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Journal of the Medical Sciences (Berkala Ilmu Kedokteran)
Published by Universitas Gadjah Mada
ISSN : 01261312     EISSN : 23563931     DOI : http://dx.doi.org/10.19106/JMedSci005303202101
Core Subject : Science,
Immunology & microbiology Neuroscience
Journal of the Medical Sciences (JMedSci) or Berkala Ilmu Kedokteran (BIK) is an international, open-access, and double-blind peer-reviewed journal, published by Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada Yogyakarta Indonesia. JMedSci aiming to communicate high-quality articles in the areas of biomedical science from basic to clinical sciences.The journal welcomes papers from original articles, case reports, reviews, and book reviews. All papers published in JMedSci are freely available as downloadable pdf files. The journal began its publication on March 1973 and published quarterly (January, April, July, and October). JMedSci is abstracted and indexed in DOAJ, Crossref, Google Scholar, Sinta, Indonesia One Search. JMedSci is accredited by Directorate of General Higher Education, the Ministry of Research, Technology, and Higher Education, Indonesia
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 14 Documents
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Search results for , issue "Vol 50, No 3 (2018)" : 14 Documents clear
The expression of COX-2 and iNOS in ethanol and aspirin induced gastric ulcer rat models sherly usman; Dewi Kartikawati Paramita; Yustina Andwi Ari Sumiwi
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 50, No 3 (2018)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (679.993 KB) | DOI: 10.19106/JMedScie/005003201807

Abstract

Aspirin or ethanol induced gastric ulcer rat models are the most frequently used in studies.Aspirin and ethanol induced gastric ulcers through different pathways involving COX-2 andiNOS. The aim of this study was to examine the expression of COX-2 and iNOS in gastriculcer rat model induced by ethanol and aspirin. Twenty-one Sprague Dawley rats weredivided into 7 groups i.e. control group (CA), ethanol 1st day (ED1), ethanol 3rd day (ED3),ethanol 5th day (ED5), aspirin 4th day (AD4), aspirin 6th day (AD6), and aspirin 8th day (AD8).Oral administration of aspirin was at 200mg/kgBW and the 100% ethanol at 1mL/200gBW.Macroscopic and microscopic observations were done to examine the gastric mucosaldamage, COX-2 and iNOS expressions. Severe gastric ulcers were observed in ED1and AD4 groups and mild gastric mucosal damage was observed in ED3, ED5, AD6 andAD8 groups. Microscopically, light erosion was shown by the CA and AD8 groups. Erosionwas also shown by ED3, ED5, and AD6 groups. The most severe damage with ulcers andheavier bleeding were shown by the ED1 and AD4 groups. Weak COX-2 expression wasfound in the CA, while the highest COX-2 expression was found in the ED1. The iNOSexpression in the ethanol groups was still increasing until the 5th day (ED5). In the aspiringroups, it reached the peak on the 3rd day (AD6), and already declined on the 5th day (AD8).In conclusion, the damage process of ethanol induced gastric ulcer occurred faster thanthat by aspirin. The highest COX-2 expression in the ethanol and aspirin groups wereshown at the onset begin. iNOS expression in ethanol induced ulcer groups still increaseduntil the 5th day, while in the aspirin induced ulcer groups already declined in the 5th day.
Comparison of corneal endothelial cell count and intraocular pressure in pure-dispersive and dispersive-cohesive viscoelastic protection in phacoemulsification surgery Agung Nugroho; R Haryo Yudono
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 50, No 3 (2018)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (420.95 KB) | DOI: 10.19106/JMedScie/0050032018013

Abstract

There are so many aspects should be regarded when use viscoelastic device during phacoemulsification surgery. The advantages and disadvantages of pure-dispersive viscoelastic and dispersive-cohesive viscoelastic always require more our attention to use it conveniently. The purpose of the study was to compare between pure-dispersive viscoelastic versus dispersive-cohesive viscoelastic in phacoemulsification surgery in that of corneal endothelial cell count and intraocular pressure (IOP) change. This was a cross-sectional study involving 41 eligible patients who underwent phacoemulsification surgery by single operator. Data including characteristics of cataract patients, corneal endothelial cell count and IOP were taken before and after surgery. Data of characteristics of cataract patients were reported descriptively and compared using Anova and t-test. The mean change in corneal endothelial cell count on pure-dispersive viscoelastic group (71.99±71.20 cells/mm²) was lower than that on the dispersive-cohesive viscoelastic group (117.62±78.29 cells/mm²). However, it was not significantly different. The mean change in IOP on pure-dispersive viscoelastic group (0.75±1.626 mmHg) was significantly lower than that on dispersive-cohesive viscoelastic group (1.90±0.995 mmHg) (p=0.000). In conclusion, the increase of IOP in dispersive-cohesive viscoelastic group is higher than that on pure-dispersive viscoelastic group. However, there is no significant difference of the mean change in corneal endothelial cell on the both groups.
Accuracy of albumin creatinine ratio in comparison with albumine excretion rate for diagnosis diabetic nephropathy in type 2 diabetes mellitus . Fatrinawati; . Windarwati; Osman Sianipar
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 50, No 3 (2018)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (417 KB) | DOI: 10.19106/JMedScie/005003201806

Abstract

Diabetic nephropathy (DN) is one of complications in diabetic patients manifested bymicroalbuminuria with minimal level of 30 mg/24 hour which is measured at least 2 timesin the period of 3 to 6 months. Microalbuminuria can be measured either albumin excretion rate (AER) or albumin creatinine ratio (ACR). Measurement of ACR is an alternative parameter recommended by WHO in 2011 to diagnose diabetic nephropathy since it is more convenient, fast and not requires special preparation. The purpose of this study was to investigate accuracy of ACR to diagnose DN in type 2 diabetes mellitus (T2DM) patients.This was a diagnostic test study involving 80 T2DM patients. In this study ACR value equal or more than 30 mg/g was independently and blindly compared with AER as the gold standard. The data were analyzed using 2x2 tables in order to calculate sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV). Other data were analyzed using statistic descriptive. Eighty T2DM patients consisting of 38males and 42 females participated in this study. They had suffered from T2DM on average9.5 years, and the average of ACR value was 55.5 mg/g. Total result of true positive andtrue negative was 77. Three result were false negative but none of false positive result.The ACR value equal or more than 30 mg/g had sensitivity, specificity, PPV, and NPV of95.9%, 100%, 100%, and 66.7% respectively. In conclusion, the ACR value equal or morethan 30 mg/g derived from morning urine sample can be used to diagnose DN in T2DMpatients.
Moderate-intensity interval exercise but not high-intensity interval exercise improves the spatial memory of ovariectomized rats Kaidah, Siti; Rauf, Saidah; Soesatyo, Marsetyawan HNE; Agustiningsih, Denny; Partadiredja, Ginus
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 50, No 3 (2018)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (518.401 KB) | DOI: 10.19106/JMedScie/005003201804

Abstract

Physical exercise exerts beneficial effects on the spatial learning and memory. High-intensity interval exercise (HIIE) has been proposed as a time-efficient physical exercise regimen. On the other hand, there were evidences that HIIE increased oxidative stress biomarkers and reduced antioxidant capacity, which resulted in oxidative damage. The present study aimed to investigate the effects of high-intensity interval exercise and moderate-intensity interval exercise on oxidative stress biomarkers and oxidative enzymes activity in the hippocampus and the spatial memory of ovariectomized rats. A total of 16 female Sprague Dawley rats aged 12 weeks were randomly assigned into 4 groups, i.e. the sham-operated (SO), ovariectomized without exercise (O), ovariectomized with high-intensity interval exercise (HIIE), and ovariectomized with moderate-intensity interval exercise (MIIE) groups. Rats of the exercise groups (HIIE & MIIE groups) performed 6 sessions of interval exercise per week for 6 weeks. The spatial memory of rats was measured using the Morris water maze procedure. The malondialdehyde (MDA) levels and activity of catalase (Cat) as well as glutathione peroxidase (GPx) in hippocampus were determined using spectrophotometry method. The spatial learning and memory retention of the moderate-intensity interval exercise group was significantly better than that of the high-intensity interval exercise group. The GPx activity of MIIE group was higher than any other groups. The SO group had the lowest hippocampal MDA level and highest Cat activity among groups. Moderate-intensity interval exercise reduces the ovariectomy induced-oxidative stress in the hippocampus and improves spatial learning and memory retention of ovariectomized rats.

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