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Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Published by Universitas Gadjah Mada

ISSN : 01261312 EISSN : 23563931 DOI : http://dx.doi.org/10.19106/JMedSci005303202101

Core Subject : Science,

Immunology & microbiology Neuroscience

Journal of the Medical Sciences (JMedSci) or Berkala Ilmu Kedokteran (BIK) is an international, open-access, and double-blind peer-reviewed journal, published by Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada Yogyakarta Indonesia. JMedSci aiming to communicate high-quality articles in the areas of biomedical science from basic to clinical sciences.The journal welcomes papers from original articles, case reports, reviews, and book reviews. All papers published in JMedSci are freely available as downloadable pdf files. The journal began its publication on March 1973 and published quarterly (January, April, July, and October). JMedSci is abstracted and indexed in DOAJ, Crossref, Google Scholar, Sinta, Indonesia One Search. JMedSci is accredited by Directorate of General Higher Education, the Ministry of Research, Technology, and Higher Education, Indonesia

Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)

Articles 34 Documents

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Search results for , issue "Vol 50, No 1 (2018)" : 34 Documents clear

Effect of exercise on lipid peroxidation in student soccer players Desty Ervira Puspaningtyas; Yuni Afriani; Silvi Lailatul Mahfida; Wara Kushartanti; Arta Farmawati
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 50, No 1 (2018)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Training is conducted to improve physiological functions that can support improvementof cardio-respiratory function (O2max). However, intensive training can lead to oxidativestress, which can contribute to health problems. The purpose of this study was to evaluatethe effect of training on serum lipid peroxidation levels in student soccer players. Thestudy was pre-experimental study with a one-shot case design conducted in April 2014.Twelve student soccer players from UGM who chosen by purposive sampling and metthe inclusion and exclusion criteria were involved in the study. Each subject receivedtraining in the form of O2max measurements using the yo-yo intermittent recovery test.Plasma malondialdehyde (MDA) levels were measured using the thiobarbituric acidmethod 30 min after O2max measurement. Pearson correlation was used to analyzethe correlation between O2max and plasma MDA levels. The mean age of subject was19.25±1.06 years old. Subjects had normal nutritional status (body mass index 20.99± 1.65) with mean body weight of 58.13±3.76 kg and mean height of 166.2±3.40cm. The mean O2max score was 49.56±0.61 mL/kg/min. The mean plasma MDA levelwas 4.32±2.09 μmol/L. There was no significant correlation between O2max and plasmaMDA levels (p=0.7717). In conclusion, training does not negatively impact oxidativestress conditions in student soccer players.

The quality of live of patients’ allegic rhinitis after posterior nasal neurectomy at Dr Sardjito General Hospital Yogyakarta, Indonesia 2016 Wahyu Dwi Kusdaryanto; Windarti Isminarsih; Luh Putu Lusy Indrawati
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 50, No 1 (2018): SUPPLEMENT
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Allergic rhinitis (AR) is disease by incidence and prevalence of high and is expected to rise to load against the economy and lowering the quality of life of patients.with AR involved many factors and an impact of highly significant on the quality of life and affect the economy. The quality of life patients done to assess the effects and result of surgery.Sino nasal outcome test-20 ( snot-20 ) was one of the instruments specific measurement the quality of life of patients AR. 10 patients who surgery action , obtained improving the quality of life based on snot- 20 observed 28 days after done the act of surgery. Rate the SNOT-20 before surgically obtained 37,3 with DS ± 7,87 and 28 days after done surgically obtained rata-rata snot-20 is 6 with DS ± 2,49. The SNOT-20 pre and post action there are different of significant (p = 0,024 ) .

Coronary Artery Calcium Score Improved Cardiovascular Disease Risk Prediction in Asymptomatic Patients I Md Ady Wirawan; Rodney Wu; Malcolm Abernethy; Sarah Aldington; Peter Larsen
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 50, No 1 (2018): SUPPLEMENT
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

This study examined whether coronary artery calcium score (CACS) has a betteraccuracy than the cardiovascular risk prediction chart (CRPC), and evaluate thereclassification improvement of CACS if it isused as a screening tool compared withthe CRPC. CACS has a better accuracy than the CRPC and reclassified a considerableproportion (39%) of a symptomatic patient into correct cardiovascular risk categories.CACS should be assessed in asymptomatic people with5-year CVD risk score of5-10% and 10-15%.

Village based information display of health facility data and public awareness of Dengue Hemorrhagic Fever: a lesson from Mlati Primary Health Care Center of Yogyakarta Province Setyaningrum, Veronika Evita; Purwandari, Ari; Sudiyo, Sudiyo; Hasanbasri, Mubasysyir
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 50, No 1 (2018): SUPPLEMENT
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Public health agencies concern about the disease contraction processes at the population level. Early detection and prompt treatment can be made to prevent transmission in the earliest stage. Understanding that their areas are endemic to DHF and the fact that cases continue to occur from year to year, community and public health stakeholders have a reduced motivation to take actions to have precaution to dengue. The village community will not be aware of the problems until patients from their areas visit health facility. The goal of this paper is to illustrate health center initiative to raise DHF precaution through village based spatial data display of dengue for the villagers attention in raising agenda in the management of dengue hemorrhagic fever at the level where they live. The paper points out the success story of the team of health facility manager, active public health program managers, an information technology literate administrators, and participation of local and private health workers asking DHF suspects to have their blood test in the health center. Supporting staff with health informatics training background has been able to work together with laboratory workers. The laboratory workers input the computer application that translate patient thrombocyte count data into village based geographic-spatial display. These data provide quick evidence about what is happening in the population. Puskesmas manager has the MPH training with population health perspective and the moral of public health problem solving. By having this data, she could make the health promotion actions at the population level. This paper shows the ability of health center manager to link health facility data and the population level evidence for public health action. The data can be used to trigger community be aware of DHF and to raise agenda in the prevention of local diseases. This is an easy and feasible things to do. Primary care and public health are under the common responsibility of the puskesmas managers. It is clear that data of health facility serve as the warning system of disease contracting process at the population level and the promotion of simple evidence to push community to get involved in prevention activities.

Effectiveness of Pyridoxin in Reducing Symptoms of Anxiety Pre Menstrual Syndrome in Adolescent Siti Nurunniyah; Eva Nurinda
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 50, No 1 (2018): SUPPLEMENT
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Pre Menstrual Syndrome (PMS) affects women’s quality of life, social and economic performance. The other study discovered that 23- 31 % of reproductive aged women experience PMS to a degree that affects their daily acivity Symptoms of Pre Menstrual Syndrome (PMS) are divided into 4 types, namely type A for Anxiety (Anxiety), type C for Craving (Hungry), type D for Depression and Type H for Hyperhydration (Liquid Stockpiling). Type A is commonly unrecognnized in indonesia. Symptoms of type A consist of anxiety, irritability, labilty and nerves tense. So it is important to know how to reduce the symptoms This study aims to determine the effectiveness of pyridoxin in reducing symptoms of Pre Menstrual Syndrome (PMS) and type of symptoms that can be most resolved. There is an effect of using pyridoxine to reduce PMS. It is known from the significance value of t-test that is 0.000. The type of PMS with the highest symptom reduction is in PMS Type A (Anxiety), because pyridoxine can increase stability estrogen and progesterone activity. Anxiety Pre Menstrual Syndrome probably caused by unstable hormone.

Comparison of Bcl-xL protein expression in placental trophoblast cells between pregnancy complicated by severe preeclampsia and normotensive pregnancy Diah Rumekti Hadiati; Arsi Palupi; Mohammad Hakimi; Sofia Mubarika Haryana
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 50, No 1 (2018)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Preeclampsia is one of the main causes of maternal and perinatal mortality and morbidity.The pathogenesis of preeclampsia remains unclear until now. It is believed thatregulation of apoptosis in trophoblast cells plays an important role in the pathophysiologyof preeclampsia. Failure of spiral arteries remodeling will eventually lead to placentalhypoxia lead to excessive trophoblast apoptosis. The molecular mechanism of apoptosisis very complicated involving many signaling molecules included Bcl-2 proteins. The Bcl-2 protein group consists of proapoptosis proteins (Bax) and apoptosis inhibitor proteins(Bcl-2 and Bcl-xL). The aimed of this stuty was to compare the expression of Bcl-xLprotein in placental trophoblast cells of pregnancy complicated by severe preeclampsiawith that normotensive pregnancy. This study was an observational study with crosssectional design involving 43 pregnancy patients with severe preeclampsia and 38normotensive pregnancy who treated in Dr. Sardjito General Hospital, Yogyakarta fromOctober 2011 until March 2012. Placenta samples were obtained from all subjects forBcl-xL protein expression analysis using immunohistochemistry technique. Data wereanalyzed using independent t-test, chi-square test, and logistic regression. A p value<0.05 was considered significant. Significant difference in Bcl-xL protein expressionin trophoblast cells of pregnancy complicated by severe preeclampsia (1.29 ± 0.12)compared to that normotensive pregnancy (1.71 ± 0.14) was reported (p = 0.00). Inaddition, logistic regression test showed that diagnosis of severe preeclampsia had astatistically significant role in Bcl-xL protein expression (p= 0.000). In conclusion, theexpression of Bcl-xL protein is lower in pregnancy complicated by severe preeclampsiacompared to normotensive pregnancy.

The influence of acetylation status of tuberculosis patients on the isoniazid serum concentrations and sputum conversion after intensive phase therapy Dwi Indria Anggraini; Erna Kristin; iwan Dwiprahasto
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 50, No 1 (2018)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Isoniazid (INH), one of the major antituberculosis drugs, is metabolized by acetylation. Previously study proved the significant differences of serum INH concentration between subject with fast and slow acetylation status. However, the correlation of acetylation status with treatment outcome after fixed-dose combination antituberculosis therapy (FDC-ATT) was not explained. The aim of this study was to evaluate the influence of acetylation status on the treatment outcome and the serum INH concentrations in the adult tuberculosis patients underwent FDC-ATT. A cross sectional study was carried out on 31 tuberculosis patients. Acetylation status was measured by spectrophotometer and serum INH concentration was measured by high performance liquid chromatography (HPLC). Sputum conversion assay was conducted by Ziehl Nelsen method. t-Test, chi square, Mann-Whitney, and Fisherman were used to analyze the data. The proportion of the fast acetylator was 61.3%, whereas the slow acetylator was 38.7%. The proportion of success and failure sputum conversion were 83.9% and 16.1%, respectively. The mean serum INH concentration in the fast acetylator groups (1.52 ± 0.15 μg/mL) was significantly lower than that in the slow acetylator groups (3.84 ± 0.35 μg/mL). The failure conversion risk of the fast acetylator group was about two folds higher than the slow acetylator group, although it was not significantly different (RR=2.53; 95% CI=0.32-20.00; p>0.05). Moreover, the mean serum INH concentration in success (2.46 ± 0.31 μg/mL) and failure (1.89 ± 0.20 μg/mL) sputum conversion was not significantly different (p>0.05). In conclusion, the acetylation status does not influence the sputum conversion in adult tuberculosis patients after FDC-ATT although the serum INH concentration on slow acetylation status is higher than that fast acetylation status.

Immunohistochemical Profile Of Breast Cancer Patients On Oncology Department, Moewardi Hospital, Surakarta, Indonesia Dian Ibnu Wahid; Kristanto Yuli Yarsa
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 50, No 1 (2018): SUPPLEMENT
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Immunohistochemical is used to show hormone receptors on their surface. The aim of this study were to find information about immunohistochemical profile of breast cancer patient on oncology department, Moewardi Hospital, Surakarta Indonesia. A total 1.395 cases of breast carcinoma with Her2 profile were reviewed. The mean age of the patients was 45.7 (Ranged 23-73 years old). At time of diagnosis 739 (53%) patients were under 50 years of age. In this group the frequency of Her2 positive was higher than other. The incidence of patients above 50 years of age were significancy higher in Her2 positive with 363 (47%). Ductal invasive carcinoma is the most common type of breast carcinoma (86.9%). HER-2 Positive subtype was the most common subtype in the woman breast carcinoma (43.6%), which was followed by Basal like (31.3%), Luminal A (16.8%) and (8.3%). For tumor grading, the highest on G3 with the results 764 (54.7%). G3 got the highest results on Her2 positive with 535. We just divide the type of tumor consist of three parts (ductal, lobular, and other). In tumor type obtained the most data on ductal carcinoma with 878 (63%).

Comparison of Quality of Life For Breast Conserving Surgery And Mastectomy In Early Stage Breast Cancer In Breast Cancer Survivors Community Dian Ibnu Wahid; Kristanto Yuli Yarsa
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 50, No 1 (2018): SUPPLEMENT
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Breast cancer surgery can impact patients psychologically as well as organically, which can manifest as Quality of life (QOL). Thirty patients, the age ranged between 25 and 60 years and the mean age 41 years. Twenty seven patients have married, a widow, and two unmarried. There was not found a difference in health related quality of life. No differences were seen in level of pain, skin sensitivity and related problems in surgical area. Woman in mastectomy group reported stastitically more problem with their body image. Beyond that, they also have a complaint about the feelings of sexual attractiveness than woman in breast conserving surgery (BCS). Women undergoing breast conserving surgery experience more positive outcomes than women undergoing mastectomy. Women in the mastectomy groups also reported experiencing more physical problems related to their surgery. The score of CES-D is above 16 both breast conserving surgery’s group and mastectomy’s groups. Higher scores are associated with more symptoms. There were also no differences seen among them as measured by the MOS, four main poins consists of emotional support, real support, affection support and good social interactions. There were also no differences seen among them as measured by the RDAS consists of three aspects (concensus, satisfaction, cohession). This can happen because the doctors give well support and education to all patients. Despite, the patients, their families, their partners also give support each other. The women sight of their body images was considered making well social interaction. Most of the study showed the declining of social interactions after the surgery. This happened beacuse they were apprehensive about rejection in social life.

Severity and treatment level of acute gastroenteritis with rotavirus in children under 5 years in INDONESIA Fatma Othman Gdara; Jarir At Thobari; Yati Soenarto
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 50, No 1 (2018)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Rotavirus diarrhea causing gastroenteritis in children under five years is an importantissue that urgently needs to be addressed globally. Delay in management of rotavirusdiarrhea can be fatal. Diagnostic tool for detecting rotavirus is, therefore, needed.However, until now the gold standard diagnostic tools are expensive, often not availableand affordable in health care settings. The aim of the study was to compare the Vesikariclinical severity score of rotavirus-positive with rotavirus-negative in hospitalized childrenwith acute gastroenteritis. Furthermore, the difference of the level of treatment betweenrotavirus-positive with rotavirus-negative was also evaluated. This was a cross sectionalstudy that using secondary data from medical records of five general teaching hospital inIndonesia. Subjects were children aged <5 years with acute watery diarrhea admitted tothe hospital. Statistical analysis used was chi square test, U-Mann Whitney, and KruskalWallis. The results showed that the patient with rotavirus positive have higher dehydration(80.2%) compared to rotavirus negative (70%). The severity level of clinical feature washigher in diarrhea due to rotavirus positive than non rotavirus (11.47± 2.89 vs 10.41± 2.70; p<0.000). The level of treatment was higher in rotavirus positive. The majorityhad treatment plan C (47.7%) higher than plan B and A (45.6% and 30.9%; p<0.050).This was opposite with patient with rotavirus negative that majority had treatment inplan A (69.1%) higher than plan B and C (54.4% and 52.3%) (p<0.001). In conclusion,the severity of gastroentrities in children under 5 years using vesikari score are higher indiarrhea due to rotavirus positive than non rotavirus. The treatment level plan C is higherthan plan B and A in diarrhea due to rotavirus. This is opposite with non rotavirus majorityhave treatment in plan A higher than plan B and C.

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Home Page

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Contact Name Nurhadiyahya

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Location Kab. sleman, Daerah istimewa yogyakarta INDONESIA

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Contact Name
Nurhadiyahya

Contact Email
nurhadiyahya@ugm.ac.id

Phone
+6289672800034

Journal Mail Official
jmedscie@ugm.ac.id

Editorial Address
https://jurnal.ugm.ac.id/bik/about/editorialTeam

Location
Kab. sleman,

Daerah istimewa yogyakarta

INDONESIA