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INDONESIA
Indonesian Journal of Pharmaceutical Science and Technology
Published by Universitas Padjadjaran
ISSN : 23561971     EISSN : 2406856X     DOI : -
Core Subject : Health, Science,
Computer Science & IT Medicine & Pharmacology
Jurnal Sains dan Teknologi Farmasi Indonesia (IJPST) adalah publikasi ilmiah pada seluruh aspek Sains dan Teknologi Farmasi. Jurnal ini diterbitkan 3 kali setahun untuk menyediakan forum bagi apoteker, dan profesional kesehatan lainnya untuk berbagi praktik terbaik, meningkatkan jaringan kerja dan pendekatan yang lebih kolaboratif dalam Sains dan Teknologi Farmasi.
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Articles 5 Documents
 1 
Search results for , issue "Vol 7, No 2 (2020)" : 5 Documents clear
Molecular Docking of Active Compounds Piper crocatum on the A-Glucosidase Enzyme as Antidiabetic Mustika Weni; Mega Safithri; Djarot Sasongko Hami Seno
Indonesian Journal of Pharmaceutical Science and Technology Vol 7, No 2 (2020)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v7i2.21120

Abstract

Ethanol extract of Piper crocatum leaves has inhibitory activity of α-glucosidase enzyme. Ethyl acetate fraction from Piper crocatum leaves has the highest antioxidant activity. Previous research has provided information that the ethyl acetate fraction of Piper crocatum leaves has an inhibition of α-glucosidase containing 6XO32ZSP1D, Ethyl L-serinate hydrochloride compound, Schisandrin B compound, Columbin compound, 4- (4-methoxy-phenylamino) -2 compound, 3-dihydro-1H-4a, 9-diazacyclopenta (b) fluorine-10-carbonitrile, compound 6-Amino-4- [3- (benzyloxy) phenyl] -3-tert-butyl-2,4-dihydropyrano [2, 3-c] pyrazole-5-carbonitrile, compound 4 - {{4.6-Bis [(3R, 5S) -3,5-diamino-1-piperydinyl] -1,3,5-triazine-2-yl} amino) benzenesulfonamide and compound 1.1 '- (1,4-butanediyl) bis {2,6-dimethyl-4 - [(3-methyl-1,3-benzothiazol-2 (3H) ylidene) methyl] pyridinium. This study aims to study the interaction between bioactive compounds contained in ethyl acetate fraction of Piper crocatum leaves with α-glucosidase enzyme in In Silico using AutoDock Vina, Columbin shows the lowest binding energy with binding sites with amino acids Ser240, Asp242, His280, Arg315, Glu411, Phe159, Arg442, Tyr158 and Phe303. Columbin has the stability and inhibits the α-glucosidase enzyme from S. cerevisiae better than the seven other compounds, because it has OH and CH3 groups which play a role in the interaction with around the active side of the α-glucosidase enzyme.Keywords: Columbin, In Silico, α-Glucosidase
Gastroprotective Effect of Green Algae Extract (Ulva lactuca L) on Gastric Rats Wahyu Widyaningsih; Siti Nurasih Afdaliah
Indonesian Journal of Pharmaceutical Science and Technology Vol 7, No 2 (2020)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v7i2.22416

Abstract

Gastric ulcer is a disease of the digestive tract characterized by mucous damage to secretion of gastric acid and pepsin. One of the potential gastroprotector plants is green algae. The purpose of this study was to examine the gastroprotective effect of ethanol extract of green algae (EEGH) Ulva lactuca L on the gastric of ethanol-induced rats. This study used 36 rats, divided into 6 groups. Group I is a normal group. Group II negative control, ethanol 96% induced. Group III positive control, given comparison of ranitidine dose of 15.75 mg/kgBW. Groups IV, V and VI were given multilevel EEGH, namely 125, 250 and 500 mg/kgBW. The treatment was carried out for 14 days, on the 14th day ethanol 96% was induced and then dissected. Research data on gastric ulcer index and protection ratio were analyzed using One Way ANOVA with a confidence level of 95%. The results of the EEGH statistical test dose of 500 mg/kgBW with negative controls showed a significant difference with p value of 0.013 (p<0.05). The EEGH 500 mg/kgBW has the ability as an effective gastroprotector, as seen from the gastric ulcer index value of 0.5 and the protection ratio of 78.94%.Keywords: Ethanol, gastroprotector, protection ratio, ulcer index, Ulva lactuca L.78,94%. 
Study of Physicochemical Characteristics of Kaolin from Belitung Regency Nurul Izzah Pasi; Marline Abdassah Bratadireja; Anis Yohana Chaerunnisa
Indonesian Journal of Pharmaceutical Science and Technology Vol 7, No 2 (2020)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v7i2.25675

Abstract

Kaolin is one of the abundant clay minerals on earth which has been widely used in various industries. kaolin as a raw material in drugs manufacturing must comply several requirements in Pharmacopoeia such as not exceeding the heavy metal content limits. In this study the analysis of heavy metal content (Pb, Sn, and As) was carried out on natural kaolin obtained from 3 different locations in Belitung regency. Testing of the brightness and particle size is also carried out to increase the value of kaolin as a pharmaceutical excipient. The highest recovery from kaolin was obtained in sample 3 which was 67.78%, while kaolin 1 and 2 which was 66.54, and 64.20%. Based on the results of heavy metal testing it is known that kaolin 1, 2, and 3 have a Pb content of 55.2, 0.0458 and 44.0 ppm, and As content of 1.05, 78.3, and 0.761 ppm. Whereas the Sn mean metal is only found in kaolin 2 which is 0.0034. White degree test results show that kaolin 1, 2 and 3 have a high brightness, namely 92.94%, 93.00%, 91.16%. From the results of particle size testing shows that all kaolin samples have size <2 μm.Keywords: Characterization of Minerals, Heavy Metals, Kaolin
Characterization of Imprinted Polymer of Diazepam With Methacrylic Acid and Hydroxyethyl Methacrylate Monomer in Chloroform for Selective Adsorption of Diazepam Michelle Ferdinand; Rimadani Pratiwi; Aliya Nur Hasanah
Indonesian Journal of Pharmaceutical Science and Technology Vol 7, No 2 (2020)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v7i2.26230

Abstract

Diazepam is a benzodiazepine class usage is regulated nationally or globally. These drugs can be used to regulate sleep patterns or sedative-hypnotic drugs because it has a calming effect. Monitoring the abuse of diazepam requires a sensitive analysis methods that required the preparation of selective methods. One of the methods that are currently developing is Moleculary Imprinted Polymer-Solid Phase Extraction (MI-SPE). In this research, step being performed include determination of the association constant, synthesis sorbent of Imprinted Polymer (IP) diazepam by bulkpolymerization method with diazepam as a template, chloroform as porogen, two kind of monomer methacrylic acid (MAA) and hydroxyethyl methacrylate (HEMA) as functional monomer. Templates extracted from polymer followed by evaluation of adsorption ability test, a test of capacity and selectivity of the polymer, and also the characterization of the IP using Fourier Transform Infra-Red (FTIR),and Scanning Electron Microscope (SEM). The results showed that IP diazepam with MAA monomer has 7.95 x 10-5 mg/g of capacity, it is better than capacity of IP diazepam monomer HEMA with 7.47x 10-6 mg/g. Selectivity of IP diazepam MAA monomer has an IF value which is 2.13, which is better than IP HEMA with 1.21. In addition, IP diazepam MAA monomer more heterogenous than its Non Imprinted Polymer (NIP).Keywords: Chloroform, Diazepam, HEMA, Methacrylic acid, MI-SPE.
Method Validation of Chloramphenicol Analysis in the Shrimp Based on Diazotization Reaction Abdul Wafi; Ganden Supriyanto; Tjitjik Srie Tjahjandarie
Indonesian Journal of Pharmaceutical Science and Technology Vol 7, No 2 (2020)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v7i2.26520

Abstract

A simple, rapid and precise spectrophotometric method has been developed and validated for the determination of Chloramphenicol (CAP) in the shrimp based on diazotization reaction at room temperature. The CAP was reduced by zinc powder and the diazotization reaction was carried out in the presence of NaNO2, bismuth nitrate pentahydrate as catalyst. The 2-napthol used as coupling agent to form a red-violet solution and the absorbance of azo dye solution was measured by UV-Vis spectrophotometer at 554 nm. The method validation parameters including linearity, accuracy, precision, limit of detection (LOD) and limit of quantification (LOQ) have been investigated. The correlation coefficient (R2) was 0.996 for concentration range 0.70 – 4.65 µg/mL. The LOD and LOQ were 0.36 µg/mL and 1.19 µg/mL. Accuracy and precision of the method were performed by spiking of CAP in the shrimp sample at concentration 1.16; 2.33; 3.49 µg/mL. Analysis result showed that the accuracy and precision of the method were 92.77-97.37 % and 0.21-2.39 % respectively.Keywords : Chloramphenicol, diazotization, shrimp, spectrophotometry, method validation.

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