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Fakultas Kedokteran Universitas Brawijaya Gedung Graha Medika Lt. 1, Ruang 104
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INDONESIA
Jurnal Kedokteran Brawijaya
Published by Universitas Brawijaya
ISSN : 02169347     EISSN : 23380772     DOI : http://dx.doi.org/10.21776/ub.jkb
Core Subject : Health,
Medicine & Pharmacology
JKB contains articles from research that focus on basic medicine, clinical medicine, epidemiology, and preventive medicine (social medicine).
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 8 Documents
 1 
Search results for , issue "Vol 22, No 3 (2006)" : 8 Documents clear
PENGARUH PAPARAN SINAR MATAHARI PAGI TERHADAP PENURUNAN TANDA IKTERUS PADA IKTERUS NEONATORUM FISIOLOGIS Puspitosari, Ratih Dewi; Sumarno, Sumarno; Susatia, Budi
Jurnal Kedokteran Brawijaya Vol 22, No 3 (2006)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (194.453 KB) | DOI: 10.21776/ub.jkb.2006.022.03.8

Abstract

Physiological jaundice is a sign usually happens tonewborn infants. The cause of icterus is the increase of indirect bilirubin that makes the skin yellow that usually disturb the people. Treatment of this yellow baby is  by exposing them to the morning sun. Sun exposure can reduce jaundice skin by changing the bilirubin indirect molecule. This research aim was to know the effect of morning sun exposure thatcan decrease jaundice skin through jaundice skin level measurement on babies. The special goal of the research was to know the jaundice skin and the difference before and after expos to the sun. The research was a quasi experimental study. The samples consisted of 5 babies,  selected by quota sampling. The measured variables were morning sun exposure and jaundice skin level. The research was done by exposing the samples on the morning sun for 30 minutes, then the jaundice skin measured in minutes 0,  5th, 10th, 15th, 20th, 25th, and 30thby using Corel Photo-Paint 12 Program. Data analysis was done with ANOVA and was continued by correlation-regression test, with confidence interval 99%.
EFEK ANTIBAKTERI EKSTRAK KULIT BUAH DELIMA (PUNICA GRANATUM) TERHADAP SHIGELLA DYSENTRIAESECARA IN VITRO Prihantoro, Teguh; Indra, Rasjad; Sumarno, Sumarno
Jurnal Kedokteran Brawijaya Vol 22, No 3 (2006)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (665.423 KB) | DOI: 10.21776/ub.jkb.2006.022.03.3

Abstract

Shigella dysentriae is the most common organisms which causes bacillary dysentery in developing countries with high mortality. Pomegranates (Punica granatum) have beenused since a long time ago in folk medicine for several purposes. The antibacterial activity was linked to the presence of major phytocompounds like flavonoids, triterpenes, phenols, and ellagitannin. The aim of this experimental study wasto evaluate the antibacterial effect of Pomegranate’s (Punica Granatum) rind extract against Shigella dysentriae  and to determine the relationship between concentrations of Pomegranate’s rind extract with the growth of Shigella dysentriae in vitro. Antimicrobial effect was determined by tube dilution method. This consists of determination of  Minimum Inhibitory Concentrations (MICs), and Minimum Bactericidal Concentrations (MBCs). The concentrations of Pomegranate’s (Punica Granatum) rind extract were 0.8%, 1%, 1.2%, 1.4%, 1.6%, and 1.8%. At low extract concentration (0.8%)bacterial growth was delayed, while at higher extract concentration (1.8%) bacterial growth was elimanated (ANOVA, p =  0.000, Regression R = -0.901)
PERUBAHAN RESPONS RESEPTOR ADRENERGIK-βDAN MUSKARINIK DI OTOT POLOS SALURAN NAFAS TIKUS WISTAR PADA PROSES PENUAAN Karyono, Setyawati Soeharto
Jurnal Kedokteran Brawijaya Vol 22, No 3 (2006)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (174.891 KB) | DOI: 10.21776/ub.jkb.2006.022.03.1

Abstract

Aging process is a unique and complex process whichcould not be prevented. Many physiologic changes could be seen for adaptation during aging process. These changes influence pharmacodynamic and pharmacokinetic of drug and cause alteration of drug effect. Pharmacodynamic changes are caused by alteration of drug receptor.The objective of this study was to evaluate the influence of aging on β-adrenergic and muscarinic receptors function in rat airway smooth muscle. Isolated tracheal ring preparation and lung strip were used to examine relaxation response to isoprenaline (β-adrenergic agonist) and contraction response to metacholine (muscarinic agonist). Tracheal ring preparations and lung strip were taken from young (4-5 weeks), adult (4-6 months) and old (24-26 months) wistar rats.
EKSPRESI CYTOSOLIC ASPARTATE-SPECIFIC CYSTEINE PROTEASE-3 (CASPASE-3) PADA JARINGAN HATI RATTUS NORVEGICUS (WISTAR) SETELAH PEMBERIAN SUBKRONIK AFLATOKSIN B1 (AFB1) Maritha, Indah Dina; Supranowo, Supranowo; Lyrawati, Diana
Jurnal Kedokteran Brawijaya Vol 22, No 3 (2006)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1838.995 KB) | DOI: 10.21776/ub.jkb.2006.022.03.4

Abstract

Aflatoksin B1(AFB1) is one of the toxic agents produced by Aspergillus flavus that frequently contaminates foods not properly stored. AFB1 undergoes biotransformation which may result in the production of reactive oxygenspecies (ROS) hazardous to liver cells. Following a cascade of oxidative reaction, ROS will cause the mitochondria torelease cytochrome c which subsequently activates caspase-3, leading to apoptosis. In this present study we evaluated the effect of aflatoxin B1 on the expression of caspase-3 in the liver. AFB1 was administered per oral, at different dosage and length of exposure, subchronically. This study was carried out as a factorial designed experiment with  two factors. The first was dosage factor i.e 0, 10, 15 and 20 µg (0; 0,05; 0,075; 0,1 µg/g BW) and the second was exposure time factor i.e. 12, 16 and 20 weeks. Rattus norvegicus strain Wistar aged approximately eight weeks old and weighed 180-200 g were used as the experimental animals. The expression of  caspase-3 was examined by using immunohistochemistry. The results showed that the expression of caspase-3 increased significantly (p = 0,000) with the escalation of AFB1 in dosage and/or exposure time (p = 0,001). In the interaction between dose and exposure time of AFB1an increase in the expression of caspase-3 was also observed (p = 0,000). Interestingly, these studies also revealed thatin the liver tissues there was a limitation in the expression of caspase-3, where the raising of further AFB1 dosage and length of exposure were not followed by further increase of the caspase-3.
PERBEDAAN PENGARUH PEMBERIAN MINYAK KELAPA SAWIT (Palm Oil) DAN MINYAK KELAPA MURNI (Virgin Coconut Oil) TERHADAP PERBAIKAN PROFIL LEMAK (KOLESTEROL) PADA TIKUS DENGAN DIET ATEROGENIK Kusumastuty, Inggita; Andarini, Sri; Anom Aswin, Anak Agung Gede
Jurnal Kedokteran Brawijaya Vol 22, No 3 (2006)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (193.125 KB) | DOI: 10.21776/ub.jkb.2006.022.03.5

Abstract

Virgin Coconut Oil (VCO) is a kind of coconut oil that most of its contained is Medium Chain Fatty Acids (MCFA) and previous stdy showed that MCFA has an ability to prevent vascular desease. This experiment was done to  prove the ability of virgin coconut oil to reduce cholesteroltotal of rats with atherogenic diet compared with palm oil. This experiment was designed as true pre test post test experiment with control groups. The number of samples were 24 male wistar rats and they were separated into 4 treatment groups in  which each of them has 2 diet sections. The First section was done within 8 weeks, group A got normal diet, group B, Cand D got atherogenic diet with lard, after this section finished all of the groups got cholesterol pre test level. The next 4 weeks, in the second section treatment diet, group A got normal diet, group B got atherogenic diet with lard, group C gotatherogenic diet with palm oil and group D got atherogenic diet with virgin coconut oil, after the second section was over rat cholesterol levels were measured by enzymatic photometric test base on “CHO-PAP”. The results from One Way Anova which was continued to Tukey test showed that group B,C and D were homogenous, but they were different significantly againts group A on pre test with p(0.001) < 0.05.
PENGARUH BERBAGAI DOSIS CITRININ TERHADAP KERUSAKAN STRUKTUR HEPATOSIT MENCIT (Mus musculus) PADA TIGA ZONA LOBULUS HEPAR Hastuti, Utami Sri
Jurnal Kedokteran Brawijaya Vol 22, No 3 (2006)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1373.747 KB) | DOI: 10.21776/ub.jkb.2006.022.03.6

Abstract

Citrinin is a sort of mycotoxin which caused mycotoxicosis. Citrinin is produced by Penicillium citrinum mold that can contaminate sort of food especially damaged beans.  Citrinin is known as nephrotoxic as well as hepatotoxic mycotoxin and caused hepatocite structure damage. This research was done: 1) to know the effect of citrinin to hepatocite structure damage; 2) to know the effect of citrinin dose difference to the value of the hepatocyte structure damage; 3) to know the effect of citrinin to the value of hepatocyte structure damage on three zones of hepar lobulus. The samples of this research were male mice (Mus musculus) var. BALB-C  at the age of three months. The experiment group of  mice was orally administered with citrinin in three doses, i.e: dose-1: 1 mg/kg BW; dose-2: 1,75 mg/kg BW; dose-3: 2,5 mg/kg BW. Hepatocyte structure damage is observed on centrilobular zone, midzone, and perifer zone. The hepatocyte structure damage examination is done by histopathologycal andultra structural examination by electron microscope.
PREDIKTOR ASMA PADA USIA 7 TAHUN SETELAH MENDERITA BRONKIOLITIS AKUT KARENA RESPIRATORY SYNCYTIAL VIRUS: SUATU STUDI PROSPEKTIF Kusuma, HMS. Chandra
Jurnal Kedokteran Brawijaya Vol 22, No 3 (2006)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (108.815 KB) | DOI: 10.21776/ub.jkb.2006.022.03.7

Abstract

Infants are at increased risk of developing asthma  after RSV (Respiratory Syncytial Virus) acute bronchiolitis. The hypothesis that cytokine production is related to the development of asthma after RSV bronchiolitis. The diagnosis of RSV bronchiolitis was verified using the Abbott test pack RSV, a rapid enzyme immuno assay for direct detection of viral antigen in nasopharyngeal secretion. Changes in FEV1 (Forced Expiratory Volume in 1 second) were determined using spirometri, IL-4 and IFN-γlevels were determined using the enzyme-linked immunosorbant assay (ELISA) method. In this study, 62 children hospitalized for RSV bronchiolitis were followed prospectively, 55 (88.7%) childrencompleted the study and 41 children (74.5%) had asthma at 7 years of age. RSV bronchiolitis children were more frequent among boys (boy /girl ratio: 2). Episodes of wheezing more than 8 had specifity and sensitivity of 100% respectivelly,might be the very useful predictor for asthma. The cut off level over 40.84 pg/ml for IL-4, below 14.12 pg/ml for IFN-γ, IL-4 / IFN-γratio over 3 and episodes of wheezing over 8 may be used to predict asthma after RCV bronchiolitis.
JENIS BAKTERI DAN SENSITIVITAS ANTIBIOTIK PADA KASUS INFEKSI NOSOKOMIAL AKIBAT PEMASANGAN KATETER DI RSSA MALANGDALAM PERIODE NOVEMBER 2000 - MARET 2001 Djunaedi, Djoni
Jurnal Kedokteran Brawijaya Vol 22, No 3 (2006)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (109.792 KB) | DOI: 10.21776/ub.jkb.2006.022.03.2

Abstract

The incidence of Nosocomial Infection (NI) includinginfection of the urinary tract attributable to catheter insertion aggravates the existing conditions. Local symptoms  and septis that occured could prolong hopitalization, and even caused death. So far, prevention of NI has been undertaken only through the adherence to the standard  procedure. The important problem that arises is whether the prevention of NI should rely only on the adherence of thestandard procedure. In order to find the solution, an appropriate investigation is called for. The materials utilized were (a) urine collected from obstetric-gynaecological patients that required catheter insertion – urine sample was taken using antiseptical procedures before and after catheter insertion within the period of 2x24 hours, (b) the end section of catheter canule when the the catheter was taken off. The materials were cultured in blood plates. Bacterial counts were performed on the data with respect to bacterial types and their sensitivity to antibiotics of the families of Cephalosporin (Cefotaxim), Aminoglycoside (Amikacin), Quinolone (Ciprofoxacine), Penicilline (Amoxicilline, Ampicilline), cotrimoxazole and Nitrofurantoin.

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