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INDONESIA
Medical Journal of Indonesia
Published by Universitas Indonesia
ISSN : 08531773     EISSN : 22528083     DOI : 10.13181
Core Subject : Health,
Medicine & Pharmacology
This quarterly medical journal is an official scientific journal of the Faculty of Medicine Universitas Indonesia in collaboration with German-Indonesian Medical Association (DIGM) Indexed in: IMSEAR; CAB Abstracts; Global Health; HINARI; DOAJ; DRJI; Google Scholar; JournalTOCs; Ulrichsweb Global Serial Directory; WorldCat; New Jour; Electronic Journals Library; ISJD Accredited (2013-2018) by DIKTI Kemendikbud Republik Indonesia (No:58/DIKTI/Kep/2013)
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Articles 1,648 Documents
 73   74   75   76   77 
A multicentred phase III comparatiye study between single-implant containing 3-ketodesogestrel (Implanon®) and implants containing levonorgestrel (Norplant®) I. Eff¯cacy, acceptability and safety (three-year results)
Medical Journal of Indonesia Vol. 8 No. 1 (1999): January-March (Special Issue: Implant Contraceptive)
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v8i1.677

Abstract

[no abstract available]
A multicentred phase III comparative study between single-implant containing 3-ketodesogestrel (Implanon®) and implants containing levonorgestrel (Norplant®) II. Vaginal bleeding patterns
Medical Journal of Indonesia Vol. 8 No. 1 (1999): January-March (Special Issue: Implant Contraceptive)
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v8i1.678

Abstract

[no abstract available]
Polymorphisms in the pfcrt and pfmdr1 genes in Plasmodium falciparum isolates from South Sumatera, Indonesia
Medical Journal of Indonesia Vol. 23 No. 1 (2014): February
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v23i1.679

Abstract

Background: Over the past decade, antimalarial drug resistance has rapidly become a major public health problem in South East Asia region including South Sumatra. This study aimed to determine the extent of gene polymorphisms associated with chloroquine resistance (CQR) in P. falciparum isolates from Lahat, Sekayu, Baturaja and Palembang district.Methods: A molecular study was conducted to identify the mutant alleles of the genes associated with the resistance to chloroquine among the isolates of Plasmodium falciparum from South Sumatera. Blood from 25 patients was collected, DNA was isolated, and the sequences of two different genes (Plasmodium falciparum chloroquine resistance transporter/pfcrt and Plasmodium falciparum multidrug resistance/pfmdr1) were analyzed using polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP).Results: This study identified polymorphism in the pfcrt 76-Thr in all isolates and pfmdr1 86-Tyr. These findings may reflect the failure of treatment with the standard dose of chloroquine within the last few years in South Sumatera. Conclusion: PCR-RFLP technique provide a simple and rapid method of detecting polymorphisms in genes that may predict chloroquine resistance (CQR). Although the identification of the polymorphism in the pfcrt and pfmdr1 genes provides a significant indicator of CQR, further studies are needed to determine the role of these polymorphisms in the in vivo and in vitro responses to drug treatment.Keywords: chloroquine, Plasmodium falciparum, pfmdr1, pfcrt
Rationale for nutrition-oriented epidemiological study of breast cancer in Indonesia
Medical Journal of Indonesia Vol. 8 No. 2 (1999): April-June (Special Issue: Breast Cancer)
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v8i2.680

Abstract

Ahstrak Penelitian kerja sama Jepang-lndonesia tentang Etiologi dan Klinikopatologi pada Kanker Payudara, yang secara resmi dimulai pada tahun 1989, diperpanjang pada tahun 1992 sebagai Penelitian kerja sama Jepang-Indonesia tentang Epidemiologi Gizi pada Kanker Payudara. Dalam makalah ini, dasar pemikiran untuk perpanjangan dan penyelenggaraan telaah epidemiologi dari segi gizi pada kanker payudara di populasi wanita Indonesia dibicarakan dalam kaitan dengan penemuan-penemuan gizi yang dihasilkan oleh peneliti kasus-kontrol tahap pertama di Jakarta pda tahun 1989-1991, dan berdasarkan makna faktor gizi sebagai faktor risiko kanker yang sekarang diketahui secara pasti dari banyak penelitian epidemiologik di dunia. Akhirnya, diuraikan pedoman-pedoman dari segi gizi yang kini dianjurkan sebagai pencegahan terjadinya penyakit yang terutama ditemukan pada orang dewasa, seperti kanker dan penyakit kardiovaskuler di antara masyarakat Jepang. Ditekankan perlunya perumusan pedoman-pedoman yang khas untuk golongan etnik Indonesia untuk menurunkan angka kejadian kanker di Indonesia. Abstract Japan-Indonesia Joint Study on Etiology and Clinicnpatlwlogy of Breast Cancer, which officially started in 1989, was extended in 1992 as Japan-Indonesia Joint Study on Nutritional Epidemiology of Breast Cancer. In this paper the rationale for extending and conducting ll nutrition-oriented epidemiological study of breast cancer in Indonesia female population was discussed in the Light of dietary fi1ulings that emerged from a case-control study of our first-batch studies conducted at Jakarta in 1989-1991, and of the dietary risk factors for cancer which were now well-established and known from numerous epidemiological investigations in the world. Finally, the dietary guidelines now suggested for preventing the occurrence of such major maladies in adulthood as cancers and cardio- and cerebro-vas­cular diseases among Japanese population, were clescribed, emphasizing the necessity of fommlating Indonesian/ethnic-specif ic dietary guidelines for reducing cancer incidence in Indonesia. Keywords: Japan, Indonesia, breast cancer, nutrition, dietary guidelines, epidemiology
Implementation, its termination phase of Japan-Indonesia collaborative and future studies of breast cancer
Medical Journal of Indonesia Vol. 8 No. 2 (1999): April-June (Special Issue: Breast Cancer)
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v8i2.681

Abstract

[no abstract available]
Comparative epidemiological analysis on two-batch study of breast cancer in Dr. Cipto Mangunkusumo Hospital, Jakarta - Indonesia
Medical Journal of Indonesia Vol. 8 No. 2 (1999): April-June (Special Issue: Breast Cancer)
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v8i2.682

Abstract

Abstrak Untuk menganalisa berbagai faktor risiko pada kanker payudara di antara wanita Indonesia, penelitian epidemiologik dilakukan dalam dua tahap, menggunakan cara studi kasus-kontrol yang baku. Tiga ratus kasus kanker payudara dibandingkan dengan 600 kelola yang matched selama studi tahap pertama pada tahun 1988-1991 dan 226 kasus dibandingkan dengan 252 kelola selama studi tahap kedua pada tahun 1992-1995. Data dianalisa dengan menghitung Odds Ratio untuk menetapkan kemaknaan berbagai faktor risiko, dan dilakukan baik analisa univariat maupun analisa multivariat. Hasilnya dievaluasi terhadap konsistensinya di antara kedua penelitian tersebut. Penelitian tahap pertama menunjukkan bahwa beberapa faktor risiko meningkatkan risiko secara bermakna, baik pada analisa univariat maupun mubivariat, i.e. menarche yang terlambat, trauma payudara, menopause, masa laktasi yang pendek, konsumsi lemak yang tinggi; sedangkan konsumsi protein yang tinggi hanya meningkatkan risiko pada analisa univariat. Faktor-faktor tersebut tidak menunjukkan risiko bermakna pada penelitiart tahap kedua. Abstract In order to analyze various risk factor in breast cancer among Indonesian women, epidemiologic studies were performed in two batches, using standard case-control study method. Three hundreds breast cancer cases were compared to 600 matched controls during the first batch study in 1988-1991 and 226 cases were compared to 252 controls during the second batch study in 1992-1995. The data were analyzed by calculating the Odds Ratios for determining the significance of various risk factors, and both univariate and multivariate analysis were petformed. The findings were evaluated for their consistency between the two studies. The first batch study showed that several risk factors significantly increased the risk in both univariate and multivariate analysis, i.e. late menarche, breast trauma, menopause, short lactation, high fat consumption, while high protein intake increased the risk only in univariate analysis. They were not significantly shown in the second batch study. Keywords: Epidemiological analysis, breast cancer comparative study
Role of allogenic mesenchymal stem cells in the reconstruction of bone defect in rabbits
Medical Journal of Indonesia Vol. 23 No. 1 (2014): February
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v23i1.683

Abstract

Background: Despite the advancement of bone reconstruction in the past decade, large bone defect remains a challenge for orthopedic surgery. As mesenchymal stem cells (MSCs) emerges as one of the possible treatment of these defects, we evaluate the effect of its transplantation, particularly in combination with hydroxyapatite-calcium sulphate pellets.Methods: Twenty eight rabbits were randomly assigned into four different treatment groups. Each group received a different type of grafts (Autograft, hydroxyapatite-calcium sulphate [HA-CaSO4], HA-CaSO4 combined with marrow aspirate, or HA-CaSO4 combined with 2x106 MSCs). One centimeter long bone defects were created then immediately fixated with mini plate-screw and two cerclage wires. It was followed by the graft transplantation. Callus thickness was measured from the x-rays taken at 4, 8, 12 week after transplantation by two authors working independently. At the end of the study, histological staining along with osteocyte index were obtained by sacrificing the rabbits. These data were analyzed by one-way ANOVA test.Results: At the fourth week, callus thickness showed significant difference (p = 0.018). Although statistically insignificant, callus in MSCs group at the eighth week seemed to be thicker than any other groups of intervention (p = 0.546). The MSCs group also tend to have a higher osteocyte index at the follow-up weeks.Conclusion: MSC transplantation on bone defect results in faster callus formation and tends to generate a thicker callus.Keywords: bone defect, callus thickness, hydroxyapatite-calcium sulphate, mesenchymal stem cells, osteocyte index
In silico study of curcumol, curcumenol, isocurcumenol, and β-sitosterol as potential inhibitors of estrogen receptor alpha of breast cancer
Medical Journal of Indonesia Vol. 23 No. 1 (2014): February
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v23i1.684

Abstract

Background: Based on data from the Hospital Information System (HIS) in 2007, breast cancer is the top ranked diagnosed cancer in Indonesia. Estrogen receptor alpha (ERα) is associated with breast cancer because it is found in high levels in cancer tissues. Curcumol, curcumenol, isocurcumenol of white tumeric rhizomes (Curcuma zedoaria (Christm.) Roscoe), and β-sitosterol from seeds of pumpkin (Cucurbita pepo L.) have been reported to have inhibitory activity against cancer cells. This study presents the in silico study of these compounds as inhibitors of ERα.Methods: Docking simulations are carried out in this paper to visualize molecular-level interactions between the four compounds with ERα. Docking simulations between estradiol and tamoxifen on ERα are carried out as well. Results: Docking results indicated that curcumol, curcumenol, isocurcumenol, and β-sitosterol showed inhibitory activity againts estrogen receptor alpha (ERα). The order of potency is shown consecutively by isocurcumenol, curcumol, curcumenol, and β-sitosterol with values 0.584 M, 1.36 M, 1.61 M, and 7.35 M respectively. Curcumenol and estradiol interacts with ERα through hydrogen bonds and hydrophobic interactions, whereas curcumol, isocurcumenol, β-sitosterol and tamoxifen through hydrophobic interactions in succession. Conclusion: Natural products containing all four compounds have the potential to be used as drugs or adjuvant drugs in breast cancer therapy. Keywords: β-sitosterol, breast cancer, curcumol, curcumenol, estradiol, ERα, isocurcumenol
Serum levonorgestrel concentration and cervical mucus viscosity after six months of monoplant® implantation
Medical Journal of Indonesia Vol. 23 No. 1 (2014): February
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v23i1.685

Abstract

Background: The use of levonorgestrel implants as a contraceptive method have undergone changes in the number of implants used, beginning from six rods in the early methods to two rods in the present method and have been proven effective. This study aims to evaluate the efficacy of single rod implant (Monoplant®) by measuring serum levonorgestrel concentration and cervical mucus quality. Methods: Thirty healthy women, aged 20-40 year old, and have been proven fertile, underwent single rod implant insertion. Levonorgestrel serum levels was measured every month and cervical mucus viscosity was examined every three month, until six months. Results: Levonorgestrel serum concentration was consistently above minimum effective level (200 pg/mL), from month 3 to 6 respectively 338.9 pg/mL, 424.8 pg/mL, 320.3 pg/mL, and 337.5 pg/mL. Almost all of the acceptors (96.7%) had good cervical mucus viscosity since three months following implant insertion. Conclusion: Levonorgestrel serum concentration in Monoplant® users was still above minimum contraceptive level until the sixth month. Viscosity of cervical mucus increased immediately following implant insertion. This indicates that single rod levonorgestrel implant is effective as a contraceptive method. Keywords: cervical mucus viscosity, implant monoplant®, serum levonorgestrel
Effect of equiosmolar solutions of hypertonic sodium lactate versus mannitol in craniectomy patients with moderate traumatic brain injury
Medical Journal of Indonesia Vol. 23 No. 1 (2014): February
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v23i1.686

Abstract

Background: Brain relaxation and prevention from cerebral edema are essential in craniectomy. Osmotherapy with 20% mannitol are generally used to withdraw fluid from the brain parenchyma, however may cause hemodynamic fluctuation, due to increase diuresis. On the other hand 0.5 M hypertonic sodium lactate (HSL) appeared as an alternative of osmotherapy. This study aimed to observe the effect of hypertonic sodium lactate (HSL) on brain relaxation, blood glucose level and hemodynamic variables in craniectomy due to moderate brain injury. Methods: A randomized controlled study of 42 cases with moderate brain injury, aged 18 - 65 years, ASA 1 - 3, between September-November 2012, was carried out. The patients were divided into group M (n = 21) that received 2.5 mL/kg 20% mannitol and group HSL that received 2.5 mL/kg 0.5M HSL. Mean arterial pressures (MAP), central venous pressures (CVP) and urine output were measured after induction, and at 15, 30, 45, 60 min after infusion. Brain relaxation was assessed at a four-point scale after opening the duramater. Blood glucose levels were measured before induction and at 60 min after the infusion. Appropriate statistical tests were used for comparison. Unpaired t-test was used to compare hemodynamic and blood glucose level, and chi-square was used to compare brain relaxation. Results: MAP at 60 minute was significantly higher in HSL group than M group (81.66 ± 7.85 vs 74.33 ± 6.18 mmHg; p = 0.002). There was no difference in brain relaxation (p = 0.988). A significant increase in blood glucose level was observed in group HSL (17.95 ± 11.46 mg/dL; p = 0.001). Conclusion: Half-molar HSL was as effective as 20% mannitol in producing brain relaxation, with better hemodynamic stability and gave significant increase in blood glucose level. Keywords: brain relaxation, hemodynamic, hypertonic sodium lactate, mannitol, traumatic brain injury

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