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Journal of the Medical Sciences (Berkala Ilmu Kedokteran)
Published by Universitas Gadjah Mada
ISSN : 01261312     EISSN : 23563931     DOI : http://dx.doi.org/10.19106/JMedSci005303202101
Core Subject : Science,
Immunology & microbiology Neuroscience
Journal of the Medical Sciences (JMedSci) or Berkala Ilmu Kedokteran (BIK) is an international, open-access, and double-blind peer-reviewed journal, published by Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada Yogyakarta Indonesia. JMedSci aiming to communicate high-quality articles in the areas of biomedical science from basic to clinical sciences.The journal welcomes papers from original articles, case reports, reviews, and book reviews. All papers published in JMedSci are freely available as downloadable pdf files. The journal began its publication on March 1973 and published quarterly (January, April, July, and October). JMedSci is abstracted and indexed in DOAJ, Crossref, Google Scholar, Sinta, Indonesia One Search. JMedSci is accredited by Directorate of General Higher Education, the Ministry of Research, Technology, and Higher Education, Indonesia
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 20 Documents
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Search results for , issue "Vol 43, No 01 (2011)" : 20 Documents clear
The role of tumor-associated macrophages in breast cancer Irianiwati, Irianiwati
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 43, No 01 (2011)
Publisher : Universitas Gadjah Mada

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Abstract

Interaction of Tumor-Associated Macrophages (TAMs) with tumor cells gives insights into tumor progression andinto a novel therapeutic strategy. In papillary thyroid cancer, patients with tumors containing TAMs had a betterprognosis than patients without TAMs . In prostatic cancer, the reduced of total TAMs can be used as a novelprognostic marker. In melanoma maligna, high number of TAMs was statistically significant associated with poorresponse to treatment . In breast cancer progression, the role of TAMs is still unclear.Key words: tumor-associated macrophages - breast cancer – angiogenesis - tumor progression - prognosis
Lipid profiles and fibrinogen levels in coronary heart disease and dyslipidemic patients in Dr. Sardjito Hospital Yogyakarta Tri Hartati, Abdul Salam M Sofro, Pramudji Hastuti Tasmini, Radityo PA, Ahmad Husain Asdi
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 43, No 01 (2011)
Publisher : Universitas Gadjah Mada

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Abstract

Epidemiological studies indicated that fibrinogen and dyslipidemia were important risk factors for cardiovasculardisease (CVD). For several populations in theworld, increase in cholesterol level and decrease in high-density lipoproteincholesterol (HDL-C) were risk factors for coronary heart disease (CHD). The role of elevated fibrinogen in thrombosissuggests that it may be the causal pathway for certain risk factors of CHD. The aim of this study is to determine therole of lipid profile and fibrinogen level as risk factors of coronary heart disease. Blood samples were obtained fromCHD patients, dyslipidemic patients, and controls after they had fasted. Lipid profiles and fibrinogen level of CHDand dyslipidemic patients were determined and compared with controls. There were 92 subjects in this study,consisted of 35 CHD patients, 31 dyslipidemic patients, and 26 controls. There were significant difference intriglyceride level between CHD and dyslipidemic patients, also between dyslipidemic patients and controls (p<0.05).Significant difference in level of cholesterol also existed between CHD patients and dyslipidemic patients, alsobetween CHD patients and controls (p<0.05). In dyslipidemic patients, decreased in HDL-C level was risk factorfor CHD. Meanwhile for controls, high level of cholesterol and LDL-C also low level of HDL-C were risk factor forCHD, but fibrinogen level was not risk factor for CHD. In conclusion, lipid profile was risk factor for CHD whereasfibrinogen level was not risk factor for CHD.Keywords: lipid profile – fibrinogen - coronary heart disease - dyslipidemia
Distal embolization durante percutaneous coronary intervention: a case report Betty Dwi Lestari, Budi Yuli Setianto
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 43, No 01 (2011)
Publisher : Universitas Gadjah Mada

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Abstract

Distal embolization is an acute complication of percutaneous coronary intervention (PCI). Distal embolization ofplaque and thrombus material is considered as a major cause of insufficient reperfusion despite a fully patent infarctrelatedartery, apart from ischemic microvascular damage and reperfusion-induced regional inflammatory responses.In a recent study, angiographic evidence of distal embolization was associated with an 8-fold increase in 5-yearmortality.We reported on our experience with distal embolization durante PCI which lead the patient developed STElevationMyocardial Infarct (STEMI) inferior and posterior accompanied with severe chest pain and was treated inthe Intesive Coronary Care Unit (ICCU). Distal embolization is the case that we should be put into our awarenessbecause it can worse the after procedural outcome.Key words: distal embolization-percutaneous coronary intervention-insufficient reperfusion- myocardial ischemiaangiographic
The difference of Natural Killer cell activities of the people live in the aircraft noise area of Adi Soemarmo Airport Boyolali, Surakarta, Indonesia Hartono, Hartono
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 43, No 01 (2011)
Publisher : Universitas Gadjah Mada

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Abstract

Exposure to noises contributes to a health risk. There is sufficient scientific evidence that noise exposure couldinduce hearing impairment, hypertension and ischemic heart disease, annoyance, sleep disturbances, and decreasedschool performance. Other evidence as changes in the immune system and birth defects is limited. The aims of thisstudy is to find out the difference of Natural Killer (NK) cell activities of the people live in the aircraft noise area ofAdi Sumarmo Airport, Boyolali, Surakarta, Indonesia. The research design was an analytical with a cross sectionalapproach, taking location at the Dibal and Gagak Sipat Villages, Ngemplak Sub district, Boyolali District. The studywas conducted from June 2008 to June 2009. The number of subjects involved was 39. They were divided into 3groups. Group 1 was exposed to 52.17 dB of noise level (13 respondents). Group 2 was exposed to 71.79 dB ofnoise level (13 respondents), and Group 3was exposed to 92.29 dB of noise level (13 respondents). The cytotoxicitiesof NK cells was measured by flowcytometric and using a non-radioactive method. The samples were taken using asimple random sampling. The data were analyzed by Anova followed by Post Hoc Test using LSD test completedwith Homogenous Subsets. The results showed that the activity of NK cells of Group 1, 2 and 3 were 12.50 +3.25%,17.20 3.06%, and 22.33 6.30 %, respectively. The Anova test showed that there was a significantdifference of NK cell activities, in the groups of respondents (p =0.000). In conclusion, there was a significantdifference of the NK cell activities of the people live in the aircraft noise area of Adi Sumarmo Airport, Boyolali,Surakarta, Indonesia.Key words : noise-immune system-flowcytometric-blood mononuclear cells-health risk
Association study of LMP-1 expression and promoter methylation status of tumor suppressor gene RASSF1A in nasopharyngeal carcinoma Harijadi, Rina Susilowati, Ageng Brahmadhi Susanna Hilda Hutajulu, Dewi Kartika
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 43, No 01 (2011)
Publisher : Universitas Gadjah Mada

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Abstract

Nasopharyngeal carcinoma (NPC) is a cancer originating fromnasopharyngeal epithelial tissue. Genetic susceptibility,exposure to carcinogens, and Epstein-Barr virus (EBV) infection are the main factors in NPC development. Latentmembrane protein 1 (LMP-1) is a product of EBV genome, which is able to interact with various intracellular signalingpathways that leads to expression of many proteins, e.g DNA methyltransferase. The increase expression of DNAmethyltransferase could induce hypermetylation of tumor suppressor genes (TSG). Ras-association domain family1A (RASSF1A) is one of TSG that frequently hypermethylated in NPC cases. The aim of this study is to determinethe association between LMP-1 expression and promoter methylation status of RASSF1A in NPC patients. Theresearch subjects were 36 NPC patients of the Dr. Sardjito Hospital, Yogyakarta, Indonesia. Latent membraneprotein 1was stained immunohistochemically using monoclonal antibody OT21C. Ras-association domain family 1Amethylation statuswas examined by methylation specific PCR (MSP) of DNA isolated fromnasopharyngeal brushing.Chi-square analysis was conducted to examine the association between LMP-1 expression and methylation status ofRASSF1A with 95%confidence interval. Latent membrane protein 1 was expressed in 44.4%subjects. The scoresof LMP-1 expression were ranged from 0-8 (average of 1.56±2.16). Ras-association domain family 1A methylatedin 66.7% of subjects. Statistical analysis showed that there was a relationship between LMP-1 expression andmethylation status of RASSF1A (p<0.05). Statistical analysis also showed association between LMP-1 expressionscore and RASSF1A methylation status (p<0.05). It can be concluded that there was an association between theexpression of LMP-1 and RASSF1A methylation status in NPC patients.Keywords: LMP1 - RASSF1A – NPC – hypermethylation - DNA methyltransferase - methylation specific PCR
Agreement between ultrasonography and histopatologic findings in diagnosing retinoblastoma Natliani, Fitria
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 43, No 01 (2011)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Retinoblastoma is a rare eye tumor of childhood that represents the most common intraocular malignancy ofinfancy and childhood. Diagnosis of retinoblastoma are based on ophthalmological examination and imaging, includingultrasonography (USG). In a typical case of retinoblastoma, it will provide a nearly pathognomonic picture withcottage-cheese calcification, with density higher than the sclera and high internal reflectivity in USG findings.Histopathologic examination is a gold standard formalignany cases and Flexner-Wintersteiner cells is a pathognomonicsign. The aim of this study is to determine the value of an agreement test comparing USG as a preoperativediagnostic tool with histopatologic examination in diagnosing retinoblastoma. This study was an observationalagreement test. All of the patients with clinically suspected intraocular lession were examined with USG followedby surgery and histopathologic examination in Eye Clinic of Dr. Sardjito Hospital, Yogyakarta. The result of USGexaminationswas interpreted by one eye oncologist and the histopathologic readingwas performed by one anatomicalpathologist. Data were analyzed to determine the agreement value. Thirty three eyes, 21 eyes were retinoblastomasuspected and 12 eyes were non-retinoblastoma suspected based on USG examination), were observed in thisstudy. One eye (3.03%) was false positive case and 1 was false negative case. The Kappa value of agreement testwas 0.87. In conclusion, ultrasonography of the eye as a pre-operative diagnostic tool had an excellent agreementcompared with histopathological examination as a gold standard in retinoblastoma.Key words: eye-retina-intraocular malignancy-diagnosis-Kappa value
Relation between -carotene and ferritin upon malondialdehyde in Javanese male smoker Sunarti, Naomi Yoshuantari Ahmad Hamim Sadewa
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 43, No 01 (2011)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Smoking of cigarette can cause additional free radicals. Oxidative damage is resulted from the accumulation of freeradicals in the body. Malondialdehyde (MDA) is the end product of free radicals, a marker of oxidative damage. -carotene is pro-vitamin A, an antioxidant known to quench singlet oxygen. Ferritin is thought to release excessiveiron in smokers, thereby increasing the oxidative stress. The aim of the study is to evaluate the relation between -carotene and ferritin toward MDA level in Javanese smokers. This study was carried out in a case-control, crosssectional design nested with cluster sampling. Participants were Javanese smokers and non-smokers in Purworejodistrict, Central Java. Samples and data were obtained secondarily. The results were analyzed using independentsamples t-test and linear regression. The results showed that there was very weak negative correlation between -carotene with MDA (R square=0.013; p value=0.320) and very weak positive correlation between ferritin withMDA (R square=0.043; p value=0.067). There was no statistically significant relation of -carotene with MDA.Ferritin level was marginally influential upon MDA level as the marker of lipid peroxidation between smokers andnon-smokers. Aging apparently became the confounding variable by influencing the lipid peroxidation more efficientlythan smoking itself (p = 0.013). In conclusion, there was no significant relation between -carotene and ferritinwith MDA in smokers.Key words : smoking – cigarette – β-carotene – ferritin – malondialdehyde
Association between environmental allergen sensitization with severity of atopic dermatitis in children and young adult at Dr. Sardjito General Hospital, Yogyakarta Brahmanti, Herwinda
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 43, No 01 (2011)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

The important role of aeroallergens and food allergens as the most common environmental allergens in exacerbationof atopic dermatitis (AD) iswell known. Sensitization is an essential processwhich correlateswith clinicalmanifestationof AD. The study of AD in Indonesia, especially in Yogyakarta, has not been reported, yet. The aim of study is toevaluate the association between sensitization of environmental allergens with clinical severity of AD in children andyoung adult at Dr. Sardjito General Hospital, Yogyakarta. An analytic observational cross sectional study wasperformed on 33 children and young adult with AD. The severity of disease was determined by SCORing AtopicDermatitis (SCORAD). Assessment of sensitization was performed using specific IgE serum, atopy patch test, andprick test. Data were analyzed using chi-square or Fisher exact test and prevalence ratio (PR) with significancevalue of p<0.05 and 95%confidence interval (CI). The results showed that specific IgE positivity was associatedwith severity of AD. Percentage of specific IgE positivity to house dust mite was significantly higher in subject withmoderate/severe AD compared to those of mild AD (p=0.049; PR 1.13; 95% CI 1.01-1.59). The result was alsosimilar for cat dander (p=0.041; PR 1.1; 95%CI 1.09-4.98), cow’s milk (p=0.038; PR 1.21; 95% CI 1.02-2.2),and egg white (p=0.027; PR 1.23; 95% CI 1.15-2.97). Whereas specific IgE positivity to fish allergen was notstatistically different in subject with moderate/severe AD compared to those with mild AD (p=0.061; PR 0.8; 95%CI 0.76-2.8). According to atopy patch test and prick test result, no association was found between allergensensitization and severity of AD. If allmethodswere combined to increase the sensitivity of sensitizationmeasurement,then the association was found for all allergens. It could be concluded that environmental allergens sensitization isassociated with severity of AD in children and young adult at Dr. Sardjito General Hospital, Yogyakarta.Key words: atopic dermatitis-disease severity-sensitization-aeroallergen-food allergen
Iterleukin-4 and interferon-in allergic contact dermatitis with atopic background in leather tannery factory worker H Kariosentono, S Widhiati AS Siswati
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 43, No 01 (2011)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Abstract

Immune response in allergic contact dermatitis (ACD) patient is dominated by T helper-1 (Th-1) response characterizedwith increase in interferon gamma (IFN-). However, in atopic individual, the immune response is dominated by Thelper-2 (Th-2) response which characterized with the presence of interleukin-4 (IL-4). Based on that condition, it ishypothesized that atopic individual was hardly to develope ACD. In leather factory, many workers are prone todevelope ACD. The aim of this study is to differentiate the cytokine profiles of IL-4 and IFN-of ACD patients withor without atopic background. Using a cross-sectional design, this study involved 30 subject assigned into twogroups, one group consisted of 15 subjects with ACD who had atopic background (ACD atopic), the other groupconsisted of 15 subjectswith ACD who had no atopic background (ACD non atopic). Both groups were examined bypatch test and confirmed to have ACD when the result was minimally+1 in 48 and/or 96 hours examination. Atopicskin diathesis score 8 was used to determine the possibility of having atopic background. Serum IL-4 and IFN-concentrationwere determined using ELISA. Data were analyzed using SPSS with Mann-Whitney non- parametrictest. The results showed that the mean value of IL-4 in both groups were 0.18±0.14 pg/mL and 0.25±0.29 pg/mL (p=0.917) whereas the mean value of IFN- in both groups were 13.03 ±23.90 pg/mL and 2.76±5.67 pg/mL, (p=0.096). In conclusion, the cytokine profiles of IL-4 and IFN-were not significantly different between ACDatopic and ACD non atopic individuals. This finding suggested that atopic and non-atopic individuals had a similarimmunologic response during development of ACD.Key words: immunologic response-cytokine-occupational contact dematitis-T helper-patch testing
Collagen synthesis on ultraviolet A irradiated human skin fibroblast treated with insulin Yohanes Widodo Wirohadidjojo, Febrina Rismauli Panggabean Satiti Retno Pudjiati
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 43, No 01 (2011)
Publisher : Universitas Gadjah Mada

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Abstract

Ultraviolet (UV) irradiation from the sun can stimulate premature skin aging because UV irradiation inhibits collagensynthesis, promotes collagen degradation and inhibits fibroblast proliferation. Insulin is capable to stimulate fibroblastgenes collagen expression, DNA synthesis, and collagen synthesis. The effect of insulin in reducing collagen synthesisamong repeated-UVA irradiation on human skin fibroblast has never been studied. This study aims to investigate theeffect of insulin in collagen synthesis among repeated-UVA irradiation on normal human skin fibroblast. To asses thecollagen synthesis collagen degradation, collagen deposition and fibroblast proliferationweremeasured. Experimentalstudy was performed among passage 3 of fibroblast which was isolated from a circumcised skin of a 6-year-old boy.Fibroblasts were irradiated with 3 repeated exposurewith total cumulative dose 9000 mJ/cm2 and treated withinsulin 0.5; 1; 2 μg/mL and placebo. Cellswere then incubated for 48 hours, collagen degradation, collagen depositionand fibroblast proliferation were read colorimetric by using Spectroscopy 550 nm. The effect of insulin 0.5; 1 and2 ìg/mL in collagen synthesis among repeated-UVA irradiation on normal human skin fibroblast with cumulative dose9000 mJ/cm2 was not capable to reduce collagen degradation, nor capable to increase collagen and fibroblastproliferation. Insulin dose 0,5 μg/ml-2 μg/ml among repeated-UVA irradiation on normal human skin fibroblast wasnot capable to increase collagen synthesis.Key words: photoaging-DNA synthesis-proliferasion-aging process-gene expression

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