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INDONESIA
Medical Journal of Indonesia
Published by Universitas Indonesia
ISSN : 08531773     EISSN : 22528083     DOI : 10.13181
Core Subject : Health,
Medicine & Pharmacology
This quarterly medical journal is an official scientific journal of the Faculty of Medicine Universitas Indonesia in collaboration with German-Indonesian Medical Association (DIGM) Indexed in: IMSEAR; CAB Abstracts; Global Health; HINARI; DOAJ; DRJI; Google Scholar; JournalTOCs; Ulrichsweb Global Serial Directory; WorldCat; New Jour; Electronic Journals Library; ISJD Accredited (2013-2018) by DIKTI Kemendikbud Republik Indonesia (No:58/DIKTI/Kep/2013)
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Articles 1,648 Documents
 94   95   96   97   98 
Epidemiologic risk factors for breast cancer related to menopausal status in Indonesia
Medical Journal of Indonesia Vol. 4 No. 3 (1995): July-September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v4i3.914

Abstract

Untuk meneliti faktor risiko kanker payudara yang berkaitan dengan status menopause, dilakukan penelitian kasus kontrol pada rumah sakit di Indonesia. Pada 300 kasus dan 600 kontrol yang berpasangan menurul umur dan keadaan sosial ekonomi dilakukan wawancara . Kasus dan kontrol dikelompokkan berdasarkan status menopausenya dan dianalisis terpisah. Diperoleh temuan-temuan bermakna berikut ini.Di antara penderita kanker payudara pra menopause ditemukan peningkatan risikopada yang mengalami trauma payudara (RR: 2,62; 95% JK: 1,09-6,31), menggunakan kontrasepsi oral (4,96; 1,51-16,24), mengkonsumsi susu (1,81; 1,01-3,35 konsumsi tiap hari versus nir konsumsi), makan buah sega r (2,42; 1,16-5,05, 3-4x per minggu versus kurang dari seka li per minggu). Penurunan risiko ditemukan pada wanita pengkonsumsi sayuran tiap hari (0,34; 0,15-0,77, konsumsi tiap hari versus tidak tiap hari). Di antara penderita kanker payudara pasca menopause ditemukan peningkatan risiko pada wanita dengan usia menard1e 15 tahun atau lebih (2,25 ·1,35-3,76), haid teratur setelah usia 30 tahun (4,61-· 2,45-8,67), konsumsi susu (5,84; 2,92-11,66, konsumsi tiap hari versus nir konsumsi). Penurunan risiko ditemukan pada wanita yang cerai atau janda (0,33; 0,18-0,58), jumlah melahirkan hidup atau bayi yang disusuinya tinggi (0,32; 0,13-0,76), menyusui 6 atau lebih bayi versus tidak menyusui). Abstract To clarify the risk factors of breast cancer in premenopausal and postmenopausal women, a hospital-based case-control study was conducted in Indonesia. Three hundred inciden.t cases were inlerviewed and 600 controls were selected, matching for age and socio-economic class. Cases and controls were divided according to their menopausal status and analyzed separately. Following significant findi ngs were revea led. For premenopausal breast cancer, an increased risk was detected in women with breast trauma (adjus ted RR: 2.62; 95% Cl: 1.09-6.31), oral contraceptive u e (4.96,- 1.51-16.24), milk consumption (1.81; 1.01-3.35, daily intake vs no intake), fresh frui ts intake (2-42; 1.16-5.05, 3-4 times/week vs less than once/week intake). A decreased risk was detected in women with cooked-vegetable intake (0.34; 0.15-0.77, daily intake vs not daily intake). For postmenopausal breast cancer, an increased risk wasfound in women having menarche at the age of 15 years or over (2.25; 1.35-3.76), regular menstruation after thirty years old (4.61; 2.45-8 .67), milk consumption (5.84; 2.92-11.66, daily intake vs no intake), and a decreased risk in women who were divorced or widowed (0.33; 0. 18-0.58), and whose number of live birth or breast-fed children was high (0.32; 0.13-0.76, six or more breast-fed children vs no breast-fed child). Keywords :case-control study, pr emenopausal women, p ost menopausal women, breast cancer, risk factors
A case-control study of breast cancer among Japanese women in Tokyo
Medical Journal of Indonesia Vol. 4 No. 3 (1995): July-September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v4i3.915

Abstract

Untuk meneliti faktor. risiko kanker payudara saat ini dilakukan penelitian kasus-kontrol pada rumah-sakit di Tokyo, dari tahun 1990 sampai 1991. Informasi mengenai faktor risiko potensial didapat dari kwesioner yang diisi sendiri oleh 5.084 pasien rawat jalan. Dari pasien tersebut didapat 300 kasus /canker payudara, dan dipilih 900 kontrol secara acak yang umunya sesuai. Temuan bermakna adalah: (a) semakin tinggijumlah kelahiran hidup, semakin kecil risikopada wanita pramenopause (risiko relatif (RR)yang disesuaikan untuk 3 atau lebih kelahiran hidup terhadap tanpa kelahiran hidup: 0,24; 95% interval kepercayaan (JK) : 0,08 - 0,65); (b)pada wanita pramenopause, siklus haid teratur meningkatkan risiko (RR yang disesuaikan: 2,50; 95% IK : 1,16-5,38), danpeningkatan lama siklus mengurangi risiko (P untuk kecenderungan linier < 0,05); (c)perokok masa kini mengalami peningkatan risiko (1,63; 1,11-2,39) untuk semua wanita, dan (2,73; 1,38-5,39) untuk wanita pasca menopause); (d) wanita yang kegemukan mengalami risiko lebih besar mendapat kanker payudara pasca menopause: RR yang disesuaikan untuk yang berbobot 70 kg atau lebih terhadap yang berbtH>ot 50 kg atau kurang adalah 4,82 (95% IK: 1,53-15,2); (e) semakin tua usia melahirkan anak pertama, semakin tinggi risiko kanker payudara pasca menopause (2,85; 1,16-6,99, dan 3,54; 1,03-12,2 untuk umur 30-34 dan 35 tahun atau lebih). Risiko kanker payudara pra menopause dan pascamenopause tidak berhubungan dengan riwayat kankerpayudara pada keluarga, riwayat penyakit payudara jinak, umur saat haid pertama dan menopause, la/etas kebiasaan minum alkohol dan tinggi badan. Abstract To explore the risk factors for recent female breast cancer, a hospital-based case-control study was conducted in Tokyo, from 1990 to 1991. Information on potential risk factors was obtained by a self-administered questionnaire from 5.084 out-patients. Of thepatients, 300 incident breast cancer cases were recruited, and 900 age-matched controls were randomly selected. Significant findings are: (a) the more the number of livebirths, the smaller the risk inpremenopausal women (adjusted relative risk (RR)for 3 or more births relative to none: 0.24; 95% confidence interval (CI): 0.08-0.65); (b) in premenopausal women, regular menstrual cycle increased the risk (adjusted RR: 2.50, 95% Cl: 1.16-5.38), and its increasing duration decreased the risk (Pfor linear trend
Pilot study of food consumption pattern: Assessment of validity of dietary history method
Medical Journal of Indonesia Vol. 4 No. 3 (1995): July-September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v4i3.916

Abstract

[no abstract available]
Preliminary analysis of nutritional factors in breast cancer
Medical Journal of Indonesia Vol. 4 No. 3 (1995): July-September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v4i3.917

Abstract

Data epidemiologi dan eksperimental menunjukkan bahwa ada hubungan antara keganasan dan faktor gizi. Baik keganasan maupun faktor gizi merupakan bidang yang kompleks, oleh karena itu mempelajari hubungan antara keganasan danfaktor gizi tidaklah mudah. Pada umumnya telah diketahui, bahwa diperlukan waktuyang lama untuk suatupertumbuhan ganas. Data gizi, terutama catatan tentang apa yang telah dimakan oleh seseorang untuk jangka waktu yang lama sulit didapat secara akurat. Tujuan dari penelitian ini adalah untuk mendapatkan cara yang cukup baik untuk dapat menjelaskan tentang adanya hubungan antara keganasan danfaktor gizi pada penderita kanker payu dara dengan menggunakan metode "Food Frequency Questionaire" untuk periode-periode terlentu dalam kehidupan penderita. Penelitian ini merupakan suatu penelitian "Case Control" yang dilakukan pada 20 triplets (1 kasus, berpasangan dengan 2 kontrol) penderita kanker payudara yang berobat jalan di Rumah Sakit Mangunkusumo Jakarta. "Food frequency amount" dari empat waktu kehidupan yaitu sebelum dan sesudah menikah, Lima dan sepuluh tahun sebelum diketahuinya penyakit dilakukan pada penderita dan mencakup 98 bahan makanan. Respons yang sama untuk I 0 bahan makanan (10.2%) diamati pada periode sebelum dan sesudah menikah, sedangkan 89.8% bahan makanan mendapat respons yang sama pada periode lima dan sepuluh tahun sebelum diketahuinya penyakit. Tidak terdapat jawaban untuk 19 bahan makanan dan respons cukup baik didapatkan untuk pertanyaan tentang tujuh cara memasak. Dapat disimpulkan bahwa waktu p ernikahan merupakan saat yang baik dipakai sebagai patokan waktu untuk bertanya tentang pola makan, terutama bila menyangkut masa yang cukup panjang/lama . Sembilan belas bahan makanan yang tidak mendapat respons (karena sangat jarang dikonsumsi) akan dikeluarkan dari daftar pertanyaan "Food Frequency amount". Penelitian ini dilanjutkan dengan menggunakan pertanyaan yang telah disesuaikan dengan hasil sementara ini. Abstract Epidemiological and experimental data indicate that cancer could be linked to nutritional factors. Both nutrition and cancer are complex subjects, therefore to investigate the link between cancer and nutrition is not an ea.ry task. It is generally believed that cancer needs a long time to develop. On the otHer hand, and accurate dietary records over a long period of time is difficult to obtain. The aim of this study is ta find a method which is able to give a better estimate in elucidating a cancer-diet relationship inpatients with breast cancer, using a modified food frequ ency questionaires for specif ic time periods. A total of twenty tiplets (one case, two matched controls) nutrit ional forms were done during a pilot case-control study on breast cancer in Cipto Mangunkumo Hospital, Jakarta. Using Food Frequency Amount (FFA) questionaire of 4 different p eriods: before and after marriage, five and ten years before disease occurence, a total of 98food items were covered. Identical responses to FFA between before and after marriage werefound only among 10food items (10.2 %), while 89.8% figur e was obtained between the five and ten year periods . No responses to 19 food items by all 60 respondents but quite good response to seven different cooking preferences questionaires. It is concluded that time of ma"iage can be used as milestone in interviewing dietary patt ern. Ninet een food items would be dropped outfrom the questionaire. The implementation of the definitive study is now in progress. Keywords: dietary assessment, nutrients, breast cancer, care-control study
The mechanisms of autoimmune response: Insights into an enigmatic repertoire
Medical Journal of Indonesia Vol. 4 No. 4 (1995): October-December
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v4i4.919

Abstract

[no abstract available]
Polyester sling scrotal cover induces oligozoospermia in normal Indonesian men
Medical Journal of Indonesia Vol. 4 No. 4 (1995): October-December
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v4i4.920

Abstract

[no abstract available]
Studies on male fertility regulation in Indonesia
Medical Journal of Indonesia Vol. 4 No. 4 (1995): October-December
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v4i4.921

Abstract

[no abstract available]
Clinical comparison of arthemeter and quinine treatment of severe and complicated falciparum malaria patients in Indonesia: A preliminary report
Medical Journal of Indonesia Vol. 4 No. 4 (1995): October-December
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v4i4.922

Abstract

[no abstract available]
IFNγ modulates human immunoglobulin receptor expression in lipoaspirate-derived mesenchymal stem cells
Medical Journal of Indonesia Vol. 23 No. 3 (2014): August
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v23i3.923

Abstract

Background: Mesenchymal stem cell (MSC) has been reported to have immunomodulator capacity against autoimmune diseases and to prevent allogenic tissue rejection. Many studies revealed that MSC’s inhibit T cell proliferation and induce immunosuppressive condition through the production of prostaglandins, and interleukin-10. In addition, MSC was reported to reduce circulating autoantibody in autoimmune patients following MSC transfusion. So far, there has been no report stating the presence of Fc receptors (receptors for immunoglobulin) on MSCs. The aim of this study was to reveal the expression of FcγRs in lipoaspirate-derived MSCs by measuring transcription of FcγR mRNA and whether the expression can be modulated. Methods: Lipoaspirate-derived MSCs were cultured in suitable medium and confirmed to be MSCs according to the criteria published by International Society for Cellular Therapy. Total mRNA of MSCs was isolated, and detection of human FcγRI, FcγRIIA and FcγRIIB mRNA was performed. Further, modulation of the expression was tested using heat aggregated gamma globulin (HAGG) and interferon (IFN)γ. Results: FcγRs mRNA was detected in the first passage of MSCs. However, the expression was no longer present after more than 4 passages. Further, increased level of FcγRI and FcγRIIA mRNA expression was detected with the addition of IFNγ in the culture. This preliminary finding opens a new insight for the understanding of interaction between MSCs and immunoglobulin G through FcγRs. Conclusion: Lipoaspirate-derived MSCs express FcγRs, and the expression is modulated by IFNγ.
Treadmill test in patients with rheumatic mitral regurgitation
Medical Journal of Indonesia Vol. 4 No. 4 (1995): October-December
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.v4i4.924

Abstract

[no abstract available]

Page 96 of 165 | Total Record : 1648

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