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INDONESIA
Jurnal Sains dan Teknologi Farmasi
Published by Universitas Andalas
ISSN : -     EISSN : -     DOI : -
Core Subject : Science, Education,
Computer Science & IT Education
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Articles 3 Documents
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Search results for , issue " Vol 15, No 1 (2010)" : 3 Documents clear
PENETAPAN KADAR FENOLAT TOTAL DAN UJI AKTIVITAS ANTIOKSIDAN EKSTRAK KULIT SEGAR BUAH MANGGIS (Garcinia mangostana Linn.) Zulharmita, Zulharmita; Prajuwita, Mia; Boestari, Agusri
Jurnal Sains dan Teknologi Farmasi Vol 15, No 1 (2010)
Publisher : Universitas Andalas

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Abstract

The determination of totally phenolic compounds in methanol extracted of cortex fruit of Garcinia manggostana Linn has been done by Folin-Ciocalteau method. The  antioxidant activity has been performed using 1,1-diphenyl-2-picrihydrazil (DPPH) as reagent, that measured spectrometrically  compared with gallic acid as antioxidant standard compound. The total phenolate compounds found in fresh peel of mangosteen was 1,64±0.18% w/w which calculated as gallic acid equivalence and the antioxidant activity with a value of IC50 was 251,12 µg. 
PENGARUH EKSTRAK ETANOL DAGING BEKICOT (Achantina fulica) TERHADAP KADAR KOLESTEROL TOTAL, HDL, DAN LDL SERUM DARAH TIKUS JANTAN GALUR WISTAR Widyaningsih, Wahyu; Prabowo, Aditya; Sumiasih, Sumiasih
Jurnal Sains dan Teknologi Farmasi Vol 15, No 1 (2010)
Publisher : Universitas Andalas

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Abstract

Cholesterol was a steroidal compounds contained in the human body. Cholesterol imbalance in the body caused hypercholesterol disease. Acharan sulfate is a compound found in snail body and potentially lowering cholesterol level. Acharan sulfate was extracted from snail body with maceration method using ethanol solvents. Research was done by using animals model, male rats (Rattus norwegicus) Wistar strain which was two months old and weighing 180 to 200 grams. The animals model were divided into six groups. One groups used as normal control. Five groups were treated with high cholesterol diet with suspense of cow fat and yellow egg for ten days. After that, three groups were treated with the ethanolic extract of snail body with doses of 40 mg/kgbw, 80 mg/kgbw, and 160 mg/kgbw. The two other groups were treated with Simvastatin and BR II feed (disease control). Total cholesterol, HDL and LDL concentrations were determined using enzymatic photometric test CHOD-PAP method. Results showed that snail body the ethenolic extract of decreased total cholesterol concentration by 6,33 mg/dl at doses 160 mg/kgbw and 4,90 mg/dl at doses 80 mg/kgbw. HDL concentration increased by 0,85 and 8,06 mg/dl respectively at doses 80 mg/kgbw and 160 mg/kgbw. LDL concentration decreased by 1.96 mg/dl, 2.22 mg/dl and 3.52 mg/dl respectively at doses 40, 80, and 160 mg/kgbw.
EFEK EKSTRAK ETANOL BIJI PINANG MUDA (Areca catechu L.) TERHADAP AKTIFITAS SISTEM SARAF PUSAT MENCIT PUTIH Arifin, Helmi; Riyono, Heppy; Elka, Elka
Jurnal Sains dan Teknologi Farmasi Vol 15, No 1 (2010)
Publisher : Universitas Andalas

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Abstract

The central nervous system stimulant activity of the ethanol extract of young areca nut (Areca catechu L.) has been studied on mice. The observation was done by assessing the indurance, motor activity, curiousity, sleeping induced time and sleeping time in many variable of doses. Results showed that the ethanolic extract of 500 mg/ Kg bodyweight dose showed significant effect (P<0,05).

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