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Imelda Maelani
Departemen Biologi, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Syiah Kuala, Aceh, Indonesia

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Targeting Growth Factor Receptors in Cancer Insights from Molecular Docking Studies: A Literature Review Imelda Maelani; Widya Syahfitri; Fitri Elizabrth Hasibuan2 Hasibuan
Jurnal Bioleuser Vol. 9 No. 3: Desember 2025
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jurnalbioleuser.v9i3.1431

Abstract

Growth factor receptors (GFRs) are essential transmembrane proteins that regulate key cellular processes such as proliferation, differentiation, migration, and survival. Their aberrant activation is strongly linked to cancer initiation, progression, and therapeutic resistance. Although several studies have explored GFR inhibition experimentally, the integration of in silico approaches remains underdeveloped. This review critically examines recent applications of molecular docking in identifying and characterizing inhibitors targeting major GFR families, including EGFRs, IGFRs, VEGFRs, TGF-βRs, FGFRs, and PDGFRs. A systematic literature search was conducted across major databases to summarize ligand–receptor interactions and binding mechanisms reported between 2004 and 2024. The analysis reveals that molecular docking effectively predicts ligand affinity and receptor selectivity, enabling the identification of natural and synthetic compounds with potent inhibitory potential. Moreover, patterns across docking studies indicate distinct binding preferences among receptor subtypes, providing valuable insights for structure-based drug design. Despite its predictive power, limitations such as receptor rigidity and lack of biological context highlight the need for integration with dynamic simulations and experimental validation. Overall, this review underscores the promise of docking-based screening as a strategic tool for accelerating the discovery of selective and safer anticancer agents targeting GFRs.
Konsentrasi Hormon Testosteron Pada Ayam Kampung Jantan (Gallus domestica) Pasca Suplementasi Vitamin E Dalam Pakan Standar Widya Syahfitri; Kartini Eriani; Dasrul Dasrul; Imelda Maelani; Hendrix Indra Kusuma; Cut Yulvizar; Widya Sari
Jurnal Bioleuser Vol. 8 No. 2: Agustus 2024
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jurnalbioleuser.v8i2.1943

Abstract

Vitamin E is one of type vitamin that is ideal to increase the reproductive function. Vitamin E has the ability to maintain fertility which related to the production of testosterone hormone. The purpose of this research was to determine the effect of vitamin E in various dosages to testosterone levels contained in the blood serum samples of local cocks (Gallus domestica). Samples of local cocks which given supplementation with vitamin E dosages of 0 mg (P0), 10 mg (P1), 20 mg (P2) dan 30 mg (P3). The collected data were analyzed statistically using Analysis of Variance (ANOVA) with a 95%, followed by Duncan's multiple range test.The examination of testosterone levels in this research used Enzyme Linked Immunosorbent Assay (ELISA) test. The result showed that testosterone significantly different among P0, P1, P2 dan P3. Highest testosterone levels obtained from P3 (12,32±1,52 ng/ml), followed by P2 (7,85±1,21 ng/ml), , P1 (5,04±0,7 ng/ml) and P0 (3,63±0,49 ng/ml), respectively. This result suggests that higher doses of vitamin E supplements in feed can elevate testosterone levels in local cocks (Gallus domestica). The P3 treatment, with a dosage of 30 mg of vitamin E, is the most effective in boosting testosterone levels in local cocks.
Co-Authors Cut Yulvizar Dasrul Dasrul Fitri Elizabrth Hasibuan2 Hasibuan Hendrix Indra Kusuma Kartini Eriani Widya Sari Widya Syahfitri