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INDONESIA
Jurnal Sains dan Teknologi Farmasi
Published by Universitas Andalas
ISSN : -     EISSN : -     DOI : -
Core Subject : Science, Education,
Computer Science & IT Education
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Articles 16 Documents
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Search results for , issue " Vol 16 No 2 (2011)" : 16 Documents clear
Pengaruh Penggunaan Kombinasi Maltodekstrin De 5-10 dari Pati Beras (Oryza sativa) dengan Laktosa sebagai Pengisi Terhadap Kompresibilitas dan Komprimabilitas Tablet Ibuprofen Syofyan, Syofyan; Rosanih, Rosanih; Arsyadi, Arsyadi
Jurnal Sains dan Teknologi Farmasi Vol 16 No 2 (2011)
Publisher : Fakultas Farmasi Universitas Andalas

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Abstract

Has conducted research on the effect of the combined use of maltodextrin DE 5-10 of starch rice (Oryza sativa) with lactose as a filler to the compressibility and comprimability ibuprofen tablets. Mass properties of compressibility and comprimability examined and evaluated according to the quality of the tablet Indonesian pharmacopoeia. The results showed that the analysis using one-way ANOVA F calculation obtained 1,130 less than the value of 3.48 which means the F table did not show any difference between the formulas. It can be concluded that the difference in the levels of the combination of lactose-maltodextrin DE 5-10 of rice starch did not affect the value of compressibility and tablet dosage ibuprofen komprimabilitas.
Analisis Aspek Farmakokinetika Klinik Pasien Gagal Ginjal pada Irna Penyakit dalam RSUP Dr. M. Djamil Padang Lucida, Henny; Trisnawati, Riah; Suardi, Muslim
Jurnal Sains dan Teknologi Farmasi Vol 16 No 2 (2011)
Publisher : Fakultas Farmasi Universitas Andalas

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Abstract

A study on the evaluation of clinical pharmacokinetic aspect to in-patient with renal failure at internal Ward Dr. M. Djamil hospital Padang has been conducted. The aspect studied was dosage individualization bades on patient’s patophysiological condition. The study aimed at comparing the dosage regimen given to the renal failure patient with that calculated using pharmacokinetic equations. This study was observasionaly prospective by using cross-sectional method. In the period of June – September 2010, 48 renal failure patients includes in inclusion criterion. Results showed that medications which mainly renal excreted or potentially nephrotoxic given to patients are ciprofloxacin, digoxin, ranitidin, metformin, captopril, furosemide and hydrochlortiazide. Patients treated with those medications were evaluated in terms of dosage regimens and clinical response. There were 4 cases of higher dose than recommended included 1 of 8 cases of captopril use, 2 of 9 cases of ciprofloxacin use and 1 of case of metformin use. It uses also found that hydrochlortiazide which should be avoided to patients with Clcr < 30 ml/min (4 cases)
Pola Pengobatan pada Pasien Hipertensi dengan Diabetes Melitus Tipe 2 di RSUD Raden Mattaher Jambi Lestari, Uce; Darwin, Deswinar; S, Lusiana Estiana
Jurnal Sains dan Teknologi Farmasi Vol 16 No 2 (2011)
Publisher : Fakultas Farmasi Universitas Andalas

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Abstract

A Study on hypertension therapy with comorbidity of type II diabets mellitus at hospitalized patients of Internal Desease Ward Raden Mattaher Hospital Jambi descriptively by using prospective data has been conducted. Samples were taken by using cencus method from patients medical record from February to June 2011. Appropriatenes of drug use was evaluated based on criterions stated. Results showed that the most common an hypertension drugs used was captopril (55.33%) and anti-diabetic was reguler insulin (R1) (31.25%). The rationality of indication reched 97.10% of patients, medicine 100%, dosage 74.12%, dosage interval 80.65%, route of administration 100% and rational of time was 45.16%
Efek Antiinflamasi Fraksi Heksan dan Fraksi Etil Asetat Daun Alpokat (Persea Americana Mill.) pada Tikus (Rattus Norvegicus) Putih Jantan Yuslinda, Elka; Hasti, Sylfia; Wati, Erda
Jurnal Sains dan Teknologi Farmasi Vol 16 No 2 (2011)
Publisher : Fakultas Farmasi Universitas Andalas

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Abstract

Avocado (Persea Americana, Mill) has been used traditionally to cure disease but the effect has not proven scientificaly. This study reports the determination of anti inflammation effect of ethyl acetate fraction and hexane fraction of avocado leaves at various dose : 100, 200 and 400 mg/KgBW respectively. Inflammation was induced by using Paw edema method with induction of 1% carrageen 0,5 ml. Phenylbutazone at dose 9 mg/KgBW was used as positive control, while 1% sodium CMC given 1 hr before induction was used as negative control. The edema volume was determined at one hour interval for 5 hours, and percentage of inhibition was then calculated. Result indicated that the ethyl acetate and the hexane fractions of avocado leaves at doses 100, 200, and 400 mg/KgBW showed significant anti-inflammation effect (p<0.05). The best effect was given by the ethyl acetate fraction at dose 400 mg/KgBW.
Uji Aktivitas Sitotoksik Ekstrak dan Fraksi dari Spon Laut Petrosia Sp dengan Metoda Brine Shrimp Lethality Test Krisyanella, Krisyanella; Handayani, Dian; unance, Lendra Y
Jurnal Sains dan Teknologi Farmasi Vol 16 No 2 (2011)
Publisher : Fakultas Farmasi Universitas Andalas

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Abstract

Determination of cytotoxic activity of the extract and fraction of marine sponge Petrosia sp suing Brine Shrimp Lethality Test has been done. The Cytotoxic activity analysis was done toward methanol extract first, then continued to n-hexane, ethyl acetate and buthanol fractions respectively. The LC50 values were 70.736 ppm, 269.153 ppm, 197.38 ppm and 70.667 ppm respectively. Results showed that the extract and fraction of Petrosia sp potentially has cytotoxic activity whereas buthanol fraction has the higest citotoxic activity among at all. Phytochemistry screening for buthanol fraction contained terpenoid, steroid and saponin.
Pengaruh Pemberian Jus Wortel (Daucus Carota, Linn) Terhadap Kadar Glukosa Darah Mencit Putih Betina Saputra, Hendra; Dharma, Surya; Suharti, Netty
Jurnal Sains dan Teknologi Farmasi Vol 16 No 2 (2011)
Publisher : Fakultas Farmasi Universitas Andalas

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Abstract

A study of the effect of carrot juice (Daucus carota, Linn) on blood glucose levels in female white mice. This experiment used Advantage blood glucose meter (Roche) with enzymatic method. Length of treatment was for 21 days with a time of observation on day 7th, 14th and 21st. Carrot juice dose given was 0.52; 1.04 and 2.08 g/20 g BW. Results showed that the addition of carrot juice at all dose lower the blood glucose levels in mice significantly (P <0.05) after giving alloxan 3 mg/20 g body weight and glucose 195 mg/20 g BW.

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