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I Ketut Gede Muliartha
Laboratorium Sentral Biomedik
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IDENTIFIKASI MUTASI GEN CYSTATIONINE-β SYNTHASE (CBS) DAN GEN METHYLENETETRAHYDROFOLATE REDUCTASE (MTHFR) PADA PENDERITA PREMATUR INFARK MIOKARD AKUT DENGAN HIPERHOMOSISTEINEMI Muliartha, I Ketut Gede; Sargowo, Djanggan; Iskandar, Abdillah
Jurnal Kedokteran Brawijaya Vol 24, No 3 (2008)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (618.881 KB) | DOI: 10.21776/ub.jkb.2008.024.03.3

Abstract

ABSTRACT Hyperhomocysteinemia appears to be an independent risk factor for coronary heart disease. Elevated levels of  plasma  total  homocysteine  (tHcy)  was  caused  by  genetic  or  nutrient-related  disturbances  in  the transsulfuration  or  remethylation  pathways  for  homocysteine  metabolism.  This  study  observed  premature myocard  infarct  acute  patients  with  hyperhomocysteinemia.The  aim  of  the  research  was  to  determine Cystarhionine-β  Synthase  and  Methylenetetrahydrofolate  Reductase  genes  mutations  in  premature  acute myocard  infarct  patients  with  hyperhomocysteinemia.This  study  was  a  cross  sectional  study  in  premature acute myocard infarct patients. Twenty three patients were examined for plasma total homocysteine, vitamin B6, vitamin B12 folic acid and lipid profile. Total DNA isolated from patients with hyperhomocystememia and normal  folic  acid,  vitamin  B6,  vitamin  B12  levels  and  lipid  profile.  Five  patients  were  assayed  for Cystathionine-β  Synthase  and  gen  Methylenetetrahydrofolate  Reductase  genese  mutations  by  Polymerase Chain  Reactions  (PCR).  Five  from  23  patients  (  21,7%  )  plasma  total
ANALISIS LOSS OF HETEROZYGOSITYGEN RAR β2 PADA PATOGENESIS KANKER PAYUDARA Muliartha, I Ketut Gede; Riawan, Wibi; Hidayat, Asnah; Armania, Fitri
Jurnal Kedokteran Brawijaya Vol 24, No 2 (2008)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (257.671 KB) | DOI: 10.21776/ub.jkb.2008.024.02.5

Abstract

The aim of this research was to investigate the event of loss of heterozygosity of retinoid acid receptor (RAR β2) gene on the chromosom 3p24 in the pathogenesis ofbreast cancer. The breast cancer is the most malignant tumor that leads the second cause of death among the female. The recent concept of the theory of pathogenesis breast cancer is molecular genetic approaches such as apoptosis gene, oncogen, suppressorgene, and growth promoting factor gene. However, the diagnostic and therapy of breast cancer are still not satisfied. The lost or decreased in the expressionof RAR  β2gene on 3p24 chromosome via loss of heterozygosity (LOH) mechanism are the role of pathogenesis of breast cancer. Design of the research is by experimental and observational. Human female breastcancer and blood samples were gained from public hospital RSUD dr. Saiful Anwar, Malang. DNA was extracted from lymphocyte and tissue using Macherey-Nagel system kit. Loss of heterozygosity (LOH) incident in 3p24 chromosome was detected by PCR and Chromogenic in situ Hybridization (CISH) method.
Pemberian Kombinasi Vitamin C dan E Peroral Memperbaiki Kerusakan Hepar Akibat Paparan Rokok Kretek Sub Kronik Muliartha, I Ketut Gede; Sriwahyuni, Endang; Yuliawati, Yuliawati
Jurnal Kedokteran Brawijaya Vol 25, No 1 (2009)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (471.627 KB) | DOI: 10.21776/ub.jkb.2009.025.01.5

Abstract

ABSTRACTFree radicals in cigarette smoke can destroy tissue and cells of the body. The activity of free radicals can bereduced by antioxidants from external and internal. The objective of this research is to investigate the effectsof vitamin C and vitamin E combination on the histopathology of rat liver exposed by subcronic cigarettesmoke. This research using true experimental study with post test only control group design. The sample othis research we used 32 Wistar rat, ages between 2-3 months, weight 150-200 grams divided 8 groupedCigarette smoke exposed for 10 weeks. Parameter will be measured is the number of liver cells damage(necrosis). Data analysis uses the One-Way ANOVA method followed by Turkey test. The result show thenumber of liver cells damage are significantly decrease. The conclution vitamin C and vitamin E combinationdecrease the number of the liver cells damage of the rat liver, that has been exposed to subcronic cigarettesmoke at optimal doze 0,20 mglg bw vitamin C and 0,04 lUlg bw vitamin E.Keywords: vitamin C, vitamin E, cigarette smoke, liver cells damage.
Outer Membrane Protein 49,4 Kda dari Porphyromonas gingivalis Merupakan Protein Hemaglutinin dan Adhesin Terhadap Netrofil Mubarokah, Siti Nurul; Sumarno, Sumarno; Muliartha, I Ketut Gede
Jurnal Kedokteran Brawijaya Vol 25, No 2 (2009)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (581.04 KB) | DOI: 10.21776/ub.jkb.2009.025.02.6

Abstract

ABSTRACTPeriodontitis is caused mostly by P. gingivalis and it is related to acute coronary syndrome. P. gingivalis readilyinvades into blood circulation and potentially induces. Collagenolytic activity of neutrophil which result incollagen vascular degradation lead to atherosclerotic plague rupture (APR). APR is responsible for occurringfatal cardiovascular events such as acute myocardial infarction (AMI). These information brought out notionconcerning the adhesion interaction of P. gingivalis with neutrophil. The aim of this study was to assessadhesion molecule of P. gingivalis outer membrane protein (OMP) by partial characterization took inhemagglutination assay using mice erythrocytes, adhesion inhibition assay by gradual concentration ofadhesion blocked in neutrophil, immunologic assay using Western-blotting and immunocytochemistry. Theresults showed that 49,4 kDa P.gingivalis OMP can agglutinate mice erythrocytes and adherence to netrophilIncrease concentration of OMP P. gingivalis 49,4 kDa reduce adhesion process to netrophil This protein wasrecognized by the polyclonal antibody of 49,4 kDa adhesion molecule. It can be concluded that P gingivalisouter membrane protein is a hemagglutinin and an adhesion molecule to netrophilKeywords : 49,4 kDa P. gingivalis OMP, neutrophil, hemagglutination, adhesin
EFFECT OF COMBINED THERAPY USING CHLOROQUINE AND VITAMIN C TO THE PERITONEAL MACROPHAGE FUNCTION IN BALB/C STRAIN MICE INFECTED BY Plasmodium berghei Fitri, Loeki Enggar; Suhendro, Wongso; Murwani, Sri; Muliartha, I Ketut Gede; Ali, Mulyohadi
Jurnal Kedokteran Brawijaya Vol 19, No 3 (2003)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1633.38 KB) | DOI: 10.21776/ub.jkb.2003.019.03.2

Abstract

In acute infection, malaria will induce cellular immunity by activating T lymphocytes and macrophages cells. This induction indirectly triggers free radicals production in order to eliminate the parasites from red blood cells, however high concentration of thismolecules can cause vital tissue pathological changes on host. In late phase of malarial infection, there are immunosupression on macrophages activity including antigen presenting and secretion of immunoregulated mediator. It has been anticipated, vitamin C as antioxidant would diminish the side effect of thesefree radicals during malarial infection and increase the immunity. To see the effect of combination chloroquin and vitamin C in hastening the recuperative process by decreasing parasitemia and increasing the phagocytosis function of macrofages during Plasmodium berghei infection. This study has been carried out using 3 groups of BALB/c mice, all group were inoculated with 1x107Plasmodium berghei infected red-blood cells. No drug was given on control group (IK). In experimental group we introduced an oral therapy ofchloroquin for 5 days in 1.4 mg/cc dosage and vitamin C for 7 days in 0.2 mg/cc dosages concurrently with a Plasmodium berghei inoculation (IKC). One group was only given chloroquin at the same dosage and no drug was given at the control group (IK).
Co-Authors Abdillah Iskandar Asnah Hidayat Djanggan Sargowo Endang Sriwahyuni Fitri Armania Loeki Enggar Fitri Mulyohadi Ali Siti Nurul Mubarokah Sri Murwani Sumarno . Wibi Riawan Wongso Suhendro