cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Muchtaridi
Contact Email
ijpsteditor@gmail.com
Phone
-
Journal Mail Official
ijpsteditor@gmail.com
Editorial Address
-
Location
Kota bandung,
Jawa barat
INDONESIA
Indonesian Journal of Pharmaceutical Science and Technology
Published by Universitas Padjadjaran
ISSN : 23561971     EISSN : 2406856X     DOI : -
Core Subject : Health, Science,
Computer Science & IT Medicine & Pharmacology
Jurnal Sains dan Teknologi Farmasi Indonesia (IJPST) adalah publikasi ilmiah pada seluruh aspek Sains dan Teknologi Farmasi. Jurnal ini diterbitkan 3 kali setahun untuk menyediakan forum bagi apoteker, dan profesional kesehatan lainnya untuk berbagi praktik terbaik, meningkatkan jaringan kerja dan pendekatan yang lebih kolaboratif dalam Sains dan Teknologi Farmasi.
Arjuna Subject : -
Articles 5 Documents
 1 
Search results for , issue "Vol 8, No 1 (2021)" : 5 Documents clear
Molecular Docking Study of Anthocyanidin Compounds Against Epidermal Growth Factor Receptor (EGFR) as Anti-Lung Cancer Riska Prasetiawati; Meilia Suherman; Benny Permana; Rahmawati Rahmawati
Indonesian Journal of Pharmaceutical Science and Technology Vol 8, No 1 (2021)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v8i1.29872

Abstract

It is presumed that antiproliferative activity of anthocyanidin has interaction with Epidermal Growth Factor Receptor (EGFR) which has effect on lung cancer cell growth. This study aimed to observe the interaction between anthocyanidin and EGFR and to find out prediction, absorption, distribution activities as well as anthocyanidin toxicity compared to Gefitinib, an EGFR inhibitor. All test compounds were optimized with Autodock Tools®, then molecular docking simulations and predictions of absorption, distribution and toxicity were carried out. Malvidin was stated to meet the Lipinski's Rule of Five, indicating good bioavailability. Result of molecular docking simulation showed that malvidin had better affinity against EGFR than Gefitinib. Molecular docking visualization result showed that malvidin had interaction with amino acid residue such as Met793, Gln791, Leu718, Thr854, Asp855 and Lys745. Absorption and distribution predictions included percentage scores of Human Intestinal Absorption (HIA), human colon adenocarcinoma (Caco-2), and Plasma Protein Binding. Toxicity test revealed that malvidin was mutagenic compound but not carcinogenic one. The findings indicated that malvidin was potential to be an anti lung cancer candidate through EGFR inhibition.Keywords: Antiproliferative, Anthocyanidin, Epidermal Growth Factor Receptor, Molecular Docking
Antiviral Activity and Toxicity Prediction of Compounds Contained in Figs (Ficus carica L.) by In Silico Method Sophi Damayanti; Khonsa Khonsa; Tasia Amelia
Indonesian Journal of Pharmaceutical Science and Technology Vol 8, No 1 (2021)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v8i1.29868

Abstract

Viral infection is a global health problem that can cause endemic to pandemic. Compounds delivered from plants has been developed as an alternative antiviral agent. One of the plants that can be used as antiviral therapy is Ficus carica L. (figs). The aim of this research is to predict the inhibitory activity and toxicity of compounds contained in figs as an antiviral for HIV-1 using in silico method. Compounds were docked to the HIV-1 Reverse Transcriptase protein (PDB ID: 3LAL). Threedimentional structures were modeled using GaussView and optimized using Gaussian 09W. Optimized compounds were docked to the target protein using AutoDock Tools and the interaction to protein binding side were analyzed in comparison with the standard compounds. The standard compound used for the analysis nevirapine, efavirenz, and doravirine. The compound toxicity was analyzed using ECOSAR and Toxtree. Based on the results, the compounds that has similar interaction to the standard compounds were campesterol which has 4 similar hydrophobic interactions. Based on the classification of Cramer Rules for toxicity test, campesterol are classified in class 3 (high toxicity) and according to the Benigni/Bossa Rulebase classification, campesterol are negative for genotoxic and nongenotoxic carcinogenicity.Keywords: Antivirus, HIV, figs, molecular docking, toxicity
In Silico Study of Compounds Contained in Hemigraphis alternata Leaves against 5-LOX for Anti-Inflammatory Yeni Yeni; Rizky Rachmania; Mochamad D. Yanuar
Indonesian Journal of Pharmaceutical Science and Technology Vol 8, No 1 (2021)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v8i1.29869

Abstract

Inflammation is a self-protection response to begin the healing process. One of the anti-inflammatory targets worth developing is lipoxygenase inhibitors, which have been studied for several diseases, including severe airways disease. The aim of this study was to predict the affinity of 23 compounds that contained in Hemigraphis alternata leaves against 5-lipoxygenase (5-LOX). The compounds of Hemigraphis alternata leaves were screened for its affinity againts 5-LOX using docking software, DOCK 6.9, with zileuton as the comparator. Based on the grid score, most of the 23 of Hemigraphis alternata leaves compounds showed a higher affinity towards 5-LOX compare to zileuton. The highest affinity was shown by n-hexadecanoid acid. The study showed that Hemigraphis alternata leaves contains potential active components that could be developed as 5-LOX-inhibitor.Keywords: In silico, Hemigraphis alternata, lipoxygenase, anti-inflammatory
Formulation and Physical Evaluation of Edible Film Dosage from Ethanol Extract of Betel Leaves (Piper betle L) for Canker Sore Drugs Yenni Puspita Tanjung; Andi Ika Julianti; Aghnia Wulan Rizkiyani
Indonesian Journal of Pharmaceutical Science and Technology Vol 8, No 1 (2021)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v8i1.29225

Abstract

Canker sore which in medical terms is called aphthous stomatitis is a wound in the mouth that can cause pain and discomfort. Piper betel leaf can be used for strengthening the teeth, cure canker sores, treat the bad breath and stop the gum from bleeding. The research aimed to determine the edible film formula of betel leaf ethanol extract that met the physical evaluation requirements and to determine the effect of variation concentration of sorbitol and HPMC (Hydroxypropyl methylcellulose) on the physical evaluation. Edible film preparation from betel leaf extract is a thin layer made from the basic ingredients of corn starch, sorbitol, and HPMC. In this research, 3 edible film formulas were made with variations in the concentration of sorbitol and HPMC, namely: F1 (5%;5%), F2 (4%;4%), F3 (3%;3%). Data of evaluation results were analyzed statistics by Kruskal wallis method. The results showed that F1, F2 and F3 meet the physical evaluation requirements for edible film dosage. Variations in the concentration of sorbitol and HPMC gave different results significantly influence (p<0.05) on weight uniformity, film thickness, solubility and dissolution time, and did not significantly influence (p>0.05) on the organoleptic test, fragility of edible film, water resistance (swelling) and moisture content.Keywords: Betel leaf extract, edible film, HPMC, canker sore, sorbitol 
The Effect of Chilli Extract on Gastroprotective Function in Male Tahyatul Bariroh; Siska Siska
Indonesian Journal of Pharmaceutical Science and Technology Vol 8, No 1 (2021)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v8i1.26988

Abstract

Chilli is one of plant from genus Capsicum and as vegetable commodities most consumed by the Indonesian people. Chilli contains a unique compound called capsaicin which gives a burning sensation like burning when consumed. This research aims to determine the effect of chilli extract on gastroprotection in the stomach of mice. The study used 35 white male rats were divided into seven groups, one group as the control group, and six groups were given extracts from three varieties of chilli (red chilli, green chilli, and chilli) with high doses (1 g / kg bb) and low doses (0.5 g / kg bb) for 14 days. On the 15th day, gastric decapitation and isolation were carried out to make histological preparations of the rat's stomach. The results showed mucosal tissue in the stomach of rats given a dose of 0.5 g/kg BW remained in normal condition compared to the group of rats given high doses of chilli. In this group, a lot of damage to the gastric mucosal tissue of rats (ulcers). This study concludes that consuming 0.5 g/kg BW chilli does not cause damage to the gastric mucosal tissue of rats.Keywords: Chilli, Gastric mucose, Gastroprotective

Page 1 of 1 | Total Record : 5

 1 

Filter by Year

2021 2021


Reset
Filter By Issues
All Issue Vol 12 (2025): Vol. 12 Suppl. 2 (2025) 2025: Vol. 12 Suppl. 1 (2025) Vol 12, No 3 (2025) Vol 12, No 2 (2025) Vol 12, No 1 (2025) 2024: Suppl. 6, no. 3 (The 3rd Mandala Waluya International Conference on Pharmaceutical Science and Vol 11, No 3 (2024) Vol 11, No 2 (2024) Vol 11, No 1 (2024) 2024: Suppl. 6, No. 2 (Universitas Halu Uleo Conference) 2024: Suppl. 6, No. 1 (Special Issue for Mulawarman Pharmaceutical Conference) Suppl. 5, No. 2 (2023) Special Issue for The 3rd Bandung International Teleconference on Pharmacy (B Vol 10, No 3 (2023) Vol 10, No 2 (2023) Vol 10, No 1 (2023) Suppl. 5, No. 1 (2023) Vol 9, No. 3, 2022 Vol 9, No. 2, 2022 Vol 9, No 1 (2022) Suppl. 4, No. 1 (2022) Vol 8, No 3 (2021) Vol 8, No 2 (2021) Vol 8, No 1 (2021) Suppl. 3, No. 1 (2021) Vol 7, No 3 (2020) Vol 7, No 2 (2020) Vol 7, No 1 (2020) Vol 6, No 3 (2019) Vol 6, No 2 (2019) Vol 6, No 1 (2019) Vol 6, No 1 (2019 In Press) Suppl. 2, No. 3 (2019) Suppl. 2, No. 2 (2019) Suppl. 2, No. 1 (2019) Vol 5, No 3 (2018) Vol 5, No 3 (2018) Vol 5, No 2 (2018) Vol 5, No 2 (2018) Vol 5, No 1 (2018) Vol 5, No 1 (2018) Suppl 1, No. 1 (2018) Suppl 1, No. 1 (2018) Vol 4, No 3 (2017) Vol 4, No 3 (2017) Vol 4, No 2 (2017) Vol 4, No 2 (2017) Vol 4, No 1 (2017) Vol 4, No 1 (2017) Supp 1, No 1 (2017) Supp 1, No 1 (2017) Vol 3, No 3 (2016) Vol 3, No 3 (2016) Vol 3, No 2 (2016) Vol 3, No 2 (2016) Vol 3, No 1 (2016) Vol 3, No 1 (2016) Vol 2, No 3 (2015) Vol 2, No 3 (2015) Vol 2, No 2 (2015) Vol 2, No 2 (2015) Vol 2, No 1 (2015) Vol 2, No 1 (2015) Vol 1, No 2 (2014) Vol 1, No 2 (2014) Vol 1, No 1 (2014) Vol 1, No 1 (2014) More Issue