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INDONESIA
Jurnal Kedokteran Brawijaya
Published by Universitas Brawijaya
ISSN : 02169347     EISSN : 23380772     DOI : http://dx.doi.org/10.21776/ub.jkb
Core Subject : Health,
Medicine & Pharmacology
JKB contains articles from research that focus on basic medicine, clinical medicine, epidemiology, and preventive medicine (social medicine).
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 9 Documents
 1 
Search results for , issue "Vol 23, No 1 (2007)" : 9 Documents clear
AKURASI METODE RADIOKOLLOID DAN BLUE DYEDALAM MENDETEKSI LIMFONODI SENTINEL PADA KANKER PAYUDARA STADIUM DINI Yueniwati, Yuyun; Yulisa, N. Diana; Iskandar, Arief
Jurnal Kedokteran Brawijaya Vol 23, No 1 (2007)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (273.094 KB) | DOI: 10.21776/ub.jkb.2007.023.01.5

Abstract

reast cancer incidence varies in many countries but in general increases. This research aimed to find  out the accuracy of radiocolloid (lymphoscintigraphy and gamma probe) as well as blue dye method in detecting sentinel node in the early stage breast cancer. Diagnostic examination was conducted on 163 nodes of 14 patients cross sectionally, comparing the accuracy of radiocolloid and blue dye methods with  histopathologic method as the gold standard. Subject characteristics were female, aged 39-53, mostly menopause, multipara and breast-feeding. Primary tumors were mostly found in the right, upper lateral quadrant, T2, histopathologic results showed that all were of invasive ductal carcinomas and 71.4% cases were lymphatic emboli. The detection of sentinel node with lymphoscintigraphy had 81.8% accuracy,sensitivity 90.4%, specificity 73.2%, NPV 98.1%, false-negative1.8% and kappa value 0.37. Detection using gamma probe resulted in 79% accuracy, sensitivity 90.4%, specificity 67.6%, NPV 97.9%, false-negative 2% and kappa value 0.31.
KADAR MDA DAN RASIO GSH/GSSH PADA KEHAMILAN NORMAL,PREEKLAMPSIA BERAT DAN EKLAMPSIA DI MALANG Candra, Siti; Widodo, M Aris; Suwarto, Soetomo; Muliartha G, I Ketut
Jurnal Kedokteran Brawijaya Vol 23, No 1 (2007)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (109.124 KB) | DOI: 10.21776/ub.jkb.2007.023.01.6

Abstract

Preeclampsia is marked by vasospasme, increasing peripheral vascular resistance and permeability, endothelial cell and reducing organ perfusion. It occurs because of the increasing of lipid hydroperoxides. The uncontrolled production of lipid hydroperoxides causes oxidative stress and destroyscell integrity. Oxidative stress condition expressthe increasing oxidant and decreasing antioxidant. One of the antioxidant is GSH that is used to neutralize the increasing of Malondialdehyde (MDA) level. The objective of this study was to see the difference of MDA content and GSH. GSSG ratio between the normal pregnancy, preeclamsia and eclampsia. This study was cross sectional study. The samples were 36 blood plasma consisted of 12 normal pregnancy, 12 preeclampsia and 12 eclampsia before birth. The bloodplasma, was measured for its MDA level and the GSH/GSSH ratio.The result showed that the level of MDA of plasma in preeclamptic and eclamptic pregnancy were higher than normal pregnancy p=0.000, due to lipid peroxidation resulted  from increased production of lipid hydroperoxides on preeclamptic  and eclamptic pregnancy.
PENGARUH PEMBERIAN PbB ASETAT DOSIS TINGGI TERHADAP KETEBALAN MIELIN N. ISCHIADICUSTIKUS PUTIH (RATTUS NORVEGICUS) Elfiah, Ulfa
Jurnal Kedokteran Brawijaya Vol 23, No 1 (2007)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1872.707 KB) | DOI: 10.21776/ub.jkb.2007.023.01.1

Abstract

Lead is commonly used in batteries, electrical cabel, and pipe manufacture. Despite its usefulness, lead has some sentrimental effects such as intoxication by chronic lead exposure results in peripheral neuropathy. This research was to determine the effect of oral administration of leadacetate to the thickness of mielin n.ischiadicus.  The post test only control group design was used assigning.Thirty male  rats into five groups of treatment. Aquadest was administered to group I. Lead acetate with doses of rats were sacrificed: 65, 125, 250, and 500 mg/kgbw/day were administered to group II, III, IV, and V. Lead acetate were given daily for 10 weeks and then to make histological preparations from n.ischiadicus using osmic acid as fixative and toloidin blue as staining agents.The results research showed that oraladministration of lead acetate affected the thickness of mielin with higher does resulted in thinner mielin. Keywords:thickness of mielin, lead acetate, oral
AKTIVASI SPONTAN SEL T LIMFOSIT MENCIT YANG MENGALAMI DEFISIENSI IL2Rβ Endharti, Agustina Tri
Jurnal Kedokteran Brawijaya Vol 23, No 1 (2007)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (262.849 KB) | DOI: 10.21776/ub.jkb.2007.023.01.7

Abstract

Homologous recombination applied to alter specific  endogenous gene, referred as gene targeting, provides the highest level of control over product mutation in cloned genes. In this experiment we showed that by using gene targeting a knock out mutation in IL-2Rβ gene could be generated. The findings of this study indicated that mice lacking the Interleukin-2 receptor β chain (IL2Rβ-/-) had spontaneously activated.T cells. In this study, we investigated abnormal expansion of activated T cells which showed high level of CD69.  These findings suggest that the IL2Rβ-/- mice may serve as animal model for autoimmune diseases and that the accumulation of activated T cell in the future could be usedin clinical setting to cure the diseases. Keywords:T cells, (IL2Rβ-/-), autoimmune
PENGARUH PEMBERIAN MINYAK BUAH MERAH (Pandanus conoideus) TERHADAP STRES OKSIDATIF SEL ENDOTEL YANG DIPAPAR DENGAN SERUM PENDERITA MALARIA FALCIPARUM DAN NETROFIL INDIVIDU SEHAT Armiyanti, Yunita; Fitri, Loeki Enggar; Widjajanto, Edi
Jurnal Kedokteran Brawijaya Vol 23, No 1 (2007)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1699.473 KB) | DOI: 10.21776/ub.jkb.2007.023.01.2

Abstract

Complication in Plasmodium falciparum malaria is associated with endothelial damage and overproductionof free radicals (oxidative stress) by activated neutrophils and endothelial cells. Red fruit (Pandanus conoideus) oil  has a very high antioxidant content, therefore it may neutralize free radicals and prevent endothelial damage. The aim of this research is to prove that red fruit (Pandanus conoideus) oil reduce Reactive Oxygen Intermediate (ROI) production  of endothelial cells exposed to severe malaria patient serum and neutrophils from healthy donor. Endothelial cells from human umbilical veins were coincubated with serum from severe malaria patient and with neutrophils from healthy donor  (positive control group). HUVEC’s normal was used as negative control,  where as  the experimental groups were given with red fruit oil in different concentrations (2.8%, 5.7% dan 11.3% ). The Reactive Oxygen Intermediate (ROI) production of  endothelial cells was semiquantitatively measured by using NBT-reduction assay and the score of ROI was counted. The results were statistically analyzed with ANNOVA (p<0.01). The rate of ROI production of endothelial cells was markedly increased after incubation with patient serum and neutrophils.
PENGARUH LINGKUNGAN KERJA PERAWAT TERHADAP PELAKSANAAN PRAKTEK KEPERAWATAN DI RUMAH SAKIT UMUM Dr. SAIFUL ANWAR MALANG TAHUN 2006 Putra, Kuswantoro Rusca; Hamid, Achir Yani S.; Mustikasari, Mustikasari
Jurnal Kedokteran Brawijaya Vol 23, No 1 (2007)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (122.872 KB) | DOI: 10.21776/ub.jkb.2007.023.01.9

Abstract

The implementation of nursing practice is related tonurses' working environment. The working environment components consist of leadership, culture and management; control over workload; control over practice; and adequate source. The purpose of this study is to identify any correlation between the nurses work environment with the implementation of nursing practice. The research was conducted in IRNA(Inpatients Ward) I and of IRNA II RSU Dr. Saiful  Anwar on May 1stuntil 20th, 2006. Correlation was chosen as the research design using cross sectional study on 196 nurses with two instruments: nurses' work environment, and implementation of nursing practice. The result based on analysis with regression linier indicates that there is a significant correlation between working nurse environment(leadership, culture and management; control over workload; control overpractice; and adequate source) with the implementation of nursing practice (p &lt; 0.05) and control over practice is the biggest sub variable that influences the implementation of nursing practice(B=1.302). In conclusion, the nurse’s working environment influences implementation of nursingpractice in hospital. Keywords:Work environment, Implementation of nursing practice
THEAFLAVIN MENGHAMBAT DIFERENSIASI PREADIPOSIT VISERAL MANUSIA MELALUI PPARγ γγ γSECARA IN VITRO Indra, Rasjad
Jurnal Kedokteran Brawijaya Vol 23, No 1 (2007)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (964.975 KB) | DOI: 10.21776/ub.jkb.2007.023.01.3

Abstract

Differentiation of pre-adipocytes into adipocytes, is a complex process that involves coordination of  expression of specific genes and proteins associated with each stage of differentiation. This process is regulated by several signaling pathways. CCAAT element-binding proteins (C/EBP)  αand  βand sterol response element-binding protein 1 (ADD1/SREBP1) are active during the early stages of the differentiation process and induce the expression and/or activity of the peroxisome proliferator-activated receptor  γ(PPARγ), a pivotal coordinator of adipocyte differentiation. Recently, many biological effects of black tea have been reported and these effects may be partially related to its antioxidant  properties. The recent study showed that black tea flavonoids inhibited adipocyte differentiation. The aim of this study was to investigate the role of theaflavin, a flavonoids in black tea, in inhibiting adipocyte differentiation through inhibition of PPARγexpression. Preadipocytes were incubated in media containing standard-differentiated stimulator: Insulin, dexamethasone, IBMX and FBS. After 24 hours, preadipocytes culture media wasadded with theaflavin 50, 100, or 200  µM. The cells were harvested after TF incubation for 24 hours and then the expression of PPARγwas identified by immunocytochemistry and Western blot.
PENGARUH PROBIOTIK PADA RESPON IMUN Djunaedi, Djoni
Jurnal Kedokteran Brawijaya Vol 23, No 1 (2007)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (126.214 KB) | DOI: 10.21776/ub.jkb.2007.023.01.4

Abstract

Probiotics (“for life”) is a live microbial feed supplement or defined as mono- or mixed cultures of live microorganisms which when administered in adequate amounts confer  a health benefit to the host by improving its microbial balance. Common descriptives for probiotics include “friendly”, “beneficial” or “healthy” bacteria.  Under natural conditions a protective gut microflora develops and there is no  need for probiotics supplement, but under rather un-natural conditions such like intestinal infections, post antibiotic treatment syndromes, pseudomembranous colitis, the probiotics preparations are needed. The beneficial effects of probiotics inthe host are promotion of the gut maturation and integrity, antagonisms against pathogens and immune modulation. Beyond those, the microflora seems to play a significant rolein diet induced superinflammation, mucosal immune system, neuroendocrine regulation, immunoglobulin production, macrophages factor restoration, apoptosis stimulation, lymphocyte function modulation, cytokine release, mucin production, intestinal immune homeostasis and inflammation prevention. However, many studies proved that probiotics have “upregulation and down-regulation” effects on immune system of the host.
LAPORAN KASUS:DICEPHALUS DIPUS TETRABRACHIUSDARI MALANG Dradjat, Respati Suryanto
Jurnal Kedokteran Brawijaya Vol 23, No 1 (2007)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Dicephalus Dipus Tetrabrachius is an extremely rare  form of conjoined twinning in which the infant has  four arms, two legs, one trunk, but two heads. The case that was born in Malang was girls had four arms that two of the arms had fused at the mid line. The case was delivered by caesareansection, due to pre-eclampsia and prolonged labor.Prior antenatal care was never done; the babies were born without any suspicion of conjoined twin. According to literature almost sixty percent of conjoined twins are either stillborn or lost in uterus, and 35% of twins that survive die within the first 24 hours. Antenatal diagnosis by ultrasound is possible in modern day obstetrics. The babies were born on Oct. 21st, 2006. The treatment planning were determined by degree of fusion and extent of joining of fetal organs. Surgicalseparation was not possible; the surgical correction is removal of fused arms in the near future, as an alternative plan for improving quality of life. Unfortunately the conjoined twin died 1 week before 6 month old. Key words:Conjoined twin, dicephalus, prognosis, treatment

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