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JC-T (Journal Cis-Trans) : Jurnal Kimia dan Terapannya
Published by Universitas Negeri Malang
ISSN : 25496565     EISSN : 25496573     DOI : 10.17966
Core Subject : Science,
Biochemistry, Genetics & Molecular Biology
JC-T (Journal Cis-Trans) : jurnal kimia dan terapannya is published by Universitas Negeri Malang, Faculty of Mathematics and Science, Chemistry Department.
Arjuna Subject : Kimia(semua kategori) - Kimia (Lain-Lain)
Articles 5 Documents
 1 
Search results for , issue "vol. 5 no. 1 (2021)" : 5 Documents clear
Studi In Silico Fitosterol dan Turunannya Sebagai Kandidat Obat Anti Kanker Payudara Julian Sagus Bramasta; I Gusti Made Sanjaya
JC-T (Journal Cis-Trans) : Jurnal Kimia dan Terapannya Vol. 5 No. 1 (2021)
Publisher : Universitas Negeri Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17977/um0260v5i12021p001

Abstract

Phytosterols and their derivatives have the potential to inhibit the growth of breast cancer, one ofwhich is β-sitosterol, which has been shown to reduce tumor size after consumption in previous studies.This study aims to examine anti-breast cancer drugs from phytosterol compounds and their derivatives.The study was conducted using the Quantitaitve Structur-Activity Relationship method and strengthened bythe molecular docking method. The QSAR descriptor used was electronic, steric and hydrophobic. Thecharacters of each descriptor were computed using NWchem and Gamess (DFT method, 6-31 * base set),SwissAdme, Molinspiration, and pkCSM. Tethering and molecular visualization were carried out withAutodock Tools 1.5.6 and Biovia Discovery Studio 2019. The results show that the best model of the HKSAequation for medicinal compounds from phytosterol compounds is Log P = 316.46 + (-1.513 * MR) + (-0.668 * V) + (3,926 * P) + (-18,235 * Homo) + (2,757 * Lumo), from this equation we get the bestcompound (9aR, 11aR) ‐7 ‐ chloro ‐ 1 - ((5R) ‐5‐ethyl‐6‐methylheptan‐2‐yl]‐9a,11a‐dimethyl‐1H, 2H, 3H,3aH, 3bH, 4H, 6H, 7H, 8H, 9H, 9aH, 9bH, 10H, 11H, 11aH‐cyclopenta[a]phenanthren7‐ol.
Aktivitas Antioksidan dan Identifikasi Senyawa Metabolit Sekunder dari Ekstrak Batang Dahu (Dracontomelon dao) Tarso Rudiana; Nani Suryani; Haerul Anwar
JC-T (Journal Cis-Trans) : Jurnal Kimia dan Terapannya Vol. 5 No. 1 (2021)
Publisher : Universitas Negeri Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17977/um0260v5i12021p008

Abstract

Dahu (Dracontomelon dao) belongs to the Anacardiaceae family which contains various secondarymetabolites that can be used as a source of natural antioxidants. The aim of this study was to extractsecondary metabolites from stems bark of D. dao, determine their antioxidant activity and analyze the contentof secondary metabolites using LC-MS/MS. The stem samples of D. dao were extracted in stages with varioustypes of solvents such as methanol ethyl acetate, and n-hexane. Each extract was analyzed for its antioxidantactivity using the 2,2-diphenyl-1 picrylhydrazyl (DPPH) method. The most active extracts werecharacterized by LC-MS/MS. The stem methanol extract of D. dao showed the best antioxidant activity withan IC50 value of 30.86 ppm, followed by ethyl acetate extract with an IC50 of 200.83 ppm and n-hexane extractwith an IC50 value of 348 ppm. Identification results with LC-MS/MS methanol extract containingtributylamine, medroxyprogesterone acetate, and flavanones.
Model QSAR dari Turunan 3- tersubstitusi 4-Anilino Kumarin terhadap Aktivitas Anti-kanker Pankreas Daratu Eviana Kusuma Putri; Harno Dwi Pranowo; Anugrah Ricky Wijaya; Aman Santoso
JC-T (Journal Cis-Trans) : Jurnal Kimia dan Terapannya Vol. 5 No. 1 (2021)
Publisher : Universitas Negeri Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17977/um0260v5i12021p013

Abstract

Quantitative structure-activity relationship (QSAR) from 3-substituted 4-anilino coumarin derivativesas anti pancreas cancer had been successfully generated and validated. The 3-substituted 4-anilinocoumarin derivatives structures and their biological activities were taken from the research of Luo et al.Each structure of 3-substituted 4-anilino coumarin derivatives was optimized using DFT/BPV86 6-31Gmethod. The QSAR models were generated by Multi Linear Regression (MLR) and the best model gainedwas: Log IC50 = 4,02 + (-7,126 x qC7) + (-5,709 x qC8) + (6,845 x qC18); n = 18; r2 train = 0.701; r2 test = 0.849, Fkal/Ftab = 3,269; SEE = 0.230. From this model, Log IC50 of pancreas cancer from 3-substituted 4- anilino coumarin derivatives can be reduced by modifying qC7, qC8, dan qC18 as the coefficient values ofeach descriptor.
Material Hibrida Mg/Al-HT Terinterkalasi Asam 3,4,5-Trihidroksibenzoat Dengan Metode Kopresipitasi Melalui Mikro Reaktor-T Danar Danar; Sri Juari Santosa; Eko Sri Kunarti
JC-T (Journal Cis-Trans) : Jurnal Kimia dan Terapannya Vol. 5 No. 1 (2021)
Publisher : Universitas Negeri Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17977/um0260v5i12021p020

Abstract

The material of Mg/Al hydrotalcite (Mg/Al-HT-ATBH) intercalated with 3,4,5-trihydroxybenzoic acid(THBA) had been successfully synthesized by coprecipitation using a T-type microchannel reactor. Thesynthesized hybrids were characterized by XRD and FT-IR. The result showed that intercalation of THBAinto Mg/Al-HT-THBA reached optimum condition at medium acidity equal to pH 8 with molar ratio ofMg2+:Al3+: THBA was 2:1:0,5. Characterization using FT-IR and XRD showed that THBA was intercalated in the interlayer of Mg/Al-HT-THBA replacing NO3-ions. The value of basal spacing d003 shifted from 11.27° to 6.74° and therefore the interlayer distance increased from 7.84 to 13.10 Å.
Pengaruh Konsentrasi dan Ukuran Partikel Logam Mg terhadap Karakter Magnesium/Grafena Berlapis Nano (Mg/GBN) Fajar Hutagalung; Rikson Siburian; Ab Malik Marwan Ali
JC-T (Journal Cis-Trans) : Jurnal Kimia dan Terapannya Vol. 5 No. 1 (2021)
Publisher : Universitas Negeri Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17977/um0260v5i12021p027

Abstract

Since graphene was synthesized in 2004, it has been widely used in electrochemical energy storagedevices and a number of other applications. This study aims to determine the effect of concentration and size ofMg metal particles on the structure, morphology, and electrical conductivity of Mg/Graphene nano sheets(GNS). This research is a laboratory experiment and descriptive research. GNS was synthesized by using amodified Hummers’ method. Mg 10, 20, 30 and 40 weight % /GNS were synthesized by using impregnationmethod using Mg salt (MgCl2.6H2O) as the precursor. Characterizations carried out on each material usingXRD (2θ = 26,768° – 26,938° for C(002) GNS and 2θ = 44,669° – 44,686° for Mg (102)), SEM-EDX and Conductometer proved that the graphene surface is able to reduce Mg2+ metal ions to Mg0 and to control the size and distribution of Mg metal particles deposited on the surface of the graphene sheets. Meanwhile, Mg metal particles that have been deposited are able to inhibit the agglomeration and re-stacking of graphene sheets so that it can increase the electron mobility and electrical conductivity of graphene

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