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All Journal Jurnal Sain Veteriner Jurnal Kedokteran Brawijaya JURNAL PERSPEKTIF BEA DAN CUKAI Jurnal Penelitian Pendidikan IPA (JPPIPA) Pendas : Jurnah Ilmiah Pendidikan Dasar Indonesian Treasury Review: Jurnal Perbendaharaan, Keuangan Negara dan Kebijakan Publik YARSI Medical Journal Veterinary Biomedical and Clinical Journal Majapahit Journal of Islamic Finance dan Management Majapahit Journal of Islamic Finance dan Management
Sri Murwani
Bagian Mikrobiologi Fakultas Kedokteran UNIBRAW Malang
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Physics Veterinary Other

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DIET ATEROGENIK PADA TIKUS PUTIH (Rattus novergicus strain Wistar) SEBAGAI MODEL HEWAN ATEROSKLEROSIS Murwani, Sri; Ali, Mulyohadi; Muliartha, Ketut
Jurnal Kedokteran Brawijaya Vol 22, No 1 (2006)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1301.176 KB) | DOI: 10.21776/ub.jkb.2006.022.01.2

Abstract

Atherosclerosis is still a major health problem, because 20% of death in the world is caused by atherosclerosis diseases like stroke and myocardial infarct. One of animal models that was successful in atherosclerosis research was New Zealand white rabbit. The purpose of this preliminary research was to determine the atherogenic diet ofwhite rats (Rattus novergicus strain Wistar) as animal model of atherosclerosis especially to find fixed composition and time of the atherogenic diet taken.This research used male; 2 months age, 150-200 grams body weight of white rats Rattus novergicus strain Wistar. The rats were divided into5 groups in equal number, 4 rats respectively. Theywere a negative control group without diet treatment and 4 groups as treatment groups which were given hipercholesterol diet. Atherogenic diet composed of PAR-S, wheat flour, cholesterol, cholic acid, pork oil and water. Data were obtained by measuring of blood cholesterol level and foam cell formation.
IDENTIIFKASI PROTEIN IMUNOGENIK CHLAMYDIA PNEUMONIAE TERHADAP SERUM PENDERITA INFARK MIOARD AKUT Murwani, Sri; Hidayati, Dwi Yuni Nur
Jurnal Kedokteran Brawijaya Vol 23, No 2 (2007)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (661.466 KB) | DOI: 10.21776/ub.jkb.2007.023.02.6

Abstract

Chlamydia pneumoniae is human respiratory tract pathogen and recently investigated as pathogen causingatherosclerosis and acute myocardial infarction (AMI). This research was carrier out to detect proteinpattern of C. pneumoniae, and to study it relation to AMI throughdetection of immunogenic protein. Design research  was laboratory observational and analyzed descriptively. The subject was C. pneumoniae. Protein pattern the bacteria was detected by electrophoresis method, and to detect the immunogenic protein was done immunoblotting. Serum was obtained from AMI patients in Saiful Anwar and Lavallette hospitals.  The result showed, protein pattern C. pneumoniae wasprotein with molecular weight 117, 107, 97, 91, 86, 61, 58, 52, 46, 44, 34, 23, 19, 9, 5, 4 kDa. Immunogenic proteins vary between AMI patients was 117, 107, 86, 61, 58, 52, 46, 44,  34 kDa. Non immunogenic proteins were 97, 91, 23, 19, 9, 5 and 4 kDa. Protein 61 kDa react to all of patient’s serum. It was concluded, C. pneumoniae have protein fractions 117, 107, 97, 91, 86, 61, 58, 52, 46, 44, 34, 23, 19, 9, 5, and 4kDa. Immunogenic proteins vary between AMI patients was 117, 107, 86, 61, 58, 52, 46, 44, 34 kDa, and 61 kDa was the  immunodominant protein. The result proved C. pneumoniae as causative agent of atherosclerosis and acute myocardial infarction, in Indonesia particularly. Key words:C. pneumoniae, immunogenic, AMI
EFFECT OF COMBINED THERAPY USING CHLOROQUINE AND VITAMIN C TO THE PERITONEAL MACROPHAGE FUNCTION IN BALB/C STRAIN MICE INFECTED BY Plasmodium berghei Fitri, Loeki Enggar; Suhendro, Wongso; Murwani, Sri; Muliartha, I Ketut Gede; Ali, Mulyohadi
Jurnal Kedokteran Brawijaya Vol 19, No 3 (2003)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1633.38 KB) | DOI: 10.21776/ub.jkb.2003.019.03.2

Abstract

In acute infection, malaria will induce cellular immunity by activating T lymphocytes and macrophages cells. This induction indirectly triggers free radicals production in order to eliminate the parasites from red blood cells, however high concentration of thismolecules can cause vital tissue pathological changes on host. In late phase of malarial infection, there are immunosupression on macrophages activity including antigen presenting and secretion of immunoregulated mediator. It has been anticipated, vitamin C as antioxidant would diminish the side effect of thesefree radicals during malarial infection and increase the immunity. To see the effect of combination chloroquin and vitamin C in hastening the recuperative process by decreasing parasitemia and increasing the phagocytosis function of macrofages during Plasmodium berghei infection. This study has been carried out using 3 groups of BALB/c mice, all group were inoculated with 1x107Plasmodium berghei infected red-blood cells. No drug was given on control group (IK). In experimental group we introduced an oral therapy ofchloroquin for 5 days in 1.4 mg/cc dosage and vitamin C for 7 days in 0.2 mg/cc dosages concurrently with a Plasmodium berghei inoculation (IKC). One group was only given chloroquin at the same dosage and no drug was given at the control group (IK).
STUDI SEROEPIDEMIOLOGIS CHLAMYDIA PNEUMONIAE DAN BEBERAPA MIKROORGANISME YANG DIDUGA MENYEBABKAN INFARK MIOKARD AKUT Murwani, Sri; Ali, Mulyohadi; Muliartha, Ketut; Purwanto, Purwanto; Susilawati, Ida; Nur Aini, Dinda; Yuni, Yuni
Jurnal Kedokteran YARSI Vol 15, No 1 (2007): JANUARI - APRIL 2007
Publisher : Lembaga Penelitian Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (138.634 KB) | DOI: 10.33476/jky.v15i1.1002

Abstract

Acute myocardial infarction (AMI) is still a major health problem. Approximately 20% of death in the world was caused by atherosclerotic diseases like stroke, myocardial infarct. Recent studies explain the role of infection in the pathogenicity of AMI. The purpose of this study was to examine seroepidemiological study of Chlamydia pneumoniae infection related to AMI and its occurrence as pathogen burden-infection with other microorganisms. Subjects for this study were patients diagnosed clinically and laboratorically as AMI, from RSUD Saiful Anwar and RS. Lavalette,Malang. Blood samples were collected from each subject and serum was analyzed for IgG antibodies against C. pneumoniae, CMV, H. pylori and S. mutans. Clinical status was analyzed to find IMA conventional risk factors, such as smoking, hypertension, hypercholesterolemia, and diabetes mellitus. The result showed that the average age of these patients were 55 years and men were more common than women. All of these patients were infected by microorganism. Patients with infection and conventional risk factors were 51,9%, infection without conventional risk factors was 48,2%, and conventional risk factors for IMA without infection was 51, 85%. The most common conventional risk factor was smoking (37, 0%). Infection by S. mutans was detected in all patients (100%), C. pneumoniae 92,6%, CMV 92,6%, H. pylori 77,8%; however multiple infections were observed in most of the patients. It was concluded that microorganisms played rolesin the pathogenicity of IMA. It was suggested that the development of IMA might be contributed by single infection as well as multiple infections. However, multiple infections tend to be observed in most of the patients.
Pemberian Ekstrak Etanol Daun Jambu Mete (Anacardium occidentale) dalam Reduksi Kadar IL-6 dan Peningkatan Kadar SOD pada Mencit Fibrosis Hepar yang Diinduksi CCl4 Hutabarat, Mariana Ruth Theresia; Hanifah, Fithria Nisa; Hadijah, Siti; Winarso, Djoko; Murwani, Sri
Jurnal Sain Veteriner Vol 38, No 1 (2020): April
Publisher : Fakultas Kedokteran Hewan Universitas Gadjah Mada bekerjasama dengan PB PDHI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (492.618 KB) | DOI: 10.22146/jsv.57361

Abstract

Liver fibrosis is the excessive accumulation of extracellular matrix. The prevalence of liver fibrosis in small animal was reported by 10% of all systemic diseases occured in the United States. One of the toxic materials that cause liver fibrosis is carbon tetrachloride (CCl4). This study aims to determine the preventive effect of ethanol extract of leaves of cashew (Anacardium occidentale) against the production of Interleukin-6 (IL-6) and increase the levels of superoxide dismutase (SOD). Leaves cashew contain of flavonoids which have anti-inflammatory and antioxidant effects. This research is an experimental study, post-test control only design using a completely randomized design. Mice (Mus musculus) were divided into 5 groups, namely the negative control group, positive control group, preventive group dose of 500 mg/kg BW, 1000 mg/kg BW, and 1500 mg/kg BW. Interleukin-6 production is calculated using flowcytometry, while SOD was measured using spectophotometer. Data were statistically analyzed within one way ANOVA (α=0.05) with advanced test Post Hoc Tukey. Conclusions from this research that the preventive use of ethanol extract of leaves of cashew to prevent an increase of IL-6 production and increasing the levels of SOD in mice models of liver fibrosis. Production of IL-6 in group of 1500 mg/kg BW is 2.58%. SOD levels in group of 1500 mg/kg BW is 4.23%. 
Detection of Staphylococcus aureus Biofilm from Subclinical Mastitis Milk Lesmana, Muhamad Arfan; Qosimah, Dahliatul; Murwani, Sri
Veterinary Biomedical and Clinical Journal Vol. 1 No. 1 (2019)
Publisher : Faculty of Veterinary Medicine Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (209.132 KB) | DOI: 10.21776/ub.VetBioClinJ.2019.001.01.3

Abstract

One of S.aureus's virulence factors is biofilm formation. When biofilms are formed, the bacteria will undergo phenotypic changes that require higher concentrations of antibiotics to inhibit proliferation. Phenotypic changes will lead to increase the production of extracellular matrix and multilayered colonies as well as decrease of metabolic rates, multiplication and polymicrobial colonization resulting in recurrent infection in the host and difficulty being treated with antibiotics due to resistance. The aim of this research was to know the formation of bacterial biofim by slime and quantitative by microplate titer method. The research method was qualitative descriptive using 27 samples of Staphylococcus aureus  with characterized from mastitis infected milk. The bacteria were grown on CRA (Congo Red Agar) media to observe the slime biofilm through bacteria black colony followed by MicrotiterPlate  method  with 570nm wave lenght. The results showed that 27 samples of Staphylococcus aureus which positive to form slime biofilm were 10 samples and continued to microtiter plate showed 3 positive samples of biofilm. The conclusions of this study, Staphylococcus aureus in subclinical mastitis milk samples were positive to form biofilms. 
Analysis of the Impact of Gross Split Production Sharing Contracts in the Upstream Oil and Gas Sector on State Revenue Rizal, Mohamad Nor; Murwani, Sri
Indonesian Treasury Review: Jurnal Perbendaharaan, Keuangan Negara dan Kebijakan Publik Vol. 10 No. 1 (2025): Indonesian Treasury Review: Jurnal Perbendaharaan, Keuangan Negara dan Kebijak
Publisher : Direktorat Jenderal Perbendaharaan, Kementerian Keuangan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33105/itrev.v10i1.1006

Abstract

Research Originality — Since 2017, Oil and Gas Cooperation Contract Contractors (KKKS) have had the option to use Gross Split (GS) Production Sharing Contracts (PSC) to manage oil and gas (migas) work areas (WK) as an alternative to the Cost Recovery (CR) PSC, which has been in place since the 1960s. However, despite its implementation since 2017, no research has specifically examined the impact of GS PSCs on state revenue. Most studies have instead focused on their effect on KKKS profitability. Research Objectives — This study aims to provide empirical evidence on the impact of GS PSC implementation in managing oil and gas WKs, particularly in relation to state revenue. Research Methods — The study employs a difference test and an impact test. The difference test utilizes data from six relatively similar WKs in 2018, while the impact test is conducted using data from 35 WKs over the period 2018–2022. Empirical Results — The findings indicate that state revenue from a WK decreases after transitioning to the gross split scheme. Additionally, gross split has a significant negative impact on state revenue. Other variables significantly and negatively affecting state revenue include operating costs, lifting, and selling prices. Conversely, contractor profit has a significant positive effect on state revenue. Implications — The results suggest that adopting gross split PSCs and/or increasing operating costs will reduce state revenue in the current year. Conversely, higher lifting volumes, selling prices, and contractor profits contribute to increased state revenue in the same period.
Development of AI-Based Hypercontent E-LKPD for IPAS Learning in Grade V Elementary School Murwani, Sri; Syarifuddin; Jaenudin, Riswan
Jurnal Penelitian Pendidikan IPA Vol 11 No 8 (2025): August
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v11i8.12403

Abstract

Learning that still relies on conventional methods, such as lectures and textbooks, often fails to facilitate understanding of complex concepts, especially in subjects like Natural and Social Sciences (IPAS), which require in-depth and contextual understanding. Learner-centered education should be enhanced through innovative learning media, including the use of AI-based Hypercontent E-Worksheets (E-LKPD) to assess learning effectiveness. This study aims to develop a valid, practical, and effective AI-based Hypercontent E-LKPD for IPAS (Social and Natural Sciences) learning in Grade V of elementary school. The research was conducted in Class V of SDN 10 Sekayu with 50 student participants. The study followed a Research and Development (R&D) approach using the Rowntree development model and Tessmer’s formative evaluation. Data were collected through interviews, questionnaires, expert reviews, one-to-one and small group evaluations, and pretest-posttest. The validity score of the developed E-LKPD was 4.62 (very good). Practicality scores were 4.6 (one-to-one) and 4.42 (small group), both considered very practical. Effectiveness was measured through learning outcomes, showing a pretest score of 42.50%, a posttest average of 84.75%, and an N-Gain of 0.72 (high category). These results indicate that the developed AI-based Hypercontent E-LKPD is valid, practical, effective, and highly suitable for use in IPAS learning for Grade V elementary students.
EVALUASI DAMPAK FASILITAS KAWASAN BERIKAT MENGGUNAKAN COST-BENEFIT ANALYSIS Nurcahyo, Marsanto Adi; Utomo, Rachmad; Murwani, Sri; Aritonang , Yoke Ruminson; Iriansyah, Nur Firman
JURNAL PERSPEKTIF BEA DAN CUKAI Vol. 9 No. 1 (2025): JURNAL PERSPEKTIF BEA DAN CUKAI
Publisher : Unit Penerbitan Politeknik Keuangan Negara STAN

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31092/jpbc.v9i1.3289

Abstract

This study analyzes the effectiveness of bonded zone facility incentives in generating economic benefits for the country compared to the fiscal costs incurred. Using the Cost-Benefit Analysis method and the Net Present Value (NPV) approach, this research is conducted as a case study on three companies receiving bonded zone facilities, namely PT. A, PT. B, and PT. C. The results show that PT. A have a Benefit-Cost Ratio of 0.238, indicating that the economic benefits generated are still lower than the fiscal costs provided. In contrast, PT. B and PT. C has a Benefit-Cost Ratio of 2.235 and 1.575, demonstrating that this company provides greater economic benefits than the costs incurred by the government. These findings have implications for optimal tax policy, suggesting that fiscal incentives should be more selectively allocated based on long-term economic potential. Therefore, this study recommends periodic evaluations of bonded zone policies to ensure the effectiveness of fiscal incentives, enhance transparency in facility utilization, and design a stricter supervision mechanism. For future research, it is recommended to conduct an analysis of all companies receiving bonded zone facilities to obtain a more comprehensive understanding of the impact of this policy on the national economy.
ANALISIS KEBUTUHAN PENGEMBANGAN E-LKPD HYPERCONTENT BERBASIS AI PADA PEMBELAJARAN IPAS DI KELAS V SEKOLAH DASAR Murwani, Sri; Syarifuddin; Riswan Jaenudin
Pendas : Jurnal Ilmiah Pendidikan Dasar Vol. 10 No. 02 (2025): Volume 10, Nomor 02 Juni 2025 publish
Publisher : Program Studi Pendidikan Guru Sekolah Dasar FKIP Universitas Pasundan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23969/jp.v10i02.24435

Abstract

This study aims to determine the needs of students and teachers in developing E-LKPD Hypercontent AI-Based Social Science Learning in Class V Elementary Schools. Specifically to find out what the learning needs are in class, the need for media and technology, interest in the Natural Appearance Science and Science material. And what are the needs and expectations of students and teachers regarding E-LKPD. So that later it can help create learning that is effective and relevant to the needs and potential of each student. Next, by using descriptive qualitative methods, researchers want to analyze the data that has been obtained in the field. The results after a needs analysis were carried out were that 83% of students and 84% of teachers had various needs in learning. 79% of students and 91% of teachers need learning media, and 79% of students and 81% need technology assistance to support learning and 79% of students and 91% of teachers want E-LKPD in learning. Furthermore, 85% of students and 95% of teachers stated that they supported the development of this E-LKPD. By looking at the results of theneeds analysis, it has indicated that media development can be carried out immediately so that later it can be used by students and teachers to help them in the learning process in the classroom.Keywords: Need analysis, E-LKPD, IPAS, Elementary School
Co-Authors Aritonang , Yoke Ruminson Djoko Winarso Dwi Yuni Nur Hidayati Hanifah, Fithria Nisa Hutabarat, Mariana Ruth Theresia I Ketut Gede Muliartha IDA Susilawati, IDA Iriansyah, Nur Firman Ketut Muliartha Lesmana, Muhamad Arfan Loeki Enggar Fitri Mulyohadi Ali Nur Aini, Dinda Nurcahyo, Marsanto Adi Purwanto Purwanto Qosimah, Dahliatul Riswan Jaenudin Rizal, Mohamad Nor Siagian, Noah Van Juanda Siti Hadijah Syarifuddin Utomo, Rachmad Wongso Suhendro YUNI, YUNI