cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Masruri
Contact Email
masruri@ub.ac.id
Phone
+62341-575838
Journal Mail Official
jpacr@ub.ac.id
Editorial Address
Departemen Kimia, Fakultas MIPA, Universitas Brawijaya, Jl. Veteran 65145 Malang
Location
Kota malang,
Jawa timur
INDONESIA
The Journal of Pure and Applied Chemistry Research
Published by Universitas Brawijaya
ISSN : 23024690     EISSN : 25410733     DOI : http://dx.doi.org/10.21776/ub.jpacr
Core Subject : Health, Science, Engineering,
Chemical Engineering, Chemistry & Bioengineering Chemistry Materials Science & Nanotechnology Medicine & Pharmacology
The Journal of Pure and Applied Chemistry Research focuses in publishing research articles in the field of Chemistry and Applied Chemistry. The target is in exploring, investigating, and developing chemicals sources from local and/or Indonesian to increase the value. Scope of the journal is organic chemistry, analytical chemistry, inorganic chemistry, biochemistry, and physical chemistry. Included the topic also organic chemistry natural product, theoretical and computational chemistry.
Arjuna Subject : Kimia(semua kategori) - Kimia (Lain-Lain)
Articles 306 Documents
 27   28   29   30   31 
Analysis of Total Phenolic Content and Antibacterial Activity of Black Pomegranate Peel (Punica granatum L.) as an Antibiotic Agent Innovation Allinha Yusfin Innaya; Majida Ramadhan; Syauqi, Ahmad
The Journal of Pure and Applied Chemistry Research Vol. 14 No. 1 (2025): Edition January-April 2025
Publisher : Chemistry Department, The University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jpacr.2025.014.01.7927

Abstract

Pomegranate is one of the most potential natural resources due to its various compounds, especially in black pomegranate skin. Pomegranate peels are often considered as unusable residue. However, black pomegranate peels have high potential phenolic content and antibacterial properties than other types of pomegranates. This study aims to analyze the total phenolic content and test the antibacterial activity of black pomegranate peel as an antibiotic agent. The method used on the total phenolic content is Folin-Ciocalteau method with UV-VIS Spectrophotometer. Meanwhile, the antibacterial activity test was carried out by the diffusion method with MHA and MHB media against Gram-Positive and Gram-Negative bacteria, namely Eschericia coli and Staphylococcus aureus and positive control using apmhicilin and chloramphenicol. Bacteria were streaked on sterile solid media using sterile cotton buds. The results obtained on the total phenolic content of black pomegranate skin resulted in 90.89 μg GAE/mL sample. Meanwhile, the antibacterial properties obtained the largest diameter of the inhibition zone on Eschericia coli and Staphylococcus aureus respectively, namely 23.4 ± 0.19 and 21.7 ± 0.35 mm. The results showed that black pomegranate peel contributes significantly to environmentally friendly antibacterial properties and can be an innovation in antibiotic development. These findings, open up new opportunities in the formulation of natural antibiotic products that are effective and safe for humans.
The Effect of Surfactant on the Characteristics of Curcumin-Loaded Nanostructured Lipid Carriers: Fluorescence and Stability Study Mega Nurul Madania; Zubaidah Ningsih; Anastasia Fitria Devi; Diah Mardiana; Ulfa Andayani
The Journal of Pure and Applied Chemistry Research Vol. 14 No. 1 (2025): Edition January-April 2025
Publisher : Chemistry Department, The University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jpacr.2025.014.01.7933

Abstract

Curcumin, a bioactive compound derived from Curcuma longa, offers significant pharmacological benefits such as antioxidant, anti-inflammatory, and anticancer properties. However, its therapeutic application is restricted due to poor water solubility, low systemic bioavailability, and limited skin penetration. This study explores the use of Nanostructured Lipid Carriers (NLCs) as a drug delivery system to improve curcumin's stability and permeability. Two formulations were developed: NLC-KUR-T80, which encapsulates curcumin using the non-ionic surfactant Tween 80, and NLC-KUR-CTAB, which uses the cationic surfactant CTAB. Both formulations were prepared using the Phase Inversion Temperature (PIT) method and characterized for particle size, polydispersity index (PI), zeta potential, encapsulation efficiency (EE%), and fluorescence properties. Results revealed that CUR-NLC-CTAB exhibited a larger particle size (1410 ± 183 nm), higher zeta potential (78.70 ± 0.67 mV), and significantly better encapsulation efficiency (27.33 ± 3.33%) compared to CUR-NLC-T80. Fluorescence studies demonstrated that curcumin within NLC-CTAB had enhanced fluorescence intensity, indicating better stability and distribution within the lipid matrix.
Design, Synthesis, and In Silico Study of Two N-Substituted Pyrazinamide Analogs as Potential Antituberculosis Agents Zulqurnain, Muhammad; Wati, First Ambar; Nurjanah, Ana; Kavin, Layli Adha Nadira; Afifah, Rizqi Nur; Suyatno; Santoso, Mardi
The Journal of Pure and Applied Chemistry Research Vol. 14 No. 1 (2025): Edition January-April 2025
Publisher : Chemistry Department, The University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jpacr.2025.014.01.7939

Abstract

Tuberculosis (TB) is an infectious yet often overlooked disease that remains a significant global challenge. Pyrazinamide (PZA), a key drug in the first-line TB treatment regimen, is used to reduce the duration of therapy, making it a compound of great interest for further exploration. Two pyrazine-2-carboxamide analogs have been successfully synthesized and reported, followed by an in-silico evaluation of their potency as antituberculosis agents. Yamaguchi reagent was employed as a coupling agent between pyrazine-2-carboxylic acid and corresponding amine, yielding N-(cyclohexylmethyl) pyrazine-2-carboxamide (D) and N-(4-cyclooctyl) pyrazine-2-carboxamide (E) in 60% and 55%, respectively. The molecular docking analysis of compounds (D) and (E) demonstrated lower binding energies (-7.65 and -7.37 kcal/mol, respectively), in comparison with the standard TB drugs, pyrazinamide and isoniazid. Additionally, ADME and pharmacokinetics evaluations revealed that compounds (D) and (E) meet the essential criteria for oral drug candidacy. These findings suggest that the pyrazinamide analogs (D) and (E) hold significant potential as promising antimycobacterial agents for tuberculosis therapy.
Utilization of Nanosilver as An Antifungal To Commercialize Nanomaterial Preservatives Taufikurohmah, Titik; Nabila, Awiddah Zuhroh; Dewi, Arfinda Mulya; Puspitasari, Putri Amalia; Safitri, Elys
The Journal of Pure and Applied Chemistry Research Vol. 14 No. 2 (2025): Edition May-August 2025
Publisher : Chemistry Department, The University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/

Abstract

Nanosilver is a silver-based material with a particle size of less than 100 nm. This study aimed to evaluate the antifungal ability of nanosilver used in a preservative in cosmetic and beverage preparations. The synthesis of nanosilver in this study produced particle with a spherical morphology and sizes ranging from 5-46 nm, with an average size of 28.33 nm and demonstrated good stability. Antifungal tests were in this study were carried out on cosmetic and beverage preparations, namely body lotion, serum, lip balm, and mangrove fruit (Sonneratia caseolaris) syrup. In the body lotion, the percentage of fungi in F0, F1, F2, F3, and F4 was 32.6%, 7.8%, 16.6%, 12.8%, and 11.4%, respectively. In serum samples, the percentage of fungial growth in F0, F1, F2, F3, and F4 was 24.6%, 10.6%, 17.4%, 15.6%, and 12.4%. In lip balm samples, the corresponding values were 30.2%, 5%, 22.6%, 18.2%, and 10.8%. In the mangrove fruit syrup sample, the percentages were 29%, 8.6%, 17%, 14.6%, and 12.2%. From these results, nanosilver at the highest percentage (15%), was unable to defeat the antifungal effectiveness of conventional preservatives.
Analyzing Curcumin Content using UV-Vis Spectrophotometry and TLC-Densitometry Methods: A Case Study in Curcuma Capsule Commercial Products Rakhmawati, Rita; Anastacia, Laura; Hadi, Saptono
The Journal of Pure and Applied Chemistry Research Vol. 14 No. 2 (2025): Edition May-August 2025
Publisher : Chemistry Department, The University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/

Abstract

Curcuma is a genus of plants commonly used in herbal medicine due to its benefits, primarily from the active compound curcumin. Accurate analytical methods are necessary to identify and quantify curcumin for quality control, especially in small-scale industries. This study compares spectrophotometry UV-visible and TLC-densitometry methods for analyzing Curcuma capsules from PT Rachmasari Group, a small-scale traditional medicine industry (UKOT) in Sukoharjo. The methods were evaluated based on linearity, LOD, LOQ, repeatability, intermediate precision, and accuracy. TLC-densitometry used a mobile phase of chloroform: methanol (95:5 v/v) and silica plates F254, while spectrophotometry used ethanol as the solvent. Both methods used a wavelength of 420 nm. Spectrophotometry showed better linearity (r2 = 0.9985) than TLC (r2 = 0.9847), while TLC-densitometry demonstrated higher sensitivity with lower LOD and LOQ values (1.2853 and 4.2845 μg/mL) compared to spectrophotometry (13.9261 and 46.4203 μg/mL). UV-Visible spectrophotometry exhibited superior repeatability (0.33 ± 0.02%) and intermediate precision (0.34 ± 0.01%) than TLC (1.86 ± 0.12% and 1.02 ± 0.88%). Accuracy ranged from 98.45–105.90% for spectrophotometry and 98.81–115.82% for TLC-densitometry. In conclusion, UV-Visible spectrophotometry is more precise, linear, and reliable overall, making it more suitable for curcumin quality control in small-scale herbal product industries.
Impact of Thermal Properties on the Swelling Behavior of Polymer Composites Reinforced with Silica Xerogel Fauziyah, Nur Aini; Fina Nidha Ulmu Fidha; Meiska Diah Kusumawardani; Putri Catur Kusumaningtyas; Primasari Cahya Wardhani; Dyah Suci Perwitasari
The Journal of Pure and Applied Chemistry Research Vol. 14 No. 2 (2025): Edition May-August 2025
Publisher : Chemistry Department, The University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/

Abstract

This study investigates the swelling behavior and thermomechanical properties of polyethylene glycol (PEG) and silica xerogel composites using Dynamic Mechanical Analysis (DMA) and Differential Scanning Calorimetry (DSC). The composites were synthesized via a hydrothermal method and prepared by wet mixing PEG with silica xerogel. The analysis revealed that the interaction between PEG and silica xerogel significantly affects both the thermal and morphological properties of the composites. DSC data showed a shift in the glass transition temperature (Tg) and an earlier onset of thermal degradation in the PEG-Silica Xerogel 10 wt.% composite (P-SX10), indicating increased molecular mobility and reduced matrix stability. Notably, the swelling behavior was strongly influenced by temperature: as the temperature increased, the composites exhibited greater expansion and surface degradation, particularly in PEG-rich systems. This thermal sensitivity is attributed to the loosening of polymer–filler interactions and the partial debonding of matrix structures. The findings suggest that both composite composition and thermal exposure play critical roles in determining swelling characteristics and long-term structural integrity. 
Characterization of Ca-Alginate-Gelatin Waste Beads Salistya, Sarahita Dinda; Ellya Indahyanti; Diah Mardiana; Zubaidah Ningsih
The Journal of Pure and Applied Chemistry Research Vol. 14 No. 2 (2025): Edition May-August 2025
Publisher : Chemistry Department, The University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/

Abstract

The rapid growth of industry in Indonesia is partly driven by the emergence of new sectors such as the pharmaceutical industry. This sector has experienced a surge in the production of various types of medical capsules, with shells made from gelatin, colorants, and other components. As capsule production increases, so does the amount of gelatin waste was generated. In this study, beads were manufactured using an extrusion technique with 0.1 M CaCl2 to induce cross-linking. The ratio of alginate to gelatin waste was varied to determine the stability of the beads. The stability of the beads was observed over seven days, and the optimal composition was found to be 1:1. From the results of the TGA/DTA characterization, thermal analysis revealed that the combination of gelatin waste and sodium alginate improved its material properties. SEM results show that the Ca-Alginate-Gelatin waste beads contained alginate network, resulting in a porous structure and amorphous shape. Based on these finding, the beads produced have the potential to serve as adsorbents for use in slowed release fertilizers.
Nutritional Analysis of Starfruit-based Nata: Macronutrient composition and Potential as Functional Food Juwita, Ratna; Manggara, algafari Bakti; Rahmi, Hanif Nabila; Wahyuni, Endang; Diva, Dhea Amalia Putri; Fadmasari, Alfrida Parma
The Journal of Pure and Applied Chemistry Research Vol. 14 No. 2 (2025): Edition May-August 2025
Publisher : Chemistry Department, The University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/

Abstract

Non-communicable diseases in the community are often linked to dietary factors. Consuming functional foods can help prevent these diseases. Functional foods can be categorized into three types: unmodified, modified, and prebiotic food. Nata is a fermented food that is rich of fiber, and able to act as a prebiotic. Starfruit (Averrhoa carambola) is a nutritious fruit with potential for various food products, but it is often underutilized. This study explores the possibility of making nata using starfruit, with variations in added liquid: coconut water, palm fruit water, a mixture of both, and mineral water. The macronutrient content (fiber, protein, and fat) of these nata variations was analyzed to assess their nutritional value. The results showed that nata made with coconut water exhibited the highest dietary fiber content (6.93%). Nata made with a combination of coconut water and palm fruit water has the highest protein content (0.48%), and nata made with palm fruit water has the lowest fat content (0.31%), respectively. This finding paves the way for further study in applicating starfruit based functional food products.
Synthesis of Zinc Oxide (ZnO) from Used Battery Waste as An Antibacterial Agent on Cotton Fabric Aryati, Nadya Putri; Fiadillah, Maulidia Fara; Lalus, Jelita Marista; Rahayu, Cindi Aulia; Rifa'i, Fitra Ahmad; Widiarti, Nuni
The Journal of Pure and Applied Chemistry Research Vol. 14 No. 2 (2025): Edition May-August 2025
Publisher : Chemistry Department, The University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/

Abstract

One of the heavy metals found in the metal coating industry waste is Zn, which can be used as a precursor to produce ZnO compounds. This study used the coprecipitation method to synthesize ZnO from used battery waste as an antibacterial agent for cotton fabric and cellulose fiber materials. The synthesized ZnO was characterized by its functional groups using FTIR, its crystal structure and size using XRD, and its surface morphology using SEM. The results of FTIR characterization were carried out at wave numbers of 400 - 4000 cm-1 and verified the presence of ZnO groups at wave numbers of 439 cm-1 and 442 cm-1. XRD characterization showed a hexagonal structure with a Zincite phase, and the crystallite sizes of X and Y batteries were 9.52 nm and 8.79 nm, respectively, with a composition consisting of 100% Zincite. SEM characterization of ZnO from X batteries at 1000x and 5000x magnifications showed more homogeneous particle sizes than Y batteries. The diameters of the inhibition zone on each ZnO synthesized from Y and X batteries were 11.8 mm and 9.7 mm, indicating moderate inhibition against S. aureus bacteria. The diameters of the inhibition zone on the cotton fabric samples coated with ZnO from Y and X batteries were 3.5 mm and 2.7 mm, respectively, indicating low inhibition against S. aureus bacteria. No inhibition zone was observed for the synthesized ZnO and the fabric samples coated with ZnO from Y and X batteries when tested against E. coli bacteria.
Development of High-SPF Sunscreen Cream Formulation Using Green Tea (Camellia sinensis L.) Extract Obtained via Combined Pulsed Electric Field and Microwave–Ultrasound Assisted Extraction (PEF-MUAE) Yulianti, Eny; Warsito; Akhmad Sabarudin; Bayyinatul Muchtarohmah; Titian Ajeng Wahyuningtyas; Okky Vara Velya
The Journal of Pure and Applied Chemistry Research Vol. 14 No. 2 (2025): Edition May-August 2025
Publisher : Chemistry Department, The University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/

Abstract

The tea plant (Camellia sinensis L.) is renowned for its medicinal benefits, largely attributed to its secondary metabolites, which demonstrate significant antioxidant potential. This study focused on evaluating the antioxidant activity of green tea extract and determining the Sun Protection Factor (SPF) of sunscreen formulations containing the extract. The green tea was extracted using a combined Pulsed Electric Field- Microwave-Ultrasonic Assisted Extraction (PEF-MUAE) with distilled water as the solvent. The obtained extract underwent phytochemical analysis and SPF assessment. Various sunscreen formulations were tested for washability, total phenolic content, antioxidant activity, and SPF. The antioxidant activity and total phenolic content of the cream were measured using UV-Vis spectrophotometry, while SPF values were determined with UV-DRS spectrophotometry. The first formulation (F0) consisted of only the cream base, made without green tea extract or TiO₂. The second formulation (F1) was made with TiO₂ but without the extract. The third formulation (F2) contained the extract without TiO₂. Finally, the last formulation (F3) included both green tea extract and TiO₂. The extraction method produced a yield of 38.8%, with all cream formulations exhibiting ease of washability. The antioxidant activity of F0, F1, F2, and F3 was measured at 30.977, 32.866, 34.661, and 28.172 ppm. The total phenolic content and SPF values for the various cream formulations (F0, F1, F2, and F3) were 156.506 ± 10.824, 266.391 ± 33.760, 604.978 ± 22.815, and 680.873 ± 25.881 mg GAE/g for total phenolics, and 14.647, 22.656, 55.136, and 62.935 for SPF values.

Page 30 of 31 | Total Record : 306

 27   28   29   30   31 

Filter by Year

2012 2025


Reset
Filter By Issues
All Issue Vol. 14 No. 3 (2025): Edition September-December 2025 Vol. 14 No. 2 (2025): Edition May-August 2025 Vol. 14 No. 1 (2025): Edition January-April 2025 Vol. 13 No. 3 (2024): Edition September-December 2024 Vol. 13 No. 2 (2024): Edition May-August 2024 Vol. 13 No. 1 (2024): Edition January-April 2024 Vol. 12 No. 3 (2023): September-December 2023 Vol 12, No 2 (2023): May-August 2023 Vol 12, No 1 (2023): Edition January-April 2023 Vol 11, No 3 (2022): Edition September-December 2022 Vol 11, No 2 (2022): Edition May-August 2022 Vol. 11 No. 2 (2022): Edition May-August 2022 Vol 11, No 1 (2022): Edition January-April 2022 Vol 10, No 3 (2021): Edition September-December 2021 Vol 10, No 2 (2021): Edition May-August 2021 Vol 10, No 1 (2021): Edition January-April 2021 Vol 9, No 3 (2020): Edition September-December 2020 Vol 9, No 2 (2020): Edition May-August 2020 Vol 9, No 1 (2020): Edition January-April 2020 Vol 8, No 3 (2019): Edition September-December 2019 Vol 8, No 2 (2019): Edition May-August 2019 Vol 8, No 1 (2019): Edition January-April 2019 Vol 7, No 3 (2018): Edition September-December 2018 Vol 7, No 2 (2018): Edition May-August 2018 Vol. 7 No. 2 (2018): Edition May-August 2018 Vol 7, No 1 (2018): Edition January-April 2018 Vol 6, No 3 (2017): Edition of September - December 2017 Vol 6, No 2 (2017): Edition of May-August 2017 Vol. 6 No. 2 (2017): Edition of May-August 2017 Vol 6, No 1 (2017): Edition of January - April 2017 Vol 5, No 3 (2016) Vol 5, No 2 (2016) Vol 5, No 1 (2016) Vol 4, No 3 (2015) Vol 4, No 2 (2015) Vol 4, No 1 (2015) Vol. 3 No. 3 (2014) Vol. 3 No. 2 (2014) Vol 3, No 2 (2014) Vol 3, No 1 (2014) Vol 2, No 3 (2013) Vol 2, No 2 (2013) Vol 2, No 2 (2013) Vol 2, No 1 (2013) Vol 1, No 1 (2012) Vol 1, No 1 (2012) More Issue