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INDONESIA
The Journal of The Indonesian Medical Students´ Association
Published by e-Publishers Community: Indonesia
ISSN : -     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology
Arjuna Subject : -
Articles 13 Documents
 1   2 
Staghorn Stone on Women: Risk Factors and Treatments Rully S, M. Azharry
The Journal of The Indonesian Medical Students Association Vol. I No. 01 January - June 2010
Publisher : The Journal of The Indonesian Medical Students Association

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Abstract

The Potency of Probiotic as Adjuvant Therapy on The Treatment of Autistic Spectrum Disoders (ASD) Khoiria Qodriani, Titisari; Setiani, Ariana
The Journal of The Indonesian Medical Students Association Vol. I No. 01 January - June 2010
Publisher : The Journal of The Indonesian Medical Students Association

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Abstract

Autistic Spectrum Disorders (ASD) is a neurodevelopment disorder which the case increases continously. Recent studies have proved the linkage between gut dysfunction and central nervous system disorders (gut-brain axis) through immunoexcitotoxic mechanism. The overgrowth of pathogen bacteria such as Clostridia in ASD childrenss intestine produce neurotoxin and induce chronic local inflammation. It stimulates the increasing of proinflammatory cytokines level and activation of microglia which induce neural damage. Moreover, dipeptidyl peptidae IV (DPP IV) deficiency in most ASD children increase exorphine level in the bloodstream which induces the presence of some ASD symptoms. Probiotic is potential in preventing gut-brain axis disorders by inducing immunomodulation and exorphine degradation as well as reducing microglial activation. Therefore, it can be an adjuvant therapy for ASD.Key words: autism, autistic spectrum disorders, probiotic.
The Potency of Propolis on Honey Bees Nest on Inhibiting The Infection of P. Falciparus as Supporting Therapy on Malaria Tropicana Azizah, Nurul; Kencono Wungu, Citrawati Dyah; Viradella, Jofan
The Journal of The Indonesian Medical Students Association Vol. I No. 01 January - June 2010
Publisher : The Journal of The Indonesian Medical Students Association

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Abstract

The incidence of malaria in Indonesia increases every year, even reached seven times higher in 2000 thank that in 1997. This disease is caused bt Plasmodium parasite. Plasmodium falciparum and Plasmodium vivax are the most common species, but the deadliest one is Plasmodium falciparum. However, there are many P. falciparum cases resistant to antimalaria drugs. Hence, it is necessary to look for other antimalaria drugs as alternative therapy.There are many medicating effects of bees products. In this paper, we try to study propolis, a compound extracted from resin, mixed with bee wax, honey, and enzyme. Luteplin 7-O glucoside is a flavonoid compound in propolis, identified as antimalaria agent. Luteolin 7-O glucoside has specific target FabI, regulator and repressor exzyme for type 2 FAS. This compound inactivated FabI enzyme, blocked the biosynthesis of Plasmodium fatty acid, and hence disturbed the metabolism and growth of Plasmodium.Another flavonoid component of propolis, chalcone, has also important effect on blocking erythrocyte hemolysis in P. falciparum infection so symptoms can be reduced. Key words: P. falciparum, flavonoid, Luteolin 7-O glucoside, type21 FAS, chalcone

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