, ethinil estradiol,epiphiseal line
EFFECT OF COMBINED THERAPY USING CHLOROQUINE AND VITAMIN C TO THE PERITONEAL MACROPHAGE FUNCTION IN BALB/C STRAIN MICE INFECTED BY Plasmodium berghei Fitri, Loeki Enggar; Suhendro, Wongso; Murwani, Sri; Muliartha, I Ketut Gede; Ali, Mulyohadi
Jurnal Kedokteran Brawijaya Vol 19, No 3 (2003)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1633.38 KB) | DOI: 10.21776/ub.jkb.2003.019.03.2

Abstract

In acute infection, malaria will induce cellular immunity by activating T lymphocytes and macrophages cells. This induction indirectly triggers free radicals production in order to eliminate the parasites from red blood cells, however high concentration of thismolecules can cause vital tissue pathological changes on host. In late phase of malarial infection, there are immunosupression on macrophages activity including antigen presenting and secretion of immunoregulated mediator. It has been anticipated, vitamin C as antioxidant would diminish the side effect of thesefree radicals during malarial infection and increase the immunity. To see the effect of combination chloroquin and vitamin C in hastening the recuperative process by decreasing parasitemia and increasing the phagocytosis function of macrofages during Plasmodium berghei infection. This study has been carried out using 3 groups of BALB/c mice, all group were inoculated with 1x107Plasmodium berghei infected red-blood cells. No drug was given on control group (IK). In experimental group we introduced an oral therapy ofchloroquin for 5 days in 1.4 mg/cc dosage and vitamin C for 7 days in 0.2 mg/cc dosages concurrently with a Plasmodium berghei inoculation (IKC). One group was only given chloroquin at the same dosage and no drug was given at the control group (IK).

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