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Fakultas Kedokteran Universitas Brawijaya Gedung Graha Medika Lt. 1, Ruang 104
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INDONESIA
Jurnal Kedokteran Brawijaya
Published by Universitas Brawijaya
ISSN : 02169347     EISSN : 23380772     DOI : http://dx.doi.org/10.21776/ub.jkb
Core Subject : Health,
Medicine & Pharmacology
JKB contains articles from research that focus on basic medicine, clinical medicine, epidemiology, and preventive medicine (social medicine).
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 13 Documents
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Search results for , issue "Vol 31, No 3 (2021)" : 13 Documents clear
Optimation of Combination of N-Hexane Solution and Ethyle Acetate on Secondary Metabolite Compounds Profile of Streptomyces hygroscopicus Ariel, Dio Giovanni; Winarsih, Sri; Putri, Fitria Febriliani; Erwan, Nabila Erina; Putri, Ajeng Maharani; Cahyono, Alfian Wika; Mardhiyyah, Kana; Fitri, Loeki Enggar; Nugraha, Rivo Yudhinata Brian
Jurnal Kedokteran Brawijaya Vol 31, No 3 (2021)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2021.031.03.11

Abstract

Streptomyces hygroscopicus (S.hygroscopicus) is a Gram-positive soil bacterium that can produce secondary metabolites from fermentation that have a therapeutic effect. The fermented S. hygrocospicus metabolites that are still in the form of crude extracts are difficult to develop as drug preparations because the active compounds are not yet known, so it will be challenging to determine the dosage of drugs that have a therapeutic effect. Therefore, it is necessary to carry out exploratory research to narrow down the secondary metabolite profile from the fermentation of S. hygroscopicus, using extraction and fractionation methods, which are then identified by Thin-Layer Chromatography (TLC) using a combination of solvents. This study used the extraction method with a separating funnel. The fractionation was carried out using the BUCHI (Sepacore®) Flash Chromatography and Reveleris® PREP Purification System column chromatography gradually using ethyl acetate and n-hexana.  47 and 60 of the fractionation results were taken as samples, that further were profiled using TLC and given the appearance of 10% KOH stains and p-Anisaldehyde - sulfuric acid, so that various classes of compounds with different Rf values were obtained, namely Monoterpenes, Triterpenes, Steroids, Saponins, Coumarin, Scopoletin, and Alkaloids.
Gender Differences in Denial-Acceptance Duration Based on Kübler-Ross Cycle After HIV Diagnosis Burhan, Niniek Budiarti; Febriliant, Muhammad Reza
Jurnal Kedokteran Brawijaya Vol 31, No 3 (2021)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2021.031.03.7

Abstract

Patients who have been diagnosed with HIV often suffer from sadness and grief that, in turn, affect the adherence to HIV treatment. This study aimed to examine gender differences in the denial-acceptance duration based on the Kübler-Ross cycle in patients after diagnosed with HIV. A cross-sectional survey was conducted on 63 adult HIV patients aged 19-60 years who received routine treatment at the HIV/VCT outpatient department of Saiful Anwar General Hospital Malang. Subjects were interviewed using the Acceptance of Disease and Impairments Questionnaire (ADIQ). Gender differences in denial-acceptance duration after diagnosed with HIV were analyzed using the unpaired T-test. Results were statistically significant if p value <0.05. The median duration of denial-acceptance in male subjects was 16 weeks with the shortest duration of 1 week and the longest duration of 144 weeks, while the median duration of female subjects was 12 weeks with the shortest duration of 1 week and the longest duration of 240 weeks. There are no gender differences in the denial-acceptance duration (p value = 0.629). In conclusion, there are no gender differences in denial-acceptance duration based on the Kübler-Ross cycle after diagnosed with HIV.
Relationship among Sexual Knowledge, Sexual Attitudes, and Sexual Behavior of Junior High School Students in West Jakarta Djohan, Putra Brillian; Tjhay, Francisca; Hasan, Surilena; Widjaja, Nelly Tina
Jurnal Kedokteran Brawijaya Vol 31, No 3 (2021)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2021.031.03.12

Abstract

Lack of sexual knowledge and increasing negative sexual attitudes in Indonesia could lead to risky sexual behavior. This problem increases teenage pregnancy, sexually transmitted infections, and abortion among adolescents. This study aimed to determine the relationship between sexual knowledge and sexual attitudes towards sexual behavior among junior high school students in West Jakarta. This study was cross-sectional, conducted on 544 junior high school students in West Jakarta. Measuring instruments used were characteristic questionnaires, sexual knowledge questionnaires, sexual attitude questionnaires, and sexual behavior questionnaires. Data analysis was performed using bivariate (chi-square). This study shows 79.2% of the respondents had low sexual knowledge, 45.6% respondents had negative sexual behavior, and 48.2% respondents had risky sexual behavior. This study finds that most male respondents had low sexual knowledge (80.8%), low sexual attitude (56.8%), and “less-safe” risky sexual behavior (60.0%), while “not-safe” risky sexual behavior (2.7%) was found higher in female respondents. Bivariate analysis shows a significant relationship between sexual knowledge (p=0.006; 95% OR=1.763 |95% CI=1.151-2.698) and sexual attitude (p=<0.001; OR=2.852 | 95% CI=2.012-4.043) towards sexual behavior. In conclusion, low sexual knowledge and negative sexual attitudes increase the risk of risky sexual behavior.

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