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Journal of Biomedical Sciences and Health
Published by Universitas Karya Husada Semarang
ISSN : 30626854     EISSN : 30477182     DOI : https://doi.org/10.34310/
Core Subject : Health, Science,
Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health
The Journal of Biomedical Sciences and Health (JBSH) accepts manuscripts in basic sciences and applied clinical research. It covers various fields of biomedical sciences, but is not limited to Medical sciences. Our journal accepts and publishes original articles and review articles that significantly contribute to the understanding of biomedical sciences and health. The Journal of Biomedical Sciences and Health is published biannually in the months of February and August. This journal is available for download to anyone, including students, researchers, and lecturers. Authors are not charged for publication in JBSH. JBSH is a journal that disseminates, discusses, and presents scientific literature to support other communities on health developments, thereby increasing the knowledge of scientists and health workers and ultimately improving the health of the global population. JBSH covers a wide range of topics, including: 1. Biomedical Sciences: Molecular biology, microbiology, anatomy, physiology, biochemistry, etc. 2. Health: Medicine, Nursing, Obstetrics, Public Health, Pharmacy, Radiology, Administration of Community Health Centers, Hospitals, and Health Services, Health analyst. Journal of Biomedical Sciences and Health (JBSH) is published by Program Studi Ilmu Biomedis Fakultas Ilmu Keperawatan dan Kesehatan Universitas Karya Husada Semarang. JBSH is expected to increase its visibility through scientific studies and research findings accessible to academic circles and researchers.
Arjuna Subject : Biokimia, Genetika dan Biologi Molekuler - Biokimia, Genetika dan Biologi Molekuler (Lain-Lain)
Articles 5 Documents
 1 
Search results for , issue "vol. 1 no. 2 (2024)" : 5 Documents clear
Antibacterial effectiveness of green tea extract (Camellia sinensis L.) liquid soap against Staphylococcus aureus and Streptococcus pyogenes Meutia Rizki Wibowo; Heni Wijayanti; Isy Royhanaty
Journal of Biomedical Sciences and Health Vol. 1 No. 2 (2024)
Publisher : Universitas Karya Husada Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34310/jbsh.v1.i2.63

Abstract

Background: S. aureus and S. pyogenes are Gram-positive bacteria that are the main causes of impetigo, a skin infection marked by a red rash. Impetigo is commonly treated with antibiotics, but long-term use risks side effects, so a complementary alternative such as green tea leaf extract (Camellia sinensis) is needed. Aim: To determine the effect of liquid soap containing 7%, 10%, and 13% green tea extract on the inhibition zone of S. aureus and S. pyogenes. Methods: A true experimental study with a post-test-only with control group design used five treatment groups. Inhibition zone diameters were measured with a caliper and analysed using one-way ANOVA with Games-Howell post-hoc comparisons and Mann-Whitney to compare the inhibition zones between the two bacterial species. Results: The 10% concentration produced the highest mean inhibition zone, 5.53 mm against S. aureus and 6.33 mm against S. pyogenes (moderate category), significantly larger than the negative control (p<0.05) but still below the tetracycline positive control. No significant difference was found between the two species (p=0.381). Conclusion: Green tea extract liquid soap shows moderate antibacterial activity against S. aureus and S. pyogenes, with comparable potential against both pathogens as a topical complementary therapy for impetigo.
Comparison of antioxidant compounds of green betel (Piper betle) and red betel (Piper crocatum) extracts using different solvents with the DPPH method Septahani Putri Raswanti; Poppy Fransisca Amelia; Heni Wijayanti
Journal of Biomedical Sciences and Health Vol. 1 No. 2 (2024)
Publisher : Universitas Karya Husada Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34310/jbsh.v1.i2.79

Abstract

Background: Green betel (Piper betle) and red betel (Piper crocatum) leaves are widely reported to contain flavonoids, tannins, alkaloids, and saponins, compounds empirically linked to free-radical scavenging activity, yet a direct, quantitative comparison of their antioxidant strength across two polar solvents remains scarce. Objective: To compare the phytochemical content and antioxidant activity of green and red betel leaf extracts using 70% ethanol and 70% methanol via the DPPH method. Method: This laboratory-experimental study was conducted at the Biomedical Science Laboratory, Universitas Karya Husada Semarang, from 22–28 February 2024 (Ethical Clearance No. 003/KEP/UNKAHA/SLE/2024). Antioxidant activity was measured across a 5–9 ppm concentration range, modeled with the linear regression curve y=ax+b, and compared across the four extract-solvent combinations using the Kruskal-Wallis test. Result: Phytochemical screening revealed a more complete compound profile in 70% ethanol than in 70% methanol for both leaf types. All four combinations exhibited DPPH inhibition above 70% even at the lowest tested concentration (5 ppm; range 72.10–97.46%), placing the true IC50 below 5 μg/mL for every combination — well under the 50 μg/mL “very strong” threshold. The Kruskal-Wallis test detected no significant difference in inhibition percentage among the four combinations (H=3.85, df=3, p=0.279). Conclusion: Both green and red betel extracts, in either solvent, qualify as very strong antioxidants with no statistically meaningful difference in potency, positioning either as an equally promising candidate for further natural antioxidant development.
Antibacterial activity of red ginger (Zingiber officinalevar. rubrum) extracts as growth inhibitors of Klebsiella pneumoniae: in vitro and in silicoanalysis Anwar Rovik
Journal of Biomedical Sciences and Health Vol. 1 No. 2 (2024)
Publisher : Universitas Karya Husada Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34310/jbsh.v1.i2.85

Abstract

Background: Pneumonia caused by Klebsiella pneumoniae remains a considerable global health burden, and antibiotic misuse has driven the bacterium toward growing antimicrobial resistance, leaving plant-derived compounds such as red ginger (Zingiber officinale var. rubrum) worth investigating as alternative antimicrobial agents. Objective: This study aimed to determine the effectiveness of red ginger extract in inhibiting the growth of K. pneumoniae, combining in vitro testing with in silico target-gene prediction. Method: Red ginger rhizomes were extracted, tested for antimicrobial activity against K. pneumoniae at four concentrations, and the dominant bioactive compounds were subjected to in silico target-gene analysis. Result: The extract inhibited K. pneumoniae growth in a dose-dependent manner, with inhibition zones ranging from 6.7 mm at 25% concentration to 8 mm at 100%. The bioactive compounds were predicted to target multiple K. pneumoniae proteins across several cellular locations, most notably the acrR gene, a transcriptional repressor of the multidrug efflux pump operon acrAB. Conclusion: Red ginger extract inhibits K. pneumoniae growth and appears to act through the acrR-acrAB efflux pump pathway, a mechanism central to the bacterium's antibiotic resistance, indicating value as a candidate antimicrobial adjunct that warrants further optimization.
Petrissage massage and lavender aromatherapy to reduce low back pain in third trimester pregnant women Dyah Ayu Wulandari; Widi Isnaeni Zubaedah; Meika Jaya Rochkmana; Mei Lia Nindya Zulis Windyarti
Journal of Biomedical Sciences and Health Vol. 1 No. 2 (2024)
Publisher : Universitas Karya Husada Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34310/jbsh.v1.i2.89

Abstract

Background: Pregnancy is a natural process that brings physical and psychological discomfort to pregnant women. One of the most common discomforts in the third trimester is lower back pain, which occurs due to increased production of the hormone relaxin, causing the pelvic bone joints to stretch and facilitate childbirth. Petrissage massage combined with lavender aromatherapy was administered to third-trimester pregnant women as a therapy to reduce this pain. Objective: This study aimed to determine the effect of a combination of petrissage massage and lavender aromatherapy on lower back pain in third-trimester pregnant women. Method: This quantitative study used a pre-experimental one-group pretest-posttest design without a control group, involving 15 samples of third-trimester pregnant women. The independent variable was the administration of petrissage massage and lavender aromatherapy, while the dependent variable was back pain. Pain was measured before and after the intervention using the Numeric Rating Scale (NRS). Result: The Wilcoxon test yielded a p value of 0.000, indicating that the combination of petrissage massage and lavender aromatherapy reduced lower back pain in third-trimester pregnant women. Conclusion: There is a significant effect of combined petrissage massage and lavender aromatherapy on lower back pain in third-trimester pregnant women; pregnant women can apply this combination as a nonpharmacological approach to reduce lower back pain.
The effect of oxytocin massage education on postpartum mothers' breastfeeding behavior at Muhammadiyah Rodliyah Achid Moga Hospital Anita Indra Afriani; Moch Jamaluddin; Sujanti P
Journal of Biomedical Sciences and Health Vol. 1 No. 2 (2024)
Publisher : Universitas Karya Husada Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34310/jbsh.v1.i2.90

Abstract

Background: At Muhammadiyah Rodliyah Achid Moga Hospital, approximately 110 postpartum mothers give birth each month; however, only 60% breastfeed their infants, while 40% do not. To date, hospital interventions have been limited to education on breastfeeding techniques and breast care, with no prior education provided regarding oxytocin massage. Objective: This study aimed to determine the difference in breastfeeding behavior among postpartum mothers before and after receiving education on oxytocin massage at Muhammadiyah Rodliyah Achid Moga Hospital. Methods: This quantitative study employed a pre-experimental design with a one-group pretest-posttest approach involving 86 respondents—determined using Slovin's formula from a population of 110 postpartum mothers—selected via accidental sampling. Data were analyzed using the Kolmogorov-Smirnov normality test and the Wilcoxon test. Results: The normality test indicated that the data were not normally distributed (p < 0.05). Following the education, there was an increase in both the mean and minimum scores for breastfeeding behavior. The Wilcoxon test yielded a p-value of 0.001 (p < 0.05), indicating a significant difference in the breastfeeding behavior of postpartum mothers before and after the oxytocin massage education. Conclusion: Oxytocin massage education contributes to improving breastfeeding behavior among postpartum mothers at Muhammadiyah Rodliyah Achid Moga Hospital; however, the pre-experimental design (lacking a control group) means these findings require further confirmation through studies that include a comparison group.

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