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Masruri
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The Journal of Pure and Applied Chemistry Research
Published by Universitas Brawijaya
ISSN : 23024690     EISSN : 25410733     DOI : http://dx.doi.org/10.21776/ub.jpacr
Core Subject : Health, Science, Engineering,
Chemical Engineering, Chemistry & Bioengineering Chemistry Materials Science & Nanotechnology Medicine & Pharmacology
The Journal of Pure and Applied Chemistry Research focuses in publishing research articles in the field of Chemistry and Applied Chemistry. The target is in exploring, investigating, and developing chemicals sources from local and/or Indonesian to increase the value. Scope of the journal is organic chemistry, analytical chemistry, inorganic chemistry, biochemistry, and physical chemistry. Included the topic also organic chemistry natural product, theoretical and computational chemistry.
Arjuna Subject : Kimia(semua kategori) - Kimia (Lain-Lain)
Articles 4 Documents
 1 
Search results for , issue "Vol 4, No 3 (2015)" : 4 Documents clear
Effect of Dexamethasone Administration toward Hematopoietic Stem Cells and Blood Progenitor Cells Expression on BALB/c Mice Wira Eka Putra; Aris Soewondo; Muhaimin Rifa'i
The Journal of Pure and Applied Chemistry Research Vol 4, No 3 (2015)
Publisher : Chemistry Department, The University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (815.457 KB) | DOI: 10.21776/ub.jpacr.2015.004.03.221

Abstract

Hematopoiesis play important roles on maintaining body homeostasis. Dexamethasone (Dex) known as synthetic glucocorticoids and widely affect many regulations i.e. immune system, inflammation, reproduction and all aspects of metabolism. Generally Dex were used as therapeutic agentsto ameliorate many kind of diseases including cancer and auto-immune diseases. The aims of this research were to investigate the effect of Dex administration toward expression of hematopoietic stem cells and blood progenitor cells. Two weeks old BALB/c mice were used and treated with 3 groups of Dex administration i.e. untreated-mice, 0.5 mg/kg BW, and 10 mg/kg BW. Mice were sacrificed on day-7 after administration of Dex. The bone marrow stromal cells were isolated, then followed by flow cytometry analysis. The result showed that, Dex administration with dose 0.5 mg/kg BW significantly increase the expression of hematopoietic stem cells, CD34+, chemokines, SDF-1+, erythroid progenitor cells, Gr-1-TER-119+, granulocytes, Gr-1+, and B progenitor cells, B220+.
The Ability of Benzoic Acid to Reduce Cr(VI) Heavy Metal Content in Aqueous Solution Anugrah Windy Mustikarini; Barlah Rumhayati; Candrawati Cahyani
The Journal of Pure and Applied Chemistry Research Vol 4, No 3 (2015)
Publisher : Chemistry Department, The University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (612.167 KB) | DOI: 10.21776/ub.jpacr.2015.004.03.172

Abstract

Chromium (VI) is an ionic heavy metal which has to be handled properly when dissolved in water due to its toxicity, corosive, carsinogenic activity.. According to the State Minister for Population and Environment’s regulation, the quality standards  of waste water,  which is allowed to be discharge on surface water contains Cr(VI) is 0.05-1 mg/L. This research used benzoic acid which is a kind of organic acid to reduce Cr(VI) content in water. Benzoic acid has an active carboxyl group which interact this metal. This paper, the elimination of Cr(VI) using benzoic acid is undertaken through pH adjustment by regulating with phosphoric acid. The result showed the best condition to reducing Cr(VI) content 41.99% when 400 ppm of benzoic acid and pH 7 was applied, respectively.
Naturally Abundance Vanillin as Starting Material to Synthesizing 4-(4-Hydroxy-3-methoxyphenyl)-6-methyl-3,4-dihydropyrimidin-2(1H)-one Masruri MASRURI; Yuga Adi Pranata
The Journal of Pure and Applied Chemistry Research Vol 4, No 3 (2015)
Publisher : Chemistry Department, The University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (767.668 KB) | DOI: 10.21776/ub.jpacr.2015.004.03.216

Abstract

Indonesia is the second biggest producer of natural vanillin. Traditionally it was isolated from the bean of vanilla (Vanilla planifolia Andrews). This paper reports on applying vanillin as starting material for synthesizing a biologically important chemical structure 3,4-dihydropyrimidinone. The reaction was undertaken in one step following multi component reaction (MCR). Products determination was undergone using FTIR and UV-Vis spectrophotometry, and also liquid chromatography-mass spectrometry (LCMS). After purification under flash column chromatography in ethyl acetate-hexane, it was found a white solid of 4-(4-hydroxy-3-methoxyphenyl)-6-methyl-3,4-dihydropyrimidin-2(1H)-one in 67% yield with a few amount of an unreacted vanillin.
Anti-Implantation Activity of Kepel (Stelechocarpus burahol) Pulp Ethanol Extract in Female Mice Suparmi Suparmi; Israhnanto Isradji; Iwang Yusuf; Dina Fatmawati; Idiah Hapsari Ratnaningrum; Shamrotul Fuadiyah; Indra Indra Wahyuni1; Dini Amelia Rahmah
The Journal of Pure and Applied Chemistry Research Vol 4, No 3 (2015)
Publisher : Chemistry Department, The University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jpacr.2015.004.03.220

Abstract

Kepel (Stelechocarpus burahol) has been used as a contraceptive remedy in Indonesia traditional Javanese royal family. It fruit contains a toxic substances to fetus. However, few studies have been conducted on the toxic effect of kepel fruit. This paper is disclosed the effect of kepel’s fruit extract on the percentage of fetus death, ovaries weight, and endometrial thickness in female mice. This study applied a post-test control group design. A 28 female of mice were divided into 4 groups. Group I (control), II, III, and IV were groups treated with kepel pulp extract using dosage 0.65, 1.30, and 3.60 mg/kg body weight (BB). The extract was dissolved in DMSO and given in 1.0 mL/mouse. The result gives implantation numbers of each group I-VI were 5.60±1.14; 6.20±1.64; 7.60±1.51; and 8.00±1.58, respectively. The percentages of fetus death 0.00%±0.00; 48.89%±22.78; 35.83%±25.27; and 30.87%±23.01 and fetus re-sorption in all groups were recorded as 0.00±0.00. Moreover, the ovaries weight of each groups I, II, III, and IV were recorded in 0.11±0.01; 0.08±0.01; 0.11±0.32; and 0.07±0.02 g, respectively. In addition, endometrial thickness were calculated as 584.86; 841.68; 659.72; and 624.10 µm. The anova test showed that insignificant difference for ovaries weight and endometrial thickness both for control and treated groups. Conversely, the LSD test showed the percentage of fetus death has a significant difference between control and treatment groups. These result suggest that kepel pulp ethanol extract has potency for anti-implantation.

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