cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
widyasari putranti
Contact Email
widyasari@pharm.uad.ac.id
Phone
-
Journal Mail Official
mediafarmasi@pharm.uad.ac.id
Editorial Address
-
Location
Kota yogyakarta,
Daerah istimewa yogyakarta
INDONESIA
Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science)
Published by Universitas Ahmad Dahlan
ISSN : 14127946     EISSN : 25035223     DOI : 10.12928
Core Subject : Health, Science,
Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology
Media Farmasi is a scientific journal published by the University of Ahmad Dahlan worked closely with Ikatan Apoteker Indonesia (IAI). Media Farmasi published two times a year, namely in March and September since 2002 with ISSN 1412-7946 and e-ISSN 2503-5223. The article published in the Journal Media Farmasi selected by editors and reviewed by the reviewer. Articles published in Media Farmasi must not be published in other journals or have been previously published. Media Farmasi publishes a review article, original article, as well as short communication in all scopes of Pharmaceutical Science.
Arjuna Subject : -
Articles 11 Documents
 1   2 
Search results for , issue "Vol. 12 No. 1: Maret 2015" : 11 Documents clear
The Influence of Polyvinyl Pyrrolidone (PVP) on Piroxicam Absorption with Everted Intestinal SAC Method Prihapsara, Fea; Artanti, Anif Nur; Murrukmihadi, Mimiek
Media Farmasi: Jurnal Ilmu Farmasi Vol. 12 No. 1: Maret 2015
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v12i1.3028

Abstract

Oral drug absorption was highly influenced by dissolution rate, especially for poorly and insoluble drugs. Piroxicam is a nonsteroidal anti-inflammatory drug that is practically insoluble in water. The oral absorption rate of piroxicam is dependent on its dissolution rate in the GI tract. Polyvinyl Pyrrolidone (PVP) as surfactant can increase drug solubility by means of a micelle forming mechanism. The aim of the study was to know the influence of addition and variation of Polyvinyl Pyrrolidone (PVP) on Piroxicam absorption with everted intestinal sac method.  The  concentration of piroxicam solution was prepared by PVP in  1.0,2.0 and 3.0 % respectively. Crane and Wilson tube containing 75 ml of themucosal fluid was taken at 37 0 C in waterbath. Than, serosal solution of 1.5 mlwas added to intestinal sac by turned upside down and tied to a cannula, then put into the tube containing the mucosal fluid and constantly flowing oxygen gas.Serosal solution of 1 ml were taken every 15 minutes and then diluted with 2 ml of Ba (OH) 2 and 2 ml of ZnSO4 then centrifuge until 25 minute. The absorbant of supernatant was measured by UV spectrophotometer and data analyse wascalculated by one-way ANAVA.  PVP at 1%,2% and 3% increased piroxicamabsorption from the phosphate buffer pH 7.5 compared with negative control.According to P app , the values were 2.52 ± 0.43 cm/minute (negative control), 3.41 ± 2.17 cm/minute (1% PVP), 2.75± 1.14 cm/minute (2% PVP) and 4.77 ± 4.93 cm/minute (3% PVP) respectively. In conclusion. Lower doses of the surfactant (1%, 2%, and 3% PVP) significantly increased absorption of the drug by altering the membrane permeability.  

Page 2 of 2 | Total Record : 11

 1   2 

Filter by Year

2015 2015


Reset
Filter By Issues
All Issue Vol. 22 No. 2 (2025): September 2025 Vol. 22 No. 1: March 2025 Vol. 21 No. 2: September 2024 Vol. 21 No. 1: March 2024 Vol 20, No 2: September 2023 Vol. 20 No. 2: September 2023 Vol 20, No 1: March 2023 Vol. 20 No. 1: March 2023 Vol. 19 No. 2: September 2022 Vol 19, No 2: September 2022 Vol 19, No 1: March 2022 Vol. 19 No. 1: March 2022 Vol. 18 No. 2: September 2021 Vol 18, No 2: September 2021 Vol 18, No 1: Maret 2021 Vol. 18 No. 1: Maret 2021 Vol 17, No 2: September 2020 Vol. 17 No. 2: September 2020 Vol 17, No 1: Maret 2020 Vol. 17 No. 1: Maret 2020 Vol. 16 No. 2: September 2019 Vol 16, No 2: September 2019 Vol. 16 No. 1: Maret 2019 Vol 16, No 1: Maret 2019 Vol 15, No 2: September 2018 Vol. 15 No. 2: September 2018 Vol 15, No 1: Maret 2018 Vol. 15 No. 1: Maret 2018 Vol 15, No 1 (2018) Vol 14, No 2 : September 2017 Vol 14, No 2 : September 2017 Vol 14, No 1: Maret 2017 Vol. 14 No. 1: Maret 2017 Vol 14, No 1: Maret 2017 Vol. 13 No. 2: September 2016 Vol 13, No 2: September 2016 Vol 13, No 2: September 2016 Vol. 13 No. 1: Maret 2016 Vol 13, No 1: Maret 2016 Vol 13, No 1: Maret 2016 Vol 12, No 2: September 2015 Vol 12, No 2: September 2015 Vol. 12 No. 2: September 2015 Vol 12, No 1: Maret 2015 Vol 12, No 1: Maret 2015 Vol. 12 No. 1: Maret 2015 Vol 11, No 2: September 2014 Vol 11, No 2: September 2014 Vol. 11 No. 2: September 2014 Vol 11, No 1: Maret 2014 Vol. 11 No. 1: Maret 2014 Vol 11, No 1: Maret 2014 Vol 10, No 2: September 2013 Vol. 10 No. 2: September 2013 Vol 10, No 2: September 2013 More Issue