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INDONESIA
Media Penelitian dan Pengembangan Kesehatan
Published by Badan Penelitian dan Pengembangan Kesehatan, Kementerian Kesehatan
ISSN : 08539987     EISSN : 23383445     DOI : -
Core Subject : Health, Science,
Decision Sciences, Operations Research & Management Public Health
Media Health Research and Development ( Media of Health Research and Development ) is one of the journals published by the Agency for Health Research and Development ( National Institute of Health Research and Development ) , Ministry of Health of the Republic of Indonesia. This journal article is a form of research results , research reports and assessments / reviews related to the efforts of health in Indonesia . Media Research and Development of Health published 4 times a year and has been accredited Indonesian Institute of Sciences ( LIPI ) by Decree No. 396/AU2/P2MI/04/2012 . This journal was first published in March 1991.
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Articles 5 Documents
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Search results for , issue " Vol 23, No 3 Sep (2013)" : 5 Documents clear
3-ACETYL -2,5,7-TRIHYDROXY-1,4-NAPHTALENEDIONE, AN ANTIMICROBIAL METABOLITE FROM THE CULTURE OF ENDOPHYTIC FUNGUS COELOMYCETES TCBP4 FROM Tinospora crispa Praptiwi, Praptiwi; Jamal, Yuliasri; Fathoni, Ahmad; Nurkanto, Arif; Agusta, Andria
Media Penelitian dan Pengembangan Kesehatan Vol 23, No 3 Sep (2013)
Publisher : Badan Penelitian dan Pengembangan Kesehatan

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Abstract

Abstract Isolation, identification and testing of antimicrobial activity of secondary metabolites of endophytic fungal culture TCBP4 isolated from bratawali (Tinospora crispa) has been performed. The fungus TCBP4 was cultivated in Potato Dextrose Broth (PDB) for 1 month, media and fungi extracted with ethyl acetate. The extract was separated and purified by several chromatographic techniques, from which 9 fractions were obtained. Fraction 3e was purified again and was obtained 6 fractions (3e1-3e6). Fractions 3e3-3e6 were tested against bacteria isolates Staphylococcus aureus Bacillus subtilis,Eschericia coli and yeast isolate Candida albicans by microdillution method. Antimicrobial activity test result showed that fractions 3e3-3e5 had better antibacterial activity compared to chloramphenicol as commercial antibiotic. It was indicated by MIC value of the fractions was lower (8 ug/ml) compared with the antibiotic chloramphenicol (16 ug/ml). Fraction 3e3 had better antifungal activity compared to commercial antifungal nystatin and cabisidin against C. albicans. GC-MS analysis showed that the chemical constituent of 3e5 fraction was identified as 3-acetyl -2,5,7-trihydroxy-1,4-naphtalenedione . Key words : Tinospora crispa, endophytic fungi, isolation, identification, antimicrobial Abstrak Isolasi, identifikasi dan uji aktivitas antimikrobia terhadap metabolit sekunder dari kultur jamur endofit TCBP4 yang diisolasi dari tumbuhan bratawali (Tinospora crispa). Jamur endofit TCBP4 dikultivasi pada media Potato Dextrose Broth (PDB) selama 1 bulan, selanjutnya media dan jamur diekstrak dengan pelarut etil asetat. Ekstrak dipisahkan dan dimurnikan dengan beberapa teknik kromatografi sehingga diperoleh 9 fraksi. Fraksi 3e dimurnikan kembali dan diperoleh 6 fraksi (3e1-3e6). Fraksi 3e3-3e6 diuji aktivitas antibakterinya terhadap beberapa isolate bakteri Staphylo-coccus aureus Bacillus subtilis, Eschericia coli dan isolate khamir Candida albicans dengan metode mikrodilusi. Hasil uji antimikrobia menunjukkan bahwa fraksi 3e3-3e5 mempunyai aktivitas antibakteri lebih baik bila dibandingkan dengan chloramfenikol, dimana nilai MIC dari fraksi (8 ug/ml) lebih rendah dari antibiotika chloramfenikol (16 ug/ml). Fraksi 3e3 mempunyai aktivitas antijamur lebih baik bila dibandingkan dengan antijamur komersial nistatin dan kabisidin terhadap  C. albicans. Analisis GC-MS menunjukkan bahwa komponen kimia dari fraksi 3e5 diidentifikasi sebagai 3-acetyl -2,5,7-trihydroxy-1,4-naphtalenedione . Kata kunci : Tinospora crispa, jamur endofit, isolasi, identifikasi, antimikrobia
HUBUNGAN ANTARA PENGETAHUAN DAN SIKAP PENGELOLA VAKSIN DENGAN SKOR PENGELOLAAN VAKSIN DI DAERAH KASUS DIFTERI DI JAWA TIMUR Pracoyo, Noer Endah; Jekti, Rabea P; Puspandari, Nelly; W, Dimas Bagus
Media Penelitian dan Pengembangan Kesehatan Vol 23, No 3 Sep (2013)
Publisher : Badan Penelitian dan Pengembangan Kesehatan

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Abstract

Abstrak Provinsi Jawa Timur merupakan daerah endemis penyakit difteri dari tahun 2000 sampai- 2012. Setiap tahunnya selalu terjadi kenaikan kasus (KLB), meskipun angka cakupan imunisasi tinggi. Kasus banyak terjadi pada anak-anak baik yang sudah diimunisasi maupun yang belum diimunisasi dengan angka kematian cukup tinggi.Tujuan penelitian ini adalah menilai pengetahuan dan sikap petugas pengelola vaksin dalam mengelola vaksin di tempat pelayanan kesehatan di daerah Jawa Timur. Metode penelitian menggunakan desain potong lintang, yang dilakukan di 6 Kabupaten/kota di Jawa Timur, dengan lama penelitian 11 bulan dari Januari sampai November 2011. Variabel dependen adalah kualitas vaksin dan variabel independen adalah cara kerja pengelola vaksin dan skor pengelolaan vaksin. Hasil penelitian menemukan bahwa  pelatihan petugas dalam mengelola vaksin berpengaruh terhadap ketepatan dalam pengelolaan vaksin di tempat pelayanan kesehatan. Kata kunci : pengelolaan, vaksin , difteri. Abstract East Java Province is an area endemic diphtheria from 2000 to-2012., Every year is always an increase in cases (KLB), despite a high rate of immunization coverage.  Common cases in both children who have been immunized or not immunized  with mortality rate is quite high. The purpose of this study was to assess the knowledge and attitude of management personnel in managing vaccine vaccines in the health service in the area of East Java. The method used is a design study using cross-sectional design, which was done in the study in six districts / cities in East Java, with a long 11-month study period is the month of January to November 2011. The dependent variable is the quality of the vaccine used and the independent variable is how the Human Resources (HR) managers vaccines and vaccine observed score management. The results found that the training of administer vaccines officer was affecting  the accuracy in vaccine management in the health service. Keywords: management, vaccines, diphtheria.
FAKTOR LANGSUNG DAN TIDAK LANGSUNG YANG BERHUBUNGAN DENGAN KEJADIAN WASTING PADA ANAK UMUR 6 – 59 BULAN DI INDONESIA TAHUN 2010
Media Penelitian dan Pengembangan Kesehatan Vol 23, No 3 Sep (2013)
Publisher : Badan Penelitian dan Pengembangan Kesehatan

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Abstract

Abstrak Hasil Riset Kesehatan Dasar menunjukkan prevalensi wasting pada anak di bawah umur lima tahun (balita) tidak mengalami penurunan yang berarti, yaitu dari 13,6 persen pada tahun 2007 menjadi 13,3 persen pada tahun 2010. Penelitian ini bertujuan untuk mengetahui faktor langsung dan tidak langsung yang berhubungan dengan kejadian wasting pada anak umur 6 – 59 bulan di Indonesia tahun 2010. Desain penelitian ialah kroseksional dengan sampel sebanyak 9897 anak balita responden Riset Kesehatan Dasar 2010. Variabel dependen pada penelitian ini ialah status wasting anak dan variabel independennya ialah variabel faktor langsung (asupan energi, karbohidrat, lemak, protein, pola menyusui, dan penyakit malaria), faktor tidak langsung dan karakteristik anak (pendidikan bapak, pendidikan ibu, pekerjaan bapak, pekerjaan ibu, persentase pengeluaran pangan terhadap pengeluaran total, status imunisasi, kondisi rumah, umur dan jenis kelamin). Odds Ratio dan 95% Confident Interval dihitung dengan menggunakan analisis regresi logistik. Hasil penelitian menunjukkan faktor langsung dominan yang berhubungan dengan kejadian wasting pada kelompok anak umur 24 – 59 bulan ialah asupan karbohidrat dengan OR (95% CI): 1,29 (1,14 – 1,47). Faktor tidak langsung yang paling dominan berhubungan dengan kejadian wasting pada kelompok anak umur 6 – 59 bulan ialah  persentase pengeluaran pangan yang tinggi (≥ 70%) dengan OR (95% CI) sebesar: 1,32 (1,11 – 1,56) setelah dikontrol variabel umur dan pekerjaan ayah. Kata kunci : wasting, balita, faktor langsung, faktor tidak langsung Abstract Baseline Health Research showed that the prevalence of wasting among under five children in Indonesia has not significantly decline, from 13,6 percent in 2006 to 13,3 percent in 2010. The objective of this study was to determine the predictors of wasting among children age 6 – 59 months in Indonesia, 2010. This study was a cross sectional study with 9897 children age 6 – 59 months as samples taken from Baseline Health Research 2010 data. The dependent variable in this study was wasting status. The independent variable were direct factors (intake of energy, carbohydrates, fats, proteins, breastfeeding pattern, and malaria), indirect factors and child characteristics (mother’s education and occupation, father’s education and occupation, the percentage of food expenditure, immunization status, number of under five children in family, type of living places, house condition, child’s age, and sex). Odds Ratio and 95% Confident Intervals were calculated by logistic regression. Analysis showed that the insufficient intake of carbohydrate was the most related factor to wasting in children aged 24 – 59 months with OR (95%CI): 1,29 (1,14 – 1,47). The most related indirect factor to wasting in children aged 6 – 59 months was the percentage of food expenditure by total expenditure ≥70% with OR(95%CI): 1,32(1,11 – 1,56) adjusted by child’s age and father’s education. Keywords: wasting, under five children, direct factors, indirect factors
FAKTOR RISIKO TUMOR/KANKER RONGGA MULUT DAN TENGGOROKAN DI INDONESIA (Analisis Riskesdas 2007)
Media Penelitian dan Pengembangan Kesehatan Vol 23, No 3 Sep (2013)
Publisher : Badan Penelitian dan Pengembangan Kesehatan

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Abstract

Abstrak Latar belakang: Tumor/kanker rongga mulut ditemukan sekitar 2-5% dari seluruh keganasan. Angka kematiannya 2-3% dari seluruh kematian akibat keganasan. Tujuan: penelitian ini adalah untuk mengetahui prevalensi serta faktor-faktor yang mempengaruhi tumor/kanker rongga mulut dan tenggorokan di Indonesia. Metode: Desain penelitian ini adalah kasus kontrol. Data diambil dari data individu Riset Kesehatan Dasar 2007. Kasus adalah semua responden yang menderita tumor/kanker rongga mulut dan tenggorokan. Kontrol adalah responden yang tidak menderita tumor/kanker pada anggota tubuh lain. Perbandingan kasus dan kontrol adalah 1 : 4 yang dipadankan dengan kabupaten kasus. Hasil: Terdapat 203 kasus tumor/kanker rongga mulut dan tenggorokan (prevalensi 0,2‰), kontrol diambil sebanyak 802 orang. Jumlah kasus terbanyak terdapat di Provinsi Jawa Tengah. Ada 5 provinsi yang tidak ditemukan adanya kasus yaitu Provinsi Jambi, Sulawesi Barat, Maluku Utara, Papua Barat dan Papua. Ditemukan OR suaian kelompok umur 11-20 tahun sebesar 2,5 dengan 95% CI 1,3-4,9 dibanding dengan umur 60 tahun atau lebih. Merokok/menyirih mempunyai OR suaian 1,6 dengan 95% CI 1,1-2,3 dibanding yang tidak merokok. Kebersihan mulut kurang mempunyai OR suaian 2,3 dengan 95% CI 1,4-3,9 dibanding dengan kebersihan mulut baik. Kesimpulan: Ditemukan hubungan yang bermakna antara umur, merokok/menyirih dan kebersihan mulut dengan tumor/kanker rongga mulut dan tenggorokan. Kata kunci: prevalensi, tumor/kanker, rongga mulut dan tenggorokan, Riskesdas 2007 Abstract Background: Globally, oral cancer is counted about 2-5% from all malignancies. The death rate of the disease is about 2-3% from all cancer related mortalities. Objective: The aim of this study was to estimate prevalence and risk factors of nasopharyngeal cancer (NPC) in Indonesia. Method: Study design was case control. Data was retrieved from individual data of Indonesia Basic Health Research 2007. Cases were all respondents who suffered NPC. Controls were all respondents who did not suffer the disease. The proportion ratio between cases and controls was 1 : 4, and they were matched based on their regency (kabupaten). Result: There were 203 cases of NPC (prevalence was 0.2‰), and 802 controls were retrieved from the study population. The majority of NPC cases were found in Central Java Province. There were five provinces where none of cases was found; these provinces were: Jambi, West Sulawesi, North Maluku, West Papua and Papua. The adjusted OR of NPC for respondents aged 60 years or older was 2.5 (95% CI 1.3-4.9) higher than those aged 11-20 years. Smoking and betel nut chewing (menyirih) have an adjusted OR of NPC as much as 1.6 (95% CI 1.1-2.3) when never smoker became the reference class. And the adjusted OR of NPC for respondents with poor oral hygiene was 2.3 (95% CI 1.4-3.9) when respondents with good oral hygiene became the reference class. Conclussion: There was paralel and significant association between age, smoking and oral hygiene with NPC. Keywords: prevalence, cancer, oral and naso-pharyngeal. Basic Health Research 2007
INFEKSI Schistosoma japonicum PADA HOSPES RESERVOIR TIKUS DI DATARAN TINGGI NAPU, KABUPATEN POSO, SULAWESI TENGAH TAHUN 2012
Media Penelitian dan Pengembangan Kesehatan Vol 23, No 3 Sep (2013)
Publisher : Badan Penelitian dan Pengembangan Kesehatan

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Abstract

Abstrak Tikus merupakan salah satu mamalia yang dapat menjadi sumber penularan di daerah endemis schistosomiasis. Telah dilakukan penangkapan tikus dengan perangkap di 22 daerah fokus keong yang tersebar di 6 desa di Dataran Tinggi Napu, Kabupaten Poso, Sulawesi Tengah untuk mengetahui tingkat infeksi Schistosoma japonicum pada tikus. Hasilnya menunjukkan bahwa tingkat infeksi pada tikus sebesar 22,7% (5/22), dimana tingkat infeksi pada Rattus norvegicus lebih tinggi dibandingkan dengan Rattus exulans. Uji statistik dengan Fisher exact menunjukkan bahwa ada hubungan antara spesies tikus dengan infeksi cacing Schistosoma japonicum (P = 0, 039). Pengendalian tikus sangat sulit dilakukan sehingga diperlukan kerja sama lintas sektor antara Kementerian Kesehatan, Pertanian, Kehutanan dan Taman Nasional Lore Lindu. Kata kunci: Schistosoma japonicum, tikus, Dataran Tinggi Napu Abstract Rat is one of the mammals that can be the source of transmission in endemic areas schistosomiasis. Rat collection was done by using trap in 22 foci that spread in 6 villages in Napu Highland, Poso District Central Sulawesi. This study was done to investigate the infection rate of Schistosoma japonicum in rats. The result showed that infection rate of Schistosoma japonicum in rats was 22.7% (5/22). The infection rate in Rattus norvergicus was higher then in Rattus exulans. Fisher exact test showed that there is a relationship between species of rats and  schistosomiasis infection (P=0.039). To control rat’s population is difficult, therefore to control the disease inter sectoral cooperation Ministry of Health, Agriculture, Foresty, and Lore Lindu National Park is needed. Key words: Schistosoma japonicum, rat, Napu Highland

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