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The Journal of Pure and Applied Chemistry Research
Published by Universitas Brawijaya
ISSN : 23024690     EISSN : 25410733     DOI : http://dx.doi.org/10.21776/ub.jpacr
Core Subject : Health, Science, Engineering,
Chemical Engineering, Chemistry & Bioengineering Chemistry Materials Science & Nanotechnology Medicine & Pharmacology
The Journal of Pure and Applied Chemistry Research focuses in publishing research articles in the field of Chemistry and Applied Chemistry. The target is in exploring, investigating, and developing chemicals sources from local and/or Indonesian to increase the value. Scope of the journal is organic chemistry, analytical chemistry, inorganic chemistry, biochemistry, and physical chemistry. Included the topic also organic chemistry natural product, theoretical and computational chemistry.
Arjuna Subject : Kimia(semua kategori) - Kimia (Lain-Lain)
Articles 313 Documents
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Crystal Structure and Microstructural Growth of Gd(III)benzenetricarboxylic Metal Organic Framework (MOF) Under Facile Sonochemical Synthesis Aini, Nur; Navidatul Rochmatul Mi’roj
The Journal of Pure and Applied Chemistry Research Vol. 15 No. 1 (2026): Edition January-April 2026
Publisher : Chemistry Department, The University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jpacr.2026.015.01.7955

Abstract

Gadolinium is one of the rare earth elements which has high magnetic susceptibility due to its 7 unpaired 4f electrons (8 µB). This magnetic susceptibility can induce both T1 and T2 relaxation in tissue where Gd substance accumulated, therefore can affect the signal of Magnetic Resonance Imaging. Gadolinium-Based Contrast Agent (GBCA) is structurally based on a complex compound formed between Gd(III) ion and certain organic ligand such as carboxylic ligand. 1,3,5-benzenetricarboxylic acid (H3BTC) ligand is one of the multicarboxylate ligands that has the potential to form GBCA through complex-based Metal Organic Framework (MOF). Gd-BTC complexes has been successfully synthesized using facile synthesis method of ultrasound wave irradiation at considerably facile time synthesis at 15, 30, and 45 minutes. The yield of white compound increases with an increase of synthesis time. The XRD powder analysis shows that the Gd-BTC complex is crystallized in a tetragonal crystal system with space group P4122. The degree of crystallinity of the obtained Gd-BTC complexes decreased as the synthesis time increased, while the crystal size increased proportionally to the synthesis time. SEM characterization displays the microrod-like morphology with various particle sizes correspond to the time ofsynthesis. Both the length and the width of the particles obtained from each complex tend to decrease along with the prolongation of synthesis time.
Development of a Renewable Keratin-Based Adsorbent from Chicken Feather Waste for Cu(II), Zn(II), and Cd(II) Removal Darjito; Ani Mulyasuryani; R. T. Tjahjanto; L.S.P. Sinambela; Yunir Ponco Prananto
The Journal of Pure and Applied Chemistry Research Vol. 15 No. 1 (2026): Edition January-April 2026
Publisher : Chemistry Department, The University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jpacr.2026.015.01.7961

Abstract

Development of keratin as an alternative of renewable adsorbent for metal ions is reported here. The keratin was isolated from sulfitolysis chicken feather waste using several concentrations of sodium sulfide. The isolated keratin was characterised by FTIR, SEM-EDX, and TGA. A batch-adsorption study of M(II) metal ions (M = Cd, Cu, Zn) in aqueous solutions was performed in various solution pH and contact time. Determination of the adsorption capacity of keratin toward each M(II) ions was performed at the optimum pH and contact time. This study reveals that the keratin was optimally obtained using sodium sulfide concentration of 2.0 M in a 49.89% yield. Batch-adsorption of M(II) ions (M = Cu, Zn, Cd) by the isolated keratin reaches optimum condition at pH 5 and contact time of 30 minutes for the Cu(II) and Cd(II) ions, and at pH 4 and contact time of 90 minutes for Zn(II) ion. Adsorption capacities of the synthesized keratin for Cu(II), Cd(II), and Zn(II) ions were (142.680 ± 2.307) mg/g, (151.318 ± 1.145) mg/g, and (156.803 ± 0.657) mg/g, respectively. Ongoing research on keratin functionalization is ongoing to enhance these adsorption capacities.
Molecular Dynamics Simulation of Heparin 8 and 12 Saccharides With 2S Sulfation Pattern and 1C4 Iduronate Conformation To FGF2-FGFR1 Ternary Complex As Environmentally Friendly Anticancer Drug Candidate Discovery Barroroh, Himmatul; Mazyadi, Muhammad; Hakim, Lukman; Safitri, Anna; Widodo, Widodo
The Journal of Pure and Applied Chemistry Research Vol. 15 No. 1 (2026): Edition January-April 2026
Publisher : Chemistry Department, The University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jpacr.2025.015.01.8000

Abstract

Heparin is a linear polysaccharide composed of repeating 1–4 linked units of iduronic acid and glucosamine and is widely used as an anticoagulant drug. This paper reports characteristics of three-dimensional structural changes and stability of the FGF2–FGFR1 ternary complex in the presence of heparin 8- and 12-saccharide fragments with a 2S sulfation pattern and ^1C₄ iduronate conformation using in silico approach. Study was performed using molecular docking followed by 100 ns molecular dynamics (MD) simulations. Heparin 8- and 12-saccharide ligands were docked to the FGF2–FGFR1 ternary complex, then was evaluated by MD using GROMACS to monitor backbone root mean square deviation (RMSD), residue root means square fluctuation (RMSF), and key residue interactions over time. Docking suggested a more favorable initial binding energy for the 8-saccharide ligand, whereas MD revealed that the 12-saccharide ligand more effectively maintained stable interactions between FGF2 and FGFR1, as indicated by lower backbone RMSD at the end of the simulation and more persistent contacts at basic residues in the heparin-binding sites of both proteins. These dynamic stability features provide a mechanistic explanation for previously reported in vitro findings, showing that 12-saccharide 2S heparin fragments exert stronger FGF2-dependent antiangiogenic and anticancer effects than shorter fragments, thereby supporting their potential as environmentally friendly anticancer drug candidates.

Page 32 of 32 | Total Record : 313

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