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INDONESIA
Medical Journal of Indonesia
Published by Universitas Indonesia
ISSN : 08531773     EISSN : 22528083     DOI : 10.13181
Core Subject : Health,
Medicine & Pharmacology
This quarterly medical journal is an official scientific journal of the Faculty of Medicine Universitas Indonesia in collaboration with German-Indonesian Medical Association (DIGM) Indexed in: IMSEAR; CAB Abstracts; Global Health; HINARI; DOAJ; DRJI; Google Scholar; JournalTOCs; Ulrichsweb Global Serial Directory; WorldCat; New Jour; Electronic Journals Library; ISJD Accredited (2013-2018) by DIKTI Kemendikbud Republik Indonesia (No:58/DIKTI/Kep/2013)
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Articles 1,657 Documents
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Versatile, low-cost ophthalmic wet lab device to improve diagnostic and surgical eye training Mardianto, Umar; Victor, Andi Arus; Yusuf, Prasandhya Astagiri; Juniantito, Vetnizah; Kekalih, Aria; Rahayu, Tri; Bustamam, Alhadi; Edwar, Lukman
Medical Journal of Indonesia Vol. 35 No. 1 (2026): March
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.bc.257865

Abstract

Ophthalmologists rely on wet lab training for both diagnostic procedures and surgical techniques. Existing wet lab devices are limited to surgical training and lack functionality for performing required perioperative diagnostic examinations. This study aimed to develop an affordable, easily manufactured eye holder to enhance ophthalmology training for wet lab simulations. A three-dimensional (3D)-printed animal eye holder was designed in 3D with a funnel-shaped structure resembling an orbital eye socket. The design was optimized for optimal wet lab activities. The animal eye holder device demonstrated potential use for ultrasound biometry, handheld keratometry, tonometry, and ophthalmological surgical training. These activities can be performed effectively after the animals’ eyes are stabilized inside the holder in flat and inclined positions. This innovative animal eye holder is the first designed to provide flexible diagnostic practice and surgical training, especially during wet lab activities.
A case of Lhermitte-Duclos disease: the classical “tiger stripes” in magnetic resonance imaging Sensusiati, Anggraini Dwi; Apriawan, Tedy; Fauziah, Dyah
Medical Journal of Indonesia Vol. 35 No. 1 (2026): March
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.cr.258118

Abstract

Dysplastic gangliocytoma or Lhermitte-Duclos disease (LDD), is a rare benign cerebellar tumor often presenting with nonspecific symptoms such as intracranial hypertension, cerebellar dysfunction, or cranial nerve deficits, and associated with phacomatosis. The characteristic “tiger stripe” sign on magnetic resonance imaging (MRI) is highly suggestive of LDD, though nodular medulloblastoma remains an important differential diagnosis. We report a 51-year-old woman with arm and leg phacomatosis who presented with a right cerebellar hypodense lesion on computed tomography extending frontally. MRI demonstrated the hallmark “tiger stripe” appearance, and histopathology following surgery confirmed LDD. On follow-up, despite evidence of a recurrent mass on MRI, her cranial nerve paresis improved postoperatively. Imaging revealed hypointense striations on T1 and alternating linear hyperintensities on T2 sequences, obscuring the cerebellar folia, features that distinguish LDD from other cerebellar tumors. This case underscores the diagnostic value of MRI, emphasizing early recognition to prevent misdiagnosis and guide surgical planning.
Effect of umbilical cord-mesenchymal stem cells on skin tensile strength in pressure ulcers: a rat model study Aulia, Indri; Dilogo, Ismail Hadisoebroto; Prasetyono, Theddeus Octavianus Hari; Pawitan, Jeanne Adiwinata; Kekalih, Aria; Siregar, Nurjati Chairani; Whulanza, Yudan; Hasibuan, Lisa
Medical Journal of Indonesia Vol. 35 No. 1 (2026): March
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.oa.268222

Abstract

BACKGROUND Stem cell therapy has emerged as a promising alternative for the management of chronic wounds, including pressure ulcers. Tensile strength, which reflects the biomechanical integrity of the skin, serves as an objective measure of wound healing. This study aimed to evaluate the effect of locally administered umbilical cord-mesenchymal stem cells (UC-MSCs) on the tensile strength of healing 3rd-degree pressure ulcers in a Sprague Dawley rat model. METHODS 21 adult male Sprague Dawley rats were divided into 3 groups: normal rats without ulcers, untreated pressure ulcer as control, and pressure ulcers treated with UC-MSCs. The treatment group received locally injected 4 × 10⁶ UC-MSCs at the ulcer site. On day-21, the tensile strength parameters (rupture point, elongation at break, and elastic modulus) of the dorsal skin were assessed using the Universal Testing System. RESULTS When expressed relative to normal skin tensile strength, the UC-MSC group exhibited higher tensile parameters that were higher than the controls by 2.08% for rupture point, 3.29% for elongation at break, and 8.42% for elastic modulus. Although these differences between the UC-MSCs and control groups across all tensile strength parameters were not statistically significant, a clear trend toward improved tensile strength parameters were observed in the UC-MSCs group. CONCLUSIONS Local UC-MSCs administration showed a consistent trend toward improved tensile strength in healing 3rd-degree pressure ulcers, albeit without statistically significant differences compared to controls. These findings support the further exploration of UC-MSCs as a potential treatment for promoting biomechanical restoration in healing pressure ulcers.
Economic burden and healthcare costs of congenital anomalies of the kidney and urinary tract: a systematic review Alvarino, Akbar Muzakki; Pahlevi, Reza; Situmorang, Gerhard Renaldi; Wahyudi, Irfan; Rodjani, Arry; Raharja, Putu Angga Risky
Medical Journal of Indonesia Vol. 35 No. 1 (2026): March
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.oa.258074

Abstract

BACKGROUND Congenital anomalies of the kidney and urinary tract (CAKUT) cause significant morbidity and economic burden worldwide, highlighting the needs to understand its associated costs. This study aimed to assess the economic burden of CAKUT management. METHODS A systematic review was conducted across 5 databases, including PubMed, ScienceDirect, ProQuest, Nature, and Google Scholar, for studies published up to September 11, 2024, focusing on both direct (e.g., hospitalizations, surgeries, and treatments) and indirect (e.g., lost work time and complications management) healthcare costs related to CAKUT and published in English. Non-economic studies, reviews, editorials, abstracts, animal/in vitro studies, and duplicates were excluded. Methodological quality was assessed using the Risk Of Bias In Non-randomized Studies - of Interventions tool. Narrative synthesis and descriptive statistics were applied. Cost-effectiveness analysis followed Joanna Briggs Institute guidelines. RESULTS 8 studies met the inclusion criteria, revealing wide variations in CAKUT-related healthcare costs across countries and interventions. These studies focused on reviewing both direct and indirect costs, along with interventions that reduce overall healthcare expenditure. Key findings include: (1) In the USA, bilateral renal agenesis costs averaged USD 26,032; (2) In Australia, early whole exome sequencing reduced diagnostic costs by 20% in genetic kidney disease cases; (3) Robotic surgery demonstrated long-term cost-effectiveness despite higher inpatient costs; (4) Other cost-saving strategies include the early renal ultrasound algorithm and genomic testing for CAKUT. CONCLUSIONS CAKUT imposes a significant and variable economic burden globally. Identifying cost-effective interventions is crucial for optimizing care and reducing the financial impact. Further research on cost management strategies is needed to improve outcomes and efficiency.
Modified BI-RADS model for stratifying borderline breast lesions based on BI-RADS: a cross-sectional study Kuntjoro, Lydia Purna; Riwanto, Ignatius; Sukmaningtyas, Hermina; Prajoko, Yan Wisnu; Suhartono; Choridah, Lina; Mahati, Endang; Tjandra, Kevin Christian; Pravitha, Clarissa Aulia
Medical Journal of Indonesia Vol. 35 No. 1 (2026): March
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.oa.258117

Abstract

BACKGROUND Breast imaging reporting and data system (BI-RADS) is a globally recognized method for categorizing breast lesions. However, it is dependent on subjective interpretation, which can result in variability between radiologists. Currently, no scoring system exists to assist in categorizing borderline findings as either benign or malignant. This study aimed to introduce a scoring system that classifies borderline breast lesion findings without altering the standard BI-RADS interpretation and minimizes inter-reader variability. METHODS This single-center retrospective cross-sectional study included 215 women who underwent breast ultrasound (US) and histopathology between January 2021 and December 2022, excluding those with non-neoplastic breast lesions. The index test was US BI-RADS features, and the reference standard was histopathology. Prevalence ratios (PRs) and probability scores were used to assess the risk contribution of individual US features. The diagnostic performance of the BI-RADS interpretation strategy and predictive scoring model was compared with that of the standard BI-RADS classification using SPSS software version 26. RESULTS Margin, orientation, and age had the highest PRs of malignancy, with odds ratios and 95% confidence intervals of 39.86 (13.19–120.47), 17.47 (2.42–125.72), and 9.74 (3.51–27.04), respectively. These three characteristics increased the probability of malignancy by 99.53%. A comparison of diagnostic tests between the modified BI-RADS interpretation strategy and the standard BI-RADS classification revealed improvements in specificity (94.0% versus 84.7%), positive predictive value (85.0% versus 70.5%), accuracy (89.3% versus 84.7%), and area under the curve (0.931 versus 0.873). CONCLUSIONS According to the interpretation strategy, margin, orientation, and age, this US scoring model appear to be promising tools for classifying borderline malignant masses.
Young editorial members and the future of medical journal Suryaningrat, Windu Cahyaningrum Handayani Notonagoro
Medical Journal of Indonesia Vol. 35 No. 1 (2026): March
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.ed.268703

Abstract

[No abstract available]
Front & Back Matter of Indonesia, Medical Journal
Medical Journal of Indonesia Vol. 35 No. 1 (2026): March
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

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