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MEDULA Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo
Published by Universitas Halu Oleo
ISSN : 23391006     EISSN : 24430218     DOI : https://doi.org/10.46496
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
MEDULA invites contributions to original and fundamental research in the field of health, which must be submitted for peer reviewed articles. The journals focus and scope are contemporary medicine through biomedical research, genetics, and medical technology, Patient care practices, Disease prevention, Disease epidemiology, Family medicine, Health care center management, New drug development through research on the effectiveness of medicinal plants in treating disease, Development of traditional medicines frequently used by local communities, Utilization of marine biota for medicinal purposes, Social aspects related to the implementation of medical education and other relevant fields
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 5 Documents
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Search results for , issue "Vol. 12 No. 1 (2024): Desember" : 5 Documents clear
Transcranial Magnetic Stimulation Can Improve Cognitive Function and Brain-Derived Neurotrophic Peptide Levels in Post-Ischemic Stroke Patients Ulima Rahma Asri; Jumraini Tammasse; Andi Kurnia Bintang; Rina Masadah; Muhammad Akbar; David Gunawan Umbas
MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo Vol. 12 No. 1 (2024): Desember
Publisher : MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46496/medula.v12i1.41

Abstract

ABSTRACT Background: Stroke can cause a significant burden of morbidity, including complications of impaired cognitive function. The problem being investigated is hypothesized to be related to brain-derived neurotrophic factor (BDNF), which can be increased by repetitive transcranial magnetic stimulation (rTMS). Purpose(s): To evaluate the effect of Repetitive Transcranial Magnetic Stimulation (rTMS) on serum BDNF levels and cognitive function in ischemic stroke patients. Methods: A pre-test post-test control group, experimental study design, was applied to research conducted at Dr Wahidin Sudirohusodo Makassar and network hospitals in June 2023 until the sample size was met. All ischemic stroke patients who experienced impaired memory function were divided into control (medicamentous, n=10) and treatment (medicamentous + rTMS, n=11). Both at baseline and 14 days following therapy, their BDNF levels and MoCA-INA scores were assessed. ELISA examination is used to measure BDNF levels. The dependent T-test was used to analyze changes in MoCA-INA and BDNF scores in each group. Results: In the treatment group, the median MoCA INA score (26.00 (18.00-28.00) vs. 16.00 (13.00-21.00; p=0.001)) and BDNF levels (1.66 (0.78-3.59) vs. 1.55 (0.01-2.76); p=0.002) increased in two weeks. In contrast, the MoCA-INA score and BDNF levels in the control group did not show a statistically significant difference over a two-week period. MoCA-INA scores and BDNF levels in the treatment group showed a significant and favorable correlation, but not in the control group. Conclusion: rTMS can improve patients' cognitive function after ischemic stroke by improving BDNF levels. Keywords: Brain-derived neurotrophic factor, cognitive function, ischaemic stroke, repetitive transcranial magnetic stimulation
The Correlation Analysis of Macronutrient Intake and Balanced Nutrition Index with the Degree of Depression in Preclinical Medical Students Nina Indriyani Nasruddin; Edy Husnul Mujahid; Arimaswati; Sufiah Asri Mulyawati
MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo Vol. 12 No. 1 (2024): Desember
Publisher : MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46496/medula.v12i1.42

Abstract

ABSTRACT Background: Depression is a mood disorder characterised by deep feelings and a loss of interest in things you like. Many teenagers, including medical students worldwide, suffer from depression, a mental health problem. Depression affects the way the body processes food and can cause changes in metabolism. A decrease in leptin levels can accompany depression symptoms, leading to a decrease in appetite and influencing changes in nutritional status. Purpose(s): This study aims to analyse the relationship between macronutrient intake and the balanced nutritional index (BNI) on depressive symptoms in pre-clinical students at the Faculty of Medicine, Halu Oleo University. Method: This study used a cross-sectional design. The number of samples in this research was 96. We obtained the macronutrient intake using the 2x24-day Food Recall and the Balanced Nutrition Index (BNI), questionnaire to assess whether the consumed food was in accordance with dietary recommendations. We obtained depressive symptoms by completing the Beck Depression Inventory-II (BDI II) questionnaire. We then analysed the data using the rank-spearman test. Results: Of the samples, 21.9% had insufficient carbohydrate intake, 16.7% had insufficient fat intake, and 3.1% had insufficient protein intake. Of the 96 samples, there were 5 students who experienced severe depression (5.2%). There is a weak positive correlation between carbohydrate intake and depressive symptoms (p = 0.017, r = 0.244). There is no correlation between BNI and depressive symptoms in pre-clinical students at the Faculty of Medicine, Halu Oleo University. Conclusion: Macronutrient intake, especially carbohydrates, has a correlation with depressive symptoms in pre-clinical students at the Faculty of Medicine, Halu Oleo University. Keywords: BNI;Depressive Symptoms;Macronutriens; Medical Students
Effect of Giving Galoba (Hornstedtia alliacea) Fruit Extract on Catalase Activity in Mice (Mus musculus) Hyperglycemia Induced by MultipleLow Dose-Streptozotocin (MLD-STZ) Elisa Melinia Perangin-angin; Rachmawati Dwi Agustin; Indrawanti Kusadhiani
MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo Vol. 12 No. 1 (2024): Desember
Publisher : MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46496/medula.v12i1.43

Abstract

ABSTRACT Background: Hyperglycemia is a medical condition in which the fasting blood sugar level is ≥100 mg/dL. Prolonged hyperglycemia causes pancreatic β-cells to malfunction and causes a decrease in insulin secretion. Diabetes mellitus is a metabolic disease characterized by chronic hyperglycemia which occurs when there is an increase in blood glucose levels due to the pancreas not producing enough insulin or the body not using insulin effectively or a combination of both. Galoba fruit (Hornstedtia alliacea) is a plant endemic to Maluku that contains antioxidant compounds which are thought to increase catalase enzyme activity after hyperglycemia. Purpose(s): This study aimed to determine the effect of giving Galoba fruit extract (Hornstedtia alliacea) on the activity of the catalase enzyme in serum mice (Mus musculus) with MLD-streptozotocin induced (Multiple Low Dose Streptozotocin) hyperglycemia. Methods: This research was an experimental study with a post-test only group design. Twenty-four mice were divided into six treatment groups: normal control (KN), negative control (K-), positive control (K+), 100% concentration of Galoba fruit extract (P1), 75% concentration of Galoba fruit extract (P2), and Galoba fruit concentration was 50% (P3). Groups P1, P2, and P3 were induced using streptozotocin at a dose of 40 mg/kg BW in hyperglycemic mice and given an extract at a dose of 0.2 mL according to the concentration of each Galoba fruit. Group K+ was induced by streptozotocin and given metformin therapy at a dose of 0.2 mL. Induction of MLD-streptozotocin at a dose of 40 mg/kg for 5 consecutive days in a row. Administration of therapy in groups of K+, P1, P2, and P3 for 21 days. After the end of treatment, blood serum was taken from the heart to measure the activity of the catalase enzyme. Results: Galoba fruit extract (Hornstedtia alliacea) increased the catalase activity, but it was not significant effect on increasing the activity of the catalase enzyme (p> 0.05). The group of mice that experienced the greatest increase in enzyme activity came from the P3 group at 0.6716 U/mL (61%), followed by P2 at 0.6119 U/mL (57%), and P1 at 0.3435 U/mL (25%). Conclusion: The increased activity of the catalase enzyme was due to the presence of secondary metabolites of flavonoids and terpenoids from the results of phytochemical tests contained in Galoba fruit (Hornstedtia alliacea). Keywords: Catalase Enzyme ; Hornstedtia alliacea; Hyperglycemia
Accuracy of Conventional Radiographic Parameters in Predicting Posterior Ligamentous Complex (PLC) Rupture in Thoracolumbar Fracture Confirmed by Magnetic Resonance Imaging (MRI) Nelly; Mirna Muis; Muh. Ilyas; Karya Triko Biakto; Andi Alfian Zainuddin
MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo Vol. 12 No. 1 (2024): Desember
Publisher : MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46496/medula.v12i1.44

Abstract

ABSTRACT Background: Most of spinal injuries involve thoracolumbar region and are unstable. Burst fracture with posterior ligamentous complex (PLC) rupture that is not treat with surgical intervention may develop progressive kyphotic. The initial radiological examination is conventional radiographs, which can be followed by computed tomography (CT) and magnetic resonance imaging (MRI). MRI provides detail-images of soft-tissue structures so that it may provide an accurate diagnosis in predicting PLC rupture. However, the usage of MRI is still limited because of its rare availability and when patients have contraindications to MRI such as metal implants. Purpose: This study aimed to predict whether some radiographic parameters are closely related to PLC rupture, as confirmed by MRI in thoracolumbar fracture. Methods: This research is a diagnostic study using secondary data from patients who had conventional radiographic and MRI examination at Radiology Department of Dr. Wahidin Sudirohusodo which is diagnose as compression fractures and burst fractures from December 2020 until August 2022 and total of 73 samples are obtained to measure the accuracy of conventional radiographic parameters with Youden index. Results: The mean age of the sample was 41.53 years (rage 21-59 years) with more male patients than female patients and most of the fracture site is at L1. Supraspinous distance (SSD), local kyphosis (LK) and Cobb’s angle (CA) have significant p values of 0.005, 0.013 and 0.000 (respectively). Meanwhile, the anterior vertebral body compression percentage (AVBC%) and anterior edge-inferior endplate angle (AEIEA) had insignificant p values. The sensitivity, specificity and accuracy of SSD, LK and CA varied, namely 68.76%, 88.89%, 79% for SSD; 75%, 66.67%, 75.3% for LK dan 75%, 77.78, 82.2% for CA. Conclusion: From five conventional radiographic parameters that is measured, only three parameters had significant p values, which is supraspinous distance (SSD), local kyphosis (LK), and Cobb’s angle (CA) with varying sensitivity, specificity and accuracy, meanwhile anterior vertebral body compression percentage (AVBC%) and anterior edge-inferior endplate angle (AEIEA) are not correlated for predicting PLC rupture. Keywords: Cobb’s angle; local kyphosis; posterior ligamentous complex; supraspinous distanc;, thoracolumbar injury
Neuroprotective Effect of Brain-Derived Neurotrophic Factor (BDNF) on Cerebral Infarct Volume and Clinical Severity of Acute Ischemic Stroke Satrio Wicaksono; Andi Kurnia Bintang; Muhammad Akbar; Muhammad Yunus Amran; Cahyono Kaelan; Isra Wahid
MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo Vol. 12 No. 1 (2024): Desember
Publisher : MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46496/medula.v12i1.45

Abstract

ABSTRACT Background: Brain-Derived Neurotrophic Factor (BDNF) plays a crucial role in protecting nerves following ischemic stroke. The neuroprotective effects of BDNF on cerebral infarct volume and clinical severity after ischemic stroke need to be further studied in-depth. Purpose(s): The purpose of this study is to understanding the relationship between BDNF levels, cerebral infarct volume, and the severity of clinical conditions in acute ischemic stroke patients. Methods: This study is an observational nalytical research with a cross-sectional design. A total of 30 individuals who meet the inclusion criteria were included as samples. Cerebral infarct volume was measured using non-contrast head CT scans with the Broderick formulation, and clinical severity was assessed using the National Institutes of Health Stroke Scale (NIHSS). The collected data were then analyzed using statistical tests. Results: There is a significant relationship between serum BDNF levels and cerebral infarct volume with a p-value of 0.004 and a correlation coefficient (r) of -0.509. Similarly, a significant relationship exists between serum BDNF levels and NIHSS with a p-value of 0.042 and a correlation coefficient (r) of -0.374. Conclusion: There is a negative correlation between serum BDNF levels and cerebral infarct volume in acute ischemic stroke patients, as well as a negative correlation between serum BDNF levels and clinical severity in acute ischemic stroke patients. Keywords: BDNF; Infarct Cerebri Volume; NIHSS

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