Garuda - Garba Rujukan Digital

p-Index From 2020 - 2025

1.203

P-Index

This Author published in this journals

All Journal Tropical Medicine Journal Jurnal Kesehatan Masyarakat Indonesia Jurnal Kebijakan Kesehatan Indonesia Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Pharmaciana: Jurnal Kefarmasian Jurnal Sains dan Teknologi Farmasi Indonesian Journal of Biotechnology JMMR (Jurnal Medicoeticolegal dan Manajemen Rumah Sakit) INDONESIAN JOURNAL OF PHARMACY Syntax Literate: Jurnal Ilmiah Indonesia PREPOTIF : Jurnal Kesehatan Masyarakat JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Jurnal Manajemen Pelayanan Kesehatan (The Indonesian Journal of Health Service Management) Indonesian Journal of Pharmacology and Therapy

Erna Kristin

Fakultas Kedokteran Universitas Gadjah Mada

Author-ID : 260539

Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Public Health Social Sciences Other

Published : 27 Documents Claim Missing Document

Claim Missing Document

Articles

1 2 3

The influence of Ferrous Sulphate @ 300 mg ingestion shortly after meal and 2 hours after meal on pharmacokinetic profiles of iron in serum sample in women with Hb 2 12 g/dL Erna Kristin, Erna Kristin
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 37, No 04 (2005)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (160.738 KB)

Background: Iron absorption is determined by iron status, heme- and nonheme-iron contents and amounts of various dietary factors that influence iron absorption. Few studies have examined the influence of food to iron absorption but only limited information is available about the net effect of these factors.Objectives: Objective of this study was to know the influence of Ferrous Sulphate @ 300 mg ingestion shortly after and 2 hours after meal on pharmacokinetic profiles of iron in serum sample in 12 women with Hb >_ 12 g/dLMethods: The study was carried out in a cross over design in which each of participants underwent 2pharmacokinetic studies. One tablet of Ferrous Sulphate @ 300 mg was taken by each subject shortly after and 2 hours after standard meal at the first and second study. Series of serum samples were taken at0, 0.25, 0.5, 1, 1.5, 2, 2.5, 3, 4, 6, 8, 10, and 12 hours after iron administration. The concentrations of ferric iron in serum were measured using Vitors Fe Slides System, while pharmacokinetics parameters were calculated using a non-compartmental method.Results: Pharmacokinetic parameters obtained from the first and second study were compared using t test with the following results (meant SEM): C,,,Â 275.92 Â± 28.97 & 284.58 Â± 30.44 ug/dL, T.3.50 Â± 0.29& 3.50 Â± 0.38 hours, K. 0.3235 t 0.0011 & 0.3816 Â± 0.0010 hours-, Ka, 0.1138 Â± 1.5696 & 0.1152 Â±1.3331 hours T,201 7.80 Â± 1.45 & 7.03 Â± 1.02 hours and AUCo-12 2493.43 Â± 397.54 & 2331.15 Â± 283.64 ug/dL.hours. No difference of all pharmacokinetic parameters were detected by intervention typeConclusions: It can be concluded that after ingestion of Ferrous Sulphate @ 300 mg in women with Hb 12 ug/dL shortly after and 2 hours after meal did not show significant diferrences on pharmacokinetic profiles of iron in serum sampleKey words: iron absorption - pharmacokinetic - ferrous sulphate - absorption rate - Cmax

Serum iron level after ingestion of repeated dose of iron shortly after and 2 hours after meal Sri Kadarsih Soejono, Lukman Hakim, Erna Kristin, Mohammad Hakim,
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 41, No 04 (2009)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (179.484 KB)

Background: The prevalence of iron deficiency anemia in pregnant women is estimated to be higher than nonpregnant women. Ironsupplementation program has been proven clinicallyto improvethe hemoglobin (Hb)level of pregnant women. The absorption of iron is affected by food, therefore iron has to be given 2 hours after meal. However, in practice, iron was given shortly after meal. The physiologicalchange in pregnant women affects drug absorption, distribution, and eliminationphases. Objective: To understand serum iron level after ingestion of repeated dose of iron shortly after and 2 hours after meal for 12 weeks in trimester 2 pregnant women with iron deficiency anemia. Method: The research design was a phase IIclinical trial. Subjects were 24 trimester 2 pregnant women with iron deficiency anemia, classified into two groups, who were treated as follows: The first group was consisted of 12 women with irondeficiency anemia, treated with twice-a-day ferrous sulphate tablet @300 mg orally,given shortly after meal for 12 weeks; the second group was consisted of 12 women with iron deficiency anemia, treated with twice-a-day ferrous sulphate tablet @300 mg orally, given 2 hours after meal for 12 weeks. Bloodsamples were taken in week 2, 4, 6, 8, 10, and 12 after treatment. Serum (ferric) iron level was measured with Vitros Fe Slides method. Result: Minimum,maximum, and average steady-state ironlevels (Css min, Css max, Css average) of treatment 1 were 104.1 ::I:14.03 ug/dL, 96.44::1:13.22 ug/dL, and 112.38::1:14.03 ug/dL (mean ::I:SEM),respectively; while minimum, maximum, and average steady-state iron levels (Css min, Css max, Css average) of treatment 2 were 125.77::1:9.31 ug/dL, 118.03::1:9.21 ug/dL, and 125.77::1:9.31 ug/dL (mean::l:SEM),respectively. No statistical significant difference was found within treatment in minimumsteady-state level between week 2, 4, 6, 8, 10, 12 after treatment. There was also no significant difference in minimumsteady-state level between treatment groups in week 2, 4, 6, 8, 10, and 12. Conclusion: There were no differences in serum iron level after ingestion of repeated dose of ironshortly after and 2 hours after meal for 12 weeks intrimester 2 pregnant women with iron deficiency anemia.

CYP3A4*1G gene Polymorphism on Javanese People Sutrisna, Em; Dwiprahasto, Iwan; Astuti, Indwiani; Kristin, Erna
Indonesian Journal of Biotechnology Vol 16, No 2 (2011)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (43.035 KB)

AbtractMost of drugs are metabolized by cytochrome P 450 (CYP) enzyme. Cytochrome P450 3A4 is the cytochrome that is involved in metabolizing more than 60% of all medicine used in human. The variation of this CYP3A4 gene will affect the catalytic activity of this enzyme. Recently, CYP3A4*1G in intron 10 was found in Chinese and Japanese population. There is a substitution of G to A at position 82266 in intron 10. The purpose of this research was to investigate the frequency of allele and genotype CYP3A4*1G. Samples were taken from bloods of the subjects of the research. The examination of CYP3A4*1G was conducted by RTLP-PCR method.As the results of this research, the frequency of CYP3A4*1G in Javanese people is CYP3A4*1/*1 0.25, CYP3A4*1/*1G 0.55 and CYP3A4*1G/*1G 0.20. Frequency of allele G: 0.53, allele A: 0.47. The Fisher’s exact- test shows that the allele and genotype frequencyis p. 1.000. The allele and genotype frequency of Javanese people isstill in Hardy-Weinberg equilibrium.Keywords : CYP3A4*1G gene, polymorphism, Javanese people

Uji Aktivitas Antioksidan Minyak Buah Merah (Pandanus Conoideus Lam.) Secara In Vitro dan In Vivo pada Tikus Yang Diberi Beban Aktivitas Fisik Maksimal Sandhiutami, Ni Made Dwi; Ngatidjan, Ngatidjan; Kristin, Erna
Jurnal Sains dan Teknologi Farmasi Vol 15 No 1 (2010)
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar

Increasing oxygen consumption during intensive physical exercise may increase production of free radicals, and if it exceeds physiological capacity may cause oxidative stress as shown as chance of MDA level. Buah merah oil contains high betacarotene and tocopherol, as well as fatty acid such as oleic acid, linoleic acid, linolenic acid and decanoic acid. Tocopherol is major biological lipid-soluble antioxidant, protecting structures and function of cell membranes from free radicals. The objective of this study was to know in vitro antioxidant activity and the effect of buah merah oil on MDA level in blood during maximum physical activity treatment. In vitro antioxidant activity test was conducted using DPPH method (2,2-diphenyl-1-picryl hydrazyl). In vivo antioxidant activity test was done by using 24 male Wistar rats in pre - post test control group design. The rats were grouped into 4 groups. The control group was given destillated water and three treatment groups were given buah merah oil in the dose of 0,15 ml/kgBW; 0,3 ml/kgBW; 0,6 ml/kgBW respectivelyfor 10 days. Before buah merah oil was given, level of MDA was measured. Ten days later, the four group were given maximum physical activity mean of swimming until the sign of fatigue occurred (nearly drowned) and the blood was taken for blood MDA examination. In vitro, the IC50 of buah merah oil was 451,51 Î¼g/ml. In vivo test, dosage 0,15 ml/kgBW could decrease MDA 5,22% Dosage 0,3 ml/kgBW could decrease MDA 11,96% and dosage 0,6 ml/kgBW could decrease MDA 8,19% . Buah merah oil showed antioxidant activity in vitro. In vivo experiment, all dosage of buah merah oil decreased blood MDA level but in the dose of 0,3 ml/kgBW decreased MDA level more than dose of 0,15 ml/kgBW and 0,6 ml/kgBW.

PENGARUH DIABETES MELLITUS TERHADAP RESISTENSI ASPIRIN PADA PASIEN STROKE ISKEMIK DI RUMAH SAKIT BETHESDA YOGYAKARTA Witasari, Hardi Astuti; Pinzon, Rizaldy Taslim; Kristin, Erna
Pharmaciana Vol 4, No 2 (2014): Pharmaciana
Publisher : Universitas Ahmad Dahlan

The secondary prevention of ischemic stroke can be implemented by giving aspirin.However, some cases of aspirin resistance have been found. The purpose of this study was toexamine the influence of diabetes mellitus on the risk of aspirin resistance in ischemic strokepatients at Bethesda Hospital Yogyakarta. This study was using a nested case-control studydesign. The Cases group was subjects who resistance to aspirin therapy. The control group wassubjects who response to aspirin therapy. The factors that affect the incidence of aspirinresistance were analyzed by bivariate analysis chi square test. The proportion of diabetesmellitus in resistant group was bigger than the aspirin responsive group. Its odds ratio (OR) was1.605 (95% CI, 0.641 to 4.017) (p=0.155). Conclusion: Ischemic stroke patients at BethesdaHospital Yogyakarta with diabetes mellitus were not proved to have a bigger risk of aspirinresistance than the patients without diabetes mellitus.

Identifikasi Faktor yang Mempengaruhi Total Biaya Inventori Obat-obatan Golongan A di Rumah Sakit Swasta Tipe B di Jakarta Tahun 2015 Susanto, Agnes; Kristin, Erna; Agastya, Agastya
JMMR (Jurnal Medicoeticolegal dan Manajemen Rumah Sakit) Vol 6, No 1 (2017): April
Publisher : Universitas Muhammadiyah Yogyakarta in Clollaboration with ADMMIRASI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jmmr.6121

Inventory is one of the crucial components in hospital operations. The value o inventory may range up until 25% of the total cost of the hospital operation. Inventory optimization may save up to 10% in the minimum. There is a lot of drugs circulation in hospital. There is always a chance for a mistake. A tight control of inventory is necessary for hospital managers to minimize any potential waste. A saving directive for 20% drugs which consume 70% of the total cost will boost the hospital efficiency. A lot of factors influences hospital inventory and how managers strategize for the inventory. Some identified factors are order frequency, order quantity, unit price, and other hidden costs. The purpose of this research is to prove the correlation of each factor and how they influence the total inventory cost. To follow up the result, henceforth a model of simulation by calculating Economic Order Quantity and Reorder Point, the research may help hospital managers in modifying the strategy of managing hospital inventory for the next year period. This study aims to identify the factors which influence total inventory cost in managing group A drugs at private type B hospital, Jakarta. This study using observational analytics, cross-sectional study.

Cost Effectiveness Analysis of Rivaroxaban Compared to Warfarin and Aspirin for Stroke Prevention Atrial Fibrillation (SPAF) in the Indonesian healthcare setting Dwiprahasto, Iwan; Kristin, Erna; Endarti, Dwi; Pinzon, Rizaldy Taslim; Yasmina, Alfi; Thobari, Jarir At; Pratiwi, Woro Rukmi; Kartika, Yolanda Dyah; Trijayanti, Christiana
Indonesian Journal of Pharmacy Vol 30 No 1, 2019
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Main drugs used in the prevention of stroke among atrial fibrillation (AF) patients are antiplatelets (aspirin) and oral anticoagulants (OAC). OAC therapy can be difficult to administer due to drug and food interactions, adds the burden of required blood monitoring, narrow therapeutic window, and requirements for dose titration. Rivaroxaban is a single-dose oral anticoagulant which does not require blood monitoring, dose titration or has dietary interactions. Phase III clinical data from the ROCKET trial have recently been reported the non-inferiority of rivaroxaban over warfarin for the prevention of strokes in AF patients. To develop an economic model evaluating the clinical and cost-effectiveness of rivaroxaban for the prevention of stroke in non-valvular AF patients in the Indonesian health care settings. We conducted cost effectiveness analysis from the perspective of payer (national health insurance). Effectiveness data used the international data from previous RCT and network metaanalysis studies. Costs data used local data of Indonesia from national health insurance’s reimbursement tariffs. Markov model was used, comprised of health and treatment states describing the management and consequences of AF. The main analysis was based on data from the phase III trials. Three months was used as cycle length. The time horizon was set at patients’ lifetime (20 years). Costs and outcomes were discounted at a 3% annual rate. Subgroup analysis and extensive sensitivity analysis was conducted. Willingness to pay (WTP) threshold in Indonesia was set as 3 times GDP of Indonesia in 2015, equal about IDR 133,375,000 per quality-adjusted life year (QALY). Base case rivaroxaban vs warfarin has ICER of IDR 141,835,063per QALY at the current cost of rivaroxaban IDR 23,500 and ICER of 130,214,687 per QALY at the proposed cost of rivaroxaban IDR 22,000. One-way sensitivity analysis showed that the key drivers of cost-effectiveness were the utility decrement applied to stable warfarin patients, discontinuation/subsequent discontinuation rates for rivaroxaban, and discontinuation/subsequent discontinuation rates for warfarin. The probabilistic sensitivity analysis suggested that rivaroxaban was cost-effective compared to warfarin in about 45% of cases at the WTP per QALY. Rivaroxaban with the proposed price of IDR 22,000 was considered to be more cost-effective when compared to warfarin.

Relationship Between Pfmdr1 Gene Polymorphisms with Therapeutic Respons of Artesunate-Amodiaquine in Uncomplicated Falciparum Malaria Patients in Puskesmas Hanura, Pesawaran Regency, Lampung Carolia, Novita; Mustofa, .; Kristin, Erna
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 50, No 4 (2018)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar

ABSTRACTBackground: The failure of artesunate-amodiaquine therapy in chloroquine resistant patients have been reported in several areas in Indonesia. One of the unexpected resistance mechanisms is associated with pfmdr1 gene polymorphisms. This study determine the frequency of pfmdr-1 polymorphisms and examine the relationship of pfmdr1 gene polymorphism with therapeutic responses to artesunate-amodiaquine therapy in uncomplicated falciparum malaria patients in Puskesmas Hanura, Pesawaran Regency, Lampung Methods: This study was conducted in accordance with the WHO protocol for anti-malarial drug efficacy test in uncomplicated falciparum malaria. Combination therapy used artesunate-amodiaquine and primaquine. Therapeutical response and Parasite Clearance Time was observed during 28 days of observation. Diagnosis polymorphism by PCR-RFLP technique used the patient's blood (EDTA and filter paper) were taken a tH0.Results: There were 63(85.1%) patients of Adequate Clinical and Parasitological Response, Early Treatment Failure were 5 (6.8%) people, Late Clinical And Parasitological Failure 2 (2.7 %) people, and Late Parasitological Failure 4 (5.4%) people. Seven (13.5%) patients were found with N86Y pfmdr1 gene polymorphism with mixed type (mutant type and wild-type) in which 1 (9.1%) people had failed therapy and 6 (14.6%) people were cured. There was no association between pfmdr1 gene polymorphism with artesunate-amodiaquine failed therapy (RR: 0.64, 95% CI0.97-4.27, p: 1.000). Parasite Clearance Time on pfmdr1 polymorphism group was 2.14 ± 1.21 days and 1.79 ± 1.06 days in group without pfmdr1 polymorphisms. There was no significant difference between both groups (p =0.434).Conclusions:The frequency of pfmdr1 N86Y polymorphism in Puskesmas Hanura, Pesawaran Regency, Lampung was 13,5%. There was no significant difference between the rate of treatment failure patients with pfmdr1 N86Y polimorphism compared with patients without pfmdr1 N86Y polymorphism. There was no significant difference between Parasite Clearance Time patients with pfmdr1 N86Y polymorphism compared with patients without pfmdr1 N86Y polymorphism.Keywords: falciparum malaria, artesunat-amodiakuin, polymorphism, pfmdr1

CYP3A4*1G gene Polymorphism on Javanese People Em Sutrisna; Iwan Dwiprahasto; Erna Kristin
Indonesian Journal of Biotechnology Vol 16, No 2 (2011)
Publisher : Universitas Gadjah Mada

Most of drugs are metabolized by cytochrome P 450 (CYP) enzyme. Cytochrome P450 3A4 is thecytochrome that is involved in metabolizing more than 60% of all medicine used in human. The variationof this CYP3A4 gene will affect the catalytic activity of this enzyme. Recently, CYP3A4*1G in intron 10 wasfound in Chinese and Japanese population. There is a substitution of G to A at position 82266 in intron 10. Thepurpose of this research was to investigate the frequency of allele and genotype CYP3A4*1G. Samples weretaken from bloods of the subjects of the research. The examination of CYP3A4*1G was conducted by RTLP-PCRmethod.As the results of this research, the frequency of CYP3A4*1G in Javanese people is CYP3A4*1/*1 0.25,CYP3A4*1/*1G 0.55 and CYP3A4*1G/*1G 0.20. Frequency of allele G: 0.53, allele A: 0.47. The Fisher’s exact- testshows that the allele and genotype frequencyis p. 1.000. The allele and genotype frequency of Javanese peopleisstill in Hardy-Weinberg equilibrium.

Mucolitic Ambroxol Versus Hypertonic Saline Nebulizer Induction: For Increasing Sputum Volume And Finding Acid-Fast Bacilli Sunarto Ang; Sumardi -; Erna Kristin
Tropical Medicine Journal Vol 2, No 1 (2012): Tropical Medicine Journal
Publisher : Pusat Kedokteran Tropis

Introduction: Tuberculosis, a major killer disease in the community, was caused by Mycobacterium tuberculosis. According to WHO (2006), pulmonary tuberculosis cases in Indonesia was third ranked in the world. Prevalence of pulmonary tuberculosis in Eastern Indonesia was higher than in Java and Bali, but the findings of positive smear was lowest. AFB discovery will be decreased because of the poor quality and quantity of sputum.The useful of mucolitic ambroxol or hypertonic saline nebulizer induction will be to increase quality and quantity of sputum smear.Objectives: The aim of this study was to determine and to compare the effectiveness of ambroxol and use a hypertonic saline induction on new suspected pulmonary tuberculosis patients to increase sputum volume and to find AFB.Methods: 76 new suspected pulmonary tuberculosis patients were divided into 2 groups with doubleblind and open-label simple randomsampling RCT (Randomized Controlled ClinicalTrial-Parallel design) study.The sputum induction using ambroxol or 3%hypertonic saline solution.The primary and secondary outcome were increasing sputum volume and finding AFB by Ziehl-Neelsen staining to calculate the AFB count per 100 fields of view. Non parametric statistical analysis and percentage of success.Results: All patients can produce sputum. Only one patient ambroxol group can’t produce it.The quality and quantity of sputum hypertonic saline induction volume better than ambroxol. AFB finding increaseboth groups, but no significant difference. AFB finding increase 26.47%(9/34)with ambroxol and 27.78% (10/36)with hypertonic saline induction compared than previous negative smear.Conclusions: Significant differences increase sputumvolume hypertonic saline induction compared than ambroxol.No significant difference AFB finding improvement hypertonic saline induction compared for ambroxol. Finding AFB increase 26.47% with ambroxol and 27.78% with hypertonic saline induction compared previous negative smear.Keywords: Tuberculosis, Ambroxol, Nebulizer induction, Sputum volume, AFB

Co-Authors Agastya, Agastya Alfi Yasmina Alfi Yasmina Anak Agung Ayu Niti Wedayani Anak Agung Gede Sugianthara Diah Ayu Putriyanti Dwi Indria Anggraini Em Sutrisna Eri Supriyanti Erwin Astha Triyono Eti Nurwening Sholikhah Firman Firman Gregorius Nesi Hanevi Djasri Hardi Astuti Witasari Hermawati, Ajitya Kurnia Indwiani Astuti Iwan Dwiprahasto Iwan Dwiprahasto iwan Dwiprahasto Jarir At Thobari Mahady, Taufik Wahyudi Mustofa Mustofa Ngatidjan Ngatidjan Ni Made Dwi Sandhiutami Novita Carolia Pratiwi, Woro Rukmi Prih Sarnianto Ratih Puspita Febrinasari Ratmasari, Dewi Rizaldy Pinzon Rizaldy Taslim Pinzon Rizaldy Taslim Pinzon Sari Mutiarani Sri Purwaningsih Sumardi - Sunarto Ang Susanto, Agnes Trijayanti, Christiana Yanri Wijayanti Subronto Yolanda Dyah Kartika

Title

Found 27 Documents
Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title Search

Found 27 Documents Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title

Found 27 Documents
Search