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Perilaku Ibu dalam Memilih Tenaga Penolong Persalinan di Wilayah Kerja Puskesmas Tembilahan Hulu Tahun 2016 Alhidayati, Alhidayati; Asmuliyanti, Asmuliyanti
JURNAL KESEHATAN REPRODUKSI Vol 3, No 3 (2016)
Publisher : Fakultas Kedokteran, Kesehatan Masyarakat dan Keperawatan UGM

Background: Maternal Mortality Rate (MMR) is an indicator of health development in Indonesia. Some effort have been done to decrease maternal mortality ie to increase range labor by health personnel. The target coverage of labor by health personnel in Tembilahan Hulu Public health center has yet to reach the target of 80%. its coverage was only 45%. The number of maternal mortality in Tembilahan Hulu Health center in 2016 was 1 cases and the number of infant maternal mortality was 5 cases.Objective: The purpose of this study was to determine the motherâ€™s behavior in selecting birth attendants in health center in the region of the upstream Tembilahan Hulu.Method: This research used qualitative method to gain the in depth information on how to Motherâ€™s Behavior In Selecting Birth Attendants In Health Centers Working Area Tembilahan Hulu 2016. The data are analysed by using content analysis, which is comparing the result from the research with the theories in the literature.Result and Discussion: There were 13 informants in this research. This studyâ€™s result showed that the decision for birth attendants were closely related to knowledge, attitude, socio-cultural, access to health center, and support from family. Advise to relevant agencies, namely health centers Tembilahan Hulu order to further increase coverage deliveries by health care and in personels villages to which access is far from health facilities to build Birth Waiting Homes (BWH).Conclusion: The Decision for birth attendants were closely related to knowledge, attitude, socio cultural, acces to health center and support from family.Keywords: birth attendant, community health center, pregnant women behavior

Kualitas Tidur dan Pola Tidur sebagai Predisposisi Postpartum Blues pada Primipara Harahap, Wahyuni; Adiyanti, M.G. Adiyanti
JURNAL KESEHATAN REPRODUKSI Vol 4, No 1 (2017)
Publisher : Fakultas Kedokteran, Kesehatan Masyarakat dan Keperawatan UGM

Background: Postpartum blues is thought to be a normal reponse after childbirth in the community. Due to that reason, this psychological disorder has not been managed well. Although mental disorder during postpartum period hasnâ€™t understood well, pain after birth, fatigue, poor sleeping quality, anxiety for unabling to care for the newborn and changes in sleep patern have become risk factors for the development of postpartum blues.Objective: To understand to relationship between sleep pattern and quality of sleep in the development of postpartum blues in primiparas.Method: The subjects for the study were 45 primaras taken from 3 community health centers with in patients facilities in Yogyakarta city. The inclusion criteria were normal deliveries, both the mothers and her babies were healthy, the baby was less than 15 days old, and the mothers were 18 â€“ 40 years old. The data were collected using questionnaires that measure the sleep pattern scale, the sleep qualityâ€™s scale and the postpartum bluesâ€™ scale. The datas were analyzed using path analysis.Result and Discussion: Sleep quality and sleep patern together influenced postpartum blues for 57,5% (p < 0,000). Sleep quality partially influenced postpartum blues for 41% (p < 0,01) and sleep pattern influenced postpartum blues for 33% (p < 0,05).Conclusion: Sleep quality and sleep pattern influenced the incidence of postpartum blues.Keywords: postpartum blues, sleep quality, sleep pattern, primipara

PAJANAN ASAP DALAM RUMAH TERHADAP KEJADIAN ISPA NONPNEUMONIA PADA ANAK BALITA DI KABUPATEN KAPUAS Hugo, Mayae; Emilia, Ova; Sitaresmi, Mei Neni
JURNAL KESEHATAN REPRODUKSI Vol 1, No 1 (2014)
Publisher : Fakultas Kedokteran, Kesehatan Masyarakat dan Keperawatan UGM

PAJANAN ASAP DALAM RUMAH TERHADAP KEJADIANISPA NONPNEUMONIA PADA ANAK BALITA DI KABUPATENKAPUASMayae Hugo, Ova Emilia,Mei Neni SitaresmiABSTRACTBackground: Acute respiratory infections (ARI) is one of themain causes of disease burden in developing countries,and 40-60% patients visits at the health center. Riskesdes analysis report the underâ€“five children who suffer fromupper respiratory tract infection prevalence 42.8%. ARI occurrence is affected by many factors, includingenvironmental factors. Little attention has been given to indoor air pollution particularly for people in ruralareas, although the known particles of smoke in the room known as the most influential factors on the health ofchildren where children spend most of their time indoorsObjective: To know whether smoke exposure inside the house is a risk factor toward non pneumonia ARI amongunder-five children.Method: This was a study using a case control study design. Subjects were under-five children aged 12-59 monthsold in Kapuas District taken by non probability sampling method. Sample size was 106, divided into two groupsnamely case (n=53) and control (n=53). Data analysis used univariate analysis, bivariate analysis, and multivariateanalysis with logistic regression.Result: Non pneumonia ARI had a 2.7 time greater risk of contracting under-five children exposed by smokeinside their house (95%CI=1.16-6.60). Multivariate analysis proportion of house condition which was not reallyhygienic, member of family who contracted ARI, bad nutritional status had a significant relationship to nonpneumonia ARI among under-five children.Conclusion: Non pneumonia ARI among under-five children had a significant relationship to smoke exposureinside the house.Keywords: non pneumonia ARI, smoke exposure inside the house, under-five childrenÂ Â Â ABSTRAKLatar Belakang: Infeksi saluran pernapasan akut (ISPA) merupakan salah satu penyebab utama beban penyakit dinegara berkembang. Terdapat 40-60% kunjungan pasien di pusat layanan kesehatan. Analisis Riskesdesmelaporkanprevalensi anak-anak balita yang menderita infeksi saluran pernapasan atas 42,8%. Kejadian ISPA dipengaruhioleh banyak faktor, termasuk faktor lingkungan. Sedikitnya perhatian yang diberikan terhadap polusi udara dalamruangan terutama bagimasyarakat di daerah pedesaan,meskipun partikel yang berasal dari asap di dalam ruangandikenal sebagai faktor yang paling berpengaruh pada kesehatan anak di mana anak-anak menghabiskan sebagianbesar waktu mereka di dalam ruangan.Tujuan: Untuk mengetahui apakah paparan asap di dalam rumah merupakan faktor risiko terhadap non pneumoniaISPA pada balita.Metode: Penelitian ini merupakan penelitian dengan menggunakan disain penelitian kasus kontrol. Subyekpenelitian adalah balita berusia 12-59 bulan di Kabupaten Kapuas diambil dengan metode non probabilitysampling. Jumlah sampel adalah 106, dibagi menjadi dua kelompok yaitu kelompok kasus (n=53) dan kelompokkontrol (n=53). Analisis data yang digunakan analisis univariat, analisis bivariat, dan analisis multivariat denganregresi logistik.Â Hasil dan Pembahasan: ISPA non pneumonia memiliki risiko 2,7 kali lebih besar menjangkiti anak yang terpaparasap di dalam rumah mereka (95% CI=1,16-6,60). Proporsi analisis multivariabel kondisi rumah yang tidak benarbenarhigienis, anggota keluarga yang terjangkit ISPA, status gizi buruk memiliki hubungan yang signifikan terhadapISPA non pneumonia pada balita.Kesimpulan: ISPA non pneumonia pada balita memiliki hubungan yang signifikan terhadap paparan asap di dalamrumah.Kata kunci: ISPA non pneumonia, paparan asap di dalam rumah, balita

Korelasi Tinggi Badan Ibu dengan Panjang Badan Bayi Baru Lahir di Kota Palu Lamana, Aspia; Julia, Madarina; Dasuki, Djaswadi
JURNAL KESEHATAN REPRODUKSI Vol 4, No 2 (2017)
Publisher : Fakultas Kedokteran, Kesehatan Masyarakat dan Keperawatan UGM

Background: Body length of newborn babies is related to health in adulthood. Some studies suggested that short people tend to have lower intellectual performance that can reduce working capacity, poor reproductive performance and increase risk of cardiovascular disease and type 2 diabetes. In addition, the less the bodyâ€™s length of newborns the more adverse long-term health such as obesity, cardiometabolic disorders, and neuro psychiatric conditions were encountered.Objective: To determine the relation of mothersâ€™ height with body length newborns in Palu. Samples are babies born in the first 24-72 hours of private hospitals, health centers, and maternity clinics in Palu. Method: An observational study with cross sectional design. The independent variable is the mothersâ€™ height and the dependent variable is the length of the body of the newborns. Data collection used questionnaires. Data analysis used linear regression.Result and Discussion: There was a correlation between the height of mothers with the body length of newborns (r = 0.26) (p <0.001). There was a significant relationship between mothersâ€™ upper arm circumference, the amount of iron preparations consumed, the height of the father (p <0.001) as well as maternal education (p <0.020) and the sex of the newborn (p <0.015) with the body length of newborns. There was no significant relationship between body length of newborns with socioeconomic status (p <0.861).Conclusion: Mothersâ€™ height is not the main factor affecting the body length of newborns in the city of Palu. Education to newly wed couples and pregnant women about the importance of knowledge that body length of newborns is not only influenced by genetic factors but also by the maternal intake.Keywords: Mothersâ€™ height, newborn body length

Peran Penambahan Misoprostol pada Penatalaksanaan Aktif Kala Tiga dalam Menurunkan Perdarahan Pasca Persalinan Geni, Puti Lenggo; Rachman, Irwan Taufiqur; Pradjatmo, Heru
JURNAL KESEHATAN REPRODUKSI Vol 4, No 3 (2017)
Publisher : Fakultas Kedokteran, Kesehatan Masyarakat dan Keperawatan UGM

Background: Postpartum haemorrhage is the leading cause of maternal mortality in both developed and developing countries, which is almost 80 % due to the failure of the uterus to contract. Misoprostol is a powerful uterotonic agent used as an alternative in preventing postpartum haemorrhage.Objective: The purpose of this study was to determine whether administration of misoprostol adjunctive therapy in active management of the third stage of labor influenced postpartum blood loss.Method: This study was a non-blinding randomized controlled trial that divided subjects into two groups. The treatment group was the group who received misoprostol 600 mcg orally for adjunctive treatment in active management of the third stage of labor and the control group did not receive misoprostol, each group also got routine oxytocin 10 IU intramuscularly. Both group were assessed of the number of blood loss in the fourth stage of labor, decreased levels of hemoglobin and hematocrit within 24 hours after delivery. Chi square test was conducted to determine the strength of the relationship between the two groups.Result and Discussion: The study recruited 104 subjects, there were significant difference for the mean number of blood loss in the fourth stage of labor and the decrease in hemoglobin levels within 24 hours of postpartum between treatment and control group (OR 2.45; 95% CI 1.05-5.71, p=0.04), (OR 2.99; 95% CI 1.26-7.11, p=0.01). The mean of the decreasing hematocrit levels was statistically not significant between the two groups (OR 0.87; 95% CI 0.38-1.99, p=0.75).Conclusion: The addition of misoprostol to the routine active management of the third stage of labor was statistically significant to decrease amount of postpartum blood loss.Keywords: misoprostol, active management of the third stage of labor, postpartum blood loss, postpartum hemorrhage.

Kinerja Bidan Desa dalam Deteksi Dini Kasus Malaria pada Kehamilan di Kabupaten Bengkulu Tengah Mizawati, Afrina; Hakimi, Moh; Kusnanto, Hari
JURNAL KESEHATAN REPRODUKSI Vol 3, No 1 (2016)
Publisher : Fakultas Kedokteran, Kesehatan Masyarakat dan Keperawatan UGM

Background: Malaria has become the health problem that cause mortality especially in high risk group such as infants, children below 5 years old and pregnant women. The incidence of malaria in Central Bengkulu, Bengkulu Province is quite high, the last three years there is an increase compared to year 2011 â€“ 2013. Annual Malaria Incidence in 2011 was 75.68/00, where the incidence in 2012 was 66.13/00. The Annual Parasite Incidence in 2013 was 52.34/00. In 2013, the amount of pregnant women who underwent malaria screening during 1st antenatal care (K1) only 784 from 2016 pregnant women(39%).Objective: To understand the malaria screening achievement among pregnant women by village midwives in Central Bengkulu District.Method: The study was observational with cross sectional design. The subjects was all of the village midwives in Central Bengkulu District. The dependent variable in this study was midwives achievement in malaria screening during pregnancy. The independent variables were training for malaria screening during pregnancy and the availability of rapid diagnostic test (RDT). The disturbing variables were age, level of education, and the duration of work. The studyâ€™s instrument was questionnare and observational sheet. The data analysis was done with t test, correlation method, chi square and linear regression.Result and Discussion: The achievement in malariaâ€™s screening during pregnancy by village midwives was better in the group who received training compared with the group who didnâ€™t (RR 2.2 ; 95% CI 1.71 â€“ 2.51). The achievement also was better in the group of midwives who had good supply of RDT compared with the group who didnâ€™t (RR 1.5; 95% CI 1.01 â€“ 1.94).Conclusion: The achievement of malariaâ€™s screening during pregnancy among village midwives who received training was better compared to midwives who didnâ€™t. The achievement was also better among midwives who had good supply of RDT compared with midwives who didnâ€™t. There is relation between level of midwivery education and the achievement in screening b ut there was no relation between age and duration of work and achievement during screening.Keywords: Achievement of Village Midwives, Screening, Training and Availability of RDT

Pemaknaan Menopause pada Perempuan Bangsawan Keraton Jawa Sulistiyani, Lisy; Suci, Eunike Sri Tyas
JURNAL KESEHATAN REPRODUKSI Vol 3, No 3 (2016)
Publisher : Fakultas Kedokteran, Kesehatan Masyarakat dan Keperawatan UGM

Background: In most cases, women experience menopause with various kind of physical and psychological symptoms. Womenâ€™s understanding on menopause is influenced by their cultural background. Royal Javanese women are not sepatared from various Javanese traditions, such as â€œpitutur-pituturâ€, â€œlaku Jawaâ€, et cetera. Such traditions are the foundation they construct menopause experience.Objective: The purpose of this research is to obtain the meaning of menopause as experienced by Royal Javanese Women.Method: A qualitative method with in-depth interview is used in this research. Informants are seven Royal Javanese Women from three Javanese palaces: Solo, Yogyakarta and Cirebon; who were selected with purposive sampling technique.Result and Discussion: Based on this research, the meaning of menopause as experienced by Royal Javanese Women is significantly influenced by their construction of Javanese culture. Menopause is understood as an important event occurred to womanâ€™s body. As an important event, Royal Javanese Women carry out several preparations and anticipative efforts prior to Menopause. Preparations are outer and inner treatment and applied in day-to-day activities such as taking Javanese traditional herbs (jamu) and carry out Javanese traditions or rituals (fasting, meditation, et cetera).Conclusion: The Acceptance of manapausal symptoms are the result of cultural exposure and aaptation in royal live enviroments.Keywords: Menopause, Javanese Culture, Royal Javanese Women, Meaning

HUBUNGAN ANEMIA DALAM KEHAMILBAayi NKeci luTntuRk MIaMsa KeEhaSmilTan E(KMRK) dTi RIS GDr. ASard jito TERHADAP KEJADIAN BAYI KECIL UNTUK MASA KEHAMILAN (KMK) DI RS DR SARDJITO Ratnawati, Lili; Siswishanto, Rukmono; Emilia, Ova
JURNAL KESEHATAN REPRODUKSI Vol 2, No 3 (2015)
Publisher : Fakultas Kedokteran, Kesehatan Masyarakat dan Keperawatan UGM

HUBUNGAN ANEMIA DALAM KEHAMILBAayi NKeci luTntuRk MIaMsa KeEhaSmilTan E(KMRK) dTi RIS GDr. ASard jitoTERHADAP KEJADIAN BAYI KECIL UNTUK MASA KEHAMILAN(KMK) DI RS DR SARDJITOLili Ratnawati*, Rukmono Siswishanto*, Ova Emilia*ABSTRACTBackground: The high prevalence of anemia during pregnancy at Yogyakarta could be associated with theadverse pregnancy outcome as SGA. Previous study reported inconsitent result about association betweenanemia during third trimester and babies with SGA. Research is needed to determine the contribution ofanemia during third pregnancy to the adverse pregnancy outcome at RS Dr Sarjito.Objective: To compare the prevalance of SGA between pregnancy with and without anemia during thirdtrimester at RS Dr Sarjito.Method: Cross sectional study based on RS Dr Sardjitoâ€™s medical record. The subjects of study werepregnant women who took delivery at RS Dr Sarjito during third trimester from 2010 to 2011. Anemiadefine as haemoglobin level < 11g/dl which performed before delivery. Babies with brith weigth < 10percentile Lubchenco curve group into SGA. Association between anemia during third trimester and SGAanalyzed with Chi square test and Fisherâ€™s exact test.Resul and Discussion: A total of 239 subjects were recruited and devided into 146 subjects with anemiaand 93 subjects without anemia. The anemia groups consist of 97,95% mild anemia, 2,05% moderateanemia, and none severe anemia. The prevalence of SGA in total population, group with anemia, andgroup without anemia was 14%, 15,8%, and 10% irrespectively. The prevalance of SGA between groupwith and without anemia was not different (p=0,27; RR 1,46; 95%CI 0,73-2,93). Maternal age, BMIpregestational, education, and parity did not influence the prevalence of anemia and SGA. Consideringmultivariat analysis, neither anemia, maternal age, BMI pregestational, education, nor parity did not affectthe prevalance of SGA.Conclusion: In this study, the prevalence of SGA in pregnancy with and without anemia during thirdtrimester did not different at RS Dr Sarjito.Kata kunci: Anemia in pregnancy, third trimester, SGA.ABSTRAKLatar Belakang: Prevalensi anemia dalam kehamilan di Yogyakarta masih cukup tinggi sehingga dapatmenyebabkan peningkatan dampak buruk anemia terhadap janin, salah satunya KMK. Penelitiansebelumnya menunjukkan perbedaan hasil tentang hubungan anemia trimester tiga terhadap kejadianKMK. Penelitian tentang hubungan anemia dalam kehamilan trimester tiga terhadap kejadian KMK di RSSarjito penting dilakukan untuk mengetahui besarnya dampak negatif yang timbul akibat anemia dalamkehamilan.Tujuan: Mengetahui perbedaan kejadian bayi KMK pada ibu hamil dengan anemia pada trimester tigadibandingkan ibu hamil tanpa anemia di RS Dr Sarjito.Metode: Penelitian ini menggunakan rancangan cross sectional bersumber data rekam medis pasien ibuhamil trimester tiga yang bersalin di RS Dr Sardjito pada tahun 2010 s.d. 2011. Subyek penelitian yangmemenuhi kriteria inklusi dibagi dalam kelompok anemia dan normal. Hubungan antara anemia dengankejadian bayi KMK dianalisis dengan Chi square test dan Fisherâ€™s exact test.Hasil dan Pembahasan: Subyek penelitian yang memenuhi kriteria sebanyak 239 orang terdiri atas 146orang kelompok anemia dan 93 orang kelompok tanpa anemia. Kelompok anemia terbagi atas 97,95%anemia ringan, 2,05% anemia sedang, dan tidak didapatkan anemia berat. Kejadian bayi KMK sebesar14% pada total populasi, 15,8% pada kelompok anemia dan 10% pada kelompok tanpa anemia. KejadianKMK kelompok anemia tidak berbeda bermakna secara statistik dibandingkan kelompok tanpa anemia(p=0,27; RR 1,46; 95%CI 0,73-2,93). Usia ibu, IMT sebelum hamil, pendidikan, dan paritas sebagai variabelluar yang diteliti tidak berpengaruh terhadap kejadian anemia maupun bayi KMK. Hasil analisis multivariatmenunjukkan bahwa anemia, usia ibu, Indeks Masa Tubuh (IMT) sebelum hamil, pendidikan, dan paritastidak berpengaruh terhadap kejadian bayi KMK.Kesimpulan: Pada penelitian ini, kejadian bayi KMK di RS Dr Sardjito tidak berbeda pada ibu hamil trimestertiga dengan anemia dibandingkan ibu hamil trimester tiga tanpa anemia.Kata kunci: Anemia dalam kehamilan, trimester tiga, KMK* Bagian Obstetri dan Ginekologi, Fakultas Kedokteran Universitas Gadjah Mada/RS Dr Sardjito Yogyakarta

Interaksi Sosial dalam Kejadian Abortus Provokatus Kriminalis di Kabupaten Bulukumba Provinsi Sulawesi Selatan Ridwan, Rizal; Prawitasari, Shinta; Prawirodihardjo, Leo
JURNAL KESEHATAN REPRODUKSI Vol 3, No 3 (2016)
Publisher : Fakultas Kedokteran, Kesehatan Masyarakat dan Keperawatan UGM

Background: Many factors influence the decision to commit abortions, among all are marital status and educational status which most are still in school, economic pressure, multiparity or contaception failure. The social interaction is a connection between t the people who perform abortion and their suggestive environment.Objective: to observe the social interaction that happend among the person who perform abortion and the surrounding society.Method: This research makes use of qualitative method to understand the motives behind abortion practice, through an indepth interview. The sample collection is performed on H. A. Sulthan Dg Radja Hospital and Daffiku Hospital Bulukumba.Result and Discussion: Subject who performed abortion was influenced by internal and external factors. The internal factors include anxiousness, financial worrisome to support the child and fear of embarrassing the family in an unmaried women. As for the external factor includes pressure from families and friends who insist on performing abortion and the help from traditional healer on performing abortion. These two factors are not independent, and between them there are interactions to materialize abortion practice.Conclussion: Social interaction between individuals and between individual and the environment are an important role against abortion in decision making to have an provocative abortion.Keywords: Social interaction, abortion, factors for abortion

PERBANDINGAN RERATA EKSPRESI Bcl-2 DAN Bcl-XL PADA PREEKLAMSIA BERAT DAN KEHAMILAN NORMOTENSI Arianto, Budi; Hadiati, Diah Rumekti; Nurdiati, Detty Siti
JURNAL KESEHATAN REPRODUKSI Vol 2, No 2 (2015)
Publisher : Fakultas Kedokteran, Kesehatan Masyarakat dan Keperawatan UGM

PERBANDINGAN RERATA EKSPRESI Bcl-2 DAN Bcl-XL PADAPREEKLAMSIA BERAT DAN KEHAMILAN NORMOTENSIBudi Arianto1, Diah Rumekti H2, Detty S Nurdiati3ABSTRACTBackground: The state of hypoxia in severe preeclampsia cause placental oxidative stress that can leadexcessive trophoblast apoptosis through the mitochondrial pathway. Apoptosis stimuli occurs throughmodulation of p53 and Bcl-2 family expression which has antiapoptosis and proapoptosis function.Antiapoptosis protein consist of Bcl-2 and Bcl-XL and is expressed lower in apoptosis.Objective: To compare the mean difference of the expression of antiapoptosis proteins Bcl-2 & Bcl-XL andidentify the type of protein that can be used as indicators of increased apoptosis.Method: A cross-sectional study which consisted of 43 severe preeclampsia pregnancies and 38 thirdtrimester normotensive pregnancies, recruited between October 2011 - March 2012. Observation ofprotein expression Bcl-2 and Bcl-XL used immunohistochemical techniques. Statistical analysis appliedindependent t test (P<0.05).Result and Discussion: There were significant differences (p<0.05)between the mean expression of Bcl-2protein in trophoblast tissue among severe preeclampsia group (1.03 Â± 0.04) compared to normotensivegroup (1.10 Â± 0.08). The mean expression of Bcl-XL protein in trophoblast tissue severe preeclampsiagroup (1.29 Â± 0.12) compared to normotensive group (1.71 Â± 0.14) were significantly difference (p<0.05).The mean difference in protein expression of Bcl-2 (0076; 95% CI 0.046 to 0.104) was lower than Bcl-XLprotein (0.42; 95% CI 0.47 to 0.36). The mean protein expression of Bcl-2 and Bcl-XL were lower in severepreeclampsia group compared with normotensive group, either in preterm or full-term gestation age withp value <0.05.Conclusion: The mean difference in protein expression of Bcl-2 and Bcl-XL is lower in severe preeclampsiapregnancies than normotensive pregnancies. The mean difference in protein expression of Bcl-2 is lowerthan Bcl-XL. Severe preeclampsia affects protein expression of Bcl-2 and Bcl-XL more than influence ofgestational age.Keywords: severe preeclampsia, trophoblast, Bcl-2 , Bcl-XL, apoptosis.ABSTRAKLatar belakang: Keadaan hipoksia pada preeklamsia berat akan menyebabkan stress oksidatif plasentayang dapat memicu terjadi peningkatan apoptosis trofoblas melalui jalur mitokondria. Stimulus apoptosisterjadi melalui modulasi ekspresi P53 dan ekspresi protein Bcl-2 family yang memiliki fungsi antiapoptosisdan proapoptosis. Protein antiapoptosis terdiri atas Bcl-2 dan Bcl-XL akan diekspresikan lebih rendah padakeadaan apoptosis.Tujuan: Untuk melihat perbedaan rerata ekspresi protein antiapoptosis Bcl-2 dan Bcl-XL dan mengidentifikasijenis protein yang dapat dijadikan indikator peningkatan apoptosis.Metode: Rancangan penelitian ini potong lintang dengan populasi penderita kehamilan preeklamsia beratdan normotensi yang dirawat di RSUP Sardjito antara bulan Oktober 2011 hingga Maret 2012. Didapatkansampel plasenta sebanyak 43 kehamilan preeklamsia berat dan 38 kehamilan normotensi. Pengamatanekspresi protein Bcl-2 dan Bcl-XL dengan teknik imunohistokimia. Analisis statistik menggunakanindependent t test (p<0.05).Hasil dan Pembahasan: Terdapat perbedaan yang bermakna (p<0,05) rerata ekspresi protein Bcl-2 padajaringan trofoblas kelompok kehamilan preeklamsia berat (1,03 Â± 0,04) dibandingkan kelompok kehamilannormotensi (1,10 Â± 0,08). Terdapat perbedaan yang bermakna (p<0.05) rerata ekspresi protein Bcl-xL padajaringan trofoblas kelompok kehamilan preeklamsia berat (1,29 Â± 0,12) dibandingkan kelompok kehamilannormotensi (1,71 Â± 0,14). Beda rerata ekspresi protein untuk Bcl-2 (0,076; CI 95% 0,046 â€“ 0,104) lebihrendah dibandingkan beda rerata ekspresi protein Bcl-xL (0,42; CI 95% 0,47- 0,36). Rerata ekspresi proteinBcl-2 dan Bcl-XL lebih rendah pada kelompok preeklamsia berat dibandingkan dengan normotensi baikpada umur kehamilan preterm maupun aterm yang ditunjukkan dengan nilai p<0,05.Kesimpulan: Beda rerata ekspresi protein Bcl-2 dan Bcl-xL lebih rendah pada kehamilan preeklamsia beratdibandingkan kehamilan normotensi. Beda rerata ekspresi protein Bcl-2 lebih rendah dibandingkan bedarerata ekspresi protein Bcl-xl. Preeklamsia berat lebih berpengaruh terhadap ekspresi protein Bcl-2 danBcl-XL dibandingkan umur kehamilanKata Kunci: preeklamsia berat, trofoblas, protein Bcl-2, protein Bcl-xl, apoptosis1,2,3 Bagian Obstetri dan Ginekologi FK UGM/RSUP Dr. Sardjito, Yogyakarta

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