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Yang Yang Endro Arjuna
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lumina.fk@uph.edu
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Universitas Pelita Harapan, Lippo Karawaci, Tangerang, Indonesia, 15811.
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INDONESIA
Lumina: Indonesian Journal of Neurology
Published by Universitas Pelita Harapan
ISSN : 31095658     EISSN : 3109564X     DOI : https://doi.org/10.19166
Core Subject :
Focus and Scope Lumina: Indonesian Journal of Neurology is an open-access, peer-reviewed journal dedicated to advancing the field of neurological sciences, with a focus on both basic neuroscience and clinical neurology. The journal publishes original research, reviews, and intriguing case reports. It also welcomes brief communications that highlight recent advancements in diagnostic techniques, treatments, or other relevant neurological health issues. Additionally, letters and commentaries on previously published articles are encouraged. Topics for publication include, but are not limited to: Neuroepidemiology Neurovascular Neurophysiology Epilepsy Sleep disorders Neurobehavior Neuroimmunology Neurodegenerative diseases Neurootology Neuroophthalmology Neuropediatrics Neurointervention Neuroradiology Neurorestoration Movement disorders Pain management and interventions Neuroendocrinology Neurosurgery Neuropathology Neuroinfection Neuroanesthesiology Neurooncology Neuropharmacology Neuroanatomy
Arjuna Subject : -
Articles 24 Documents
 1   2   3 
Contributions of Nursing Professionals and Primary Care Physicians in Interdisciplinary Oncology Teams for Cancer Pain Management: An Analytical Review Henry Riyanto Sofyan; Anne Dina Soebroto; Eunike Novrilia; Ratu Novia Putri Aulia; Daniel Budi Utomo; Liliana Mangkuwerdojo; Erico Mulfiardi; Radja Buntal Sotarduga Simanjuntak; Made Agus Mahendra Inggas
Lumina : Indonesian Journal of Neurology Vol. 2 No. 1 (2026): April: Lumina: Indonesian Journal of Neurology
Publisher : Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/lijn.v2i1.10963

Abstract

Introduction: Cancer-related pain remains inadequately managed in a substantial proportion of oncology patients, despite established clinical protocols. Current systematic evidence indicates that up to 55% of patients experience undertreated pain.35 Interdisciplinary oncology teams — comprising nursing professionals and primary care physicians (PCPs) — are a critical organizational strategy for improving cancer pain management across the care continuum. Methods: A systematic narrative synthesis was conducted using 30 peer-reviewed sources identified through structured searches of the PubMed, CINAHL, Scopus, and Cochrane databases. Inclusion criteria encompassed studies, reviews, and guidelines published from 2002 to 2025 that addressed professional roles, team structure, barriers, and clinical outcomes in cancer pain management. Results: Nursing professionals contribute substantially to pain assessment and management through validated instruments, pharmacological and non-pharmacological interventions, patient self-management education, and interdisciplinary advocacy. PCPs facilitate care coordination, ensure analgesic prescribing continuity, and manage the primary–specialty interface. Effective interdisciplinary teams improve patient outcomes through structured communication, clear roles, and integrated care pathways. Persistent barriers include care fragmentation, professional role ambiguity, competency gaps, and regulatory constraints on opioid prescribing. Conclusions: Although current evidence supports the effectiveness of interdisciplinary approaches to improving cancer pain outcomes, significant gaps remain in comparative effectiveness data, implementation science, and health equity research. Enhanced clinical training, organizational investment, and policy reform are necessary to optimize collaborative cancer pain management across diverse healthcare settings. Keywords: Cancer Pain, Interdisciplinary Teams, Nursing Professionals, Primary Care Physicians, Collaborative Care, Palliative Care, Pain Mechanisms
Brainstem Stroke From Rare Case of Foville Syndrome Kevin Aldenio Hatma Krista; Rizaldy Taslim Pinzon; Kehat Dowie Setiabudi Arrung; John Kelvin Bastian Dowansiba
Lumina : Indonesian Journal of Neurology Vol. 2 No. 1 (2026): April: Lumina: Indonesian Journal of Neurology
Publisher : Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/lijn.v2i1.10998

Abstract

Introduction: Foville syndrome is a rare neurological syndrome resulting from infarction in the perforating branches of the basilar artery, involving the nuclei of cranial nerves VI and VII and the corticospinal tract. It is clinically characterized by ipsilateral horizontal gaze palsy, ipsilateral peripheral facial paralysis, and contralateral hemiparesis. Its rarity often poses diagnostic challenges in clinical practice. Case Presentation: A 54-year-old woman presented with sudden diplopia and right-sided weakness for 16 hours. She had a history of controlled hypertension and diabetes mellitus. Neurological examination revealed left horizontal gaze palsy, left peripheral facial weakness, and right hemiparesis (muscle strength 2/5). Brain CT showed pontine infarction with severe basilar artery stenosis. The patient was treated with dual antiplatelet therapy, high-intensity statin, and supportive therapy including eye patching and physiotherapy. She was discharged after 8 days with moderate disability (mRS 3) and showed improvement to mild disability at 3-month follow-up. Discussion: Foville syndrome results from lesions in the pontine tegmentum involving the abducens nucleus, facial nerve fibers, and corticospinal tract. It is commonly caused by ischemic infarction due to atherosclerotic basilar artery disease. Clinical findings in this case align with the classic triad. Management depends on onset time; thrombolysis was not indicated due to delayed presentation. Dual antiplatelet therapy and risk factor control remain the mainstay treatment. Conclusions: We report a rare case of Foville syndrome that arises as a result of an infarction stroke affecting the pons. Keywords: Basilar Artery Stenosis, Brainstem Stroke, Foville Syndrome, Pontine Infarction
The Association Between Body Mass Index and Carpal Tunnel Syndrome Among Medical Students of Universitas Pelita Harapan: A Cross-Sectional Study Riona Sutanto; Vivien Puspitasari; Astra Dea Simanungkalit; Pricilla Yani Gunawan
Lumina : Indonesian Journal of Neurology Vol. 2 No. 1 (2026): April: Lumina: Indonesian Journal of Neurology
Publisher : Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/lijn.v2i1.11012

Abstract

Introduction: Carpal Tunnel Syndrome (CTS) is one of the most common entrapment neuropathies, though its exact cause remains unclear.  Obesity has been identified as a potential risk factor, but previous studies have reported inconsistent findings.  This study aimed to analyze the association between Body Mass Index (BMI) and CTS among pre-clinical medical students at Universitas Pelita Harapan. Methods: This cross-sectional study utilized the Boston Carpal Tunnel Syndrome Questionnaire (BCTQ) to assess symptom severity and functional status.  Body weight and height were self-reported via questionnaire to calculate BMI. Bivariate analyses are used to examine the association statistically, followed by stratified analyses to assess potential confounding factors. Results: A total of 201 participants met the inclusion and exclusion criteria for this study. Among them, 7.5% of the subjects presented with symptoms of CTS, and 5.0% experienced functional impairment. The association between BMI and CTS based on the severity of symptoms and functional status impairment was found to be significant (p = 0.004 and 0.049, respectively). Conclusion: Higher BMI was significantly associated with an increased likelihood of CTS symptoms and functional impairment. Gender and a history of diabetes mellitus were identified as potential confounding factors. Keywords: Carpal Tunnel Syndrome, Body Mass Index, Obesity
Diagnostic Accuracy of Blood-Based Biomarkers for Early Detection of Alzheimer’s Disease: A Systematic Review Cindy Permata Sari; Rocksy Fransiska V. Situmeang; Tandry Meriyanti
Lumina : Indonesian Journal of Neurology Vol. 2 No. 1 (2026): April: Lumina: Indonesian Journal of Neurology
Publisher : Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/lijn.v2i1.11078

Abstract

Introduction: Alzheimer’s disease (AD) continues to impose a significant global health burden, while early detection remains limited by the reliance on invasive and costly diagnostic methods such as PET imaging and cerebrospinal fluid (CSF) analysis. Blood-based biomarkers have gained attention as a more accessible alternative. This study aims to assess the diagnostic performance of plasma p-tau217, p-tau181, and Aβ42/40 in detecting early-stage AD. Methods: A systematic review was conducted using predefined inclusion criteria. Studies were selected if they evaluated plasma biomarkers against established reference standards (CSF biomarkers, PET imaging, or neuropathology), reported diagnostic accuracy measures, and included individuals with early cognitive impairment. Extracted data covered study characteristics, assay methods, population profiles, cutoff approaches, and longitudinal outcomes. Results: Seventeen studies involving more than 7,000 participants were included. Plasma p-tau217 consistently demonstrated the highest diagnostic accuracy across studies, with AUC values generally exceeding 0.90. Plasma p-tau181 also showed good diagnostic performance but with greater variability, particularly in early disease stages. In contrast, Aβ42/40 alone exhibited lower and less consistent accuracy, although its performance improved when combined with phosphorylated tau biomarkers. Variability in assay platforms, population characteristics, and cutoff values contributed to heterogeneity across studies. Conclusions: Plasma p-tau217 shows strong and consistent diagnostic performance across different populations and settings, approaching that of CSF and PET biomarkers. It holds considerable potential as a practical and minimally invasive tool for early AD detection, although further standardization is still needed. Keywords: Alzheimer’s Disease, P-tau217, Blood-based Biomarkers, Early Detection, Diagnostic Accuracy

Page 3 of 3 | Total Record : 24

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