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Majalah Kedokteran Bandung
Published by Universitas Padjadjaran
ISSN : 0126074X     EISSN : 23386223     DOI : 10.15395/mkb
Core Subject : Health,
Medicine & Pharmacology
Majalah Kedokteran Bandung (MKB)/Bandung Medical Journal publishes peer-reviewed original articles and case reports in basic medical research, clinical research, and applied medical science. This journal is published quarterly (March, June, September, and December) by Faculty of Medicine Universitas Padjadjaran. Articles are original research that needs to be disseminated and written in English. All submitted manuscripts will go through the double-blind peer review and editorial review before being granted with acceptance for publication.
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Articles 12 Documents
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Search results for , issue "Vol 56, No 2 (2024)" : 12 Documents clear
Correlation Between CA 15-3 And Miller Payne Histopathological Response In Locally Advanced Breast Cancer Undergoing FAC Regiment Neoadjuvant Chemotherapy Rizki, Kiki Akhmad; Azhar, Raden Yohana; Dewayani, Birgitta; Fahman, Aulia Novariza
Majalah Kedokteran Bandung Vol 56, No 2 (2024)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v56.3145

Abstract

Response to chemotherapy for breast cancer can be assessed using the CA 15-3 tumor marker, or through histopathological means such as Miller Payne assessment. This study aimed to explore the correlation between CA 15-3 level and histopathological response in locally advanced breast cancer. This is a cross-sectional study measuring CA 15-3 before and after neoadjuvant chemotherapy using the FAC regiment. This study took place in Dr. Hasan Sadikin Hospital Bandung, Indonesia, from January to August 2022. Data on histopathological responses before chemotherapy and after surgery were also collected. Thirty-nine patients were admitted as subjects. Most patients had invasive carcinoma of no special type (79.5%) and luminal B HER 2 molecular subtype (38.5%). A significant decrease in CA 15-3 level after chemotherapy (from 23.54±18.38 ng/ml to 16.30±6.51 ng/mL) was observed. No significant correlation between CA 15-3 level and Miller Payne histopathological responses were found in the subjects.
Comparison of Phaco-Chop versus Stop-and-Chop Nucletomy Techniques in Patients with Soft to Moderate Nucleus Cataracts Budiman, Budiman; Knoch, Andrew M. H.; Sugiarti, Emmy Dwi; Tjokrovonco, Ludwig Melino
Majalah Kedokteran Bandung Vol 56, No 2 (2024)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v56.3184

Abstract

Various phacoemulsification techniques are commonly used, with phaco-chop and stop-and-chop techniques as the most popular ones. Phacoemulsification inevitably leads to endothelial cell destruction, which, in severe cases, might result in vision impairment. This study aimed to compare endothelial cell characteristics between two phacoemulsification procedures, phaco-chop, and stop-and-chop, in patients with soft to moderate nucleus cataracts. This study was conducted on 142 patients at the National Eye Center of Cicendo Hospital between April and August 2018. Of those, 66 patients underwent the phaco-chop technique, while 76 patients underwent the stop-and-chop technique. Intraoperative parameters such as effective phaco time (EPT), phaco time, average power, and duration were recorded. Endothelial density, hexagonality, coefficient of variation (CV), and central cornea thickness (CCT) were also recorded before surgery, as well as one week and four weeks after surgery. Mean power, EPT, phaco time, and duration in the phaco-chop group were significantly lower than in the stop-and-chop group. Mean (SD) endothelial density at one-week and four-week evaluation in the phaco-chop group were considerably lower than in the stop-and-chop group (p-value=0.024 and p-value=0.000, respectively). Mean (SD) CV at one-week evaluation in the phaco-chop group was significantly higher compared to a stop-and-chop group, 43.3 (8.0) versus 40.0 (6.7) % (p-value=0.009). Mean (SD) hexagonality at four-week evaluation in the phaco-chop group was significantly higher compared to a stop-and-chop group (43.1 (17.6) versus 48.7 (13.2) respectively, p-value=0.045). Phaco-chop technique have significantly lower EPT, average power, phaco time, and surgery duration than stop-and-chop techniques at one-week and four-week evaluation after phacoemulsification.

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