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INDONESIA
Majalah Kedokteran Bandung
Published by Universitas Padjadjaran
ISSN : 0126074X     EISSN : 23386223     DOI : 10.15395/mkb
Core Subject : Health,
Medicine & Pharmacology
Majalah Kedokteran Bandung (MKB)/Bandung Medical Journal publishes peer-reviewed original articles and case reports in basic medical research, clinical research, and applied medical science. This journal is published quarterly (March, June, September, and December) by Faculty of Medicine Universitas Padjadjaran. Articles are original research that needs to be disseminated and written in English. All submitted manuscripts will go through the double-blind peer review and editorial review before being granted with acceptance for publication.
Arjuna Subject : -
Articles 663 Documents
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Correlation of Age, PSA Value, Gleason Score, and Staging with Metastasis in Prostate Cancer Esfandiary, Puti Rania; Safriadi, Ferry; Mustafa, Akhmad
Majalah Kedokteran Bandung Vol 48, No 1 (2026)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v58.4225

Abstract

Prostate cancer is the fifth most common cancer among men in Indonesia and carries a substantial risk of metastasis. However, data on prognostic factors such as age, prostate-specific antigen (PSA) value, Gleason score, and local stage among Indonesian patients are still limited. This retrospective cross-sectional study analyzed medical records of prostate cancer patients treated at Dr. Hasan Sadikin General Hospital, Bandung, between 2019–2022. Independent variables were age, PSA value, Gleason score, and local stage; the dependent variable was metastatic status. Data were analyzed using chi-square and multivariate logistic regression tests. A total of 81 patients were included, of whom 44 (54.3%) had metastases. Bivariate analysis showed significant associations of PSA value, Gleason score, and local stage with metastasis (p<0.05). In multivariate analysis, only Gleason score and local stage remained significant independent predictors (p<0.05). The findings indicate that Gleason score and local tumor stage are reliable predictors of metastasis in prostate cancer, while age and PSA are not independent predictors in this cohort. Gleason score and local stage should be prioritized for risk assessment in prostate cancer management in Indonesian hospitals.
Prevalence of Multidrug-Resistant and Biofilm-Forming Salmonella enterica in Beef from Peshawar Ullah, Muhammad Jawad; Ahmad, Kafeel; Khattak, Faryal; Inayat, Fawad; Huriya, Sawaira; Menhaj, Naila
Majalah Kedokteran Bandung Vol 48, No 1 (2026)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v58.4138

Abstract

Salmonella enterica is a major public health concern and is frequently linked tobeef contamination, particularly in developing countries where the emergence of multidrug-resistant (MDR) strains has increased health risks associated with the consumption of contaminated meat. This study aimed to determine the prevalence, seasonal distribution, antimicrobial resistance patterns, and biofilm-forming ability of S. enterica isolated from different points of the beef supply chain in Peshawar, Pakistan. A total of 250 beef samples were collected from retail shops, butcheries, and slaughterhouses across 23 locations between February 2021 and February 2023. The isolates were identified using standard biochemical tests, and antimicrobial susceptibility was evaluated against 16 antibiotics using the Kirby–Bauer disk diffusion method. Biofilm-forming ability was assessed using a quantitative microtiter plate assay. The overall prevalence of S. enterica was 68.0% (170/250), and 150 isolates were further subjected to molecular analysis. A clear seasonal pattern was observed, with the highest prevalence in summer (85.7% in August) and the lowest in winter (43.8% in January), showing a strong positive correlation with temperature (r=0.89, p<0.001). Spatial analysis showed higher odds of contamination near slaughterhouses (OR=2.21, 95% CI: 1.15–4.23) and in urban centers (OR = 2.41, 95% CI: 1.38–4.22) compared to rural areas. High resistance levels were detected against azithromycin (87.3%), tetracycline (61.3%), and streptomycin (48.0%). The MDR phenotype was observed in 56.7% of isolates with a mean MAR index of 0.342. Biofilm formation was detected in 87.3% isolates, and strong producers exhibited a higher prevalence of MDR
ESBL-Producing Enterobacteriaceae Isolated from Hospital and Community Health Center Wastewater in Pekanbaru, Indonesia Afham, Muhamad; Anggraini, Dewi; Adrianison, Adrianison; Sarassari, Rosantia; Sundari, Sundari
Majalah Kedokteran Bandung Vol 48, No 1 (2026)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v58.4418

Abstract

Wastewater originating from medical facilities, particularly hospitals, serves as an important reservoir for Extended-Spectrum Beta-Lactamase (ESBL)-producing bacteria. This study assessed ESBL-producing strains of Escherichia coli and Klebsiella pneumonia in the inlet and outlet of wastewater treatment systems, as well as in downstream sewage from a community health center and a public provincial referral hospital in Pekanbaru, Indonesia, during the period of Oktober to December 2023. The analysis included the enumeration of bacterial colonies for presumptive ESBL-producing E. coli and K. pneumoniae, phenotypic confirmation of ESBL production, and identification of ESBL-associated genes. Substantial quantities of presumptive ESBL-producing E. coli and K. pneumoniae were identified in both the inlet and outlet of hospital wastewater, as well as in downstream sewage water. In contrast, wastewater from the community health center contained only E. coli in the inlet samples. Phenotypic testing confirmed ESBL production in two samples (11.1%). The ESBL genes blaCTX, blaTEM, and blaSHV were detected in seven (38.9%), three (16.7%), and one isolates (11.1%), respectively. These findings highlight wastewater as a significant reservoir of ESBL-producing bacteria and underscore the need for strengthened strategies to limit their release into the environment. Effective mitigation requires targeted measures to reduce ESBL-producing bacteria in wastewater, along with continuous monitoring and control of wastewater treatment systems to prevent further dissemination of antibiotic resistance into aquatic ecosystems.

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