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INDONESIA
Medical Journal of Indonesia
Published by Universitas Indonesia
ISSN : 08531773     EISSN : 22528083     DOI : 10.13181
Core Subject : Health,
Medicine & Pharmacology
This quarterly medical journal is an official scientific journal of the Faculty of Medicine Universitas Indonesia in collaboration with German-Indonesian Medical Association (DIGM) Indexed in: IMSEAR; CAB Abstracts; Global Health; HINARI; DOAJ; DRJI; Google Scholar; JournalTOCs; Ulrichsweb Global Serial Directory; WorldCat; New Jour; Electronic Journals Library; ISJD Accredited (2013-2018) by DIKTI Kemendikbud Republik Indonesia (No:58/DIKTI/Kep/2013)
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Articles 1,648 Documents
 75   76   77   78   79 
Histopathologic profile of mastectomy specimens of operable breast cancer cases
Medical Journal of Indonesia Vol. 8 No. 2 (1999): April-June (Special Issue: Breast Cancer)
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v8i2.698

Abstract

[no abstract available]
Clinicopathology profile evaluated against several risk factors in breast cancer cases
Medical Journal of Indonesia Vol. 8 No. 2 (1999): April-June (Special Issue: Breast Cancer)
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v8i2.699

Abstract

Telah dilakukan penelitian dua ratus dua puluh enam kasus kanker payudara (KPD) yang berhubungan dengan aspek klinik dan patologi serta faktor risiko yang berhubungan dengan terjadinya keganasan payudara. Distribusi terbanyak pada umur antara 35-55 tahun dengan frekuensi tertinggi antara umur 40-50 tahun. Tidak didapatkan perbedaan lokasi tumor pada payudara kanan atau kiri serta distribusi pre-menopause maupun post-menopause. Delapan puluh satu koma enam persen KPD ditemukan pada stadium lanjut (stadium llf A: 17,7%, JJJB: 56,2% dan JV: 11,9%), sedangkan stadium !: 1,3% dan stadium fl: 11,9%. Tujuh puluh Lima dari 226 kasus dilakukan tindakan pembedahan: 60% mastektomi simpel, 26,7% mastektomi radikal dan 1,3%: breast concerving treatment (BCT). His­ topatologi dari jaringan payudara dari 214 kasus didapatkan karsinoma invasif yang terdiri dari: 90,4% karsinoma duktal invasif dan 9,6% tipe khusus. Dilakukan analisa dari beberapa faktor risiko seperti status kawin, umur pada saat kawin pertama, umur menarche, status menopause, laktasi, riwayat keluarga KPD, penggunaan kontrasepsi dan konsumsi tinggi lemak. Hasil dari metode kasus kontrol menunjukkan bahwa faktor-faktor status menopause, laktasi dan konsumsi tinggi lemak meningkatkan risiko terjadinya KPD, dengan risiko relatif masing-masing: 1,51, 1,83 dan 2,61. Abstract The second batch case-control study on breast cancer has been conducted as a joint study between Indonesian and Japan. Two hundred and twenty six ( 226) cases of breast cancer was collected to assess the risk factors and evaluated for their clinical presentation of the disease. The age distribution in some high risk areas showed at age 35 to 55 years, with a single peak between 40 to 50. There was no difference in number of cases in respect to tumor site and menopausal status. The majority of cases 81.6 % were in advanced stage ( l!JA: 17.7%, JflB: 56.2% and JV: 11.9%) while in contrast stage l and fl were very rare (1.3% and 11.9% respectively ). Only 75 cases were operable; simple mastectomy was the most frequent surgery carried out (60.0%), followed by modified radical mastectomy (26.7%), classical radical mastectomy (12%) and breast conserving treatment (1.3%). The specimens were reviewed using classification recommended by the Japanese Breast Cancer Society revealed invasive ductal carcinoma (90.4%) and the special type (9.6%) . Several risk factors were analyzed for their influence to the development of breast cancer; namely: marital status, age at first marriage, menarche, menopausal status, lactation, family history of breast cancer; use of contraceptive and fat consumption. Among the characteristics studied, the following factors significantly increased the risk of breast cancer: menopausal status (RR= 1.51; 95% Cl: 1.10-2.09), non-lactating children (RR=1.83; 95% Cl: 1.07-3. Jl ) and fat consumption (RR=2.61; 95% Cl: 1.86-3.68), while the use of contraceptive showed pro­ tective effect. The findings will be discussed in its benefit relative to both the improvement of the treatment modality and the cancer control prog ram. Keywords: Breast cancer, clinicopathological, case-control study, epidemiology
Breast cancer risk factors among Sundanese and other ethnic groups in Indonesia
Medical Journal of Indonesia Vol. 8 No. 2 (1999): April-June (Special Issue: Breast Cancer)
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v8i2.700

Abstract

Penelitian cara kasus-kontrol telah dilakukan untuk analisafaktor risiko pada kanker payudara wanita Indonesia. Tiga ratus kasus dan 600 kontrol diwawancara menggunakan kuesioner baku untuk pengumpulan data epidemiologik. Subyek diteliti untuk berbagai data demografik, status reproduksi, perilaku seks, kebiasaan makan dan cara-cara hidup lain. Data dianalisa untuk menentukan faktor risiko yang bermakna menggunakan analisa univariat dan multivariat. Perhatian khusus diberikan untuk evaluasi faktor risiko berkaitan dengan golongan etnik yang berbeda. Suku Sunda, yang dikenal berbeda dengan suku-suku lain dalam hal kebiasaan makan dan cara hidup yang lebih tradisional, dibandingkan dangan suku-sulw non-Sunda. Hasilnya menampakkan bahwa faktor-faktor risiko berikut: tingkat sosial ekonomi dan pendidikan, tempat tinggal (pedesaan versus perkotaan), status perkawinan dan pekerjaan tidak bermakna, se­ dangkan di antara suku non-Sunda, menstruasi yang tidak teratur dan trauma payudara meningkatkan risiko, dengan OR dan C/95% masing-masing = 1,60; 1,12-2,28 dan 1,89; 1,02-3,48. Pengaruh semacam itu ditunjukkan juga oleh populasi seluruhnya. Peningkatan risiko karena kebiasaan makan ditunjukkan oleh konsumsi makanan yang mengandung santan dan daging berlemak, baik pada suku Sunda maupun non-Sunda dan pada populasi seluruhnya. Rasia Odd (OD) pada suku Sunda lebih tinggi daripada OD pada kelompok lain, yaitu 1,95 versus 1,31 dan 1,43 untuk makanan yang mengandung santan dan 1,93 versus 1,37 dan 1,47 untuk daging berlemak. Penurunan risiko ditunjukkan oleh konsumsi sari sayuran/buah pada suku Sunda dan populasi seluruhnya dengan OD yang lebih rendah pada suku Sunda, yaitu 0,31 versus 0,61. Pengaruh protektif tersebut ditunjukkan juga oleh konsumsi sayuran segar; telur dan daging tidak berlemak pada suku Sunda dan populasi seluruhnya, dengan nilai OD yang mirip. Dengan analisa multivariat, pengaruh konsumsi telur dikonfirmasi baik pada suku Sunda maupun non-Sunda, sedangkan pengaruh sari sayuran dan buah hanya terlihat pada suku Sunda dan pengaruh susu hanya terlihat pada suku non-Sunda. Abstract A case control study has been performed for analyzing risk factors of breast cancer in Indonesia females. Three hundred cases and 600 controls were interviewed using standard questionnaires for epidemiological data collection. The subjects were probed for various demographic data, reproductive status, sexual behaviors, dietary habits and other lifestyles. The data were analyzed for determining significant risk factors using both univariate and multivariate analysis. Special attention has been pay on evaluating the risk factors in relation to different ethnic groups. Sundanese ethnic group known to differ in their dietary habits and certain lifestyles to the other ethnic groups, was compared to non-Sundanese. The results showed that among Sundanese, the following risk factors: socio-economic and education levels, living area ( rural versus urban), marital status and working status were not significant, while among non-Sundanese, the irregular menstruation and breast trauma increased the risk, with OR and 95%Cl of 1.60; 1.12-2.28 and 1.89; 1.02-3.48 respectively. Such an effect was shown also by the whole population. Increased risk due to dietary habits was shown by intakes of coconut milk con­ taining food and fatty meat in both Sundanese and non-Sundanese groups and in the whole population. The Odds ratios (OD) in the Sundanese were higher than the OD in the others, i.e. 1.95 versus 1.31 and 1.43 for coconut milk containing food and 1.93 versus 1.37 dan 1.47 for fatty meat. Decreased risk was shown by vegetable(fruit intake in the Sundanese and the whole population, with lower Odds Ratio in the farmer; i.e. 0.31 versus 0.61. Such protective effect was also shown by intakes of fresh vegetable, egg and non-fatty meat in the non-Sundanese group and in the whole population, with similar figures of Odds Ratios. By multivariate analysis, the effect of egg consumption was confirmed in both Sundanese and non-Sundanese, while the effect of vegetable(fruit juice was only seen in Sundanese and the effect of milk was only seen in non-Sundanese. Keywods: Breast cancer; case control study, ethnic analysis, risk factors.
Histopathological aspects of breast cancer in relation to some epidemiological risk factors
Medical Journal of Indonesia Vol. 8 No. 2 (1999): April-June (Special Issue: Breast Cancer)
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v8i2.701

Abstract

Penelitian epidemiologik dengan cara kasus kontrol pada 300 kasus kanker payudara di Rumah Sakit Dr. Cipto Mangunkusumo, telah dilakukan pada tahun 1989-1991. Dengan menggunakan klasifikasi yang dianjurkan oleh Japanese Breast Cancer Society, gam­ baran histopatologik kanker payudara menunjukkan bahwa dari tipe karsinoma duktus invasif, jenis skirus ditemukan pada 147 kasus ( 49%), jenis padat tubuler pada 79 kasus ( 26.33%) dan jenis pa pilotubuler pada 39 kasus ( 13%). Sedang dengan menggunakan klasi­ fikasi WHO ( 1981), ditemukan 265 kasus ( 88.33%) invasif duktus karsinoma, karsinoma invasif lobuler pada 7 kasus ( 2.33%), karsinoma moduler pada 17 kasus ( 5.68%), karsinoma adenoid kistik pada 1 kasus (0.33%), penyakit Paget pada puting 2 kasus (0.67%) dan 4 kasus pada karsinoma noninvasif adalah karsinoma duktal insitu. Analisa terhadap faktor-faktor risiko yang bermakna pada kanker payudara wanita Indonesia menunjukkan bahwa faktor-faktor: aktivitas seksual dini, tinggal di daerah perkotaan, trauma payudara, obesitas ( kegemukan), haid pertama/menarche yang terlambat, siklus haid yang tidak teratur, menopause, konsumsi makanan berlemak dan yang mengandung santan dapat meningkatkan risiko. Juga telah dianalisa hubungan antara faktor-faktor risiko yang bermakna tersebut dengan jenis histopatologik. Hasilnya menunjukkan bahwa Konsumsi makanan bersantan meningkatkan kemungkinan jenis karsinoma duktus invasif. Pengaruh tersebut berhubungan dengan ketiga subtipe histologik, yaitu papiler tubuler; solid tubuler dan skirus. Konsumsi minuman dengan santan/air kelapa dan sayuran segar menurunkan kemungkinan jenis tersebut, dengan sifat tidak bergantung kepada subtipe histologik. Abstract Case control epidemiological study of 300 breast cancer cases from Dr. Cipro Mangunkusumo Hospital has been performed in 1989-1991. By applying the Japanese Breast Cancer Society classification, the histopathological pattern of breast cancer showed that from the invasive ductal carcinoma type, scirrhous type was found in 147 cases (49%), solid-tubular type in 79 cases ( 26.33%) and papilotubular type in 39 cases ( 13%). According to WHO classification ( 1981); they were diagnosed as: invasive ductal carcinoma in 265 cases ( 88.33%), invasive lobular carcinoma in 7 cases ( 2.33%), medullary carcinoma in 17 cases ( 5.68%), adenoid cystic carcinoma in 1 case (0.33%), pure Paget's disease of the nipple in 2 cases (0.67%) and 4 cases ( 1.33%) of the noninvasive carcinoma were ductal carcinoma in situ. Analysis of the significant risk factors among the Indonesian female breast cancer revealed that thefollowing factors: living at urban area, young sexual activity, trauma, obesity, late menarche, irregular cycle, menopause, fatty diet and coconut milk con­ taining food consumption increased the risk. Relationship of the risk factors to histopathological types has been stastistically analyzed. The results showed that increased possibility to have the invasive ductal carcinoma was related to consumption of coconut milk containing food. The effect was related to the three histological subtypes, namely: papillary tubular, solid tubular and scirrhous types. Coconut milk drinks and fresh vegetables showed decreasing effect, which was irrespective to subtypes. Keywords: Breast cancer, histopathological, epidemiological, risk factors .
A putative localization of the ureaplasma urealyticum IgA1 protease
Medical Journal of Indonesia Vol. 8 No. 3 (1999): July-September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v8i3.702

Abstract

[no abstract available]
Prion: the infectious protein in neurodegenerative diseases
Medical Journal of Indonesia Vol. 8 No. 3 (1999): July-September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v8i3.703

Abstract

[no abstract available]
Evaluation of anti-phenolic glycolipid-I IgM and CD4/CD8 T cell subsets value as high risk determination indicator for individuals residing in a leprosy endemic area in Indonesia
Medical Journal of Indonesia Vol. 8 No. 3 (1999): July-September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v8i3.704

Abstract

[no abstract available]
The kinetics of endotoxin and cytokines in dengue hemorrhagic fever
Medical Journal of Indonesia Vol. 8 No. 3 (1999): July-September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v8i3.705

Abstract

[no abstract available]
Endotoxin as a predictor of severe dengue infection
Medical Journal of Indonesia Vol. 8 No. 3 (1999): July-September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v8i3.706

Abstract

[no abstract available]
Risk of ectopic pregnancy associated with gynecological history, past contraceptive use, and smoking habit
Medical Journal of Indonesia Vol. 8 No. 3 (1999): July-September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v8i3.707

Abstract

[no abstract available]

Page 77 of 165 | Total Record : 1648

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