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Majalah Kedokteran Bandung
Published by Universitas Padjadjaran
ISSN : 0126074X     EISSN : 23386223     DOI : 10.15395/mkb
Core Subject : Health,
Medicine & Pharmacology
Majalah Kedokteran Bandung (MKB)/Bandung Medical Journal publishes peer-reviewed original articles and case reports in basic medical research, clinical research, and applied medical science. This journal is published quarterly (March, June, September, and December) by Faculty of Medicine Universitas Padjadjaran. Articles are original research that needs to be disseminated and written in English. All submitted manuscripts will go through the double-blind peer review and editorial review before being granted with acceptance for publication.
Arjuna Subject : -
Articles 651 Documents
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Ajwa Date (Phoenix dactylifera L.) Extract to Prevent Alzheimer’s Disease in Rat Model Rizka Muthia Nuruddin; Brian Wasita; Adi Magna Patriadi Nuhriawangsa
Majalah Kedokteran Bandung Vol 55, No 1 (2023)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v55n1.2871

Abstract

Alzheimer's disease (AD) is the most common disease of aging characterized by increased extracellular deposits of amyloid-β (Aβ) in the brain. Globally, the number of people affected by AD has increased from 35.6 million in 2010 to 46.8 million in 2015. Ajwa dates contain phenolic compounds that can protect against inflammation and oxidative stress in the brain. This study aimed to analyze the effect of the dose and duration of Ajwa date extract administration on IL-6 levels and SOD activity in rats induced with 400 mg/day homocysteine to trigger Alzheimer's Disease. This was a laboratory experimental study with a pretest-posttest group design conducted at the Laboratory of the Center for Food and Nutrition Studies (PSPG), Universitas Gadjah Mada, Yogyakarta, Indonesia from December 2020 - January 2021. A total of 48 rats were divided into one control group, one untreated group, and 4 treatment groups that received different doses of Ajwa Date Extract (ADE) for 21 and 28 days in rats. The results showed that the administration of ADE (Ajwa date extract) for 21 and 28 days could reduce IL-6 levels but did not have the same effectiveness as donepezil. The administration of 800 mg/kg BW ADE for 28 days can increase SOD activities with the same effectiveness as donepezil. Ajwa date extract can be proven to have beneficial effects to prevent Alzheimer's disease and can be used to prevent decreased antioxidant and increased inflammation. Thus, further studies to explore the potential clinical use of the extract to manage Alzheimer's Disease may be beneficial.
Age, Gender, and Preoperative LVEF Influence on ICU Length of Stay After CABG Rara Amourra Arviolla; Budiana Rismawan; Muchammad Erias Erlangga
Majalah Kedokteran Bandung Vol 55, No 1 (2023)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v55n1.2952

Abstract

Coronary artery bypass graft (CABG) surgery is a surgical therapy for coronary artery disease (CAD) patients who cannot be solely treated using pharmacological therapy. Patients undergoing CABG surgery require careful postoperative monitoring in the intensive care unit (ICU). This leads to the need for careful selection of patients due to the limited number of ICU beds available. A prolonged stay in ICU could delay surgery for other patients. This retrospective study analyzed how preoperative factors such as age, gender, and preoperative left ventricular ejection fraction (LVEF) may influence patient's length of stay (LOS) in the ICU. For this study, subjects were patients undergoing isolated CABG in Dr. Hasan Sadikin General Hospital Bandung, Indonesia, during the period of January 2019- December 2020 who were selected using the simple random sampling method. The subjects were categorized into  <65 years old and ≥65 years old age groups;  man and woman gender; preoperative LVEF of <40% and ≥40%; and prolonged ICU LOS (>96 hours) and non-prolonged ICU LOS (<96 hours). Deceased patients in the ICU were excluded.  Results of the bivariate and multivariate analyses showed that age was the only factor (p-value of 0.017) that increased the risk of prolonged ICU LOS (OR of 3.34) after CABG surgery that was statistically significant. This study concluded that patient of old age (>65 years old) is at a higher risk of having prolonged ICU LOS after CABG; thus, a careful scheduling of patients for CABG surgery by age is important to prevent prolonged ICU LOS after CABG.
Effect of High Fat and Cholesterol Diet on Total Blood Cholesterol Levels in Pregnant Wistar Rats Desmawati Desmawati; Annisa Yuda Mahdiyah; Husnil Kadri
Majalah Kedokteran Bandung Vol 55, No 1 (2023)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v55n1.2651

Abstract

Hypercholesterolemia during pregnancy is a physiological condition resulting from increased insulin resistance, lipoprotein synthesis, and lipolysis in adipose tissue, which mobilizes lipids as an energetic substrate for fetal growth. Consumption of foods high in fat and cholesterol may lead to an increase in total blood cholesterol levels during pregnancy due to saturated fat and cholesterol contents that will increases the synthesis of lipoproteins in the blood. The objectives of this study were to determine the effects of high fat and cholesterol diet on the total blood cholesterol levels in pregnant Wistar rats. This study was a true experimental research using a randomized post-test-only control group design  conducted from November 2020 to October 2021on fourteen female Wistar rats that were divided into control and intervention groups. Cow brain was provided as the high fat and cholesterol diet and after the rats gave birth, blood was drawn from the heart. The total blood serum cholesterol levels were assessed  using Micro Lab 300 with the CHOD-PAP method and the data were analyzed using an independent t-test. This study showed that the mean total blood cholesterol levels for the control and treatment groups were 80.43±18.512 mg/dL and  142.57±24.786 mg/dL, respectively, which reflected a significant differences in the mean total blood cholesterol level between the control and treatment groups (p-value <0.01). In conclusion, a high fat and cholesterol diet affects the total blood cholesterol level in pregnant Wistar rats.
Malaria Infection and Socioeconomics in Malaria Endemic Areas of East Nusa Tenggara, Indonesia Nisa Fauziah; Edina Anindhita; Savira Ekawardhani; Deviyanthi Nur Afifah; Jontari Hutagalung
Majalah Kedokteran Bandung Vol 55, No 1 (2023)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v55n1.2902

Abstract

More than 1.1 million people, or 20.90% of the population in East Nusa Tenggara (NTT), Indonesia, live below the poverty line, making NTT the third province with the highest number of poor people in Indonesia. The region of NTT, which is well known as one of the endemic areas for malaria in Indonesia, also has the highest number of adults with low nutritional status. This study aimed to assess the influence of socioeconomic factors on malaria-endemic areas in eastern Indonesia. A cross-sectional study was conducted in East Nusa Tenggara from January to March 2020. Bivariate and multivariate analyses were then performed on 317 population data of adults with low socioeconomic status. It was found that one of the socioeconomic factors, i.e., the age, is significantly associated with malaria (p-value = 0.031; OR = 1.684) with 40 being the age with the highest association. Thus, age is associated with malaria incidence in endemic areas.
Association of Lower Urinary Tract Symptoms and Benign Prostatic Enlargement in Patients with Hypertension Dicky Stefanus; Safendra Siregar
Majalah Kedokteran Bandung Vol 55, No 1 (2023)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v55n1.2689

Abstract

Development of hyperplastic nodules in the transition zone of the prostate is the characteristic of Benign prostatic enlargement (BPE). Men with hypertension have a high risk of severe lower urinary tract syndrome (LUTS). This restrospective cohort analytic study investigated the association between LUTS and BPE in hypertension patients. Subjects were BPE patients with primary hypertension who visited the urology clinic of Dr. Hasan Sadikin General Hospital Bandung that were sampled consecutively from 2017 to 2020. Three hundred and twenty-four patients from the urology department participated in the study. These patients were categorized into  mild LUTS (IPSS 1-7)  (n=37, 11.4%), moderate LUTS (IPSS 8-19) (n=169, 52.2%), and severe LUTS (IPSS 20-35) (n=118, 36.4%). A positive correlation (r = 0.761, p = 0.000) and weak positive correlation (r = 0.152, p = 0.006) were found between systolic blood pressure and prostate volume and between LUTS and systolic blood pressure, respectively. In addition, there was also a weak positive correlation between diastolic blood pressure and prostate volume (r = 0.065, p = 0.245) and LUTS (r = 0.015, p = 0.784). Thus, there is an association between hypertension and prostate enlargement and the severity of lower urinary tract symptoms
Impact of First Eye Cataract Surgery on Quality of Life Mayasari Wahyu Kuntorini; Maya Primagustya Achmad; Aldiana Halim
Majalah Kedokteran Bandung Vol 55, No 1 (2023)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v55n1.2935

Abstract

Cataracts are the second leading cause of visual impairment and the first cause of blindness, both globally and Indonesia. Cataracts do not only reduce vision but also the quality of life of the patients. Cataract surgery of at least one eye is expected to improve the patient's visual function and quality of life. This study aimed to assess the quality of life of patients with bilateral senile cataracts after the first eye surgery compared to people with normal vision. This was a cross-sectional study on 75 patients who underwent their first eye cataract surgery at the Cataract and Refractive Surgery Unit and 75 people with normal vision who visited the Refraction, Contact Lens, and Low Vision Unit of the National Eye Center of Cicendo Eye Hospital during the period of March-June 2020. The quality of life assessment was conducted through interviews using the National Eye Institute Visual Function Questionnaire-25. The non-inferiority test with a margin of 20% was performed. The mean age of the subjects was 63.49 years with no difference in the proportion of gender. Presenting visual acuity of binoculars after the first cataract surgery was 0.26 LogMAR and normal vision was 0.07 LogMAR. With a margin of 20%, the patient's quality of life after the first cataract surgery was not inferior to the normal vision subjects (d = -2.45% (95% CI -6.3% to 1.4%).) Hence, patients' quality of life after the first cataract surgery is not inferior to those with normal vision.
Case Report on Painful Patellar Crepitation Following a Knee Replacement with Preserved Patella John Christian Parsaoran Butarbutar; Joshua Edward Hananto; Irvan Irvan
Majalah Kedokteran Bandung Vol 55, No 1 (2023)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v55n1.2727

Abstract

Patellar clunk crepitation is a well-known complication following knee replacement surgery and is associated with posterior stabilized knee replacement surgery and surgical technique. Currently, patellar clunk or crepitation management following knee replacement surgery with preserved patella remains unclear. The purpose of this case report is to discuss whether patellar clunk or crepitation management should include debridement with patellar resurfacing or debridement alone. This case describes a patellar crepitation after knee replacement surgery with the preserved patella. The surgery went uneventfully using the standard medial parapatellar approach. However, the patient was still unsatisfied with the chronic left knee pain (>3 months) and crepitation that developed following the surgery, and the patient was diagnosed with patellar clunk and crepitation (PCC). A patellar resurfacing procedure was performed with a satisfactory clinical outcome. Replicating the original joint line level and placing the tibial component posteriorly play a pivotal role in preventing PCC. Debridement and patellar resurfacing procedures are recommended in this type of case to overcome the valgus knee alignment and the placement of the tibial component.
Pneumonia Clinical Features in Under-Five Children Treated in Atma Jaya Hospital in 2017-2020 Rachel Roselany; Edward Surjono
Majalah Kedokteran Bandung Vol 55, No 1 (2023)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v55n1.2966

Abstract

Pneumonia is the leading cause of infection-related death among children and still remains a global health problem, especially for children under five. This study aimed to identify the clinical features of pneumonia in under-five chilren treated at Atma Jaya Hospital during the period of 2017-2020. This was a cross-sectional retrospective descriptive study on all under-five patients diagnosed with pneumonia treated in Atma Jaya Hospital. Data were collected from November 2021-January 2022 from the medical records of these children (n=148) and analyzed using the univariate analysis.  Results showed that most subjects of this study were boys (60.8%), in the age group of 1-4 years old (62.2%), with fever as the most common pnemonia clinical symptom (93.9%). Physical examinations revealed that the average pulse of the subjects were 131.2 beats/minute and the average temperature was 37.1°C. Other signs and symptoms identified during physical examinations were tachypnea (20,3%), retractions (56.1%), crackles (82.4%), and wheezing (22,3%). The laboratory findings presented a mean hemoglobin of 11.0 g/dL, a mean hematocrit of 32.5%, and a mean CRP of 13.2 mg/dL, while most subjects had normal leukocyte (58.1%) and platelet counts (52.0%). The most common chest X-ray finding of pneumonia in these children was infiltrate (92.6%) and the average length of stay was 4 days. Most under-five children experiencing pneumonia recovered after treatment (97.3%).
Hospital Management Information System Implementation Assessment Using HOT-FIT Model in Langsa General Hospital Aceh, Indonesia Sri Wahyuni Nasution; Chairunnisa Chairunnisa
Majalah Kedokteran Bandung Vol 55, No 1 (2023)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v55n1.280

Abstract

In providing the best health care to the community, hospitals as health care facilities utilize technologies that are influenced by developments and advances in medical sciences and technologies. One of such technologies is the information management technology. Since the quality of information processing is an essential factor for succesful medical care of patients, Regulation of the Minister of Health of the Republic of Indonesia Number 82 of 2013 requires all hospitals to implement a hospital information management system (HIMS). To assess the successful implementation of HIMS, various models and frameworks have been developed, including the HOT-FIT model. This study aimed to analyze the implementation of the hospital management information system at Langsa General Hospital, Aceh, Indonesia, using the HOT-FIT model which applied the SEM-PLS method. This quantitative study was performed in approximately three months using the HOT-FIT (company, technology-FIT human,) framework that includes nine variables of system quality, information quality, service quality, organization structure, facility situations, support from leadership, system usage, user satisfaction, and net benefits. Data analysis was performed using the SEM-PLS analysis in SmartPLS application (V.3.2.9). Results showed that human, organization, and technology supports were factors that influence the successful implementation of HIMS. To conclude, the HOT-FIT model can be used to identify the factors that influence the successful implementation of HIMS to inform the HIMS improvement in the hospital that will eventually improve the hospital’s quality system, information, service quality, and user satisfaction.
Correlation Analysis of Lactic Acid Level as A Predictor of Severity of Patients with Acute Appendicitis Reno Rudiman; Tommy Ruchimat; Cytra Givanni Rossy
Majalah Kedokteran Bandung Vol 55, No 1 (2023)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v55n1.2816

Abstract

Perforated appendicitis is a leading cause of morbidity and mortality in all appendicitis cases, both for adults and children. Delay in preoperative diagnosis is the main reason for perforation. In previous studies, it was revealed that diagnostic modalities such as radiological examination and the current scoring system have not been able to predict the onset of perforated appendicitis. Serological biomarkers of lactic acid are associated with intestinal obstruction and ischemia. The increase in the serological value of lactic acid in perforated appendicitis compared to acute one was shown to increase significantly by 0.25 mmol/L (p<0.05) according to a previous study. This study aimed to determine the correlation between lactic acid level and the severity of appendicitis in patients visiting Dr. Hasan Sadikin General Hospital. This was a cross-sectional prospective analytic observational study on adult patients diagnosed with appendicitis who were admitted to the emergency room of Dr. Hasan Sadikin General Hospital from January 1, 2021 to June 1, 2021. Data analysis was performed using bivariate analysis and correlation tests of difference. This study involved 54 subjects with a mean lactic acid level of 2,5093 mmol/L (0.9 mmol/L - 11.8 mmol/L). In the complicated appendicitis group, 20 subjects (37%) was found to experience an increase in lactic acid (OR 1.07; 95% CI: -0.03-0.22; p=0.14). The correlation analysis showed the direction of negative correlation. Thus, it is concluded that there is no significant correlation between lactic acid level and the severity of appendicitis in patients with appendicitis.

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