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Science Get Journal
Published by CV. Get Press Indonesia
ISSN : -     EISSN : 30626595     DOI :  http://doi.org/10.69855/science
Core Subject : Science, Education,
Biochemistry, Genetics & Molecular Biology Chemistry Mathematics Physics
A Peer Reviewed Research Science Get Journal e-ISSN: 3062-6595 Science Get Journal is an Open Access and Anonymous Reviewer/Anonymous Author journal. The field of Science is a vehicle for scientific communication in the field of Science which covers the cross-fields of Mathematics, Physics, Chemistry, Biology, Geography and Mathematics,  Natural Sciences Education and Social Sciences. Science Get Journal is published by Get Press Indonesia. Science Get Journal is used to publish research published every month January, April, July, and October. The Science Get Journal template can be downloaded here (Click). Information about article submission: Articles sent by the author (author) will be seen and read by the editor, if there are still discrepancies with the applicable template and do not comply with the scope of Science Get Journal then the article will be returned to the author. If it is appropriate, the article will be forwarded to the Science Get Journal reviewer for a review process carried out by the Science Get Journal reviewer. A total of two reviewers within a two week period of evaluating the article.
Arjuna Subject : Matematika - Matematika (Lain-Lain)
Articles 51 Documents
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Discovery of Active Bacterial Microbiome in Human Brain Tissue: Implications for Neurodegenerative Diseases and Depression Pratiwi Ratih Halimatus Sya'diah; Eka Cahya Muliawati
Science Journal Get Press Vol 1 No 1 (2024): January, 2024
Publisher : CV. Get Press Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69855/science.v1i1.449

Abstract

The concept of a sterile human brain has recently been challenged by emerging evidence suggesting the presence of microbial DNA and components within brain tissue. This study aimed to investigate the presence and disease-specific patterns of microbial signatures in human brains affected by Alzheimer’s disease and depression, compared to healthy controls. Using 16S rRNA sequencing on post-mortem brain samples, we detected microbial DNA in all groups, with notable differences in diversity and composition. Alzheimer’s brains exhibited reduced microbial richness and were enriched in genera such as Cutibacterium and Streptococcus, which may contribute to neuroinflammation and amyloid aggregation. Depressive brains showed increased abundance of Eggerthella, potentially influencing neurotransmitter metabolism and systemic inflammatory pathways, while control brains had higher prevalence of Lactobacillus and Bifidobacterium, consistent with neuroprotective roles. These findings support the emerging “brain microbiome” concept and suggest that low-abundance microbial communities may reflect disease-associated processes or interactions via the microbiota-gut-brain axis. While causality and microbial viability remain to be established, the study highlights the potential relevance of brain-associated microbes in neurodegenerative and psychiatric disorders and provides a foundation for future experimental and translational research exploring microbiome-targeted diagnostic and therapeutic strategies.

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